The Radiopharmaceutical Therapy and Dosimetry Lab at Johns Hopkins Medicine, headed by George Sgouros, Ph.D., has been awarded a $15 million grant, to be dispersed over the next five years, from the National Cancer Institute at the National Institutes of Health. They will use these funds to investigate a type of radiation therapy for hard-to-treat cancers.
The award will fund several research projects, all of which will investigate a promising cancer treatment known as alpha-particle emitter radiopharmaceutical therapy, or alpha-emitter RPT. This therapy has proved successful in treating widespread, treatment-resistant cancers through directly delivering radiation to cancer cells.
Administered into the bloodstream, alpha-emitter RPT treatment delivers highly potent radiation directly to cancer cells. Radioactive atoms that emit alpha-particles (helium nuclei) are attached to special molecules that target, or latch on to, dispersed cancer cells in the body. Alpha-particles delivered to cancer cells cause massive DNA damage that kills the cancer. Alpha-emitter RPT also limits the amount of damage to normal tissues surrounding the cancer, which can prevent some of the debilitating side effects patients with cancer may face with radiation and chemotherapy.
Sgouros, who has investigated this particular treatment his entire career, has previously demonstrated that this therapy is highly effective in targeting a variety of metastatic cancers that do not respond to traditional radiation and chemotherapy.
Within the last decade, several agents that use this approach of delivering radiation therapies that target treatment-resistant cancer have been approved by the FDA, and Sgouros explains that the need to improve delivery of these treatments and investigate additional specific radiation treatments is growing. The study of these types of radiation treatments is a very active field that is also very niche. It is a unique area of study because a multidisciplinary team is needed to fully optimize such therapies, everything from physics, radiochemistry, biology and pharmacokinetics impacts this treatment approach."
George Sgouros, director of the radiological physics division and professor of radiology and radiological science at the Johns Hopkins University School of Medicine Related StoriesCinnamon extract shows promise in reducing obesity by inhibiting fat cell growth and boosting fat breakdownPomegranate's power: Studies show promise in cardiovascular and diabetic healthLeaky gut linked to depressive disorders: New insights into microbiota-induced epigenetic changes
Now, with the $15 million award, Sgouros and a diverse set of researchers in the lab will work to hone alpha-emitter RPT and optimize its application. This includes developing approaches to imaging and understand how the radiation is deposited in tissues so that treatment can be tailored to individual patients. Sgouros and his assembled team will specifically focus on the mathematical and physics-based components of alpha-emitter RPT to address these issues.
"We received this grant because we're the group that can solve these problems," says Sgouros. "This award is a testament to the collective expertise we have here at Hopkins, and what we've proposed to do with this grant can only be done with the group of investigators we have assembled here." Source:
On Friday, Paola Paiva waited in a hotel near Caracas airport, nervous but giddy with excitement to be reunited with her brother, finally.
For five months, Arturo Suarez has been detained in a notorious prison in El Salvador.
“I am going to wait for my brother to call me,” she told Sky News, “and after giving him a hug, I want to just listen to him, listen to his voice. Let him talk and tell us his story.”
Suarez was one of the more than 250 Venezuelan migrants who had been living in America but were arrested in immigration raids by the Trump administration and sent to El Salvador, a showpiece act in the president’s promise to deport millions of migrants.
Image: Paola Paiva holds a vigil for brother Arturo Suarez. Pic: Reuters
Most of the men had never even been to El Salvador before. Their detention has been controversial because the White House claims the men are all part of the dangerous Tren de Aragua gang but has provided little evidence to support this assertion.
The only evidence Paola had that Suarez was still alive was a picture of him published on a news website showing the inside of the maximum security CECOT jail.
He is one of dozens of men with their hands and feet cuffed, heads shaved and bodies shackled together.
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Now he is returning to his home country, one of the bargaining chips in a deal that saw the release of ten Americans and US permanent residents who had been seized by the Venezuelan authorities.
Image: Venezuelans arrive back in home country after being detained in El Salvador
Paola had tried to go to the airport to greet her brother as he disembarked a charter plane bringing the men back from El Salvador but authorities told her to wait at a nearby hotel.
“They told us they are taking them all to a hotel to rest,” she said.
“But I managed to get someone to give my phone number on a piece of paper to my brother, so I am expecting his call tomorrow, as soon as he can access a phone.
“We heard they are going to perform some medical exams on them and check their criminal records,” she added. “I’m not afraid; I’m not worried since my brother has a clean record.
“I am so happy. I knew this day would happen, and that it would be unexpected, that no one was going to notify us. I knew it was going to be a total surprise.”
Image: US citizens released from Venezuela. Pic: Reuters
The Trump administration had paid the El Salvador government, led by President Nayib Bukele, millions of dollars to imprison the men.
Homeland security secretary Kristi Noem visited CECOT last month, posing in front of prisoners for a photo opportunity.
But Cristosal, an international human rights group based in El Salvador, says it has “documented systematic physical beatings, torture, intentional denial of access to food, water, clothing, health care,” inside the prison.
A video which was seemingly filmed aboard the charter flight bringing the Venezuelan migrants back to Caracas shows Arturo briefly talking about his experience inside.
He looks physically well but speaks into the camera and says: “We were four months with no communication, no phone calls, kidnapped, we didn’t know what (the) day was, not even the time.
“We were beat up at breakfast, lunch and dinner,” he continues.
Sky News interviewed Arturo Suarez‘s brother Nelson near his home in the US in April, weeks after Arturo – an aspiring singer – had been arrested by immigration and customs enforcement (ICE) agents while filming a music video inside a house.
Nelson said he believed Arturo’s only crime was “being Venezuelan and having tattoos.” He showed me documents that indicate Arturo has no criminal record in Venezuela, Chile, Colombia or the United States, the four countries he has lived in.
Now Nelson is delighted Arturo is being released – but worries for his future.
“The only thing that casts a shadow in such a moment of joy is that bit of anger when I think that all the governments involved are going to use my brother’s story, and the others on that flight, as political gain,” he said.
“Each of them will tell a different story, making themselves the heroes, when the reality is that many innocent people suffered unfairly and unnecessarily, and many families will remain separated after this incident due to politics, immigration and fear.”
At least 34 people have died after a tourist boat capsized in Vietnam, according to state media reports.
The Wonder Sea boat was reportedly carrying 53 people, including five crew members, when it capsized due to strong winds in Ha Long Bay on Saturday.
It happened at roughly 2pm local time (7am GMT). Rescue teams have found 11 survivors and recovered 34 bodies, eight of them children, the state-run Vietnam News Agency said, citing local authorities.
Image: Rescuer in Ha Long Bay are searching for survivors. Pic: QDND via AP
The People’s Army Newspaper, which cited local border guards, said authorities have not yet confirmed details about the tourists, including their nationalities, as the rescue operation continues.
Most of the passengers were tourists, including about 20 children, from the country’s capital city, Hanoi, the newspaper said.
The incident comes shortly after the arrival of Storm Wipha in the South China Sea, bringing strong winds, heavy rain and lightning to the area.
Image: A body being carried on stretcher after a tourist boat capsized in Ha Long Bay, Vietnam. Pic: QDND via AP
The named storm is the third typhoon to hit the South China Sea this year, and is expected to make landfall along the northern coast of Vietnam early next week.
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Disruptions linked to the storm have also had an impact on air travel, according to Noi Bai Airport.
The airport reported that nine incoming flights were diverted to other airports, while three outgoing flights were temporarily grounded due to adverse weather conditions.
Image: Tourist boats cruise in Halong Bay. File pic: Reuters
The winds brought by Storm Wipha reached up to 63mph (101kmph) and gusts of up to 68mph (126kmph) as it passed south of Taiwan on Saturday, according to the island’s Central News Agency.
More than 30 people have been killed after Israeli troops opened fire towards crowds of Palestinians waiting for aid, according to witnesses and hospital officials.
The deaths occurred near distribution hubs operated by the US-Israeli-backed Gaza Humanitarian Foundation (GHF), which began distributing food packages in Gaza at the end of May, after Israel eased its 11-week blockade of aid into the territory.
At least 32 people were killed on Saturday, according to the Hamas-run Gaza health ministry, while a further 100 people were injured, according to local reports.
Most of the deaths came as Palestinians massed in the Teina area, around 3km (2 miles) away from a GHF aid distribution centre east of the city of Khan Younis.
Image: More than 30 people killed near aid distribution centres. Pic: Mariam Dagga/AP
Mahmoud Mokeimar said he was walking with crowds of people – mostly young men – towards the food hub when troops fired warning shots as the crowd advanced, before opening fire towards the marching people.
“It was a massacre… the occupation opened fire at us indiscriminately,” he said.
Image: Injured Palestinians are brought to Nasser Hospital in Khan Younis. Pic: Mariam Dagga/AP
Akram Aker said troops fired machine guns mounted on tanks and drones.
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“They encircled us and started firing directly at us,” he said.
The Nasser Hospital in Khan Younis said it received 25 bodies, along with dozens of wounded.
Seven other people, including one woman, were killed in the Shakoush area, hundreds of yards north of another GHF hub in Gaza’s southernmost city of Rafah, the hospital said.
The army and GHF did not immediately comment on Saturday’s violence.
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The GFH, which has four distribution centres, three of which are in the southern Gaza Strip, says it has distributed millions of meals to hungry Palestinians.
But local health officials and witnesses say hundreds of people have been killed by Israeli army fire as they try to reach the distribution hubs.
The GHF, which employs private armed guards, says there have been no deadly shootings at its sites, though this week, 20 people were killed at one of its locations, most of them in a stampede.
The group accused Hamas agitators of causing a panic, but gave no evidence to back the claim.
The army, which is not at the sites but secures them from a distance, says it only fires warning shots if crowds get too close to its forces.
The 21-month war in Gaza was triggered when Hamas militants stormed into southern Israel on 7 October 2023, killing 1,200 people and taking 250 others hostage.
An Israeli military offensive has killed more than 58,000 Palestinians, according to the Gaza health ministry, while Gaza’s more than two million Palestinians are living through a catastrophic humanitarian crisis.
Israel and Hamas have been holding ceasefire talks in Qatar in recent weeks, but international mediators say there have been no breakthroughs.
US President Donald Trump said another 10 hostages will be released from Gaza shortly, without providing details.