Blood tests which help detect Alzheimer’s could be made available on the NHS within five years as charities join forces for a £5m project.
Diagnosing the condition is often difficult and relies on drawing a sample of spinal fluid from the lower back – a process known as a lumbar puncture – or brain imaging.
Many can face long waits to be seen, with less than two-thirds of people in England with dementia having a formal diagnosis.
In the hope of speeding up diagnosis and reaching more people, Alzheimer’s Research UK and the Alzheimer’s Society are working with the National Institute for Health and Care Research to bring blood tests to the NHS.
Dr Susan Kohlhaas, executive director of research and partnerships at Alzheimer’s Research UK, said they “expect more people to be coming forward for diagnosis”.
More will come forward at a younger age, she added, and she expects them to have “less obvious symptoms”.
“We need better, more scalable tests that are also accurate, and compare to current gold-standard methods,” she said.
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New tests for detecting the signs of Alzheimer’s are in the research stages, including those looking for specific proteins that occur before dementia symptoms, while pharmaceutical giants Roche and Eli Lilly have also joined forces to develop a blood test.
Some tests are already available in private clinics in Hong Kong and the US, but UK charities said more work is needed to ensure tests were measuring the right combination of biomarkers.
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‘New era’ of treatment only possible with better tests
Both these drugs are set to be assessed for use in the UK.
Why early Alzheimer’s tests are so important
Around 900,000 people have Alzheimer’s disease, but only two thirds or so have been diagnosed – and even they can wait months, if not years, to be told the cause of their symptoms.
That delay really matters now that the first effective drugs could soon be approved in the UK.
Lecanemab and donanemab have both been shown to significantly slow the decline in memory and thinking abilities. The earlier in the disease they are given, the more effective they are.
But an accurate diagnosis depends on detecting a rogue protein called amyloid that builds up in the brains of people with the disease.
At the moment, that can only be done by looking for clumps of the protein in the brain with a hugely expensive PET scanner – and they are few and far between in the NHS.
Or the protein can be detected by removing a sample of spinal fluid for lab analysis, a procedure that requires staff with specialist training to be done safely. Again, the NHS doesn’t have enough.
That’s why hopes are high that a blood test could offer an accurate, early diagnosis at scale.
Alzheimer’s Research UK and the Alzheimer’s Society are pushing forward with funding for a trial of a blood test that could be used on the NHS.
Blood tests for Alzheimer’s biomarkers are already available abroad privately.
But doctors need to be sure that a test is accurate enough, not wrongly confirming or ruling out the disease.
Unfortunately, a test could be five years away and there’s a real danger that in the meantime patients could lose out on life-changing drugs simply because their disease hasn’t been diagnosed in time.
“We’re sitting on the cusp of a new era of dementia treatments,” Dr Kohlhaas explained. “But the NHS doesn’t possess the required levels of diagnostic infrastructure to cope with this growing demand.”
“Currently, only 2% of people are offered advanced diagnostic tests like PET scans and lumbar punctures,” Dr Kohlhaas added.
“Significant investment is needed to ensure the NHS has the right tools to identify people with dementia much earlier than it is currently able to.”
The new project, called the Blood Biomarker Challenge, will work with researchers to pilot new blood tests in the NHS.
There is no suggestion that the tests could be used for mass population testing.
But Fiona Carragher, director of research and influencing at the Alzheimer’s Society, said introducing a blood test for dementia into UK healthcare systems would be “a truly game-changing win in the fight against this devastating disease”.
Dementia affects around 900,000 people in the UK and experts predict that will rise to 1.7 million people by 2040.
An emergency debate will take place in parliament today over Sir Keir Starmer’s controversial appointment of Peter Mandelson as his ambassador to the US.
Speaker Lindsay Hoyle has agreed to allot three hours for questions about what the government, and particular the prime minister, knew and didn’t know about the depth of Lord Mandelson’s relationship with billionaire paedophile Jeffrey Epstein.
Lord Mandelson was appointed in January 2025 to the UK’s most senior overseas diplomatic position – the ambassador to the US.
Among the tributes to Epstein in it, Lord Mandelson had described him as “my best pal”.
Image: A picture of Epstein and Mandelson together in the ‘birthday book’ released by the US Congress. Pics: US House Oversight Committee
Then, emails published by The Sun and Bloomberg were even more damning, showing the former Labour minister sympathising with the convicted sex trafficker, saying: “I think the world of you and I feel hopeless and furious about what has happened.”
Lord Mandelson was removed from his ambassadorial post on Thursday, but not before Sir Keir had defended him at PMQs the day before. He has come under fire over his handling of the issue.
He told Channel 4 News he was “angry” to have ended up in a situation where he pivoted from defending him to sacking him within 24 hours, suggesting he was unaware of the “detailed allegations” before PMQs.
But questions remain about what exactly the PM – or the vetting team – knew, and the government has declined to release the details of the procedure Lord Mandelson underwent before he was appointed.
The Conservatives hope to use today’s emergency debate to increase pressure on the government to publish all the information – just hours before Donald Trump lands in the UK for a state visit.
The US president is himself embroiled in questions about his own relationship with the disgraced billionaire.
It’s all added up to a rotten start to the new parliamentary term for the prime minister, who just two weeks ago confidently declared “phase two” of his government was now under way.
He’s ruled out resigning, despite discontent on his backbenches and Reform UK’s sustained lead in the polls.
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Former PM Gordon Brown rallied to Sir Keir’s defence
But former prime minister Gordon Brown has come to Sir Keir’s defence.
Image: Constance Marten and Mark Gordon. Pic: Met Police/PA
‘No genuine expression of remorse’
Judge Mark Lucraft told the pair during sentencing that “neither of you gave much or any thought to the care or welfare of your baby”.
“Your focus was on yourselves,” he said, before adding: “There has been no genuine expression of remorse from either of you.
“Whilst there have been expressions of sorrow about the death throughout, you’ve adopted the stance of seeking to blame everyone else other than yourselves for what happened.”
Sky’s home affairs reporter Henry Vaughan reported that neither showed much emotion during sentencing, and that after they stood up, Gordon stared at Marten as she left the dock.
Image: Constance Marten being interviewed by police.
Pic: Met Police/PA
They had previously been found guilty of perverting the course of justice, concealing the birth of a child, and child cruelty after an Old Bailey trial lasting almost five months.
A second trial was ordered after the first jury failed to reach a verdict on the manslaughter charges.
Marten is now seeking permission to appeal against her conviction for manslaughter. A previous application to appeal her conviction of cruelty to a child was rejected in February this year.
Both trials were hampered by disruption and delays, taking up more than 33 weeks of court time, which – at an estimated £30,000 per defendant a day – could have cost in the region of £10m.
A search for Marten and Gordon was launched after a placenta was found in the couple’s burnt-out car on a motorway in Bolton in January 2023.
Marten said they went on the run so their fifth child would not be removed from them after her other children were “stolen by the state”.
The couple spent vast sums of cash from her family trust fund on taxi journeys as they travelled from Bolton, to Liverpool, to Harwich in Essex, to London and then to Newhaven on the south coast.
Image: Constance Marten and Mark Gordon were captured on CCTV with their baby
Baby’s clothing inadequate, judge says
Prosecutors said the baby was inadequately clothed in a babygrow and that Marten had got wet as she carried the infant underneath her coat, alleging Victoria died from hypothermia or was smothered while co-sleeping.
Judge Lucraft said that while Marten and Gordon claimed they wanted dignity for Victoria’s body, their “conduct showed the opposite”.
He also said the baby had died by 12 January 2023, and that the couple then concealed her and perverted the course of justice before her “decomposed body” was found.
“When you were arrested,” the court heard, “neither of you was willing to give any assistance to the police about the whereabouts of your daughter’s body.
“Your silence at that stage of events is highly significant.”
Image: Police at the allotment where Victoria’s body was found
Met Police Detective Chief Inspector Joanna Yorke, who led the investigation, said the couple’s “selfish actions” resulted in the death of Victoria, “who would have recently had her second birthday and should have had the rest of her life ahead of her”.
She added: “We know today’s sentencing won’t bring Victoria back, but I am pleased our investigation has resulted in the couple who caused her death finally being brought to justice.”
Prosecutors have dropped charges against two men, including a former parliamentary researcher, who had been accused of spying for China.
Christopher Cash, 30, and Christopher Berry, 33, had both denied accusations of providing information prejudicial to the interests of the state in breach of the Official Secrets Act between December 2021 and February 2023.
It was alleged they obtained, recorded and published information “for a purpose prejudicial to the safety or interests of the state” and which could be “directly or indirectly, useful to an enemy”.
They were due to go on trial next month, but prosecutor Tom Little told London’s Old Bailey they would offer no evidence against the pair.
He said: “We simply cannot continue to prosecute.”
A spokesperson for the Home Office said it was “disappointing” the pair would not face trial “given the seriousness of the allegations”.
They said the decision was made by the Crown Prosecution Service “entirely independently of government”.
“National security is the first duty of government and we remain steadfast in upholding this responsibility,” the spokesperson said. “We will continue to use the full range of tools and powers to guard against malign activity.”
A Crown Prosecution Service spokesperson said: “In accordance with the Code for Crown Prosecutors, the evidence in this case has been kept under continuous review and it has now been determined that the evidential standard for the offence indicted is no longer met. No further evidence will be offered.”
Mr Cash’s lawyer said his client was “entirely innocent and should never have been arrested, let alone charged”.
Speaking outside court, Mr Cash said: “While I am relieved that justice has been served today, the last two and a half years have been a nightmare for me and my family.”
He said he hoped “lessons are learned from this sorry episode”.
China had dismissed the charges as “self-staged political farce”.
Mr Cash previously worked as a parliamentary researcher and was closely linked to senior Tories including former security minister Tom Tugendhat and Alicia Kearns, who served as chair of the Commons Foreign Affairs Committee.
He was director of the China Research Group, which was chaired by Mr Tugendhat and then Ms Kearns.
Mr Berry has worked in various teaching posts in China since September 2015.