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By Dr. Chinta Sidharthan Jan 17 2024 Reviewed by Benedette Cuffari, M.Sc.

In a recent study published in The Lancet Respiratory Medicine, researchers examine whether coronavirus disease 2019 (COVID-19) vaccines could prevent long COVID symptoms and compare the effectiveness of the Oxford AstraZeneca ChAdOx1 and Pfizer BioNTech BNT162b2 vaccines, which are the two most used COVID-19 vaccines in Europe.

Study:  The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia. Image Credit: Prostocok-studio / Shutterstock.com Background

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has infected over 800 million individuals worldwide since March 2020.

Since the start of the pandemic, concerted efforts throughout the world led to the rapid development of numerous vaccines and subsequent vaccination of large parts of the global population, particularly the elderly and those at high risk of severe COVID-19 due to the presence of comorbidities. These global vaccination efforts successfully reduced the transmission and severity of SARS-CoV-2 infections, thereby significantly lowering mortality rates.

In addition to the Oxford-AstraZeneca ChAdOx1 and Pfizer-BioNTech BNT162b2 vaccines, Ad26.COV2.S and mRNA-1273 developed by Janssen and Moderna, respectively, were the four most commonly used COVID-19 vaccines in Europe. However, the persistence of COVID-19 symptoms and long-term complications affecting multiple organ systems, now cumulatively referred to as long COVID, remains a significant health burden.

To date, the impact of COVID-19 vaccines in preventing the development of long COVID is unclear. About the study

In the present study, researchers used electronic health records and primary care data from the United Kingdom, Spain, and Estonia to evaluate whether COVID-19 vaccination prevented long COVID symptoms.

Data registries comprised information on the demographic characteristics of patients, as well as their medical histories, comorbidities, lifestyle factors, diagnoses, prescriptions, insurance claims for procedures, laboratory tests, clinical measurements, and secondary care referrals. Regional and national registries linked to these databases were used to obtain information on vaccination status and the type of vaccine administered. Related StoriesJN.1 variant's spread not due to enhanced immune escape, study suggestsNew Omicron subvariants test vaccine limits, reveal unique infection challengesmRNA COVID-19 vaccines highly effective in preventing hospitalizations among adolescents in Nordic study

Study participants were divided into four cohorts based on the enrollment period, which also corresponded to the priority groups, with cohort one primarily consisting of individuals above the age of 75 years with no history of COVID-19. Individuals above the age of 65, those who were considered clinically vulnerable, and those above the age of 18 with underlying health conditions that increased the risk of COVID-19 were included in cohort two. Cohort three comprised individuals above the age of 50, whereas the fourth cohort included individuals 18 years of age or older.

Long COVID was defined as the presence and persistence of any one of the 25 symptoms, such as fatigue, dyspnea, or cognitive dysfunction 90-365 days after a clinical COVID-19 diagnosis and with no indication of those symptoms during the six months before infection. Alternate definitions of long COVID, with varying time intervals for the presence of persistent symptoms, were used for sensitivity analyses. Study findings

The current study included over 20 million vaccinated and unvaccinated individuals across three European countries and showed that vaccination against SARS-CoV-2 had a 29-52% effectiveness in reducing the risk of long COVID risk. These findings were consistent across numerous sensitivity analyses and varying definitions of long COVID based on clinical diagnoses and differing symptom durations.

The comparative analyses between the effectiveness of BNT162b2 and ChAdOx1 indicated that BNT162b2 was associated with slightly greater long COVID preventative effects than the adenoviral vector vaccine ChAdOx1. Other studies have reported similar results while comparing the efficacies of BNT162b2 and ChAdOx1 in preventing SARS-CoV-2 infection.

The younger population was believed to be at a lower risk of severe SARS-CoV-2 infection than adults above the age of 65 years, which led to lower vaccination uptake rates among younger age groups. However, these individuals are equally vulnerable to long COVID; thus, there remains an urgent need for vaccination across all age groups to reduce the risk of developing long COVID. Conclusions

COVID-19 vaccination reduces the risk of severe SARS-CoV-2 infection and effectively decreases the risk of developing long COVID. Furthermore, as compared to the adenoviral vector vaccine ChAdOx1, the mRNA vaccine BNT162b2 was more effective in preventing COVID-19 severity and long COVID symptoms. Journal reference: Català, M., Mercadé-Besora, N., Kolde, R., et al. (2024). The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia. The Lancet Respiratory Medicine. doi:10.1016/S22132600(23)004149

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Amazon submits bid for TikTok as ban deadline nears

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Amazon submits bid for TikTok as ban deadline nears

Guests including Mark Zuckerberg, Lauren Sanchez, Jeff Bezos, Sundar Pichai and Elon Musk attend the Inauguration of Donald J. Trump in the U.S. Capitol Rotunda on January 20, 2025 in Washington, DC. Donald Trump takes office for his second term as the 47th president of the United States. 

Julia Demaree Nikhinson | Getty Images

Amazon submitted a bid to the White House to purchase the social media app TikTok from its Chinese owners, CNBC has confirmed.

The company sent its proposal in a letter this week to Vice President JD Vance and Commerce Secretary Howard Lutnick, according to a source familiar with the matter who asked not to be named because the discussions are confidential. The parties aren’t treating the bid seriously, however, given that it was submitted just days before a deadline staving off a U.S. ban is set to expire, the person said.

Amazon declined to comment.

The e-commerce company’s offer, which was first reported by The New York Times, comes as TikTok’s fate in the U.S. is up in the air. The short-form video app faces another potential shutdown in the U.S. on April 5 if ByteDance, its parent company, can’t reach a deal to divest TikTok’s American operations. Lawmakers passed a bill last year setting a Jan. 19 deadline for the sale, but Trump signed an executive order granting a 75-day extension for a potential deal.

Trump could announce a decision on TikTok’s fate in the U.S. as soon as Wednesday, sources familiar with the situation told CNBC’s David Faber. Mobile technology company AppLovin has also made a bid for TikTok, Faber reported separately, citing sources familiar with the matter.

TikTok has emerged as a major hub for e-commerce as it has poured money into growing its online marketplace, called TikTok Shop. TikTok’s lucrative marketplace, coupled with the app’s more than 170 million users, could be an attractive asset for Amazon. Following TikTok’s success, Amazon launched and then shuttered a short-form video service of its own.

Last August, the two companies formed a partnership that allowed TikTok users to link their account with Amazon and make purchases from the site without leaving the app. The deal attracted scrutiny from lawmakers who were concerned about its potential national security risks.

WATCH: How TikTok Shop is beating Amazon and Temu in social shopping

How TikTok Shop Became The Fastest Growing Social Media Shopping Platform

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Ford is preparing for an all-new EV at its Louisville assembly plant, but which one?

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Ford is preparing for an all-new EV at its Louisville assembly plant, but which one?

The Louisville assembly plant is scheduled for an extensive retooling starting later this year to produce a new Ford EV model. After the Escape is phased out, Ford will upgrade the facility to introduce an all-new EV.

What new EV will Ford build in Louisville?

Since 2022, Ford has had the same three electric vehicles available in the US. The Mustang Mach-E, F-150 Lightning, and E-Transit. However, that could change soon.

According to Todd Dunn, president of UAW Local 862, Ford’s Louisville plant will likely see some major changes later this year.

Dunn told The Courier Journal that the retooling could take upwards of 10 months. Ford is expected to begin the upgrades in December when the Escape and Lincoln Corsair, which are made at the plant, are phased out.

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Although Ford has yet to confirm the retooling, according to Dunn, the downtime will impact around 2,300 workers at the plant. They are expected to be temporarily laid off during the retooling, but Dunn said they will qualify for supplemental unemployment benefits and will also be able to draw unemployment.

Ford-new-EV-Louisville
Ford Mustang Mach-E (left) and F-150 Lightning (right) (Source: Ford)

The upgrades are part of a 2023 UAW and Ford agreement to make the Louisville plant one of three due for a future EV model.

As to which EV, Dunn still doesn’t know, or when Ford will officially announce it. Since Ford already scrapped plans for a three-row electric SUV, that’s out.

Ford-new-EV-Louisville
Ford’s electric Explorer for Europe (Source: Ford)

Ford is planning to launch the first model on its long-awaited low-cost EV platform, a midsize electric pickup, in 2027. But this is expected to be built in Tennessee. A new “digitally advanced” electric van that will be built in Ohio is also due out next year.

2025-Ford-F-150-Lightning
2025 Ford F-150 Lightning (Source: Ford)

So, what mysterious new EV is Ford planning for Louisville? Ford spokesperson Jess Enoch told The Courier-Journal last year that the company is “committed to an all-new electric vehicle” at the plant but said, “We will share details closer to launch.”

The news comes after Ford’s Mustang Mach-E notched its highest first-quarter sales since its launch, with 11,607 units sold in the first three months of 2024. F-150 Lightning sales, on the other hand, fell 7%.

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Eric Trump says he moved to crypto after family business became ‘most canceled company’

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Eric Trump says he moved to crypto after family business became 'most canceled company'

American Bitcoin co-founder Eric Trump: Crypto's the 'future of the modern financial system'

Eric Trump says his family was “the most canceled company, probably on Earth.”

That was then.

With his dad, President Donald Trump, back in the White House, he sees a new money-making opportunity.

“It actually is what drove us toward cryptocurrency,” the president’s middle son told CNBC, referring to the Trump family’s latest business endeavors. “You realize that cryptocurrency was a lot faster, it was a lot more pragmatic, it was a lot more transparent, it was exponentially cheaper.”

In 2022, about two years after the end of President Trump’s first term, two subsidiaries of the Trump Organization were convicted by a jury in New York of multiple crimes, including tax fraud, falsifying business records and conspiracy. The guilty verdicts on all 17 charged counts came three weeks after Trump declared his 2024 candidacy.

Last month, the Trump Organization sued Capital One in Florida over allegedly “unjustifiably” closing more than 300 of the company’s bank accounts following the Jan. 6, 2021, riot at the U.S. Capitol. The lawsuit claimed Capitol One was acting on “unsubstantiated, ‘woke’ beliefs that it needed to distance itself from President Trump and his conservative political views.”

Prior to Trump’s return to the White House, the Trump Organization unveiled a new ethics plan that said it would limit the president’s involvement in management decisions and other aspects of the business while he’s in office.

President Donald Trump (2R), flanked by US Secretary of Commerce Howard Lutnick (L), US Secretary of Treasury Scott Bessent (2L) and White House AI and Crypto Czar David Sacks (R), attends a the White House Crypto Summit in Washington, DC, March 7, 2025. 

Jim Watson | Afp | Getty Images

But crypto is another matter. President Trump and First Lady Melania Trump launched meme coins just before the new term, adding billions of dollars of paper wealth to the family’s net worth.

Eric Trump and older brother Donald Trump Jr. are going even bigger. They recently announced plans to launch a U.S. dollar–backed stablecoin through their new venture, World Liberty Financial, and a new bitcoin mining company called American Bitcoin, co-founded with Hut 8 CEO Asher Genoot.

Eric Trump described his entry into crypto not as a financial bet, but as a form of resistance, and said the move began during what he calls the “war on the industry.” Banks were closing accounts, the SEC was cracking down on exchanges, and crypto users were being “debanked” for simply holding coins, he said.

“They were going after people,” he said. “They were suing everybody. Banks were closing down people that just wanted to own bitcoin.”

That’s when Eric Trump said he started associating with like-minded people in and around crypto.

“At this point, I know almost everybody in the industry in some way, shape or form,” he said. “I fell in love with the industry, you know, a few years ago, and really dove head in.”

At World Liberty Financial, the Trump brothers are backing a stablecoin play aimed at competing with players like Tether. Eric Trump didn’t have a specific answer when asked how the project would stand out in a crowded field, saying only, “We’re gonna do it better, cheaper, faster, and we’re gonna do it with a lot of passion.”

Read more about tech and crypto from CNBC Pro

Meawhile, he’s working with Genoot to stand up American Bitcoin, a new mining venture that aims to scale quickly, and possibly go public.

Genoot told CNBC he connected with the Trump kids through mutual friends and began trading stories about their paths into crypto, leading to a business alliance.

Genoot said the company is being separated from Hut 8’s broader energy and artificial intelligence infrastructure platform.

“We’re actually carving out the majority of our assets,” Genoot said. “We’re putting them into American Bitcoin.”

Eric Trump, who is co-founder and chief strategy officer of American Bitcoin, said “every single sophisticated country is using their excess power to mine bitcoin.”

Though his family is closely linked to the current administration’s pro-crypto stance, Eric Trump said he has no role in policy and no contact with the White House. His dad’s presidency was heavily funded by the crypto industry and, since returning to the White House, President Trump has rewarded his backers, signing an executive order to create a strategic bitcoin reserve, and pardoning Silk Road creator Ross Ulbricht as well as the three co-founders of the BitMEX crypto exchange.

“I don’t have anything to do with government, and frankly, I don’t want anything to do with government,” Eric Trump said.

But he made clear that the U.S. needs a regulatory framework that allows crypto to thrive.

“You better believe that China is running very hard at this. The entire Middle East is running very hard,” he said. “We won the space race. We better win the crypto race.”

WATCH: Eric Trump, Hut 8 CEO outline partnership to launch new bitcoin mining company

Eric Trump, Hut 8 CEO outline partnership to launch new bitcoin mining company: CNBC Crypto World

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