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The World Health Organisation (WHO) has approved a low-cost, readily available vaccine for malaria that promises to help ease one of the greatest disease burdens on the developing world.

The R21 vaccine, developed by the University of Oxford, the Serum Institute of India and drug maker Novavax, could help reduce the 500,000 malaria-associated deaths that occur each year.

It is only the second vaccine to have been approved for the prevention of malaria, after the RTS,S vaccine developed by drug giant GSK was authorised in 2022.

Although the WHO concluded R21 has similar levels of efficacy as RTS,S the new vaccine is expected to be cheaper and should be more widely available.

The Serum Institute of India has production capacity for 100 million doses of R21 each year, which it says will be doubled over the next two years.

Cost and availability are both crucial factors for a vaccine being deployed chiefly in sub-Saharan Africa, where there are nearly 250 million cases of malaria each year.

“The vaccine is easily deployable, cost-effective and affordable, ready for distribution in areas where it is needed most, with the potential to save hundreds of thousands of lives a year,” said Sir Adrian Hill, who led the team developing the vaccine at Oxford University’s Jenner Institute.

The approval of the vaccine follows 30 years of work on malaria at the Jenner Institute. The same lab developed an effective COVID-19 vaccine in less than a year.

But malaria is an altogether tougher challenge.

The disease is caused by a protozoan parasite, a single-celled organism with multiple life stages, each evolved to evade the immune response.

The constantly shape-shifting parasite spends much of its life hiding in the liver and red blood cells of its human host, or in the gut and salivary glands of the mosquitoes who transmit malaria.

Compared to some vaccines against infectious diseases like measles or polio, malaria vaccines aren’t good enough to prevent transmission.

In trials, R21 prevented between 68-75% of recipients from contracting malaria. However, in infants – who are most at risk of dying from malaria – levels of protection were between 75-79%.

However, given the fact malaria is such a huge burden and a very difficult target – the WHO set its criteria for an effective vaccine at 75%.

Read more:
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Ghana becomes first country to approve Oxford malaria vaccine

“As a malaria researcher, I used to dream of the day we would have a safe and effective vaccine against malaria,” said Dr Tedros Adhanom Ghebreyesus, Director-General of the WHO.

“Now we have two.”

“Demand for the RTS,S vaccine far exceeds supply, so this second vaccine is a vital additional tool to protect more children faster, and to bring us closer to our vision of a malaria-free future,” he added.

The approval of R21 offers additional hope for those working to combat malaria.

Between 2000 and 2015, cases and deaths fell significantly due to prevention measures like insecticide-treated bed nets.

Since then, however, progress had been backsliding and WHO was struggling to raise the money needed for its malaria programmes from donor countries.

The rollout of both the RTS,S and R21 vaccines is expected as soon as next year.

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Mushroom murderer Erin Patterson left me ‘half alive’, sole survivor says

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Mushroom murderer Erin Patterson left me 'half alive', sole survivor says

The sole surviving guest of a lunch where three others died after being served food laced with toxic mushrooms has told an Australian court that the actions of murderer Erin Patterson have left him feeling “half alive”.

Ian Wilkinson, who received a liver transplant and spent months in hospital after the poisoning in July 2023, described how he had been left traumatised as he delivered his victim impact statement at Patterson’s pre-sentencing hearing in Melbourne.

Patterson, 50, was found guilty last month of luring her mother-in-law Gail Patterson, father-in-law Donald Patterson and Gail’s sister, Heather Wilkinson, to lunch at her home in Leongatha and poisoning them with individual portions of Beef Wellington that contained toxic death cap mushrooms.

A jury also found her guilty of the attempted murder of Mr Wilkinson, Heather’s husband.

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Australian mother found guilty of killing three relatives by serving toxic lunch

Speaking at the start of the two-day hearing, Mr Wilkinson, a Baptist pastor, said the death of his wife had left him bereft.

“It’s a truly horrible thought to live with that somebody could decide to take her life. I only feel half alive without her,” he said, breaking down in tears.

“It’s one of the distressing shortcomings of our society that so much attention is showered on those who do evil and so little on those who do good.”

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Ian and Heather Wilkinson. Pic: The Salvation Army Australia - Museum
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Ian and Heather Wilkinson. Pic: The Salvation Army Australia – Museum

‘I bear her no ill will’

He described Gail and Don Patterson, the parents of Erin Patterson’s estranged husband Simon Patterson, as the closest people to him after his wife and family.

“My life is greatly impoverished without them,” Mr Wilkinson said.

“I’m distressed that Erin has acted with callous and calculated disregard for my life and the lives of those I love. What foolishness possesses a person to think that murder could be the solution to their problems, especially the murder of people who have only good intentions towards her?”

Pic: AP
Image:
Pic: AP

He called on Patterson, who said the poisonings were accidental and continues to maintain her innocence, to confess to her crimes.

“I encourage Erin to receive my offer of forgiveness for those harms done to me with full confession and repentance. I bear her no ill will,” he said.

“I am no longer Erin Patterson’s victim and she has become the victim of my kindness.”

Read more from Sky News:
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Flesh-eating screwworm parasite detected in person in US for first time

The court received a total of 28 victim impact statements, of which seven were read publicly.

Don and Gail Patterson. Picture: Facebook
Image:
Don and Gail Patterson. Picture: Facebook


‘An irreparably broken home’

Patterson’s estranged husband Simon Patterson – who was invited to the lunch but declined – spoke of the devastating impact on the couple’s two children.

“The grim reality is they live in an irreparably broken home with only a solo parent, when almost everyone else knows their mother murdered their grandparents,” he said in a statement that was read out on his behalf.

Patterson attended the court in person on Monday rather than watch via a video link from prison which she did during a hearing earlier this month.

The hearing is scheduled to continue on Tuesday.

Patterson faces a potential life sentence for each of the murders and 25 years for attempted murder.

She has 28 days from the day of her sentencing to appeal, but has not yet indicated whether she will do so.

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Israel pounds outskirts of Gaza City overnight as military offensive plans continue

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Israel pounds outskirts of Gaza City overnight as military offensive plans continue

Israel pounded the outskirts of Gaza City overnight, as Benjamin Netanyahu’s government vowed to press on with a planned offensive on the city.

Families streamed out of the city as the explosions hit.

“I stopped counting the times I had to take my wife and three daughters and leave my home in Gaza City,” said Mohammad, 40.

“No place is safe, but I can’t take the risk. If they suddenly begin the invasion, they will use heavy fire.”

Mahmoud Abedrabo mourns over the body of his son Hamada in Gaza City on 24 August. Pic: Reuters
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Mahmoud Abedrabo mourns over the body of his son Hamada in Gaza City on 24 August. Pic: Reuters

Others said they would prefer to die and not leave.

“We are not leaving, let them bomb us at home,” said Aya, 31, who has a family of eight, adding that they couldn’t afford to buy a tent or pay for the transportation.

“We are hungry, afraid and don’t have money,” she said.

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Mourners pray next to the body of Palestinian boy Hamada Abedrabo on 24 August. Pic: Reuters
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Mourners pray next to the body of Palestinian boy Hamada Abedrabo on 24 August. Pic: Reuters

Witnesses said that overnight they heard nonstop explosions in Zeitoun and Shejaia.

Tanks shelled houses and roads in Sabra, and buildings were blown up in Jabalia.

On Sunday, the IDF said its forces had returned to combat in Jabalia to strengthen its control of the area and dismantle militant tunnels.

Smoke rises following an Israeli strike in Gaza City. Pic: Reuters
Image:
Smoke rises following an Israeli strike in Gaza City. Pic: Reuters

It added that the operation there “enables the expansion of combat into additional areas and prevents Hamas terrorists from returning to operate in these areas.”

This month, Israel approved a plan to seize control of Gaza City. The offensive isn’t expected to start for another few weeks.

Read more from Sky News:
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‘I’m deprived of my UK citizenship but I’m not a convicted terrorist’
Ghislaine Maxwell was given ‘platform to rewrite history’, say Giuffre’s family

In the meantime, mediators in Egypt and Qatar are trying to resume ceasefire talks between the two sides.

On Friday, Israel’s defence minister Israel Katz said that Gaza City will be razed unless Hamas releases all its remaining hostages and ends the war on Israel’s terms.

Mourners transport the body of  Ahmed Balata on 24 August. Pic: Reuters
Image:
Mourners transport the body of Ahmed Balata on 24 August. Pic: Reuters

Around half of Gaza’s two million residents currently live in the city and on Friday a global hunger monitor said that Gaza City and its surrounding areas are officially suffering from famine that will likely spread.

Israel said the monitor ignores steps Israel has taken since late July to increase aid supplies into and across Gaza.

Eight more people died of malnutrition and starvation in Gaza, according to the Hamas-run Gaza health ministry on Saturday.

281 people, including 114 children, have now died of malnutrition and starvation since the war started, according to the ministry.

The war began on 7 October 2023, when Hamas-led gunmen killed around 1,200 people in southern Israel, mainly civilians, and took 251 hostages.

Since then, Israel has killed at least 62,000 Palestinians, according to the Gaza health ministry, and internally displaced nearly its entire population.

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Two married couples found dead in British car after crash in Germany

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Two married couples found dead in British car after crash in Germany

Two married couples have died after a British car veered off the road and crashed in Germany, according to police.

The fatal accident happened shortly after midnight on Saturday in the trees near a highway in the Kassel district, north of Hesse in central Germany.

The 32-year-old male driver, a 31-year-old female passenger, a 32-year-old female passenger, and a 30-year-old female passenger all died at the scene, despite the efforts of German emergency services.

Sky News understands UK officials have not been contacted for assistance.

At roughly 12.30am on Saturday, the car appears to have veered off the road and crashed into nearby trees around 30m from the road, according to the Kassel police department.

Pic: Feuerwehr Reinhardshagen
Image:
Pic: Feuerwehr Reinhardshagen

One of the victim’s phones automatically alerted the emergency services to the incident, who sent an ambulance to the scene.

Soon, fire engines, ambulances, command vehicles and emergency support vehicles were all dispatched.

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When emergency workers arrived, the car was lying on its side, wedged between several trees.

It wasn’t until they removed the roof that they found all four passengers.

Pic: Feuerwehr Reinhardshagen
Image:
Pic: Feuerwehr Reinhardshagen

The accident happened on Highway L3229
Image:
The accident happened on Highway L3229

The emergency workers who dealt with the victims were immediately supported by the specialist mental health workers at the fire station in Reinhardshagen.

“This high number of deaths is an extraordinary operation for our Reinhardshagen Volunteer Fire Department,” said a fire department spokesperson.

“For some of the emergency personnel, it is the first time they have been confronted with death in this way.

“Therefore, a great deal is being done to help us process these images. We will also discuss this among ourselves and within families, because not everyone can easily shake off what they have seen.”

An investigation into the accident is ongoing and is being conducted by the Hofgeismar police station.

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