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flood the zone — US verges on vaccination tipping point, faces thousands of needless deaths: FDA Top regulatory officials call for clinicians to speak up and drown out misinformation.

Beth Mole – Jan 10, 2024 11:18 pm UTC Enlarge / A child with measles.Greene, Charles Lyman reader comments 207

The US may be heading to a “dangerous vaccination tipping point,” with immunization rates falling so low that population-level immunity is now at risk, and we will likely see thousands of needless deaths this respiratory virus season, two top officials for the Food and Drug Administration warned in a recent JAMA commentary.

FDA Commissioner Robert Califf and top FDA vaccine regulator Peter Marks noted the profound benefits of lifesaving vaccineswhich save millions of lives in the US each yearand their established safety, which is monitored both passively and actively through multiple, overlapping federal safety monitoring systems. And yet, “an increasing number of people in the US are now declining vaccination for a variety of reasons, ranging from safety concerns to religious beliefs,” thanks to the rise of anti-vaccine misinformation spread on social media and elsewhere on the Internet.

Further ReadingProtective vaccination rates falling out of reach in US; exemptions hit recordData from the Centers for Disease Control and Prevention last year found that, for the third consecutive year, vaccination rates among kindergartners had continued to slip, with rates of non-medical vaccination exemptions rising to an all-time high. There are now 10 states with vaccination exemption rates over 5 percent, meaning that even if clinicians and health officials manage to vaccinate all non-exempt children, the state will not be able to reach the target of 95 percent coverage needed to curb the spread of disease on a population level.

Califf and Marks lamented that the efficacy of vaccines has meant that the “disturbing” suffering and deaths from vaccine-preventable diseases, such as the extremely contagious measles, are no longer visible to people in the US. Thus, vaccines’ benefits are underappreciated. But that reality is changing as vaccination rates slip, particularly in small pockets of the country. Advertisement

“Regrettably, pediatric vaccine hesitancy now has been responsible for several measles outbreaks in the US, including a recent one in central Ohio involving local-acquired cases in 85 children, 36 of whom (42 percent) had to be hospitalized for complications,” Califf and Marks write.

A measles outbreak is ongoing in Philadelphia, where an unvaccinated person who contracted the virus outside the US exposed other unvaccinated people at the Childrens Hospital of Philadelphia and an area daycare. So far, eight cases have been confirmed (one adult and seven children), six of which were hospitalized. Some of the cases occurred when an infected, unvaccinated child broke quarantine and attended the daycare.

While childhood vaccination rates suffer and bygone diseases flare, there’s also concern for older people and more familiar diseases. The respiratory virus season is now peaking. Influenza-like illness activitywhich can capture not just flu but also RSV and COVID-19is high and rising throughout much of the country, posing a high risk to older people. Flu is infecting the most people right now, but COVID-19 is causing more than six times more deaths, with over a thousand deaths a week in recent weeks. Yet, the CDC estimates that only about 19 percent of adults have gotten the latest COVID-19 vaccine booster so far, while nearly 45 percent have gotten their annual flu shot.

Califf and Marks pose the question of what can be done to reverse course, and they point to a possible solution of calling on doctors, nurses, and even pharmacists to speak up about the benefits and importance of vaccination. Clinicians who provide care remain the most trusted sources of information for health decisions, they write.

“We believe that the best way to counter the current large volume of vaccine misinformation is to dilute it with large amounts of truthful, accessible scientific evidence,” they conclude. They called on health care providers to take every chance to help people make well-informed decisions about vaccinations. “By doing so, we can both help prevent pediatric infectious diseases and dramatically reduce the harm from pathogens such as COVID-19, influenza, and respiratory syncytial virus [RSV] disease before we have another large wave of any of these vaccine-preventable illnesses.” reader comments 207 Beth Mole Beth is Ars Technicas Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes. Advertisement Channel Ars Technica ← Previous story Next story → Related Stories Today on Ars

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Florida regroups, sends LSU to 3rd straight loss

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Florida regroups, sends LSU to 3rd straight loss

GAINESVILLE, Fla. — DJ Lagway threw for a touchdown and set up another with a long completion in his return from a strained left hamstring, and Florida upset No. 21 LSU 27-16 on Saturday to give the Gators their first series victory since 2018.

Jadan Baugh‘s 55-yard scoring scamper with 3:48 remaining essentially sealed it and put the Gators (5-5, 3-4 Southeastern Conference) on the verge of becoming bowl-eligible. Florida had dropped eight in a row against ranked opponents and was 1-10 under coach Billy Napier in rivalry games.

Former Florida coach Steve Spurrier suggested all week that fans should rush the field named after him if the Gators win. But it didn’t happen.

Florida’s defense, though, deserved to be celebrated. The unit sacked Garrett Nussmeier seven times — one more than LSU (6-4, 3-3) had allowed in its first nine games combined.

Lagway provided the big plays on offense for Florida. After sitting out most of the past two losses with the injury, he connected with Elijhah Badger for a 23-yard score in the first quarter. Lagway never scrambled but was mobile enough to create extra time by moving around the pocket.

He completed 13 of 26 passes for 226 yards. Badger caught six for 131 yards.

“Elite play,” Florida coach Billy Napier said of Lagway. “God blessed that young man.”

The game started to turn in Florida’s favor when T.J. Searcy sacked Nussmeier late in the third quarter. Nussmeier fumbled, one of his linemen scooped it out of the air then fumbled again. Caleb Banks recovered in what was one of several huge plays for the defensive tackle.

The Gators went backward from there despite the solid field position and ended up punting. But Jeremy Crawshaw pinned the Tigers inside the 10-yard line.

Florida then forced a punt and started another drive in LSU territory. This time, Lagway found Badger for a 36-yard gain that set up Ja’Kobi Jackson‘s 1-yard scoring run.

LSU dominated time of possession in the first half and doubled up Florida in plays. But Nussmeier struggled to find time in the second half. He completed 27 of 47 passes for 260 yards with a touchdown and the fumble, and the Gators’ defense frustrated him in bouncing back from a subpar effort the week before in a blowout loss at Texas.

“Last week was unacceptable, and they took ownership of that,” Napier said of his defense. “There was no moping around.”

Losing three in a row — to Texas A&M, Alabama and now Florida — makes it impossible for LSU coach Brian Kelly to continue his streak of 10-win seasons, which will end at seven. Kelly won double-digit games in each of his last five seasons at Notre Dame and extended it with consecutive 10-win campaigns in Baton Rouge.

“This is a simple exercise of do you want to fight or not?” Kelly said after the loss. “Do you want to fight and take responsibility as coaches and players that we’re not playing well and we’re struggling right now? … There’s a rough spot here that we have to fight through, and we have to do it together.”

As Napier left the field following handshakes and postgame interviews, he was cheered by the fans hovering at the team’s tunnel.

“You’ve got to be a tough guy, and you got to be up for the challenge,” Napier said. “This group has proven they’re up for that. It’s harder than ever in my opinion. These guys could have pointed fingers and splintered a long time ago. That’s what I’m most proud of.”

The Associated Press contributed to this report.

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8-2 Buffs roll, still looking for ‘our best game’

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8-2 Buffs roll, still looking for 'our best game'

BOULDER, Colo. — Deion Sanders watched his Colorado offense put up 49 points on the top scoring defense in the Big 12 on Saturday, but he isn’t satisfied. The coach expects dominance in all three phases of the game.

The Buffaloes outplayed Utah in two out of three phases and eventually got rolling on offense in a 49-24 victory, extending their win streak to four games and ensuring they’ll remain in the Big 12 championship race the rest of the way. Afterward, Sanders delivered a critique that sounded a little more like a warning to others.

“We haven’t even put it all together yet,” Sanders said. “Like, we haven’t even played our best game. That should be, in itself, scary. Like, man, when I said we comin’, we still comin’. We never stopped comin’. We are comin’. And we ain’t nearly there yet.”

Colorado (8-2, 6-1) got a strong start from its defense, which held the Utes (4-6, 1-6) to 83 yards on 33 plays in the first half, and a 76-yard punt return touchdown from receiver LaJohntay Wester to help make up for a bumpy start on offense. Quarterback Shedeur Sanders was intercepted on his first pass and later fumbled a snap for another turnover.

It may not have been the Buffaloes’ finest performance of the season, but it was a 25-point win over the preseason Big 12 front-runner, snapping a seven-game losing streak against a program whose last win at Folsom Field came by a score of 63-21.

“I think that speaks a lot about the program and where we are,” Deion Sanders said. “We’ve got to tighten some things up and get some things together, but you see we’re trending in the right direction.

“We started off rough. That wasn’t indicative to who Shedeur is, and I thought he was kind of OK all game long. Then I look at the stats and he’s 30-for-41 for 340 [yards] and three [touchdowns]. Like, c’mon man. I guess I’m just a hard dad to please at times, as well as a hard head coach.”

Sanders praised Utah’s defense and the problems it presented throughout the contest and said he was thankful for the challenge. It took complementary football to overcome the two first-half turnovers, with Colorado’s defense holding Utah to field goals after both takeaways. The Buffaloes didn’t surrender a touchdown until midway through the third quarter.

“Those type of things can’t happen,” Shedeur Sanders said, “and I’m going to have a talk with the whole offense and apologize for my performance out there at the very beginning, because I can’t put the team in that type of situation. I’m thankful for the defense. I may have to take them out to dinner this week for saving me and saving the team.”

Sanders responded after the fumble by guiding an 85-yard touchdown drive that featured another highlight-reel moment for Travis Hunter. Sanders threw deep to Colorado’s two-way star on a fourth-and-8, and Hunter made a leaping grab over two Utah defenders for a 25-yard gain. Sanders hit Will Sheppard for an 8-yard score on his next throw to extend Colorado’s lead to 21-6.

Hunter added to his Heisman Trophy résumé Saturday with 55 receiving yards on five catches, a 5-yard rushing touchdown on a reverse and his third interception of the season while playing 132 snaps.

When asked if he had a message for undecided Heisman voters, Deion Sanders did not hold back.

“If they can’t see, they can’t see,” Sanders said. “It is what it is. I mean, Travis is who he is. It’s supposed to go to the best college football player. I think that’s been a wrap since, what, Week 2? So we ain’t petitioning for nobody. We ain’t doing that. We’ve got a wonderful display of cameras here and I think we’re on national television every week. If they can’t see it, there’s a problem.

“Don’t allow their hatred for me to interfere with our kids’ success. They gotta stop that. Y’all gotta stop. Some of y’all are like that. Y’all gotta stop that, man. Give the kids what they deserve, man. I had my turn. I played 14 years. You had 14 years to hate me. Now let it go.”

Hunter was the Heisman front-runner in ESPN BET odds entering Week 12 at +125, ahead of Oregon quarterback Dillon Gabriel, Boise State running back Ashton Jeanty and Miami quarterback Cam Ward.

Colorado’s defense was able to constantly pressure freshman quarterback Isaac Wilson, forcing four sacks and three interceptions, and Utah finished with a mere 31 rushing yards, their fewest in a game since 2011. The preseason No. 12 Utes were considered the Big 12 favorites entering their first season in the conference but are now in danger of their first losing campaign since 2013.

“I’m in the twilight zone,” Utah coach Kyle Whittingham said. “… It’s the most difficult year of my coaching career, hands down, not even close.”

Colorado continues to control its destiny in chasing a Big 12 championship game bid, as the lone team in the 16-member conference that has lost just one conference game entering Saturday. The Buffaloes’ four-game win streak since a 31-28 home loss to Kansas State on Oct. 12 is the longest of Sanders’ two-year tenure.

After a 4-8 debut season, he has this once struggling program right where he planned to be for Year 2. In a league known for dramatic games decided by one-score margins, Sanders isn’t just trying to survive and advance to Arlington, Texas. He says he’s aiming for “flawless.”

“We expect to be here,” Sanders said. “A lot of y’all didn’t expect us to be here, and don’t think we don’t know that. But we expected to be where we are. Matter of fact, we expected to be a little better.”

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Pulp’s fan club president dished out Jarvis Cocker’s trouser scraps – and his car – to fans. Then he joined the band

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Pulp's fan club president dished out Jarvis Cocker's trouser scraps - and his car - to fans. Then he joined the band

Mark Webber’s role as Pulp’s fan club manager started simply enough, writing newsletters and posting out small bits of memorabilia such as postcards, stickers and badges. But, just like the band he loved, he wanted to do things a little differently.

A balloon launch to drum up publicity in their hometown of Sheffield didn’t attract too many people, he recalls, but one did make it all the way to Slovenia. The following year, he cut up a pair of Jarvis Cocker‘s trousers into 500 pieces, “all put in individually numbered envelopes and sent out to fans”.

It was 1993, a decade on from the release of Pulp‘s debut album, but still two years before they were to achieve huge mainstream success. A few years later, they decided to offer Cocker’s old Hillman Imp car, no longer roadworthy, as a competition prize. “It was crushed, compacted into a cube, someone won it, and we delivered it in a truck to their garden.”

It was genius silliness, indicative of the time. Nowadays, if you’re a young fan who loves a band or an artist, you assemble on social media – but back in the 1990s, it was all about signing up to the official fan club.

Scraps of Jarvis Cocker's trousers were once sent to Pulp fans. Pic: Mark Webber
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Some 500 Pulp fans were once treated to scraps of Cocker’s trousers in the post. Pic: Mark Webber

For Webber, who started out as a Pulp fan himself, it was a dream job which eventually led to him becoming the band’s tour manager – and then, just before they hit the height of their fame, joining as guitarist.

Following the group’s second and long hoped-for reunion in 2023, he is now telling his story – from super fan to joining the band – in I’m With Pulp, Are You?.

It’s not an autobiography as such, but a scrapbook of moments told mainly through ephemera collected over the last five decades, from photographs and flyers to set lists and press clippings, as well as other notes and scribblings kept through the years.

Webber went through his hoard during the pandemic lockdown. “It was in disarray at the time,” he says. “I hadn’t looked at it for so long I was finding things I couldn’t even remember what they were.”

‘We were in a bubble – suddenly the world caught up’

Pulp's Jarvis Cocker performing in Wolverhampton in 1992
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Jarvis Cocker on stage in Wolverhampton in 1992. Pic: Mark Webber

His story with Pulp starts in 1985, when he was an “obsessive” teenage music fan hanging out at a small independent record store in Chesterfield “where all the weird kids would go”. Back then, the band’s fan base was small, he says, and they were “amused” by the “daft, psychedelic kids” who followed them. They got to know them.

Webber eventually started helping out with stages sets before taking on the fan club duties. Then his role morphed again as he was called on to play guitar and keyboards at live shows, and began to contribute to songwriting.

He became an official member in 1995 – just before they became one of the biggest bands in the UK with their fifth album, Different Class, thanks to songs such as Disco 2000, Sorted For E’s and Whizz, and signature track Common People.

Pulp People kept fans up to date with the band's news
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In the days before social media, Pulp People kept fans up to date. Pic: Mark Webber

“Do you think it’s a coincidence that happened just as I joined?” Webber asks, laughing. “There was this trajectory. There was such a momentum building that it just became clear that, like, every next thing the group did was going to be more successful.”

It was a strange feeling, he says. “Because we were in the bubble at the time, just doing our thing, and suddenly the world had caught up and kind of realised how great Pulp was.”

I’m With Pulp documents some of the milestone moments in the band’s history, such as the 1995 Glastonbury headline set, before the release of Different Class, which came about at short notice after The Stone Roses were forced to pull out. Webber recalls how the band spent the night camping backstage.

“That was horrible because I hate camping,” he says. “And the concert, at the time it didn’t feel like such a great show. But everyone seemed to love it.”

Headlining Glastonbury – but camping in tents

British band Pulp perform on the Arena Stage as 'surprise guests' at Glastonbury Festival in Glastonbury, England on Saturday June 25, 2011. (AP Photo/Mark Allan)
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Pulp played a secret set at Glastonbury when they first reunited in 2011 – but didn’t camp that time. Pic: AP/ Mark Allan


Looking back at the roster of recent Glastonbury headliners – Elton John, Paul McCartney, Adele, Dua Lipa, The Killers – it’s hard to imagine any of them pitching a tent in the mud before performing to 100,000 people.

“Well, I’ve never spent the night in a tent since then,” says Webber. “So it changed my life.”

A more infamous incident in Pulp’s history was Cocker rushing the stage during Michael Jackson’s performance of Earth Song at the Brits the following year.

At the time, it didn’t feel as significant a moment as it has become in popular culture, Webber says. “There was disbelief in the moment, that he actually dared to do it. And that it was so easy to do. That’s the thing none of us could really understand, that there was no security or anything stopping anyone getting on the stage that easily.”

Pulp's Jarvis Cocker invaded the stage during Michael Jackson's performance of Earth Song at the Brit Awards in 1996. Pic: Reuters
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Cocker invaded the stage during Michael Jackson’s performance of Earth Song at the Brit Awards in 1996. Pic: Reuters

The aftermath was more concerning. “Like, ‘is Jarvis going to go to prison?’ Because we were starting a tour the next day.”

Ultimately, says Webber, most awards ceremonies and industry events are “boring – you have to do something to amuse yourself”.

After splitting in 2002, Pulp reunited for the first time in 2011, and then again for shows last year.

The response was “kind of amazing”, Webber says. It’s “quite likely we will play in England before we disappear again”, he hints. “There’s nothing confirmed yet but we expect there’ll be more concerts next year.”

‘I probably should have enjoyed it more’

Pulp's Mark Webber says his tour manager briefcase is one of his favourite pieces from his early days before joining the band. Pic: Mark Webber
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Webber says his tour manager briefcase is one of his favourite items from his early days. Pic: Mark Webber

The book documents Webber’s story. The item he was most happy to rediscover, he says, was the briefcase he used during his time as tour manager, adorned with a vintage ‘I’m With Pulp, Are You?’ sticker, which provided inspiration for the title.

“I knew I had it somewhere, but what I didn’t expect when I opened it up was that it still contained some contracts, to do lists, itineraries, a Bic biro, a packet of Setlers, and the business cards of various guest houses,” he says. “I used to carry this around everywhere, and in the days before we all had mobile phones, it had to contain everything we’d need for a concert or tour.”

After taking the time to look back, is there anything he would change?

Well, I mean, I probably should have enjoyed it more.” Webber laughs. “I’m always like the slightly glass half-full, grass is always greener type outlook… I did maintain quite a normal life, I didn’t have an address book full of celebrities that I’d go and hang out with – not that that’s something to aspire to, but, you know, maybe I should have been a bit more wild at the time when I had the chance.”

I’m With Pulp, Are You, published by Hat & Beard, is out now, with a launch night at the ICA in London on 27 November

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