Noor Siddiqui, founder and CEO of Orchid, during the web summit for careers during Day 2 of the 2014 Web Summit in Dublin, Ireland, Nov. 5, 2014.
Stephen McCarthy | Getty Images
Reproductive technology startup Orchid on Tuesday announced a comprehensive new genetic test that may help many prospective parents across the U.S. breathe a little easier.
The company is launching the first commercially available whole genome sequencing report for embryos, designed for couples undergoing in vitro fertilization, which is a type of treatment for people experiencing infertility or who are at risk of passing on genetic problems.
With IVF, after a woman has had around two weeks of daily hormone injections, her mature eggs are extracted and fertilized in a lab, and the viable embryos are later transferred into the uterus.
Orchid said its new test will help couples identify whether their embryos present genetic risks such as birth defects, neurodevelopmental disorders, chromosomal abnormalities, or pediatric and adult-onset cancers that were previously only detectable after birth.
“This is a major advance in the amount of information parents can have,” Noor Siddiqui, Orchid’s founder and CEO, told CNBC in an interview. “The way that you can use that information is really up to you, but it gives a lot more control and confidence into a process that, for all of history, has just been totally left to chance.”
Orchid’s technology sequences more than 99% of an embryo’s genome, while existing tests typically read around .25%, the company said in a release.
IVF is a taxing process that can cost an average of more than $12,000 in the U.S., according to the Institute for Reproductive Health. Success is not guaranteed, and some people go through multiple rounds of IVF before a pregnancy develops.
Orchid’s genetic test will cost couples an additional $2,500 per embryo sequenced, but it does not add any new steps or risks to the IVF process, Siddiqui said. She added that the cost of the report should come down as the company is able to scale up its operations and introduce more automation.
“We want to make this something that’s accessible to everyone,” Siddiqui said.
Beginning Tuesday, Orchid’s technology will be available at IVF clinics in major cities such as Los Angeles, Chicago, Miami and Austin, and Siddiqui said Orchid can be made available at additional clinics at the request of patients.
Couples will receive their report back from Orchid after about three weeks, the company said, and a board-certified genetic counselor will help them understand the results.
Orchid’s whole genome embryo report
Courtesy: Orchid
Orchid has secured $12 million in funding from investors such as Prometheus Fund and Refactor Capital. Anne Wojcicki, the co-founder and CEO of 23andMe; Dylan Field, the co-founder and CEO of Figma; Fidji Simo, the CEO of Instacart; Brian Armstrong, the co-founder CEO of Coinbase, and others are also backers.
For many hopeful parents, the peace of mind is worth Orchid’s steep price.
Roshan George, a 35-year-old engineer in San Francisco, began the IVF process with his wife, Julie, in the fall.
George said they were feeling some anxiety about having a baby at an older age, and their nerves were amplified after their IVF clinic discovered they are both carriers for nonsyndromic hearing loss, which can result in a partial or total loss of hearing.
George had heard of Orchid through some friends, he said, and the couple decided to sequence all three of their viable embryos with the company. He said getting the embryos tested was very straightforward, and when the results came back, they discovered that two out of the three embryos were healthy.
“We were super relieved right off the bat,” George told CNBC in an interview. “That was very gratifying to hear.”
“Just having some degree of certainty — you’re going to make sure they’re not sick when they’re born and all that sort of stuff — it’s a huge amount of anxiety that’s been lifted off,” George said.
George Church, a professor of genetics at Harvard Medical School, is an investor and an adviser at Orchid. Church developed the first direct genome sequencing method, he said, and Orchid’s technology will give parents the ability to access a hundred times more information about their baby than they could attain previously.
Church said it is “perfectly logical” for parents to care about helping their children, whether it pertains to their genetic health, the quality of their food or whether they get enough sleep and exercise.
He added that people often think that genetic risks don’t apply to them, or that there’s nothing they can do if something is wrong. But with Orchid, Church said parents have the detailed information they need to make informed decisions.
“If you went to Las Vegas with a 97% chance of winning, you would definitely go to Las Vegas,” Church told CNBC in an interview. “But it’s different when you’re talking about quarters as opposed to children.”
Orchid’s primary focus after the launch Tuesday will be on scaling up its technology and making it more accessible, Siddiqui said.
She said Orchid has spent an “enormous amount of effort” identifying the mutations that will cause severe disease during pregnancy or early childhood or result in serious chronic conditions. She wanted to ensure the company is able to provide parents with information that is “super meaningful.”
“I think this has the potential to totally redefine reproduction,” Siddiqui said. “I just think that’s really exciting to be able to make people more confident about one of the most important decisions of their life, and to give them a little bit more control.”
When Shreya Murthy and Joy Tao decided to launch a party-planning startup in 2020, they settled on a business goal of “bringing people together in person.”
The Covid-19 pandemic demanded the exact opposite.
Despite the challenge of the pandemic, Partiful survived, and five years later, the New Yorkstartup is now used by millions of people to plan events such as birthday parties, housewarmings and weddings.
The app’s a favorite of those ages 20 to 30, and it’s added 2 million newusers since January, Partiful CEO Murthy told CNBC. The company has never revealed its exact base of monthly users.
Partiful drew attention on social media after Apple, known for replicating features from popular apps on the iPhone, launched its own event-planning service in February, and the startup posted a joke about “copycats” on its X account.
Of course, Partiful isn’t the first party-planning app. It competes against not only Apple Invites, but also Eventbrite, Evite, Punchbowl and others.
Each service differs slightly in its target markets and features. Evite, for example, uses a “freemium” model, where certain invitation designs and other features are paywalled. Eventbrite is often used to promote and sell admission to large public events.
What sets Partiful apart from its competitors — and appeals to its Gen Z user base — is its often humorous, casual designs, some of which are created by Partiful’s in-house designers.
“Friend invited me to a gathering that doesn’t have a Partiful….feeling lost, confused, unprepared…much like when I (Gen Z) receive a phone call out of the blue,” X user Athena Kan posted in August.
For the first quarter of 2025, Partiful averaged 500,000 monthly active users, up 400% year over year, with 9 out of 10 users on the app based in the U.S., according to estimates provided to CNBC by Sensor Tower, a market research firm. That compares with Eventbrite’s 4.4 million monthly active users, which is up 2% year over year, and Punchbowl with approximately 85,000 monthly users, which is down about 2% compared to a year ago. A spokesperson for Evite told CNBC that the service saw more than 20 million monthly active users for the first quarter of 2025.
It’s unclear how many people still use Facebook’s once-popular event-planning feature Facebook Events. Facebook’s parent company, Meta, shut down the standalone app.
Sample invitations from the Partiful app
Source: Partiful
Bringing people together in real life
Murthy and Tao both went to Princeton University and worked at Palantir Technologies at the same time, but they didn’t meet until they were introduced later by a mutual friend. Both were looking to move to the consumer-facing side of tech.
Tao, then a software engineer at Meta, wanted to leave the company to focus on products that were more relatable to daily life, and said that the social media company’s goal of keeping users engaged on their apps sometimes can create “perverse incentives.”
“For me, driving more people to spend more time staring at their phone, staring at this endless feed of content, wasn’t super motivating, wasn’t super meaningful to me personally,” said Tao, Partiful’s tech chief and a self-described “avid party planner.”
Meta declined to comment.
Tao and Murthy went through a sort of “dating period” where they asked each other what they thought leading a startup together could look like. Among the voids they identified was howintimate social events, such as birthday parties where a host would be likely to see the attendees again, were still planned on text chains that made it difficult to track, communicate or plan an ideal event time with guests.
“If you’re not sure when people are free, that’s a really annoying problem,” Murthy said.
She and Tao took the leap.
With few in-person events happening during the 2020 lockdowns, Partiful’s engineering team focused on building the platform’s text message-based infrastructure so that the service could be used by both iPhone and Android users.
Partiful’s team, which has now grown to 25, operates out of downtown Brooklyn. The service is no longer limited to text messages and its website. The company launched apps for the iPhone and Android devices in 2023 and 2024, respectively, and Partiful now serves as a one-stop destination for organizing the different phases of planning and hosting a party. The company has reportedly raised $20 million in a funding round led by Andreessen Horowitz.
Speaking Gen Z’s language
What makes Partiful fun for users is how customizable an invite can be.
Hosts can create a free birthday invite with a lime-green parody cover of Charli XCX’s “brat” album, for example, or plan a girls’ night out with a cover photo of Shrek in sunglasses. They can track “yes,” “no” or “maybe” RSVPs under a portrait of Martha Stewart and Snoop Dogg, and invited guests can use a “boop” feature to send random emojis rather than a direct message to each other.
Party planners can also send out uniform text blasts to the group before and after the event and manage an in-app photo album for uploading memories.
Partiful is available for anyone to use, but Murthy said the company sees the most need for the service among young users in the “postgrad” period of life. That’s a stage where people might be moving to new cities and away from their established college friend groups.
“You’re starting your adult life and have to not only figure out, ‘How do I rent an apartment? How do I work a new job? How do I exist in this new version of myself?'” Murthy said. “On top of that, you’re also having to rebuild your entire social circle.”
For the hosts and partiers in its user base, Partiful has become part of their social routine, and it has continued to gain traction online. The company told CNBC that over 60% of its active app users check Partiful every week.
As for Apple, Partiful isn’t sweating its new rival just yet.
Apple Invites requires that users have an iCloud+ subscription to create events, though it’s free to RSVP if a guest doesn’t have an Apple account. That service starts at 99 cents a month in the United States. Apple did not respond to a request for comment.
Partiful is free, at least for now.
Like many other tech companies that rely on distribution services such as Apple’s App Store, Partiful has a nuanced relationship with its much-larger counterpart. Partiful could lose some users to Apple, but it can also benefit from promotion by the app distributor.
That’s what happened in 2024, when Partiful was named a finalist for Apple’s App Store Awards for Cultural Impact, and won Google Play’s “Best App of 2024.” The app remained an “editor’s choice” pick on the App Store as of publication.
For now, Partiful remains confident.
“We haven’t really seen any users that have been leaving Partiful for Apple Invites,” Murthy said.
Inside a secretive set of buildings in Santa Barbara, California, scientists at Alphabet are working on one of the company’s most ambitious bets yet. They’re attempting to develop the world’s most advanced quantum computers.
“In the future, quantum and AI, they could really complement each other back and forth,” said Julian Kelly, director of hardware at Google Quantum AI.
Google has been viewed by many as late to the generative AI boom, because OpenAI broke into the mainstream first with ChatGPT in late 2022.
Late last year, Google made clear that it wouldn’t be caught on the backfoot again. The company unveiled a breakthrough quantum computing chip called Willow, which it says can solve a benchmark problem unimaginably faster than what’s possible with a classical computer, and demonstrated that adding more quantum bits to the chip reduced errors exponentially.
“That’s a milestone for the field,” said John Preskill, director of the Caltech Institute for Quantum Information and Matter. “We’ve been wanting to see that for quite a while.”
Willow may now give Google a chance to take the lead in the next technological era. It also could be a way to turn research into a commercial opportunity, especially as AI hits a data wall. Leading AI models are running out of high-quality data to train on after already scraping much of the data on the internet.
“One of the potential applications that you can think of for a quantum computer is generating new and novel data,” said Kelly.
He uses the example of AlphaFold, an AI model developed by Google DeepMind that helps scientists study protein structures. Its creators won the 2024 Nobel Prize in Chemistry.
“[AlphaFold] trains on data that’s informed by quantum mechanics, but that’s actually not that common,” said Kelly. “So a thing that a quantum computer could do is generate data that AI could then be trained on in order to give it a little more information about how quantum mechanics works.”
Kelly has said that he believes Google is only about five years away from a breakout, practical application that can only be solved on a quantum computer. But for Google to win the next big platform shift, it would have to turn a breakthrough into a business.
An attendee wearing a Super Mario costume uses a Nintendo Switch 2 game console while playing a video game during the Nintendo Switch 2 Experience at the ExCeL London international exhibition and convention centre in London, Britain, April 11, 2025.
Isabel Infantes | Reuters
Nintendo on Friday announced that retail preorder for its Nintendo Switch 2 gaming system will begin on April 24 starting at $449.99.
Preorders for the hotly anticipated console were initially slated for April 9, but Nintendo delayed the date to assess the impact of the far-reaching, aggressive “reciprocal” tariffs that President Donald Trump announced earlier this month.
Most electronics companies, including Nintendo, manufacture their products in Asia. Nintendo’s Switch 1 consoles were made in China and Vietnam, Reuters reported in 2019. Trump has imposed a 145% tariff rate on China and a 10% rate on Vietnam. The latter is down from 46%, after he instituted a 90-day pause to allow for negotiations.
Nintendo said Friday that the Switch 2 will cost $449.99 in the U.S., which is the same price the company first announced on April 2.
“We apologize for the retail pre-order delay, and hope this reduces some of the uncertainty our consumers may be experiencing,” Nintendo said in a statement. “We thank our customers for their patience, and we share their excitement to experience Nintendo Switch 2 starting June 5, 2025.”
The Nintendo Switch 2 and “Mario Kart World“ bundle will cost $499.99, the digital version “Mario Kart World” will cost $79.99 and the digital version of “Donkey Kong Bananza” will cost $69.99, Nintendo said. All of those prices remain unchanged from the company’s initial announcement.
However, accessories for the Nintendo Switch 2 will “experience price adjustments,” the company said, and other future changes in costs are possible for “any Nintendo product.”
It will cost gamers $10 more to by the dock set, $1 more to buy the controller strap and $5 more to buy most other accessories, for instance.