A “repurposed” drug that could prevent breast cancer as well as treat it will be offered to almost 300,000 women, NHS officials have revealed.
Anastrozole has been used to treat hormone-sensitive breast cancer.
But trials have shown it can also stop the disease from occurring in the first place. It’s predicted cases could be cut by by 49% over 11 years.
The drug will be offered to 289,000 post-menopausal women who are considered to have at least a moderate risk of breast cancer in England.
“This is the first drug to be repurposed though a world-leading new programme to help us realise the full potential of existing medicines in new uses to save and improve more lives,” NHS chief executive Amanda Pritchard said.
Anastrozole was first recommended as a preventive option by the National Institute for Health and Care Excellence (Nice) in 2017, but, with the drug unlicensed in this use, uptake remained low.
Now scientists have found the protective effect lasts for years after a woman has stopped taking the drug – and has been licensed by the Medicines and Healthcare products Regulatory Agency .
Lesley-Ann Woodhams, who has a family history of the condition, completed the full five-year course of anastrozole in January 2023 and described it as a “gift”.
Image: Lesley-Ann Woodhams has a history of breast cancer in her family
“I’d watched my mum battle breast cancer and my risk was very high,” she said.
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“I could live a life without constantly worrying or giving a thought to what could be if I’d developed breast cancer.
“It really was a gift, it gave my family and myself peace of mind and more importantly, a continued future to look forward to.”
breast cancer symptoms
You should see a GP if you notice any of the following:
• a new lump or area of thickened tissue in either breast that was not there before;
• a change in the size or shape of one or both breasts;
• a discharge of fluid from either nipple;
• a lump or swelling in either armpit;
• a change in the look or feel of skin, such as puckering or dimpling, a rash or redness;
• a rash (like eczema), crusting, scaly or itchy skin or redness on or around the nipple;
• a change in the appearance of a nipple, such as becoming sunken into the breast.
How does it work?
The treatment is taken as a 1mg tablet, once a day for five years and works by cutting down the amount of oestrogen the body makes by blocking an enzyme called aromatase.
The most common side effects of the medicine are hot flushes, feeling weak, pain or stiffness in the joints, arthritis, skin rash, nausea, headache, osteoporosis, and depression.
Breast cancer is the most common cancer in England, with around 47,000 women in England diagnosed each year.
Baroness Delyth Morgan, chief executive at the charity Breast Cancer Now, said the move is a “major step forward” that will enable more women to reduce their chance of developing the disease.
Health Minister Will Quince said: “We’ve already seen the positive effect anastrozole can have in treating the disease when it has been detected in post-menopausal women and now we can use it to stop it developing at all in some women.”
The moves adds to the NHS’s armoury of preventative breast cancer medication, with tamoxifen and raloxifene already licensed to prevent breast cancer.
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3:11
Poem shows how to check for breast lumps
According to the NHS, the first symptom of breast cancer most women notice is a lump or an area of thickened tissue in their breast.
Most breast lumps are not cancerous, but it’s always best to have them checked by a doctor, officials say.
It started with a strong espresso in a simple cafe on a side street in north London.
Several Algerian men were inside, a few others were outside on the pavement, smoking.
I’d been told the wanted prisoner might be in Finsbury Park, so I ordered a coffee and asked if they’d seen him.
Image: Spotting a man resembling the suspect, Tom and camera operator Josh Masters gave chase
They were happy to tell me that some of them knew Brahim Kaddour-Cherif – the 24-year-old offender who was on the run.
One of the customers revealed to me that he’d actually seen him the night before.
“He wants to hand himself to police,” the friend said candidly.
This was the beginning of the end of a high-profile manhunt.
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The Algerian convicted sex offender had been at large since 29 October, after he was mistakenly released from HMP Wandsworth in south London.
Within an hour of meeting the friend in the cafe, he had followed myself and camera operator Josh Masters to a nearby street.
Image: Kaddour-Cherif was accidentally freed five days after the wrongful release of convicted sex offender Hadush Kebatu (pictured). They were both arrested separately in Finsbury Park. Pic: Crown Prosecution Service/PA
We weren’t yet filming – he didn’t want any attention or fuss surrounding him.
“Follow me, he’s in the park,” the man told me.
“Follow – but not too close.”
We did.
I was in the same park a few weeks ago after fugitive Hadush Kebatu, the Ethiopian sex offender – also wrongly released from prison – was arrested in Finsbury Park.
It was odd to be back in the same spot in such similar circumstances.
As he led us through the park past joggers, young families and people playing tennis, the man headed for the gates near Finsbury Park station.
All of a sudden, two police officers ran past us.
The Met had received a tip-off from a member of the public.
It was frantic. Undercover officers, uniformed cops, screeching tyres and blaring sirens. We were in the middle of the manhunt.
As they scoured the streets at speed, we walked by some of the Algerian men I’d seen in the cafe.
Image: Kaddour-Cherif walked up to a nearby police van as Tom continued to question him
One man near the group was wearing green tracksuit bottoms, a beanie hat and had glasses on.
“It’s him, it’s him,” one of the other men said to me, gesturing towards him.
The man in the beanie then quickly turned on his heel and walked off.
“It’s him, it’s him,” another guy agreed.
The suspect was walking off while the police were still searching the nearby streets.
Josh and I caught up with him and I asked directly: “Are you Brahim?”
You may have watched the exchange in the Sky News video – he was in denial, evasive and pretended the suspect had pedalled off on a Lime bike.
I can only guess he knew the game was up, but for whatever reason, he was keeping up the lie.
Image: Police moved in to handcuff him and used their phones to check an image of the wanted man from one of Sky News’ online platforms
Image: Once his identity was confirmed, Kaddour-Cherif was put into the back of the police van
Moments later, one of the bystanders told me “it is him” – with added urgency.
Only the prisoner knows why he then walked up to the nearby police van – officers quickly moved to handcuff him and tell him why he was being arrested.
Over the next 10 minutes, he became agitated. His story changed as I repeatedly asked if he had been the man inside HMP Wandsworth.
Officers needed confirmation too – one quickly pulled out a smartphone and checked an image of the wanted man from one of Sky News’ online platforms.
Nadjib had been on the lookout for the convicted sex offender, who had been spending time in different parts of north London since his release from HMP Wandsworth.
He even had a folded-up newspaper clipping in his pocket so that he could check the picture himself.
He told Sky News he was “very happy when he got arrested”.
“I don’t like the sex offenders,” he said.
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“I know him from the community. He has been around here every night since he was released from prison.”
Image: Nadjib (L) told Sky’s Tom Parmenter he had been looking out for the offender
Not only did he tip the police off about the prisoner’s whereabouts, but he also witnessed the other high-profile manhunt that ended in the same park last month.
Ethiopian asylum seeker Hadush Kebatu was also arrested in Finsbury Park after a 48-hour manhunt in the capital. He was then deported to Ethiopia.
Image: Brahim Kaddour-Cherif
“When he [Kebatu] got arrested in the park I was there,” Nadjib said.
I asked him why both men ended up in the same park in north London.
“Because the community, he came here for the community of Algerians,” he said.
Several Algerian people that I spoke to on Friday told me how shameful they thought it was that this sex offender was still on the run.
An NHS trust and a ward manager will be sentenced next week for health and safety failings – more than a decade after a young woman died in a secure mental health hospital.
Warning: This article contains references to suicide.
The decisions were reached after the joint-longest jury deliberation in English legal history.
Alice was 22 years old when she took her own life at London’s Goodmayes Hospital in July 2015.
Her parents sat through seven months of difficult and graphic evidence – and told Sky News the experience retraumatised them.
Image: Mother Jane Figueiredo
Jane Figueiredo said: “It’s very distressing, because you know that she’s been failed at every point all the way along, and you’re also reliving the suffering that she went through.
“It’s adding trauma on top of the wound that you’ve already got, the worst wound you can imagine, of losing your child.”
Image: Step-father Max Figueiredo
Alice’s stepfather Max said he remains “appalled” that she died in a place they thought would care for her.
“The fact we have these repeated deaths of very young people in secure mental health units shocks me to the core. How can society look at that event and portray it as something that happens as a matter of course?”
Ms Figueiredo said Alice had predicted her own death.
“She said to us – out of fear really: ‘The only way I’m going to leave this ward is in a body bag.’
Image: Alice had predicted her own death, her mother says
In a statement, the North East London NHS Foundation Trust said: “We are deeply sorry for Alice’s death, and we extend our heartfelt condolences to her family and loved ones.
“We have taken significant steps to continually improve the physical and social environment, deliberately designed to support recovery, safety, wellbeing, and assist our workforce in delivering compassionate care.”
For Alice’s family, the convictions have brought some justice, but they will never have complete closure.
“As a mum your bereavement doesn’t ever end, it changes over years as you go on, but it’s unending. The thought I won’t even hear her voice is unbearable and I still miss it. I still miss her voice,” Ms Figueiredo said.
Anyone feeling emotionally distressed or suicidal can call Samaritans for help on 116 123 or email jo@samaritans.org in the UK. In the US, call the Samaritans branch in your area or 1 (800) 273-TALK.