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Share on Pinterest New research suggests that an inexpensive and common prescription drug used to treat migraine, nerve and back pain, and depression may also help improve irritable bowel syndrome (IBS) symptoms. Dima Berlin/Getty ImagesAn inexpensive and widely available drug called amitriptyline has been shown to improve IBS symptomsThe drug was found to be almost twice as effective as a placebo in a recent trial. Amitriptyline may improve IBS symptoms by regulating the nervous system and stopping the reuptake of serotonin by the brain. Experts say this is promising news for people with IBS, but Amitriptyline is not without risk.

New research has found that amitriptyline, a cheap and widely available prescription drug, can improve symptoms of Irritable Bowel Syndrome (IBS).

The research presented Monday at UEG Week 2023 found that doses of the drug (commonly used to treat a range of health concerns, including migraine, nerve and back pain, and depression) could also improve IBS.

Conducted by researchers at the Universities of Leeds, Southampton, and Bristol the study shows that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.

During the study, doctors prescribed amitriptyline and patients managed their own dose based on the severity of their symptoms, using an adjustment document designed for the trial.

As a result of the study, the trial team are now recommending that doctors support their patients with IBS to use amitriptyline to manage their symptoms.

Amitriptyline is an effective treatment for IBS and is safe and well tolerated, co-chief Investigator Dr. Alexander Ford, Professor of Gastroenterology at the University of Leedss School of Medicine, said in a press release. This new rigorously conducted research indicates that general practitioners should support patients in primary care to try low-dose amitriptyline if their IBS symptoms havent improved with recommended first-line treatments.

The trial team has made an adjustment document available to clinicians and patients. How amitriptyline may help treat IBS symptoms

Jaspreet Randhawa, holistic pharmacist and founder of Whole Body Pharmacist, says the results of this study are promising for patients who are living with IBS.

She isnt surprised that amitriptyline is beneficial for gut issues, as well as many other ailments.

The results make sense when looking at the method of action of amitriptyline on the nervous system; it works by stopping the reuptake of serotonin by the brain, she explains. With 90-95% of serotonin production occurring in the gut, it would seem viable that the gut can be affected by a regular dose of amitriptyline.

Dr. Semiya Aziz, a general practitioner and founder of Say GP, agrees with this synopsis. She notes that many of the conditions amitriptyline is used to treat are associated with nerve-based issues.

We know that IBS is a condition which affects the gastrointestinal tract and currently a large amount of research is being carried out on the effects of gut-brain axis and nervous system, she points out.

Therefore, its not difficult to understand how amitriptyline can help with IBS symptoms when we have used this drug to treat people with nerve-related problems in the past.

In particular, amitriptyline may play an important role in regulating the vagus nerve.

Irritation of this nerve can cause vagal nerve dysfunction and possibly IBS symptoms, Aziz explains.

Effecting both the nervous system and serotonin, Aziz reasons that amitriptyline alleviates IBS symptoms by having an overall calming effect on gut function, relieving pain and causing changes in bowel activity. Amitriptyline may improve future treatment of IBS symptoms

So, what does all this mean for how IBS may be treated in the future?

Aziz believes the findings of the study may be an important milestone in helping to relieve individuals who have exhausted all other options of treatment for IBS, especially where IBS has impacted their work, social and daily lives.

In reality, this is a drug that could easily be prescribed in primary care for patients suffering from IBS because it is cheap and widely available but it has its limitations, she warns.

In particular, she says it may be difficult for patients to adjust or self-dose themselves safely.

Realistically if the medication is given out for IBS, it will need to be regularly monitored and dosages adjusted by the patients [doctor] or the healthcare support system, Aziz notes.

Still, Randhawa thinks that amitriptyline can be of great benefit to a proportion of people living with IBS.

I believe some people will find significant relief of their IBS symptoms and I am confident that [doctors] will be able to assess the patients ability to manage their symptoms and hope they will review frequently to support them on their healthcare journey, she surmises. Concerns and risks of using amitriptyline to treat IBS

Common IBS symptoms include cramping, bloating, excessive gas, and diarrhea or constipation which can be debilitating and can range from mild to severe.

In primary care, it is difficult to identify the severity of IBS, so it is difficult to know who would benefit from the treatment the most, Aziz points out.

Add to that, there is still much uncertainty about the causative factor for IBS.

Aziz says its often the result of many factors, such as muscle contractions of the intestine or irritation of the nervous system due to stress or infections.

Most patients who present in primary care with IBS will present with multifactorial medical issues which may not easily be resolved by using just amitriptyline alone, she explains.

Therefore, it can be difficult to know just how effective amitriptyline will be for you.

Another point to consider is that the drug may have serious side effects at higher doses. These can include headaches, dizziness, and suicidal thoughts. Takeaway

While there is rarely a one-size-fits-all treatment to improve any health condition, its certainly promising that a cheap and widely available drug has been shown to positively impact IBS symptoms in a trial.

IBS is a debilitating condition that affects many people and amitriptyline appears to be an effective and accessible way to treat it.

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Punjabi music sees huge rise in streams – but not all fans are happy

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Punjabi music sees huge rise in streams - but not all fans are happy

Streams of Punjabi music have seen a massive rise, but some fans aren’t pleased with the direction the genre is heading in.

The 2002-hit Mundian To Bach Ke by UK-based producer Panjabi MC is what put the music on the map for the very first time.

Since then, the music has changed, and many more people are listening.

Data from Spotify shared exclusively with Sky News reveals that UK streams have risen by 286% over the past five years and a massive 2077% globally.

“The signs are there that Punjabi music is only going to continue to grow in influence around the world,” said Safiya Lambie Knight, head of music, UK & Ireland at Spotify.

The blend with hip-hop alongside collaborations with mainstream artists such as Burna Boy and Ed Sheeran has captivated listeners, regardless of their spoken language.

With billions of views and streams, one of the top-performing artists in the genre right now is Karan Aujla.

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Originally from a village called Ghurala in India, the 27-year-old’s quick-witted bars and innovative melodies helped him make history earlier this year as the first Punjabi artist to win a Juno Award.

Karan Aujla has performed three shows as part of his UK tour. Pic: Manny 4PM, Catalyst Management, Rehaan Records
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Karan Aujla has performed three shows as part of his UK tour. Pic: Manny 4PM, Catalyst Management, Rehaan Records

Speaking exclusively to Sky News after his show at London’s O2 arena, Aujla said: “I’m just a kid that came from nothing, from a small village so if you told me 10 years before I’ll be performing at the O2 London and selling out the whole arena, I wouldn’t know if that’d be possible, but we did it today.

“So if anybody out there is watching me, just know that it’s all possible.

Aujla’s ability to fuse genres such as hip-hop and R&B with Punjabi folk music has earned him a fanbase of non-Punjabis too.

“I feel like music itself has no language, and it’s just so lovely how somebody that doesn’t know your language could still vibe to your music. And I’ve seen that with my own eyes at my shows and in my DMs, or like on Facebook or wherever, when people send me videos of jamming to my songs, but they’re from a whole different country.”

Punjabi music has gone from its humble beginnings in the fields of rural Punjab to the flashy stages of international concerts. Pic: Manny 4PM, Catalyst Management, Rehaan Records
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Punjabi music has gone from humble rural beginnings to the flashy stages of international concerts. Pic: Manny 4PM, Catalyst Management, Rehaan Records

He added: “I feel like Punjabi music will be one of the biggest things in this whole world in the next few years, and I believe in that.”

But as the genre has grown over the last few years, some of the top singers have come under increased scrutiny for promoting and glorifying drugs, violence and gun culture through their lyrics and music videos.

It was this trend that forced one of the genre’s biggest radio stations – Panjab Radio, based in London – to ban some singers from their airwaves.

The station’s managing director, Surjit Singh Ghuman MBE, who made the decision three years ago, said: “My personal belief is that lots of youngsters went from Punjab to Western countries, especially Canada and America, where there’s a big drug scene there, there’s a big gun culture there, and I think it all stemmed from there.

“It makes me feel sad because that is not our culture. Guns and drugs is not Punjabi culture.”

Surjit Singh Ghuman MBE created the world’s first 100% Panjabi speaking radio station.
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Surjit Singh Ghuman MBE created the world’s first 100% Punjabi-speaking radio station

Mr Ghuman said that when the station started broadcasting in 2000: “We didn’t need to listen to the whole song, but now with the new music, we have to listen to every single song before it goes onto the system because there’s lots of swear words.

“I think it’s all about the views now. It doesn’t matter what the message is you’re giving to the youngsters or the community, it is to do with earning money.”

But Mr Ghuman is hopeful “positive changes are coming” and that singers will “start to focus their songs on the rich Punjabi culture rather than violence”.

However, while there’s hope, the controversies don’t seem to be fading.

Just last month, singer AP Dhillon, who’s signed to the same record label as Taylor Swift, released a song called Old Money, which contains violent scenes throughout its music video, so much so that it required a warning at the start.

This month, Dhillon’s home in Canada was shot at several times and vehicles were set alight. Nobody is believed to have been injured in the attack.

Preliminary investigation suggests that this was a targeted event according to the Royal Canadian Mounted Police, who are still investigating the suspects in the attack to establish a motive.

Sky News asked AP Dhillon’s team for a comment.

For now, the UK stands as a quieter but important player in the world of Punjabi music – a place where the focus remains on cultural celebration rather than controversy.

While controversies have accompanied its rise, the genre’s ability to evolve and resonate with diverse audiences suggests a bright future ahead.

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UNC’s Brown: No plans to resign after 70-50 loss

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UNC's Brown: No plans to resign after 70-50 loss

Mack Brown told ESPN on Saturday he’s not resigning after an emotional locker room scene with his players following North Carolina’s embarrassing 70-50 loss to James Madison, which is in only its third season as an FBS school.

Brown, a College Football Hall of Famer, said he told the players that it was his fault and would step away if he couldn’t get things fixed. The 70 points were the most ever given up by the Tar Heels, who fell to 3-1.

“I’m not resigning. I’ll be back at work Monday,” Brown told ESPN.

Brown, 73, is in his sixth season at North Carolina. He told ESPN he was aware of some reports and that messages in emotional locker rooms can be misconstrued, but was adamant that he’s not stepping down.

Brown has led UNC to winning records in four of his five seasons. The Tar Heels won eight games last season and nine the season before when they finished first in the ACC’s Coastal Division. Brown was at Texas for 16 seasons and won a national championship in 2005 and played for another in 2009. He resigned under pressure following the 2013 season, and after taking a break from coaching, returned in 2019 to North Carolina for his second stint in Chapel Hill. Brown was North Carolina’s coach from 1988 to 1997.

The Tar Heels travel to rival Duke next Saturday.

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U-M runs down USC, wins with 32 passing yards

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U-M runs down USC, wins with 32 passing yards

ANN ARBOR, Mich. — Michigan kept pounding the ball and pounding the ball. And when it mattered most, No. 11 USC couldn’t stop it.

Powered by running back Kalel Mullings, who scored the winning touchdown in the final seconds, the defending national champion Wolverines rumbled to a 27-24 victory in their Big Ten opener Saturday.

“That’s a representation of who we are,” Mullings said of Michigan’s run-heavy game plan. “Just grit and grinding up … grinding meat that whole time.”

The Wolverines rushed for 290 yards, including 79 on the final drive. Mullings got all eight carries and broke through a pair of tackles for a 63-yard run that put Michigan in the red zone. He finished off the drive with a 1-yard scoring plunge on fourth-and-goal with 37 seconds remaining.

“A will to not give in,” Michigan coach Sherrone Moore said of his senior back. “A will to want it more than them. To want it more than the man who’s trying to tackle him.”

The No. 18 Wolverines (3-1, 1-0 Big Ten) prevailed despite passing for only 32 yards, their fewest in a game since 1987, according to ESPN Research. Michigan’s 32 yards through the air were the fewest by any FBS team in a win over a top-15 opponent since 2014, when Florida beat Georgia with 27 rushing yards.

“Love it,” said Moore, a former college offensive lineman at Oklahoma. “You want to throw the ball, but when you can run the ball effectively, you bring [the defense] down.”

Mullings finished with a career-high 159 yards on 17 rushes, scoring another touchdown in the first quarter with a 53-yard dash through the middle of the USC defense.

Donovan Edwards added 74 yards on the ground, including a 41-yard touchdown run. But his fumble in the fourth quarter gave USC (2-1, 0-1) the ball deep in Michigan territory, and Miller Moss‘ 24-yard touchdown toss to Ja’Kobi Lane handed the Trojans their first lead of the game with just over 7 minutes to go.

Michigan turned back to Mullings the rest of the way. And Moore said the Wolverines put the game in the hands of Mullings and the offensive line, especially on fourth-and-goal.

“The game’s on the line,” Moore said, “whatcha gonna do?”

Mullings followed fullback Max Bredeson, who delivered the kickout block, clearing the way for Mullings to barrel in for the winning score.

“We knew we were going to get it,” quarterback Alex Orji said. “That was just confidence. Do or die, backs against the wall.”

The Wolverines changed starting quarterbacks this week, moving from Davis Warren to Orji. Warren had thrown six interceptions in three games, including three last weekend against Arkansas State. Orji had only seven career passing attempts coming into the game, and attempted only 12 passes against USC, completing seven of them. But Orji rushed for 43 yards, giving the Wolverines an offensive identity they had been lacking, especially in a 31-12 loss to Texas in their second game.

Michigan rushed for 199 yards in the first half alone, the most USC had surrendered in a first half since Lincoln Riley became its coach in 2022.

“Schematically, we knew they were going to run the ball,” USC linebacker Easton Mascarenas-Arnold said, “and it was just mano a mano who could win — and they just did.”

With an inexperienced quarterback, Moore said he challenged his team to be more physical against the Trojans. The Wolverines didn’t have All-America tight end Colston Loveland, who missed the game with an undisclosed injury. That put even more onus on the running game.

“The guys responded,” Moore said. “So proud of what they did and how they played.”

ESPN’s Paolo Uggetti contributed to this report.

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