Nitazenes: The new synthetic opioids stronger than heroin that are being cut into drugs
Charlotte, not her real name, wanders back and forth with her empty coffee cup held out towards the tide of commuters coming through the barriers.
Rush hour at Whitechapel underground station is the best time of day for the small, frail, 23-year-old to earn enough change to pay for her next hit.
She’s agitated, but for the briefest moment agrees to talk. I ask if any symptoms from her drug use have changed recently. “I’ve got holes in my legs,” she says. “There’s no skin, just holes. It’s painful.”
Synthetic opioids seized by officers. Pic: Met Police
Her legs are bandaged. She says the strange bores in her flesh have only appeared in the last few months and is unsure why.
But drug charity workers are convinced this is a symptom of a terrifying evolution in the drug market – a growing prevalence of dangerous synthetic opioids being cut into drugs like heroin.
The deadliest, nitazenes, are the newest killer on the streets.
“I’m seeing people coughing up blood. I’m seeing people dying,” says crack cocaine user Rory, who we meet in Aldgate in East London.
“Any drug you are buying off the street you’re taking a risk. These people are in it for the money and the purer it is, the less they make – so they are putting other stuff in it.”
Crack cocaine user Rory
The opioid fentanyl is 50 times stronger than heroin and is the primary drug in North America, where synthetic opioids are estimated to have caused 75,000 deaths in the US last year.
Nitazenes have similar properties to fentanyl, but can be up to 300 times stronger than heroin. Only this week, several have been classified as Class A drugs.
First detected in the UK from a sample of white powder found in the back of a taxi in Wakefield in April 2021, nitazenes have since been found in heroin, cannabis, cocaine, in a vape and most prevalently in black market pills sold as the anti-anxiety drug diazepam.
‘Substantial risk of overdose, hospitalisation, and death’
In October, a police raid on a “sophisticated factory” in Waltham Forest recovered approximately 150,000 nitazene tablets, the largest-ever recovered stash of synthetic opioids. Eleven people were arrested.
Detective Superintendent Helen Rance, who is leading the investigation, said: “Synthetic opioids have been detected in batches of heroin found in London and across the UK; they substantially raise the risk of incredibly serious harm to the user and are believed to be linked to a number of deaths.”
Recently, the opioid is thought to have been cut into a batch of drugs in Dublin, causing 57 people to overdose within a few days.
Professor Eamon Keenan, from the Health Safety Executive, said: “These pose a substantial risk of overdose, hospitalisation, and death.”
Meg Jones, director of social justice charity Cranstoun, said: “We are seeing nitazenes pop up in pockets all over the UK and it is incredibly concerning.”
She added: “There are an increasing number of synthetic opioids being detected in drugs that people thought were very different. We need to see government action quickly on this, because we are sleepwalking into what I would deem to be a public health crisis, and we are not prepared for it in the UK at all.”
Action means more testing and provision of drugs that can counter the effects of opioid overdose.
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Outreach worker Abdirahim Hassan, founder of East London community group Coffee Afrik, agrees. He showed me a video of a young woman who appears to have overdosed. She is slumped unconscious on the pavement in Whitechapel.
Outreach worker Abdirahim Hassan
Her body is in the prayer position, her torso flat over her knees, her face pressed against the ground. “She’s just frozen. Her eyes are closed, and people are just walking past,” said Abdirahim. “She’s a young woman, maybe 24, somebody’s daughter.”
Abdirahim said a crackdown on heroin production by the Taliban has successfully stemmed the flow of heroin from Afghanistan which had previously provided 95% of the UK heroin market. That’s led to a boom in the easier to produce, more deadly synthetics.
“What it means is there’s a much higher risk of overdose and death,” he said. “But it’s a cheaper product and more potent so people are in greater crisis and there is not enough testing.”
Birmingham also saw a spike in the detection of nitazenes. Sky News was given access to a unique project in West Midlands police cells, run by the charity Cranstoun.
Steve Whitby is a drug and alcohol worker who visits suspects in their cells. The idea is that drug rehabilitation services reach out to offer support to addicts while they are in police custody.
Drug and alcohol worker Steve Whitby is interviewed by Farrell
On one cell visit, Steve warns an addict, who is also a suspected shoplifter, about the dangers of nitazenes. He told him: “So these are synthetic drugs that dealers are putting into heroin – but it’s causing lots of people to die from overdose.”
He told the man he shouldn’t take drugs alone and that he will leave a kit with his belongings which includes two syringes of naloxone, an antidote of opioid overdose. He explained the man will have to teach whoever is with him how to use it.
Naxolone is a treatment for people who have overdosed
This pilot in Birmingham is believed to be the first time naloxone has been given to addicts in custody, and the charity said this needs to become a national provision.
The Cranstoun programme in police custody suites is funded by the West Midlands police and crime commissioner.
“In essence, this saves more lives than any other intervention,” said Steve as he demonstrated how to inject the clear liquid into the side of the thigh.
He said sometimes it’s dispensed to the children of addicts so they can save their parents lives if they overdose.
As such a newcomer to the UK market and often concealed as something else, there is little data about the prevalence of nitazenes.
Pic: Met Police
The opioid is even more dangerous for those who have never taken it before
However, Wedinos, a service based in Wales where people can send in their drugs anonymously, to get them tested for what they contain, has started to increasingly detect it in other illicit drugs.
They only found nitazenes five times in 2021, but have discovered it 57 times so far this year. It was in what users thought was cannabis in Manchester and cannabis vape liquid in Portsmouth.
They’ve been found most often in what users thought were the black market versions of the anti-anxiety drug diazepam, and pain medication oxycodone, 21 times each.
They are even more dangerous to people who don’t already use opioids, and therefore have no tolerance.
The reported side effects include hallucinations, irregular heartbeat, chest pains, nosebleeds, vomiting, memory loss, aggression, and overdose.
Back on the streets of Whitechapel, another heroin addict, called Rebel, sits waiting for her methadone script outside a drug rehabilitation centre.
Drug user Rebel
She said heroin has changed. She hates the synthetics, describing them as a waste of money and said they don’t work, but she agrees that not knowing what she’s using makes life more dangerous. Health workers have run urine tests and warned her of other substances cut into her drugs.
“They text me and tell me something is cut in it – it’s really bad.” Rebel becomes emotional talking about the impact of her addiction. “I’m 60 now. I don’t want to die a junkie,” she said.
This week, 15 new synthetic opioids were categorised as Class A drugs by the government, but that doesn’t make them any easier for drug users to detect.
A dangerous market has become more deadly. Users like Rebel are rolling the dice every day.
UK
UK has no plans for conscription – but future decisions will respond to ‘new reality’, says minister
The UK is not considering introducing conscription to ready the country for a potential war – but decisions may be needed in the future to respond to the “new reality” we are now living in, a minister has told Sky News.
In an interview with Trevor Phillips, Latvian President Edgars Rinkeviks has urged European countries to follow his country’s lead and “absolutely” introduce conscription, conceding the continent is “quite weak” militarily.
Politics latest: Calls for European nations to reintroduce conscription
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‘Debate’ in Latvia about introducing conscription for women
Asked if the UK government is considering introducing the measure to boost the armed forces, Cabinet Office minister Pat McFadden said it is important the UK does not find itself operating under “old assumptions” – and that it may be “decisions are needed in the future that respond to a new reality”.
He told Sunday Morning with Trevor Phillips: “We are not considering conscription, but of course we have announced a major increase in defence expenditure.
“We do have to recognise that the world has changed. The phrase ‘step up’ is used a lot. Europe does have to step up in terms of its own defence.
“President Trump isn’t actually the first president to say that, but he said it more loudly and with more force than his predecessors – so, I think we have got to recognise that moment.”
‘UK cannot cling to old assumptions’
He added: “When the world is changing as fast as it is, it’s important that we don’t cling on to old assumptions.
“I think the prime minister has played a tremendous role in recent weeks in responding to that situation and explaining it to the public.
“That is why the decision on increasing defence expenditure was needed.
“It may be why other decisions are needed in the future that respond to a new reality, and that we don’t find ourselves caught operating under the same assumption as we used to in the past when the situation has changed.”
‘Battlefield is changing’
Sir Keir Starmer has promised to increase defence spending to 2.5% of GDP but has not set out when this will be achieved. Ministers say a defence review to be published this spring will set out a “roadmap” to it.
The number is much lower than the US president has demanded NATO members spend on defence, with Mr Trump saying they should all be spending 5% – an amount last seen during the Cold War.
Asked if the “new reality” involved a bigger army, Mr McFadden said ministers were waiting for the conclusion of the review.
But he added: “One thing is for sure, you would not spend money today on the same things as you would 10 years ago.
“The experience of the three years of the war in Ukraine has shown just how fast the battlefield is changing in terms of cyber, drones, the use of intelligence.”
The Conservatives’ first policy announcement of last year’s general election campaign was that the party would introduce a new form of mandatory National Service for 18-year-olds.
Asked if the Tories still stood by the plan which was in their manifesto, shadow home secretary Chris Philp told Sunday Morning with Trevor Phillips: “We are obviously not going to write our manifesto now, so I am not going to recommit to things in the previous manifesto.
“We’ll need to do the thinking properly. I am not going to speculate four years ahead of the election.
“I don’t think it was really exactly conscription that was being proposed, it was a National Citizen Service which is a bit different.
“The idea of getting younger people to do voluntary work and perform useful tasks is not a bad idea.”
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‘Right time’ to think about conscription
Last year, Britain’s former top NATO commander told Sky News it was time to “think the unthinkable” and consider introducing conscription.
General Sir Richard Sherriff, ex-deputy supreme allied commander of the military organisation, said: “I think we need to get over many of the cultural hang-ups and assumptions, and frankly think the unthinkable.
“I think we need to go further and look carefully at conscription.”
Police searching for the suspect in the Kent pub shooting on Valentine’s Day have recovered a body from the River Thames.
Lisa Smith, 43, was killed after she was shot outside The Three Horseshoes in Knockholt on the evening of Friday 14 February.
Later that night, the suspect, named as Edvard Smith, was believed to have fallen into the Thames from the Queen Elizabeth II Bridge which crosses the river at Dartford 17 miles away.
Lisa Smith
Around that time, the suspect’s car containing a handgun was found abandoned on the bridge and a man was seen on the wrong side of the barrier.
About a week after the shooting, Kent Police said they believed Edvard Smith had died after falling into the water.
The force has now said a body was found in the Thames near Rainham in Essex on Friday afternoon. It has not been formally identified but the suspect’s family have been told of the development.
Edvard Smith was known to Ms Smith and there had been no prior contact between the police and the victim or suspect.
‘So much commotion’
Following the shooting, the landlady of The Three Horseshoes, Michelle Thomas, told Sky News she heard two loud bangs that she initially “thought were fireworks” on the night of the attack.
She said there was “so much commotion – screaming, shouting, crying” and the shooting had left the community in “absolute shock”.
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CCTV captures sound of gunshots near fatal shooting site
She said Ms Smith, from Slough, had been to the pub before, “mostly in the summer” but “wasn’t a regular”.
Ms Thomas also said about 30 people were at the pub for dinner, while 20 more were in the bar as the incident unfolded just after 7pm.
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Kent Police said on Saturday: “A body has been recovered by police from the River Thames, which is being linked to a murder investigation in Knockholt.
“On Friday 14 February 2025, Lisa Smith, 43, was killed after she was shot outside a pub in Main Road. The suspect was known to Lisa and later that evening officers found his car abandoned on the Queen Elizabeth II Bridge. Enquiries established he had fallen into the water below.
“At around 3.45pm on Friday 7 March, a body was located near Rainham, Essex. Formal identification has not yet taken place; however, the man’s family have been informed.”
Parts of the UK are expected to be hotter than the Balearic Islands, Costa del Sol and the Amalfi Coast this weekend.
The country is set to reach the highest temperatures of the year so far, with central England heating up to 20C on Sunday.
Saturday is also set to reach temperatures in the high teens, with East Anglia, northwest England, the north Midlands and North Wales hitting 18-19C, the Met Office said.
Those temperatures are believed to be above average for this time of year.
Get the latest forecast for your area here
Craig Snell, a meteorologist at the Met Office, said there are a “few exceptions” to the “fine and sunny” weekend weather, including areas in the far north of Scotland, but those areas will still be generally dry and sunny.
A map showing warm fronts over the UK on Saturday
Meanwhile, popular holiday destinations in Europe are expected to record cooler temperatures.
A high of 15C is forecast this weekend for Marbella on the south coast of Spain, a maximum of 17C is expected in Ibiza, and 18C is forecast for Sorrento on Italy’s Amalfi Coast.
People were out in force on Saturday, enjoying the warmer weather. Pic: PA
Joggers run along the sea front in Southend-on-Sea, Essex.
Pic: PA
Sky News meteorologist Chris England said the warm weekend is not expected to last, with conditions “cooling off from the North on Sunday night and through Monday”.
Colder fronts will start to move across the UK on Monday
By Wednesday the UK will experience wintry showers and cold temperatures
A spell of rain will move south across the country early next week, bringing the return of a few wintry showers in the North and North East.
“While there is uncertainty in the extent of rain and wintry showers through the middle of next week, there is higher confidence that below average temperatures will continue through the week, bringing a very different feel to the mild weather over the weekend,” deputy chief meteorologist Chris Bulmer said.
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Temperatures will drop back below average across the UK from Tuesday, according to the Met Office.
Rural spots in Scotland could plummet as low as -4C, with maximum daytime temperatures typically between 5-8C.
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