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A diabetes drug has been approved by a UK regulator to help obese and overweight adults lose weight.

Patients with weight-related health problems – such as prediabetes, high blood pressure, high cholesterol or heart problems – will have access to the drug Mounjaro privately after it was approved by the Medicines and Healthcare Products Regulatory Agency (MHRA).

It needs further approval from the National Institute for Health and Care Excellence (NICE) to be made available on the NHS.

Health Secretary Steve Barclay said: “Although further approvals are needed to use this in the NHS, Mounjaro has the potential to help thousands of people living with obesity and support those suffering from weight-related illnesses – if used alongside diet and physical activity.

“Tackling obesity could help cut waiting lists and save the NHS billions of pounds.”

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The active ingredient in the drug – tirzepatide – works by making a patient feel full and less hungry, and making them experience fewer food cravings.

More on Obesity

The MHRA’s authorisation is based on the results of two clinical trials, one of which showed patients who received the highest dose of the drug lost 22.5% of their body weight over a 72-week period.

The second showed patients with Type-2 diabetes lost 15.7% of their body weight over 72 weeks.

The trials showed patients treated with Mounjaro “had a significant weight loss over time compared to patients who took a placebo”.

The agency listed the potential side effects of the medicine, including nausea, diarrhoea, vomiting – which usually goes away over time – and constipation.

Low blood sugar is also “very common” in patients with diabetes, it added.

It also warned the drug may affect how well the contraceptive pill works in obese or overweight female patients.

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Julian Beach, MHRA interim executive director, healthcare quality and access, said: “We have prioritised rapid assessment of this new indication for Mounjaro, given the public health importance of access to new medicines to help tackle obesity.

“We have drawn on advice from the independent Commission on Human Medicines in coming to our decision, and as with all products, will keep the safety of Mounjaro under close review.”

The MHRA said it will keep the safety and effectiveness of Mounjaro under close review.

In September weight-loss jab Wegovy was launched in the UK to help tackle obesity.

The drug was approved for NHS use by NICE earlier this year and is now available to patients via specialist services.

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UK weather: New snow warning as temperatures could drop to -16C this week

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UK weather: New snow warning as temperatures could drop to -16C this week

A fresh weather warning for snow has been issued for southern England, with cautions for snow and ice already in place across much of the country.

The Met Office’s yellow weather warning for snow covers the southern counties of England from 9am until midnight on Wednesday.

The warning stretches from Kent to Cornwall and up to south London and the Met Office said between two and five centimetres of snow could accumulate fairly widely, with as much as 10cm over higher ground.

Pic: Met Office
Image:
Pic: Met Office

This week is expected to see the coldest nights of the year, with temperatures potentially reaching -14C on Wednesday night and -16C on Thursday night, both in the North East of England and Scotland, the Met Office said.

Weather warnings issued on Tuesday for snow and ice covering the Midlands, parts of North Wales, the North West of England, west and northern parts of Scotland as well as Northern Ireland will remain in place until midday on Wednesday.

The forecaster said some roads and railways are likely to be affected and there could be icy patches on untreated roads.

Members of the public walk through heavy snowfall on the high street of Saddleworth.
Pic: AP
A woman walks through heavy snowfall on the high street of Saddleworth.
Pic: AP
Image:
Pics: AP

Meanwhile the Environment Agency has said at least 300 properties have flooded across England since New Year’s Eve. It estimates more than 41,000 properties have been protected.

Heavy rainfall over the New Year caused significant river and surface water flooding across the North West of England and Yorkshire and snowmelt has brought further disruption to parts of England, particularly the Midlands, the agency said.

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Man says flooding ‘came out of nowhere’

Floods minister Emma Hardy said: “My sympathies go out to the people, businesses and communities impacted by the recent flooding across the country.

“I want to express my heartfelt thanks for the vital work that the Environment Agency and emergency services are doing to keep people safe. People must continue to follow their advice and sign up for flood warnings.”

Flood warnings

Some 100 flood warnings were in force across England on Wednesday, with people urged to remain vigilant over the coming days.

A danger-to-life warning was issued on Tuesday morning for the River Soar near Barrow upon Soar, Leicestershire, but was later removed.

People living in caravan parks in the area were urged by the Environment Agency to act, with a large-scale evacuation needed to save lives.

Firefighters have rescued dozens of people across Leicestershire since Monday, Leicestershire Fire and Rescue Service said.

Hundreds of schools were closed across the UK, with road and rail links blocked, as Manchester, Bristol and Liverpool John Lennon airports suspended flights because of the conditions.

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Family of baby killed in car park crash on family holiday fundraise for funeral

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Family of baby killed in car park crash on family holiday fundraise for funeral

A six-month-old baby who died after a collision in a multi-storey car park was on a family holiday to Wales. 

Sophia Kelemen from Leigh, Manchester, died after the crash in a car park in the coastal town of Tenby, Pembrokeshire, on 2 January.

Sophia’s aunt, Adriana Kelemen, has now launched a fundraiser to help cover funeral costs.

Writing on the page, Ms Kelemen said “never in a million years” did she think she would have to write such a post.

Ms Kelemen said she hoped to “ease a very small part of [her] brother and sister-in-law’s hurt” by raising money to cover part of the funeral costs.

Sophia was taken to hospital after the crash and treated for her injuries but died the following day, police confirmed.

Dyfed-Powys Police said the crash happened on the ground floor of the car park and that a man had been charged in connection with the incident.

Sophia Kelemen. Pic: Adriana Kelemen/GoFundMe
Image:
Sophia Kelemen. Pic: Adriana Kelemen/GoFundMe

Speaking to the Manchester Evening News, Ms Kelemen described her niece as “smiley and bubbly” and “so advanced for her age”.

Sophia was “playful and energetic” and “the cutest and most adorable girl”, her aunt added.

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A spokesperson for Dyfed-Powys Police said Sophia’s family were being supported by specialist officers.

The force said it was a “tragic incident” and asked the public not to speculate on the circumstances.

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Jess Phillips does not rule out new national inquiry into grooming gangs

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Jess Phillips does not rule out new national inquiry into grooming gangs

Jess Phillips has said “nothing is off the table” when dealing with the grooming gangs scandal – including a new national inquiry if victims want one.

The safeguarding minister told Sky’s political editor Beth Rigby on the Electoral Dysfunction podcast that she would listen to victims on a new panel that was announced by the government this week.

“Nothing is off the table,” she said.

“And if the victims come forward to me in this victims panel and they say, ‘actually, we think there needs to be a national inquiry into this’, I’ll listen to them.”

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Beth Rigby and Jess Phillips

Her comments come days after it emerged she had rejected calls from Oldham Council to hold a government inquiry into grooming gangs in the town, and said the council should commission one instead.

That has led to tech billionaire Elon Musk attacking her and Sir Keir Starmer for not holding a national inquiry and accusing the prime minister of being “complicit” in the abuse.

Professor Alexis Jay finished an eight-year national inquiry into child sexual abuse in 2022 and set out recommendations for the government.

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The Conservatives tabled an amendment to the Children’s Safeguarding and Schools Bill on Wednesday to require a statutory inquiry into grooming gangs.

However, Education Secretary Bridget Phillipson told Sky News the Tories “don’t care about children” as the amendment could prevent the entire bill from going forward.

She said: “The measures that I’m setting out today and the legislation in many ways go further because it puts a requirement on all councils to have teams working to keep children safe.

“And the bandwagon jumpers that have come along in recent days, they don’t care about children, they don’t care about making sure that we stop this and we take action.

“They had years to do it and they didn’t do it.”

The Conservatives also rejected a call from Oldham Council for a government inquiry in 2022.

You can listen to Beth’s full interview with Jess Phillips in a special episode of Electoral Dysfunction released on Thursday.

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