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As the popularity of semaglutide weight loss medications continues to grow, so does the rate of potentially dangerous overdoses, experts are warning. 

Reported overdoses of semaglutide products such as Ozempic and Wegovy more than doubled between 2022 and 2023, according to Americas Poison Centers in Virginia.

“U.S. Poison Centers have documented 3,316 exposures to products containing semaglutide through Dec. 31, 2023, more than two times the number of cases reported in 2022,” Dr. Kait Brown, clinical managing director of Americas Poison Centers, told Fox News Digital via email.

“These cases include exposures to prescription semaglutide, compounded semaglutide and counterfeit semaglutide,” he said. 

“Most of these cases are associated with accidental therapeutic errors in adults.” Whats causing the overdoses?

Semaglutide medications are intended to be given in a low dose and increased slowly over a four-week period, according to Dr. Seth Kipnis, director of bariatic and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center in Neptune, New Jersey. 7 Reported overdoses of Ozempic and Wegovy doubled between 2022 and 2023, according to Americas Poison Centers in Virginia. REUTERS

“If people jump right to the high dose, they will have more initial negative side effects,” he told Fox News Digital. 

In some cases, people who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication, the doctor noted.

People with a semaglutide prescription should follow the manufacturers and prescribing physician’s instructions, Kipnis advised.  7 This photo combo provided by the FDA shows an authentic Ozempic needle, left and a counterfeit needle, right. AP

“The dose is weekly,” he said. “If it is taken daily, it is too much.”

Dr. Maryann Amirshahi, co-medical director of the National Capital Poison Center in Washington, D.C., confirmed that there has been a large overall increase in semaglutide overdoses reported to poison centers nationally. 

“In addition, I have noticed a similar increase at my individual center,” Amirshahi, who is also professor of emergency medicine at the Georgetown University School of Medicine, told Fox News Digital. 7 Injection pens of Novo Nordisk’s weight-loss drug Wegovy are shown in this photo. REUTERS

The doctor attributes the increase to several factors, chiefly the “huge increase” in semaglutide prescribing.

“Secondarily, it is available in several different forms, which can cause confusion,” Amirshahi noted. 

“Ozempic is a dial-up pen with multiple doses while Wegovy is a single-dose pen.” 7 A person is seen injecting themselves with an Ozempic needle at their home. REUTERS

Another source of confusion is that many people are using compounded products. 

“Compounded versions have their own unique risks when it comes to a potential overdose, especially when theyre dispensed in multi-dose vials,” noted Alyssa Billingsley, PharmD, Missouri-based director of pharmacy content at GoodRx.

“These injections are often dispensed in vials, so theres a greater opportunity for dosing errors since youre measuring out your specific dose with a syringe,” she warned.  7 People who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication. REUTERS

“In some cases, the vial may contain as much as 10 times the amount of semaglutide as a single-use injection pen.” Warning signs and symptoms

The most commonly reported overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea, Brown noted. 

“Some people have reported hypoglycemia (low blood sugar), which can be life-threatening,” she said.

Symptoms of low blood sugar include confusion, tremor, lightheadedness and palpitations, according to Amirshahi. 

“Semaglutide slows stomach emptying, which can lead to nausea, vomiting and abdominal pain,” she said.

In some cases, the stomach becomes almost paralyzed, a condition called gastroparesis, which can lead to dehydration, abnormal electrolytes and kidney damage, said Amirshahi.  7 Pens for the diabetes drug Ozempic sit on a production line. REUTERS

Another potential effect of semaglutide overdose is inflammation of the pancreas. 

“Symptoms of pancreatitis are very similar and can include nausea, vomiting, abdominal pain and dehydration,” Amirshahi noted. 

These signs and symptoms can also occur among patients taking normal doses of the medication as well as in overdoses, she added.

While any drug overdose can be serious, experts noted that taking too much semaglutide is rarely fatal. 

“Semaglutide is generally well-tolerated in overdose compared to other diabities medications,” Amirshahi said.

7 The most common overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea.  REUTERS

However, for people who develop gastroparesis or pancreatitis, potential complications can include dehydration and kidney damage. 

“While low blood sugar is rare with semaglutide overdose, if it is not detected and treated early, it can lead to seizures,” Amirshahi added.

Kipnis noted that in terms of adverse effects, “anything is possible when an FDA-approved drug is taken inappropriately.” Start your day with all you need to know

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Anyone who is taking a prescribed semaglutide should have a primary care physician or medical provider to provide close follow-up support, especially in the first several weeks as the dose increases, Kipnis advised. 

Although there is no specific antidote for a semaglutide overdose, the primary course of action is to treat the abdominal symptoms with nausea and pain medications, correct electrolytes, and give fluids for dehydration, said Amirshahi.

“We also treat the low blood sugar by giving glucose or dextrose,” she said. “The care is really supportive until the effects of the medication wear off.”

In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, Billingsley noted. 

“For example, severe vomiting can result in serious dehydration and electrolyte imbalances, which can be dangerous if left untreated,” she told Fox News Digital. “Severe cases of hypoglycemia can also be life-threatening.”

To prevent an overdose, Billingsley said to make sure you feel comfortable and confident using the injection pen and selecting your specific dose. 

“Understand how often you should be injecting your dose, and consider using alarms, medication reminder apps, or other tools to help keep you on track,” she recommended. “Your pharmacist can be a helpful resource if any questions come up.”

For emergency assistance, call Poison Help at 1.800.222.1222 to speak with a poison expert or visit PoisonHelp.org for support and resources.

When contacted by Fox News Digital regarding the potential for overdoses, Novo Nordisk, maker of Ozempic and Wegovy, provided a statement.

“Novo Nodisk is the only company in the U.S. with FDA-approved products containing semaglutide, identified under the trade names Wegovy, Ozempic and RYBELSUS, and should only be prescribed after a close consultation between a health care provider and a patient and should only be taken under the supervision of a health care provider,” the company said.

It added, “Novo Nordisk stands behind the safety and efficacy of our FDA-approved semaglutide medicines when used as indicated and when taken under the care of a licensed health care professional.”

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Harrods plots legal action against estate of former owner al-Fayed

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Harrods plots legal action against estate of former owner al-Fayed

Harrods is preparing to take legal action against the estate of its former owner, Mohamed al-Fayed, as the multimillion-pound legal bill for compensating his sexual abuse victims continues to escalate.

Sky News has learnt that the Knightsbridge department store, which has been owned by a Qatari sovereign wealth fund since 2010, plans to file a so-called passing-over application in the High Court as early as next week.

The intention of the application is to secure the removal of Mr al-Fayed‘s estate’s current executors, and replace them with professional executors to administer it instead.

Professional executors would be expected to investigate the assets and liabilities of the estate, while Harrods insiders claimed that the current executors – thought to be close family members of the deceased billionaire – had “ignored” correspondence from its lawyers.

Sources close to Harrods said the passing-over application paved the way for it to potentially seek to recover substantial sums from the estate of the Egyptian tycoon as it contends with a compensation bill likely to run to tens of millions of pounds.

In a statement issued to Sky News on Saturday, a Harrods spokesperson said: “We are considering legal options that would ensure that no doors are closed on any future action and that a route to compensation and accountability from the Fayed estate remains open to all.”

Mr al-Fayed is believed to have raped or sexually abused hundreds of women during his 25-year tenure as the owner of Harrods.

More on Mohamed Al Fayed

He died in 2023, since when a torrent of details of his abuse have been made public by many of his victims.

Earlier this year, Sky News revealed details of the compensation scheme designed by Harrods to award six-figure sums to women he abused.

In a form outlining the details of the Harrods redress scheme overseen by MPL Legal, which is advising the department store, it referred to the potential “for Harrods to recover compensation paid out under this Scheme from Mohamed Fayed’s estate”.

“You are not obliged to assist with any such claim for recovery,” the form told potential claimants.

“However, if you would be willing to assist Harrods including potentially by giving evidence against Fayed’s estate, please indicate below.”

This weekend, there appeared to be confusion about the legal representation of Mr al-Fayed’s estate.

In March, the BBC reported that Fladgate, a UK-based law firm, was representing it in an article which said that women who worked for him as nannies and private air stewards were preparing to file legal claims against the estate.

This weekend, however, a spokesman for Fladgate declined to comment on whether it was acting for Mr al-Fayed’s estate, citing confidentiality restrictions.

A source close to the law firm, meanwhile, insisted that it was not acting for the estate.

KP Law, another law firm acting for some al-Fayed abuse survivors, has criticised the Harrods-orchestrated process, but has itself faced questions over proposals to take up to 25% of compensation awards in exchange for handling their cases.

Harrods insiders said there was a growing risk that Mr al-Fayed’s estate would not be responsibly administered given that the second anniversary of his death was now approaching.

They added that as well as Harrods itself seeking contribution for compensation paid out for Mr al-Fayed’s abuse, its legal action would also potentially open way for survivors to claim directly against the estate.

Victims with no direct connection to Harrods are not eligible for any compensation through the store’s own redress scheme.

Even if Harrods’ passing-over application was approved by the High Court, any financial recovery for the department store would be subject to a number of additional legal steps, sources said.

“The passing-over action would achieve the goals of acknowledgement and accountability from the estate for survivors who don’t have the resource to undertake a passing-over application themselves,” an insider said this weekend.

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Children orphaned as father killed in Air India plane crash days after mother dies

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Children orphaned as father killed in Air India plane crash days after mother dies

A father returning home after scattering his wife’s ashes was among the victims of the Air India crash, leaving his two young children suddenly orphaned.

Flight 171 was carrying 242 people when it struck a medical college hostel less than a minute after taking off from Ahmedabad airport, in western India.

Twenty-nine people on the ground were killed, taking the total number of victims to 270. A hospital official confirmed 270 bodies have been recovered from the crash site, but DNA testing is being conducted to identify the bodies.

Just one passenger, a British man from Leicester, survived what has become the worst aviation crash in a decade.

Among the victims, 37-year-old Arjun Patoliya had been visiting India to fulfil his wife Bharti’s “final wish” to be laid to rest in her hometown of Gujarat.

Bharti had died just over two weeks ago, following a “courageous battle with cancer”.

A GoFundMe page, set up to raise funds for their two children, says: “Arjun left to bid farewell to his wife, never returned to the children they both raised.

“Now, these two beautiful young girls have been left without parents – their world turned upside down in just over two weeks.”

A fundraiser, which has topped more than a quarter of a million pounds, confirms all money raised will go directly into a legal trust, “to ensure every penny is dedicated to the girls’ needs”.

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Families in India wait for bodies of relatives

Read more on Air India crash:
Air India’s lone survivor is nothing short of miracle

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Everything we know about the crash

Investigation will take three months

India’s aviation minister has said a government panel reviewing the crash will complete its assessment in three months.

Ram Mohan Naidu said the government has also ordered “extended surveillance” of Boeing 787 planes. Air India operates 33 Boeing 787s, while rival airline IndiGo has one, according to data from Flightradar24.

Mr Naidu said the plane started descending after reaching 650 feet.

Every theory as to what happened will be looked into, he said. But in the meantime, he has instructed the airline to assist the families of passengers to ensure there is no delay in handing over the bodies of those who died.

Black box has been found

India’s aviation ministry says workers have recovered the digital flight data recorder – one of two black boxes on the plane, from the rooftop of the building where it crashed.

This box has data on engine and control settings, so will be able to show if there was a loss of engine power or lift after takeoff.

The investigation will initially focus on the engine, flaps and landing gear, a source told Reuters on Friday.

A possible bird-hit is not among the key areas of focus, the source said, adding that teams of anti-terror experts were part of the investigation process.

There is no information yet on the cockpit voice recorder, the other black box, which will be a crucial part of understanding what caused the plane to crash.

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UK

Weather warnings: 30,000 lightning strikes hit UK – with roads flooded and landslip disrupting trains

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Weather warnings: 30,000 lightning strikes hit UK - with roads flooded and landslip disrupting trains

Roads have been flooded and a landslip has disrupted trains as the UK was hit by tens of thousands of lightning strikes during thunderstorms – with severe weather warnings in place for large parts of the country.

It follows the hottest day of the year on Friday, which saw a high of 29.4C (84.9F) in Santon Downham in Suffolk.

The Met Office has issued an amber weather warning until 6pm across the South West, North East and North of England, Wales and much of Scotland.

Check the weather forecast where you are

It said there had been more thann 30,000 lightning strikes during the night, with the “vast majority” over the sea.

The Met Office has warned some areas could see 30-50mm of rain in a few hours, while a few locations could reach up to 80mm.

At the same time, strong wind gusts and hail accompanying the storms could potentially bring road flooding, difficult driving conditions, power cuts and flooding of homes and businesses.

The Environment Agency urged the public not to drive through flood water, reminding drivers that “just 30cm of flowing water is enough to move your car.”

A further yellow warning is in force in the eastern half of Northern Ireland from 6am to 6pm on Saturday, while a similar warning has been in place across the South East of England overnight following an amber alert on Friday.

Thunderstorm warnings are in place until Saturday evening. Pic: Met Office
Image:
Thunderstorm warnings are in place until Saturday evening. Pic: Met Office

Kent experienced heavy rainfall overnight, with flooded roads in parts of Dover, while a fire in a residential building in St Leonards-on-Sea on Friday night was likely caused by a lightning strike, the East Sussex Fire and Rescue Service say.

Devon received five flood warnings overnight by the Environment Agency, alongside 46 flood alerts in the South West, South East and Midlands.

A further six flood alerts have been put in place by Natural Resources Wales in South Wales.

National Rail said a landslip had stopped all services between Exeter St Davids and Okehampton, with the weather conditions meaning it is not safe for engineers to reach the site. Disruption is expected until around 1pm.

Other rail operators also warned customers to check for updates on services on Saturday morning.

Heathrow Airport apologised to passengers late on Friday night for flights delayed by “adverse weather conditions”.

Sky News weather producer Steff Gaulter said: “The most active thunderstorms are over parts of Wales, Northern Ireland, Northern England and Scotland, and some are still bringing localised downpours and strong winds.

“The storms will continue northwards, becoming largely confined to Northern Ireland and Scotland by the afternoon. Elsewhere will see a mixture of sunshine and showers, with the showers tending to ease during the day.

“Then from tomorrow an area of high pressure will start to stretch towards us, and the weather next week is looking far calmer and quieter.”

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Despite the risk of heavy showers and thunderstorms, not everyone will see rain during the day, with the driest and brightest weather expected in the South East, which will remain very warm.

The UK Health Security Agency (UKHSA) has issued its first yellow heat-health alert of the year, active until 8am on Sunday in the east of England, East Midlands, London, and the South East.

Under the UKHSA and the Met Office’s weather-health alerting system, a yellow alert means there could be an increased use of healthcare services by vulnerable people.

A yellow alert warns of a possible spike in vulnerable people accessing healthcare, and health risks for the over-65s and those with conditions such as respiratory and cardiovascular diseases.

While scientists have not assessed the role of global warming in this short-term event, in general they expect more heavy downpours as the climate changes.

That’s largely because hotter air can hold more moisture and so releases more water when it rains.

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