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A world-first clinical trial has found a common drug used to treat rheumatoid arthritis can suppress the progression of type 1 diabetes in recently diagnosed patients.

Researchers at St Vincent’s Institute of Medical Research in Melbourne, Australia, discovered baricitinib can preserve the body’s own insulin production.

They described the finding as “a huge step-change” in how the condition is managed and treated and said their work “shows promise as a fundamental improvement in the ability to control type 1 diabetes”.

Type 1 diabetes is a chronic condition that causes a person’s blood sugar level to become too high because their body is unable to make insulin.

Their body’s immune system mistakenly attacks and kills the cells in the pancreas that produce the hormone, which means they are dependent on regular insulin injections in order to survive.

Professor Thomas Kay, who led the trial, said: “We wanted to see whether we could protect further destruction of these cells by the immune system.”

The scientists recruited 91 people, aged between 10 and 30 years old, to take part in the double-blind randomised trial.

It meant neither the researchers nor the volunteers knew who was taking baricitinib (60 people) and who was receiving a placebo (31 people).

All patients had been diagnosed with type 1 diabetes within the last 100 days and continued with their prescribed insulin therapy throughout the study.

The researchers monitored their total daily dose of insulin, the amount of insulin produced in the body, as well as their blood sugar levels.

The results showed those in the baricitinib group were able safely and effectively to preserve their body’s own insulin production and suppress the progression of type 1 diabetes.

It is thought the drug works by dampening down the immune response mounted against insulin-producing cells in people with type 1 diabetes.

Professor Kay said: “Up until now, people with type 1 diabetes have been reliant on insulin delivered via injection or infusion pump.

“Our trial showed that, if started early enough after diagnosis, and while the participants remained on the medication, their production of insulin was maintained.

“People with type 1 diabetes in the trial who were given the drug required significantly less insulin for treatment.”

It is estimated around 8.4 million people across the world had type 1 diabetes in 2021, with numbers projected to rise to 17.4 million by 2040.

In the UK, around 8% of people with diabetes have type 1 diabetes.

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Dr Faye Riley, research communications manager at Diabetes UK, said of the latest trial: “These findings show by tackling the root of type 1 diabetes – an immune system attack – an existing drug can help to shield the pancreas, in people recently diagnosed with type 1, so they can continue making more insulin for longer.

“This can give people with type 1 diabetes much steadier blood sugar levels and help to protect against serious diabetes complications down the line.

“Immunotherapies are edging us towards a new era in type 1 diabetes treatment, and could help us overcome a major hurdle en route to finding a cure for the condition.

“This trial takes us another step closer.”

The study was funded by JDRF, a non-profit organisation which focuses on type 1 diabetes research.

The research has been published in the New England Journal of Medicine.

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Ferocious wind and rain as super typhoon brings megacities to a standstill

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Ferocious wind and rain as super typhoon brings megacities to a standstill

In the end, the damage wrought by typhoon Ragasa, on mainland China at least, was not as bad as many had feared, but its power still brought multiple megacities to an almost complete standstill.

The city of Zhuhai, just across the water from Macao, is one such example.

On our drive in, we passed street after street of shuttered businesses, debris littering the roads, and precious few other vehicles.

Typhoon, hurricane or cyclone – what’s the difference?

Super typhoon Ragasa
Image:
Super typhoon Ragasa

Pic:  The Warthog Air Squadron/Reuters
Image:
Pic: The Warthog Air Squadron/Reuters

People here had either been evacuated or told to stay at home and, by and large, they listened.

And you can see why.

Pic: The Warthog Air Squadron/Reuters
Image:
Pic: The Warthog Air Squadron/Reuters


Damaged cars in Hualien, Taiwan. Pic: Reuters
Image:
Damaged cars in Hualien, Taiwan. Pic: Reuters


The wind and the rain were ferocious.

Even some time after the eye of the storm had passed, the gusts were still plenty strong enough to knock you off balance.

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Moment hotel doors smash in super typhoon

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They are used to typhoons in this part of the world, and they are well prepared for them, but experts say the regularity and intensity of storms like this are increasing.

Waves crash against the waterfront in Hong Kong. Pic: AP
Image:
Waves crash against the waterfront in Hong Kong. Pic: AP

Pic: The Warthog Air Squadron/Reuters
Image:
Pic: The Warthog Air Squadron/Reuters


Shenzhen, southern China. Pic: AP
Image:
Shenzhen, southern China. Pic: AP

Indeed, Ragasa is the ninth typhoon to have hit Hong Kong this year and the annual average is normally six.

A growing problem for this hugely populous region.

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Israel kills 22 people including nine children in ‘horrific massacre’ in Gaza, Palestinian officials say

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Israel kills 22 people including nine children in 'horrific massacre' in Gaza, Palestinian officials say

Israel killed 22 people – including nine children – in strikes on Gaza City today, Palestinian officials have said.

Gaza civil defence spokesman Mahmoud Bassal described the killings as a “horrific massacre”.

Video purportedly from the scene of the attack on the Souq Firas area of the city showed the bodies of children being pulled from rubble.

“We were sleeping in God’s care, there was nothing – they did not inform us, or not even give us a sign – it was a surprise,” said Sami Hajjaj.

“There are children and women, around 200 people maybe, six to seven families – this square is full of families.”

Men carry the bodies of Palestinian children killed in a strike on a building where people were sheltering in Gaza City. Pic: Reuters
Image:
Men carry the bodies of Palestinian children killed in a strike on a building where people were sheltering in Gaza City. Pic: Reuters

The Israeli military claimed the strike targeted Hamas militants and that its forces tried to reduce harm to civilians in the area.

A total of 51 people have been killed across Gaza today, according to hospital medics in the Hamas-run territory.

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Israeli forces pushed towards the heart of Gaza City on Wednesday, placing at risk the lives of Palestinians who had stayed put in hopes that growing pressure on Israel for a ceasefire would mean they would not lose their homes.

“We moved to the western area near the beach, but many families didn’t have the time, tanks took them by surprise,” said Thaer, a 35-year-old father of one from Tel Al-Hawa.

Meanwhile, the Palestinian Red Crescent Society said the oxygen station at Al-Quds Hospital in Gaza had stopped operating “due to Israeli occupation forces firing at it”.

“Operations are currently being conducted using pre-filled oxygen cylinders, which are sufficient for only three days,” the group said.

“Occupation forces are currently stationed at the southern gate of the society’s Al-Quds Hospital in the Tal al-Hawa neighbourhood of Gaza City, preventing anyone from entering or leaving the hospital.”

The world’s leading authority on hunger crises said last month that Israel’s blockade and ongoing offensive had pushed Gaza City into famine.

Palestinians inspect the site of deadly overnight Israeli strikes on a building where displaced people were taking shelter. Pic: Reuters
Image:
Palestinians inspect the site of deadly overnight Israeli strikes on a building where displaced people were taking shelter. Pic: Reuters

More than 300,000 people have fled the city in recent weeks as Israel has ordered the population to move south, but UN agencies and aid groups say an estimated 700,000 remain.

More than 65,000 Palestinians have been killed since October 2023, according to the Gaza Health Ministry, more than half of them women and children.

Its figure does not differentiate between civilians and fighters.

The current wave of violence began on 7 October, 2023, when Hamas-led militants carried out an attack inside Israel that killed 1,200 people, most of them civilians, and saw around 250 people taken hostage.

Hundreds of thousands of people have been fleeing northern Gaza. Pic: Reuters
Image:
Hundreds of thousands of people have been fleeing northern Gaza. Pic: Reuters

Pic: Reuters
Image:
Pic: Reuters

Israel claims its operation in Gaza is aimed at pressuring Hamas to surrender and return the remaining 48 hostages. Israel believes around 20 of the captives are still alive.

Critics say Israeli Prime Minister Benjamin Netanyahu is not interested in peace negotiations and wants to continue the war with a view to displacing Gaza’s population and expand Israeli settlements.

He has repeatedly rejected the possibility of a Palestinian state.

Addressing the United Nations General Assembly on Tuesday, UN secretary-general Antonio Guterres said: “In Gaza, the horrors are approaching a third monstrous year.

“They are the result of decisions that defy basic humanity,” he continued, citing “a scale of death and destruction beyond any other conflict” in his years as secretary-general.

“Nothing can justify the collective punishment of the Palestinian people and the systematic destruction of Gaza,” he added.

The world’s leading association of genocide scholars, the International Association of Genocide Scholars (IAGS), declared in August that Israel was committing genocide in Gaza.

Several other leading rights organisations, including two Israeli groups, have also said Israel is committing genocide.

Israel has repeatedly denied its actions in Gaza amount to genocide and claims they are justified as a means of self-defence.

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Spanish defence minister’s jet suffers GPS disturbance near Russian enclave

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Spanish defence minister's jet suffers GPS disturbance near Russian enclave

A Spanish military jet with a defence minister on board suffered a GPS “disturbance” while on the way to Lithuania, according to Spanish officials.

The military aircraft was flying near Russia’s Kaliningrad enclave on Wednesday morning when the incident is reported to have happened.

Margarita Robles was the minister on the flight, according to Spanish officials.

A commander onboard the Spanish plane said such incidents are common when flying near Kaliningrad, both for civil and military aircraft – and military satellites could also be used to navigate.

A Spanish defence ministry spokesperson said: “There has been an attempt to disrupt the GPS signal, but as our aircraft has an encrypted system, it was not affected.

“It must be common on this route and also with commercial flights. It is not because it is our aircraft.”

Read more: Who is messing with GPS signals – and why?

Ms Robles was due to have a bilateral meeting with her Lithuanian counterpart Dovile Sakaliene during a visit to the Siauliai airbase on Wednesday, according to the Spanish government’s agenda.

The plane was also carrying relatives of Spanish airmen forming part of the new NATO air defence mission on Europe’s eastern flank.

It was launched earlier this month after Poland shot down drones that had violated its airspace.

The Spanish contingent last week intercepted eight Russian aircraft operating over the Baltic Sea, Spain’s defence ministry added in a statement.

Ms Robles, 68, has been Spain’s defence minister since 2018.

In June, she said Spain was “absolutely committed” to NATO and the European Union.

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Ursula von der Leyen speaks in Lithuania on 1 September. Pic: AP
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Ursula von der Leyen speaks in Lithuania on 1 September. Pic: AP

Then in August, the minister said Spain would work to “invigorate” the European fighter jet project, known as FCAS.

It came after Spain revealed it was no longer considering the option of buying US-made F-35 fighter jets and would refocus its defence spending on buying European-made equipment.

At the end of August, a plane carrying European Commission President Ursula von der Leyen suffered GPS jamming as a result of suspected Russian interference, an EU spokesperson told Sky News.

Estonia and neighbouring Finland have also previously blamed Russia for jamming GPS navigation devices in the region’s airspace.

Russia has denied interfering with communication and satellite networks.

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