The Nobel Prize in medicine has been awarded to two scientists for their research which led to the development of effective mRNA vaccines against COVID-19.
The accolade, among the most prestigious in the scientific world, went to Katalin Kariko, from Hungary, and Drew Weissman, from the United States.
“Through their groundbreaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times,” the panel that awarded the prize said.
Both COVID-19 vaccines Pfizer/BioNTech and Moderna use something called messenger RNA (mRNA) to send genetic instructions to the body’s cells to recognise and destroy a particular part of the coronavirus called the spike protein.
When the body develops an immune response to this spike protein it is then able to fight off the coronavirus without having ever been exposed to the virus itself.
Ms Kariko is a professor at Sagan’s University in Hungary and an adjunct professor at the University of Pennsylvania.
She was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the German firm.
Mr Weismann performed his prize-winning research with Ms Kariko at the University of Pennsylvania.
Thomas Perlmann, secretary of the Nobel Assembly, announced the prize and said both scientists were “overwhelmed” by the news when he contacted them.
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Image: The winners of the 2023 Nobel Prize in medicine were announced during a ceremony in Stockholm, Sweden
“This year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system, and had a major impact on society during the recent pandemic,” said Rickard Sandberg, a member of the Nobel Assembly at Karolinska Institute.
“Together they have saved millions of lives, prevented severe COVID-19, reduced the overall disease burden and enabled societies to open up again.”
Dr Paul Hunter, a professor of medicine at the University of East Anglia, described the mRNA vaccines as a “game changer” in helping to shut down the coronavirus pandemic, crediting the jabs with saving millions of lives.
“If it hadn’t been for the mRNA technology, COVID would have been much worse,” he said.
“Vaccines generally were the turning point in slowing down COVID and the mRNA vaccines were just so much better than all the others.
“We would likely only now be coming out of the depths of COVID without the mRNA vaccines,” he added.
Monday’s announcement in Stockholm, Sweden, kicks off this year’s awards with the remaining five to be unveiled in the coming days.
The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in physics, chemistry, literature and peace, and in later years also for economics.
They carry a cash award of 11 million Swedish kronor (£820,000). The money comes from a bequest left by the prize’s creator, who died in 1896.
The IDF has admitted to mistakenly identifying a convoy of aid workers as a threat – following the emergence of a video which proved their ambulances were clearly marked when Israeli troops opened fire on them.
The bodies of 15 aid workers – including eight medics working for the Palestine Red Crescent Society (PRCS) – were found in a “mass grave” after the incident, according to the head of the UN Office for Coordination of Humanitarian Affairs Jonathan Whittall.
The Israeli military originally claimed an investigation found the vehicles did not have any headlights or emergency signals and were therefore targeted as they looked “suspicious”.
But video footage obtained by the PRCS, and verified by Sky News, showed the ambulances and a fire vehicle clearly marked with flashing red lights.
In a briefing from the IDF, they said the ambulances arrived in the Tel Sultan neighbourhood in Rafah shortly after a Hamas police vehicle drove through.
Image: Palestinians mourning the medics after their bodies were recovered. Pic: Reuters
An IDF surveillance aircraft was watching the movement of the ambulances and notified troops on the ground. The IDF said it will not be releasing that footage.
When the ambulances arrived, the soldiers opened fire, thinking the medics were a threat, according to the IDF.
The soldiers were surprised by the convoy stopping on the road and several people getting out quickly and running, the IDF claimed, adding the soldiers were unaware the suspects were in fact unarmed medics.
An Israeli military official would not say how far away troops were when they fired on the vehicles.
The IDF acknowledged that its statement claiming that the ambulances had their lights off was incorrect, and was based on the testimony from the soldiers in the incident.
The newly emerged video footage showed that the ambulances were clearly identifiable and had their lights on, the IDF said.
The IDF added that there will be a re-investigation to look into this discrepancy.
Image: The clip is filmed through a vehicle windscreen – with three red light vehicles visible in front
Addressing the fact the aid workers’ bodies were buried in a mass grave, the IDF said in its briefing this is an approved and regular practice to prevent wild dogs and other animals from eating the corpses.
The IDF could not explain why the ambulances were also buried.
The IDF said six of the 15 people killed were linked to Hamas, but revealed no detail to support the claim.
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Bodies of aid workers found in Gaza
The newly emerged footage of the incident was discovered on a phone belonging to one of the workers who was killed, PRCS president Dr Younis Al Khatib said.
“His phone was found with his body and he recorded the whole event,” he said. “His last words before being shot, ‘Forgive me, mom. I just wanted to help people. I wanted to save lives’.”
Sky News used an aftermath video and satellite imagery to verify the location and timing of the newly emerged footage of the incident.
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Aid worker attacks increasing
It was filmed on 23 March north of Rafah and shows a convoy of marked ambulances and a fire-fighting vehicle travelling south along a road towards the city centre. All the vehicles visible in the convoy have their flashing lights on.
The footage was filmed early in the morning, with a satellite image seen by Sky News taken at 9.48am local time on the same day showing a group of vehicles bunched together off the road.
Ukrainian President Volodymyr Zelenskyy has hit out at the US over its “weak” response to lethal Russian attacks on his hometown on Friday.
President Zelenskyy posted a lengthy and emotional statement on X about Russia’s strikes on Kryvyi Rih, which killed 19 people.
Meanwhile Ukrainian drones hit an explosives factory in Russia’s Samara region in an overnight strike, a member of Ukraine’s SBU security service told Reuters.
In his post, President Zelenskyy accused the United States of being “afraid” to name-check Russia in its comment on the attack.
“Unfortunately, the reaction of the American Embassy is unpleasantly surprising: such a strong country, such a strong people – and such a weak reaction,” he wrote on X.
“They are even afraid to say the word “Russian” when talking about the missile that killed children.”
America’s ambassador to Ukraine Bridget Brink had written on X: “Horrified that tonight a ballistic missile struck near a playground and restaurant in Kryvyi Rih.
“More than 50 people injured and 16 killed, including 6 children. This is why the war must end.”
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Strike on Zelenskyy’s home city
President Zelenskyy went on in his post to say: “Yes, the war must end. But in order to end it, we must not be afraid to call a spade a spade.
“We must not be afraid to put pressure on the only one who continues this war and ignores all the world’s proposals to end it. We must put pressure on Russia, which chooses to kill children instead of a ceasefire.”
Grandmother ‘burned to death in her home’
Oleksandr Vilkul, head of the city’s defense council, said the missile attack, followed by a drone attack, had killed 19 people, including nine children.
“The Iskander-M missile strike with cluster munitions at the children’s playground in the residential area, to make the shrapnel fly further apart, killed 18 people.
“One grandmother was burnt to death in her house after Shahed’s direct hit.”
Russia’s defence ministry said it had struck a military gathering in a restaurant – an assertion rebutted by the Ukrainian military as misinformation.
“The missile hit right on the street – around ordinary houses, a playground, shops, a restaurant,” President Zelenskyy wrote.
Mr Zelenskyy also detailed the child victims of the attack including “Konstantin, who will be 16 forever” and “Arina, who will also be 7 forever”.
The UK’s chief of the defence staff Sir Tony Radakin said he had met the Ukrainian leader on Friday, along with French armed forces leader General Thierry Burkhard.
“Britain and France are coming together & Europe is stepping up in a way that is real & substantial, with 200 planners from 30 nations working to strengthen Ukraine’s long term security,” Sir Tony wrote.
Global financial markets gave a clear vote of no-confidence in President Trump’s economic policy.
The damage it will do is obvious: costs for companies will rise, hitting their earnings.
The consequences will ripple throughout the global economy, with economists now raising their expectations for a recession, not only in the US, but across the world.