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An eight-year-old girl has become the first person in the UK to have a transplant – and not need to take immunosuppressant drugs for the rest of her life.

Aditi Shankar, who has a rare genetic condition, has received both a new kidney and bone marrow from her mother, Divya.

Because she had a stem cell transplant, via the bone marrow, she was able to come off immunosuppressants a month after receiving the new organ.

Following pioneering work by doctors at London’s Great Ormond Street Hospital (GOSH), her body has accepted the new kidney as its own.

Immunosuppressants are an important part of most transplant patients’ lives, because they stop the body from rejecting a donated organ.

But while they provide a vital function, they work by dampening down the body’s immune system.

Anyone taking them is therefore at higher risk of infection, among other complications.

Aditi with father Uday and mother Divya at Great Ormond Street Hospital
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Aditi is now able to dance and swim

Aditi was referred to GOSH when she was five and doctors discovered she had a condition called Schimke’s immuno-osseous dysplasia, which impacts the immune system and kidneys.

In the UK, it affects about one child in every three million.

Aditi’s underlying immune condition initially meant she would “not be able to receive a kidney transplant”, said Professor Stephen Marks, children’s kidney specialist at GOSH.

But working with international colleagues, the renal, immunology and stem cell transplant teams at GOSH came up with a treatment plan.

Prof Marks added: “Her immune deficiency had to be corrected by having her mum’s bone marrow first, and because Aditi was able to accept her mum’s bone marrow, that therefore meant her body could then see her mum’s kidney as being part of her.

“A month after the transplant, we were able to take her off all of her immunosuppression, which means she doesn’t get the side effects of the drugs.”

Aditi with her parents and Professor Stephen Marks
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Aditi with her parents and Professor Stephen Marks

Only last year, Scrabble-loving Aditi was spending a lot of time in hospital receiving dialysis – a procedure that removes waste products and excess fluid from the blood when the kidneys have stopped working properly.

Now, she is able to swim, sing, dance, and play on her trampoline.

Mum Divya said: “I was so happy to give her blood cells and a kidney. I just feel so proud.”

Aditi said: “My mum gave me my new blood cells. I got the kidney transplant when I went to special sleep and closed my eyes.

“Now I have got the line out, I can go swimming.”

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UK calls for investigation after IDF fired warning shots as British diplomats travelled through West Bank

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UK calls for investigation after IDF fired warning shots as British diplomats travelled through West Bank

The UK government is calling for Israel to launch an investigation after the country’s troops fired warning shots while British diplomats were travelling through the West Bank.

Diplomats from Ireland, France, Germany and Turkey were also travelling with the delegation in the city of Jenin when the gunshots rang out on Wednesday.

All four countries have condemned the shooting, which comes after Western nations criticised Israel’s latest offensive in Gaza.

Two British diplomats are understood to be among the group of around 20 people who have been confirmed as safe following the incident in the Israeli-occupied West Bank.

Footage shows the moment members of the delegation were gathered outside before fleeing the scene as the gunshots rang out.

Foreign Office minister Hamish Falconer has described the incident in Jenin as “unacceptable”.

He wrote on X: “I have spoken to our diplomats who were affected. Civilians must always be protected, and diplomats allowed to do their jobs. There must be a full investigation and those responsible should be held accountable.”

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Members of the delegation flee as gunshots are fired
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Members of the delegation flee as gunshots are fired

Members of the delegation flee as gunshots are fired

In response to the situation, UK Foreign Secretary David Lammy has announced measures, including financial restrictions and travel bans, targeting prominent settler leader Daniella Weiss and two other individuals.

The measures also target two illegal outposts and two organisations accused of backing violence against Palestinian communities.

It came after Ireland’s deputy premier Simon Harris condemned the shooting in “the strongest terms” and France’s foreign minister Jean-Noel Barrot said he would summon the Israeli ambassador over the incident.

Meanwhile, Turkey’s foreign ministry said the shooting showed Israel’s “systematic disregard for international law” and called for an immediate investigation.

Germany’s foreign office had earlier condemned what it referred to as “unprovoked gunfire”, adding: “We are fortunate that nothing worse occurred.”

The Israeli military said the delegation had “deviated from the approved route” of their visit and Israel Defence Force (IDF) soldiers fired warning shots to push them from the area.

The IDF apologised and said it would contact all countries involved in the visit.

The shooting took place a day after the UK announced it would cease all talks of a trade deal with Israel, and summoned the country’s ambassador to make clear Britain is unhappy with the situation in Gaza.

Members of the delegation flee as gunshots are fired
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Members of the delegation flee as gunshots are fired

Hospitals in northern Gaza encircled by IDF

Elsewhere, staff and aid groups have said that two of northern Gaza’s last functioning hospitals have been encircled by Israeli troops – preventing anyone from entering or leaving.

The Indonesian and al Awda hospitals are among the region’s only remaining medical facilities, with both coming under fire this week.

Tedros Adhanom Ghebreyesus, the director general of the World Health Organisation, has warned Israel’s military operations and evacuation orders “are stretching the health system beyond the breaking point”.

Just 20 of the territory’s 36 hospitals remain partially functioning – with centres in northern Gaza now said to be “at a serious risk of shutting down completely”.

According to the WHO, there have been almost 700 attacks on medical facilities since the war began.

Israel’s military has accused Hamas of using hospitals as command centres and to hide fighters, but has only provided evidence for some of these claims.

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Former spy chief: PM’s stance on Israel ‘overdue’

UK unveils new aid package to Gaza

Elsewhere, UK ministers announced they will send £4m of aid to Gaza, including essential medicines, safe drinking water and food parcels.

Minister for development Jenny Chapman, who is visiting Israel and the occupied territories, said the lack of aid reaching Gazans is “appalling”.

She added: “The Israeli government’s failure to allow full humanitarian access to aid workers is abhorrent. Far too few trucks are crossing into Gaza.

“The UN has warned nearly half a million Palestinians, including children, are facing starvation.

“The UK is clear – Israel will not achieve security through prolonging the suffering of the Palestinian people.”

It comes as British Prime Minister Sir Keir Starmer said humanitarian aid needs to get into Gaza “at pace”.

On Wednesday, Downing Street did not rule out more sanctions on Israeli ministers after a report said Number 10 and other countries were drawing up plans to target key figures in Israeli Prime Minister Benjamin Netanyahu’s government.

Sir Keir’s official spokesman said he would not speculate on future sanctions but added it has been made clear that if Israel does not cease its military offensive and lift aid restrictions then the UK will take further “concrete actions”.

The shooting in the West Bank came hours before the Israeli military said 100 aid trucks carrying flour, baby food and medical equipment had travelled from the Kerem Shalom crossing into Gaza.

Palestinian workers unload an aid truck, in Khan Younis. Pic: Reuters
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Palestinian workers unload an aid truck, in Khan Younis. Pic: Reuters

The transfer of aid into Gaza has become an increasingly controversial topic over the last couple of days as the international community fears the territory is on the brink of famine.

The UN said earlier that no aid has been distributed in Gaza since Mr Netanyahu said an 11-week blockade on the territory had been lifted.

On Wednesday evening, the Israeli prime minister held a news conference where he said he would not allow European leaders to “influence” Israel after he was asked about the diplomatic row over the gunfire in Jenin and the humanitarian crisis in Gaza.

“We have to complete the war,” Mr Netahayu said. “We are going to continue what is needed to end the war.”

He said it was a “mark of shame” that Britain was sanctioning Israel and not Hamas, calling the sanctions an “absolutely horrible thing”.

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Jay Slater’s mother breaks down in tears at inquest – as friends fail to appear as witnesses

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Jay Slater's mother breaks down in tears at inquest - as friends fail to appear as witnesses

Friends of Jay Slater have failed to appear as witnesses at an inquest into his death – as a coroner heard the British teenager had drugs in his system before he died from a “devastating” head injury.

Jay Slater, 19, from Oswaldtwistle in Lancashire, disappeared in Tenerife after attending a music festival in June last year.

In the early hours of the following day, he is believed to have travelled to an apartment where people he had met were staying – before he went missing.

His body was recovered in a remote part of La Masca village on 15 July following an extensive search of the island by authorities and his family.

The valley where Mr Slater's body was found
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The valley where Mr Slater’s body was found in Tenerife

His mother Debbie Duncan, stepfather and other family members attended the inquest into Mr Slater’s death at Preston Coroner’s Court on Wednesday.

Ms Duncan broke down in tears as she told the hearing she still had questions that needed answers.

The hearing, scheduled to last one day, was told extensive efforts had been made to reach several witnesses who were in contact with Mr Slater before he disappeared, which included summonses being issued.

However, a number of witnesses had failed to respond, including Mr Slater’s friends Bradley Geoghegan, Brandon Hodgson and Lucy Law, who were out with him at the music festival.

Jay Slater. Pic: LBT Global/Slater family
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Jay Slater disappeared in Tenerife in June last year before his body was found the following month. Pic: LBT Global/Slater family

The two men who were staying at an Airbnb that Mr Slater went back to before he disappeared have also not been traced.

Ms Duncan said: “How can we ever get any understanding?

“There’s things we want to question. We want these people to be sat in front of us, because our son went on holiday and didn’t come back, so there’s questions we need to ask.”

Coroner Dr James Adeley agreed to adjourn the hearing, at the request of Mr Slater’s tearful mother, who asked for the witnesses to be brought to court to give evidence before the inquest concludes. A further hearing date has yet to be set.

Earlier, the court heard analysis of Mr Slater’s body showed traces of drugs including cocaine, ketamine and ecstasy.

During Wednesday’s hearing, Home Office pathologist Dr Richard Shepherd detailed Mr Slater’s injuries.

Jay Slater is an apprentice bricklayer. Pic: PH Build Group
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Mr Slater died from a ‘devastating’ head injury, a coroner heard. Pic: PH Build Group

He described “extensive fractures of the left side of his head… extending into the bottom of his skull”.

Mr Slater also sustained “fractures to the left side of the pelvis and hip joints”.

Dr Shepherd said the injuries were “entirely consistent with a heavy fall, from a height, landing on his head”.

Asked by the coroner if there was any suggestion of assault or restraint, he replied: “Nothing to suggest an assault, gripping, holding, nothing of that sort.”

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Dr Adeley asked the pathologist about the impact of Mr Slater’s injuries.

Dr Shepherd replied: “It would have had an immediate and devastating effect on Jay’s consciousness.

“The injuries were so severe I have no doubt he would have been instantly unconscious from the moment of that blow to the head. Death could well have been instant, the injury was so severe.”

Failing that, it would have most likely occurred “extremely soon after” the fall, he added.

Dr Shepherd gave an official cause of death as a head injury.

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UK weather: Tornado and funnel cloud could hit parts of country today, Met Office forecaster warns

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UK weather: Tornado and funnel cloud could hit parts of country today, Met Office forecaster warns

A tornado could batter parts of the UK, experts are warning – as southern England endures heavy rain following the driest start to spring in decades.

Met Office meteorologist Alex Burkill said it was “not out of the question that we could see a funnel cloud, maybe even a brief tornado across parts of the South East” of England on Wednesday, with southern areas facing thunder, lightning, and hail.

He added there was a “bit of a North-South split in our weather through today”.

“Northern parts having a lot of fine, sunny weather, meanwhile in the South we’ve seen some wet weather push its way in… and there will be further showery bursts to come as we go through the rest of today,” he said.

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Wednesday’s showers follow the driest start to spring in nearly six decades.

As of Friday, 80.6mm of rain had been recorded for the UK in spring 2025, nearly 20mm less than the record low for the full season of 100.7mm set in 1852.

The Environment Agency is warning that it could contribute to drought this summer if there continue to be long periods without any rainfall.

Drier weather to return tomorrow

The UK is set to return to more dry weather on Thursday, with only a few showers forecasted in the South West of England.

They will not be “as intense” as those throughout the UK today, Mr Burkill said, with “a good amount of sunshine on offer” elsewhere.

Friday is due to be “mostly fine” but more wet and windy conditions are earmarked for the weekend.

Mr Burkill described this week’s wet spells as a “real change from what we’ve become used to so far this spring”.

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