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A world-first clinical trial has found a common drug used to treat rheumatoid arthritis can suppress the progression of type 1 diabetes in recently diagnosed patients.

Researchers at St Vincent’s Institute of Medical Research in Melbourne, Australia, discovered baricitinib can preserve the body’s own insulin production.

They described the finding as “a huge step-change” in how the condition is managed and treated and said their work “shows promise as a fundamental improvement in the ability to control type 1 diabetes”.

Type 1 diabetes is a chronic condition that causes a person’s blood sugar level to become too high because their body is unable to make insulin.

Their body’s immune system mistakenly attacks and kills the cells in the pancreas that produce the hormone, which means they are dependent on regular insulin injections in order to survive.

Professor Thomas Kay, who led the trial, said: “We wanted to see whether we could protect further destruction of these cells by the immune system.”

The scientists recruited 91 people, aged between 10 and 30 years old, to take part in the double-blind randomised trial.

It meant neither the researchers nor the volunteers knew who was taking baricitinib (60 people) and who was receiving a placebo (31 people).

All patients had been diagnosed with type 1 diabetes within the last 100 days and continued with their prescribed insulin therapy throughout the study.

The researchers monitored their total daily dose of insulin, the amount of insulin produced in the body, as well as their blood sugar levels.

The results showed those in the baricitinib group were able safely and effectively to preserve their body’s own insulin production and suppress the progression of type 1 diabetes.

It is thought the drug works by dampening down the immune response mounted against insulin-producing cells in people with type 1 diabetes.

Professor Kay said: “Up until now, people with type 1 diabetes have been reliant on insulin delivered via injection or infusion pump.

“Our trial showed that, if started early enough after diagnosis, and while the participants remained on the medication, their production of insulin was maintained.

“People with type 1 diabetes in the trial who were given the drug required significantly less insulin for treatment.”

It is estimated around 8.4 million people across the world had type 1 diabetes in 2021, with numbers projected to rise to 17.4 million by 2040.

In the UK, around 8% of people with diabetes have type 1 diabetes.

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Dr Faye Riley, research communications manager at Diabetes UK, said of the latest trial: “These findings show by tackling the root of type 1 diabetes – an immune system attack – an existing drug can help to shield the pancreas, in people recently diagnosed with type 1, so they can continue making more insulin for longer.

“This can give people with type 1 diabetes much steadier blood sugar levels and help to protect against serious diabetes complications down the line.

“Immunotherapies are edging us towards a new era in type 1 diabetes treatment, and could help us overcome a major hurdle en route to finding a cure for the condition.

“This trial takes us another step closer.”

The study was funded by JDRF, a non-profit organisation which focuses on type 1 diabetes research.

The research has been published in the New England Journal of Medicine.

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‘Horrific incident’ at sheriff training facility in LA – at least three people dead

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'Horrific incident' at sheriff training facility in LA - at least three people dead

At least three people have been killed after a “horrific incident” at a Los Angeles County Sheriff’s Department training facility, officials have said.

A spokesperson for the department said there was an explosion at the Biscailuz Center Academy Training in east LA.

The incident was reported at around 7.30am local time (3.30pm UK time).

Aerial footage from local channel KABC-TV suggests the blast happened in a parking lot filled with sheriff patrol cars and box trucks.

The Eugene Biscailuz Center Academy Training in East Los Angeles. Pic: NBC Los Angeles
Image:
The training centre in east LA. Pic: NBC Los Angeles

Attorney general Pam Bondi wrote on X: “I just spoke to @USAttyEssayli about what appears to be a horrific incident that killed at least three at a law enforcement training facility in Los Angeles.

“Our federal agents are at the scene and we are working to learn more.”

California congressman Jimmy Sanchez said the explosion had “claimed the lives of at least three deputies”.

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“My condolences to the families and everyone impacted by this loss,” he said.

Media and law enforcement stage near the site of an explosion at the LA County Sheriff's Special Operations Bureau on Friday, July 18, 2025, in Los Angeles. (AP Photo/Etienne Laurent)
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Media and law enforcement officials near the explosion site. Pic: AP

The attorney general said in a follow-up post that agents from the FBI and the Bureau of Alcohol, Tobacco, Firearms and Explosives are “on the ground to support”.

The mayor of Los Angeles, Karen Bass, said the LAPD bomb squad has also responded to the scene.

“The thoughts of all Angelenos are with all of those impacted by this blast,” she said.

California Governor Gavin Newsom has been briefed on the incident, his press office said in a post on X.

“The Governor’s Office of Emergency Services is in contact with the Sheriff’s Department and closely monitoring the situation, and has offered full state assistance,” it added.

The cause of the explosion is being investigated.

This breaking news story is being updated and more details will be published shortly.

Please refresh the page for the latest version.

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Unmasked: The 18 Russian spies who mounted series of attacks on UK

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Unmasked: The 18 Russian spies who mounted series of attacks on UK

Dozens of Russian spies have been sanctioned by the government – including those responsible for targeting Yulia Skripal five years before her attempted murder in Salisbury.

The Foreign Office has announced that three units of the Russian military intelligence agency (GRU) have been hit with sanctions, alongside 18 military intelligence officers.

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GRU officers attempted to murder Yulia Skipal and her father Sergei using the deadly Novichok nerve agent in Salisbury.

The 18 military intelligence officers have been targeted because of a sustained campaign of malicious cyber activity over many years, including in the UK, the Foreign Office said.

Yevgeniy Mikhaylovich SEREBRIAKOV.
Pic: FBI
Image:
Yevgeniy Mikhaylovich SEREBRIAKOV.
Pic: FBI

The government also accused the GRU of using cyber and information operations to “sow chaos, division and disorder in Ukraine and across the world”.

One of the groups sanctioned, Unit 26165, conducted online reconnaissance to help target missile strikes against Mariupol, including the bombing of Mariupol Theatre where hundreds of civilians, including children, were murdered.

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ALEKSEY VIKTOROVICH LUKASHEV
Pic -  FBI
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ALEKSEY VIKTOROVICH LUKASHEV
Pic – FBI

Other military officers who have been sanctioned previously targeted Yulia Skripal’s mobile phone with malicious malware known as X-Agent.

The Skripals had moved to the UK after Sergei Skripal became a double agent, secretly working for the UK. He was tried for high treason and imprisoned in Russia – and later exchanged in a spy swap.

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But five years after Yulia’s phone was targeted, the pair were poisoned with the nerve agent, Novichok, in Salisbury. Russia has always denied being involved in the chemical attack.

Foreign Secretary David Lammy said: “GRU spies are running a campaign to destabilise Europe, undermine Ukraine’s sovereignty and threaten the safety of British citizens,” Foreign Secretary David Lammy said.

“The Kremlin should be in no doubt: we see what they are trying to do in the shadows and we won’t tolerate it.”

He said the UK was taking “decisive action” with the sanctions against Russian spies.

“Putin’s hybrid threats and aggression will never break our resolve. The UK and our allies’ support for Ukraine and Europe’s security is ironclad.”

Those sanctioned today include:

  • Aleksandr Vladimirovich Osadchuk
Aleksandr Vladimirovich OSADCHUK 
Image:
Aleksandr Vladimirovich OSADCHUK 

  • Yevgeniy Mikhaylovich Serbriakov
Yevgeniy Mikhaylovich SEREBRIAKOV.
Pic: FBI
Image:
Yevgeniy Mikhaylovich SEREBRIAKOV.
Pic: FBI

  • Anatoliy Sergeyvich Kovalev
Anatoliy Sergeyvich KOVALEV 
Image:
Anatoliy Sergeyvich KOVALEV 

  • Artem Valeryvich Ochichenko
ARTEM VALERYEVICH OCHICHENKO. Pic: FBI
Image:
ARTEM VALERYEVICH OCHICHENKO. Pic: FBI

  • The 161st Specialist Training Centre (TsPS) (Unit 29155) of the GRU
  • Vladislav Yevgenyevich Borovkov
VLADISLAV YEVGENYEVICH BOROVKOV
Image:
VLADISLAV YEVGENYEVICH BOROVKOV

  • Nikolay Aleksandrovich Korchagin
NIKOLAY ALEKSANDROVICH KORCHAGIN.
Pic: FBI
Image:
NIKOLAY ALEKSANDROVICH KORCHAGIN.
Pic: FBI


  • Yuriy Federovich Denisov
YURIY FEDOROVICH DENISOV.
Pic: FBI
Image:
YURIY FEDOROVICH DENISOV.
Pic: FBI

  • Vitaly Aleksandrovich Shevchenko
  • Ivan Sergeyevich Yermakov
Ivan Sergeyevich Yermakov.
Pic: FBI/Reuters
Image:
Ivan Sergeyevich Yermakov.
Pic: FBI/Reuters

  • Aleksey Viktorovich Lukashev
ALEKSEY VIKTOROVICH LUKASHEV
Pic -  FBI
Image:
ALEKSEY VIKTOROVICH LUKASHEV
Pic – FBI

  • Sergey Sergeyevich Vasyuk
  • Andrey Eduardovich Baranov
  • Aleksey Sergeyevich Morenets
ALEKSEI SERGEYEVICH MORENETS.
Pic: FBI
Image:
ALEKSEI SERGEYEVICH MORENETS.
Pic: FBI

  • Sergey Aleksandrovich Morgachev
SERGEY ALEKSANDROVICH MORGACHEV
Image:
SERGEY ALEKSANDROVICH MORGACHEV

  • Artem Adreyevich Malyshev
SERGEY ALEKSANDROVICH MORGACHEV.
Pic: FBI
Image:
ARTEM ANDREYEVICH MALYSHEV

Pic: FBI

  • Yuriy Leonidovich Shikolenko
  • Victor Borisovich Netyksho
  • Dmitriy Aleksandrovich Mikhaylov
  • African Initiative
  • Artyom Sergeevich Kureyev
Artyom Sergeevich KUREYEV
Image:
Artyom Sergeevich KUREYEV

  • Anna Sergeevna Zamaraeva
  • Victor Aleksandrovich Lukovenko

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Antarctica’s oldest ice arrives in UK for analysis on climate shifts

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Antarctica's oldest ice arrives in UK for analysis on climate shifts

Antarctica’s oldest ice has arrived in the UK for analysis which scientists hope will reveal more about Earth’s climate shifts.

The ice was retrieved from depths of up to 2,800 metres at Little Dome C in East Antarctica as part of an international effort to “unlock the deepest secrets of Antarctica’s ice”.

The ice cores – cylindrical tubes of ancient ice – will be analysed at the British Antarctic Survey (BAS) in Cambridge, with the ultimate goal of reconstructing up to 1.5 million years of Earth’s climate history, significantly extending the current ice core record of 800,000 years.

The research is also expected to offer valuable context for predicting future climate change, Dr Liz Thomas, head of the ice cores team at the British Antarctic Survey, said.

Over the next few years, the samples will be analysed by different labs across Europe to gain understanding of Earth’s climate evolution and greenhouse gas concentrations.

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Dr Thomas said: “It’s incredibly exciting to be part of this international effort to unlock the deepest secrets of Antarctica’s ice.

“The project is driven by a central scientific question: why did the planet’s climate cycle shift roughly one million years ago from a 41,000-year to a 100,000-year phasing of glacial-interglacial cycles?

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“By extending the ice core record beyond this turning point, researchers hope to improve predictions of how Earth’s climate may respond to future greenhouse gas increases.”

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The ice was extracted as part of the Beyond EPICA – Oldest Ice project, which is funded by the European Commission and brings together researchers from 10 European countries and 12 institutions.

“Our data will yield the first continuous reconstructions of key environmental indicators-including atmospheric temperatures, wind patterns, sea ice extent, and marine productivity-spanning the past 1.5 million years,” Dr Thomas said.

“This unprecedented ice core dataset will provide vital insights into the link between atmospheric CO₂ levels and climate during a previously uncharted period in Earth’s history, offering valuable context for predicting future climate change.”

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