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By Dr. Priyom Bose, Ph.D. Oct 5 2023 Reviewed by Lily Ramsey, LLM

In a recent study published in Scientific Reports, researchers investigated the potential of minimal exercise (MAE) to prevent dementia in cognitively normal older individuals with osteoarthritis (OA).

Study:  Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: a retrospective longitudinal follow-up study . Image Credit: Ground Picture/Shutterstock.com Background

Numerous studies have highlighted the benefits of regular aerobic exercise in preventing cardiovascular diseases (CVD) and degenerative brain disorders like senile dementia.

However, older adults with OA often face challenges in maintaining regular exercise due to joint pain and mobility limitations. Since about 10% of the elderly population worldwide develops dementia, finding preventive measures is crucial.

Physicians can play a vital role in influencing exercise behavior in older adults, but time constraints, limited training, and inadequate reimbursement hinder their ability to provide effective counseling.

MAE refers to the smallest amount of physical activity that can enhance health and reduce mortality, often involving brief, sporadic, or infrequent exercise sessions. About the study

This longitudinal, retrospective cohort study examined the impact of MAE on dementia prevention in older adults with OA. Participants from the History-Based Artificial Intelligence Activities of Daily Living (HAI-ADL) database were screened.

The study included participants aged 50 or older, diagnosed with OA, and possessing comprehensive medical records. The research compared dementia incidence among different MAE frequency groups. Study findings

The study included 242 participants without dementia but with OA, divided into MAE-no (121 participants), MAE-weekly (51 participants), and MAE-daily (70 participants) groups. The conversion rates to dementia were estimated at 47.9%, 33.3%, and 17.1% for the MAE-no, MAE-weekly, and MAE-daily groups, respectively. Related StoriesResearch could lead to the development of new weight-loss drug that mimics exerciseUnderstanding how exercise suppresses appetite could pave the way for new obesity drugsTraumatic life events may directly increase your risk for dementia

Adjusted for various factors, the Cox proportional hazards model indicated that both MAE-daily and MAE-weekly groups had a significant decrease in dementia incidence compared to the reference group.

The multivariate logistic regression model showed that MAE-daily significantly reduced dementia incidence and improved cardiac conditions. These findings align with previous research indicating that even minimal exercise can prevent cognitive decline in older individuals with OA. Conclusions

While the study has limitations, such as a small sample size and recruitment from specific centers in Taiwan, it underscores the importance of promoting MAE interventions, such as walking, in older populations with OA.

Even minimal exercise, when performed regularly, can enhance joint health and cognitive well-being, making it a valuable strategy for preventing dementia in this demographic. Journal reference:

Chung, Y. et al. (2023) Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: A retrospective longitudinal follow-up study. Scientific Reports, 13(1), pp.1-9. doi: https://doi.org/10.1038/s41598-023-42737-3. https://www.nature.com/articles/s41598-023-42737-3

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A look at OpenAI’s tangled web of dealmaking

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A look at OpenAI's tangled web of dealmaking

OpenAI CEO Sam Altman speaks to media following a Q&A at the OpenAI data center in Abilene, Texas, U.S., Sept. 23, 2025.

Shelby Tauber | Reuters

OpenAI CEO Sam Altman is everywhere.

His artificial intelligence startup, now valued at $500 billion, has been inking deals valued in the tens to hundreds of billions of dollars with infrastructure partners, even as it continues to burn mounds of cash.

Those expenditures are driving the market.

The Nasdaq and S&P 500 rose to record highs this week after Nvidia agreed to invest up to $100 billion in OpenAI. That followed a $300 billion deal between OpenAI and Oracle in July as part of the the Stargate program, a $500 billion infrastructure project that’s also being funded by SoftBank.

Its commitments don’t stop there. CoreWeave on Thursday said it’s agreed to provide OpenAI up to $22.4 billion in AI infrastructure, an increase from the $11.9 billion it initially announced in March. Earlier this month, chipmaker Broadcom said it had secured a new $10 billion customer, and analysts were quick to point to OpenAI. 

While OpenAI says that scaling is key to driving innovation and future AI breakthroughs, investors and analysts are beginning to raise their eyebrows over the mindboggling sums, as well as OpenAI’s reliance on an increasingly interconnected web of infrastructure partners. 

OpenAI took a $350 million stake in CoreWeave ahead of its IPO in March, for instance. Nvidia formalized its financial stake in OpenAI by participating in a $6.6 billion funding round in October. Oracle is spending about $40 billion on Nvidia chips to power one of OpenAI’s Stargate data centers, according to a May report from the Financial Times. Earlier this month, CoreWeave disclosed an order worth at least $6.3 billion from Nvidia. 

And through its $100 billion investment in OpenAI, Nvidia will get equity in the startup and earn revenue at the same time.

OpenAI is only expected to generate $13 billion in revenue this year, according to the company’s CFO Sarah Friar. She told CNBC that technology booms require bold bets on infrastructure. 

“When the internet was getting started, people kept feeling like, ‘Oh, we’re over-building, there’s too much,'” Friar said. “Look where we are today, right?”

Altman told CNBC in August that he’s willing to run the company at a loss in order to prioritize growth and its investments. 

‘Troubling signal’

But some analysts are raising red flags, arguing that OpenAI’s deal with Nvidia is reminiscent of vendor financing patterns that helped burst the dot-com bubble in the early 2000s.

Nvidia has been the biggest winner of the AI boom so far because it produces the graphics processing units (GPUs) that are necessary to train models and run large AI workloads. Nvidia’s investment in OpenAI, which will be paid out in installments over several years, will help the startup build out data centers that are based around its GPUs. 

“You don’t have to be a skeptic about AI technology’s promise in general to see this announcement as a troubling signal about how self-referential the entire space has become,” Bespoke Investment Group wrote in a note to clients on Tuesday. “If NVDA has to provide the capital that becomes its revenues in order to maintain growth, the whole ecosystem may be unsustainable.” 

Sam Altman, CEO of OpenAI (L), and Jensen Huang CEO of Nvidia.

Reuters

Peter Boockvar, chief investment officer at One Point BFG Wealth Partners, said names of companies from the late 1990′s were ringing in his ears after the OpenAI-Nvidia deal was announced. 

A key difference, however, is that this transaction is “so much bigger in terms of dollars,” he wrote in a note.

“For this whole massive experiment to work without causing large losses, OpenAI and its peers now have got to generate huge revenues and profits to pay for all the obligations they are signing up for and at the same time provide a return to its investors,” Boockvar said.

An OpenAI spokesperson referred CNBC to comments from Altman and Friar this week, adding that the company is pursuing “a once-in-a-century opportunity that demands ambition equal to the moment.”

The total amount of demand for compute could reach a staggering 200 gigawatts by 2030, according to Bain & Company’s 2025 Technology Report. Building enough data centers to meet this anticipated demand would cost about $500 billion a year, meaning AI companies would have to generate a combined $2 trillion in annual revenue to cover those costs.

Even if companies throw their whole weight behind investing in the cloud and data centers, “the amount would still fall $800 billion short of the revenue needed to fund the full investment,” Bain said.

There’s a clear uphill battle ahead, but OpenAI’s Altman brushed off concerns on Tuesday, rejecting the idea that the infrastructure spending spree is overkill.

“This is what it takes to deliver AI,” Altman told CNBC. “Unlike previous technological revolutions or previous versions of the internet, there’s so much infrastructure that’s required, and this is a small sample of it.”

–CNBC’s Yun Li and MacKenzie Sigalos contributed to this report

WATCH: OpenAI’s Sam Altman defends Stargate expansion as demand for AI soars

OpenAI's Sam Altman defends Stargate expansion as demand for AI soars

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5 takeaways from CNBC’s investigation into ‘nudify’ apps and sites

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5 takeaways from CNBC’s investigation into 'nudify' apps and sites

Jessica Guistolise, Megan Hurley and Molly Kelley talk with CNBC in Minneapolis, Minnesota, on July 11, 2025, about fake pornographic images and videos depicting their faces made by their mutual friend Ben using AI site DeepSwap.

Jordan Wyatt | CNBC

In the summer of 2024, a group of women in the Minneapolis area learned that a male friend used their Facebook photos mixed with artificial intelligence to create sexualized images and videos.   

Using an AI site called DeepSwap, the man secretly created deepfakes of the friends and over 80 women in the Twin Cities region. The discovery created emotional trauma and led the group to seek the help of a sympathetic state senator.

As a CNBC investigation shows, the rise of “nudify” apps and sites has made it easier than ever for people to create nonconsensual, explicit deepfakes. Experts said these services are all over the Internet, with many being promoted via Facebook ads, available for download on the Apple and Google app stores and easily accessed using simple web searches.

“That’s the reality of where the technology is right now, and that means that any person can really be victimized,” said Haley McNamara, senior vice president of strategic initiatives and programs at the National Center on Sexual Exploitation.

CNBC’s reporting shines a light on the legal quagmire surrounding AI, and how a group of friends became key figures in the fight against nonconsensual, AI-generated porn.

Here are five takeaways from the investigation.

The women lack legal recourse

Because the women weren’t underage and the man who created the deepfakes never distributed the content, there was no apparent crime.

“He did not break any laws that we’re aware of,” said Molly Kelley, one of the Minnesota victims and a law student. “And that is problematic.”

Now, Kelley and the women are advocating for a local bill in their state, proposed by Democratic state Senator Erin Maye Quade, intended to block nudify services in Minnesota. Should the bill become law, it would levy fines on the entities enabling the creation of the deepfakes.

Maye Quade said the bill is reminiscent of laws that prohibit peeping into windows to snap explicit photos without consent.

“We just haven’t grappled with the emergence of AI technology in the same way,” Maye Quade said in an interview with CNBC, referring to the speed of AI development.

The harm is real

Jessica Guistolise, one of the Minnesota victims, said she continues to suffer from panic and anxiety stemming from the incident last year.

Sometimes, she said, a simple click of a camera shutter can cause her to lose her breath and begin trembling, her eyes swelling with tears. That’s what happened at a conference she attended a month after first learning about the images.

“I heard that camera click, and I was quite literally in the darkest corners of the internet,” Guistolise said. “Because I’ve seen myself doing things that are not me doing things.”

Mary Anne Franks, professor at the George Washington University Law School, compared the experience to the feelings victims describe when talking about so-called revenge porn, or the posting of a person’s sexual photos and videos online, often by a former romantic partner.

“It makes you feel like you don’t own your own body, that you’ll never be able to take back your own identity,” said Franks, who is also president of the Cyber Civil Rights Initiative, a nonprofit organization dedicated to combating online abuse and discrimination.

Deepfakes are easier to create than ever

Less than a decade ago, a person would need to be an AI expert to make explicit deepfakes. Thanks to nudifier services, all that’s required is an internet connection and a Facebook photo.

Researchers said new AI models have helped usher in a wave of nudify services. The models are often bundled within easy-to-use apps, so that people lacking technical skills can create the content.

And while nudify services can contain disclaimers about obtaining consent, it’s unclear whether there is any enforcement mechanism. Additionally, many nudify sites market themselves simply as so-called face-swapping tools.

“There are apps that present as playful and they are actually primarily meant as pornographic in purpose,” said Alexios Mantzarlis, an AI security expert at Cornell Tech. “That’s another wrinkle in this space.”

Nudify service DeepSwap is hard to find

The site that was used to create the content is called DeepSwap, and there’s not much information about it online.

In a press release published in July, DeepSwap used a Hong Kong dateline and included a quote from Penyne Wu, who was identified in the release as CEO and co-founder. The media contact on the release was Shawn Banks, who was listed as marketing manager. 

CNBC was unable to find information online about Wu, and sent multiple emails to the address provided for Banks, but received no response.

DeepSwap’s website currently lists “MINDSPARK AI LIMITED” as its company name, provides an address in Dublin, and states that its terms of service are “governed by and construed in accordance with the laws of Ireland.”

However, in July, the same DeepSwap page had no mention of Mindspark, and references to Ireland instead said Hong Kong. 

AI’s collateral damage

The alarming rise of AI ‘nudify’ apps that create explicit images of real people

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Team GB chief Anson to head online retailer Sportscape

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Team GB chief Anson to head online retailer Sportscape

The outgoing boss of the British Olympic Association will this week be named as the new chief executive of one of Europe’s biggest e-commerce platforms for sports and outdoor enthusiasts.

Sky News has learnt that Andy Anson, who will step down next month as chief executive of Team GB, is joining Sportscape Group, which boasts a ‘member community’ of over 25 million people.

Sportscape is owned by bd-capital and Bridgepoint, which merged their respective portfolio companies SportPursuit and PrivateSportShop in 2022.

Prior to leading the BOA, Mr Anson was chief executive of Kitbag, which was subsequently sold to Fanatics.

He is also a former commercial director of Manchester United Football Club.

Sportscape trades across core markets including the UK, France, Germany, Italy and Spain.

“Sportscape has already established itself as a key player in the European sports e-commerce landscape, and I look forward to working with the team to unlock its next phase of growth,” Mr Anson said in a statement issued to Sky News.

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Andy Dawson, bd-capital’s co-founder and managing partner, said Mr Anson’s experience in global sports commerce made him the right choice to head Sportscape.

Since his departure as the BOA boss was announced during the summer, Mr Anson had agreed to work with another bd-capital-backed company, Science In Sport, by joining its board.

His successor as Team GB chief has yet to be announced.

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