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By Pooja Toshniwal Paharia Feb 22 2024 Reviewed by Lily Ramsey, LLM

In a recent review published in Frontiers in Oncology, researchers investigated eating patterns and indices related to gastric cancer and explored their association with stomach cancer risk.

Study:  Review of dietary patterns and gastric cancer risk: epidemiology and biological evidence . Image Credit: Peakstock/Shutterstock.com Background

Gastric cancer is a common cancer worldwide, accounting for considerable global mortality. Despite attempts to minimize Helicobacter pylori prevalence and enhance food storage, the incidence and fatality rates of stomach cancer have decreased.

Epidemiological studies have found links between eating habits and stomach cancer risk. Individual dietary components, on the other hand, have produced inconsistent results in terms of the stated risk of stomach cancer.

Assessing eating patterns yields more reliable effect estimates and outcomes, emphasizing the need for comprehensive cancer prevention recommendations. About the review

In the present review, researchers reviewed existing data on the impact of diet on gastric cancer risk.

Diet patterns can be posteriori (formed from cohort population data) or a priori (created using existing information about food, nutrients, and illness). Posteriori patterns are determined using statistical approaches such as principal component analysis, factor analysis, and cluster analysis.

A priori patterns may derive from country-specific standards, chronic disease-preventive diets, or cultural eating habits. Association between a posteriori eating patterns and stomach cancer

In case-control studies, healthy eating patterns minimized the risk of stomach cancer, but an "unhealthy" dietary pattern raised the risk.

A comprehensive meta-analysis revealed that greater compliance with "prudent" diet patterns was related to a lower incidence of stomach cancer [odds ratio (OR) 0.8].

In contrast, increased compliance with Western diets increased the risk of total stomach cancer (odds ratio, 1.5). The association between poor eating habits and stomach cancer risk was more robust for cardia stomach cancers (OR, 2.1) than for distal stomach cancers (OR, 1.4).

Other meta-analyses showed that individuals consuming healthy foods had decreased stomach cancer risks (OR, 0.7) considerably.

In contrast, following unhealthy diets increased stomach cancer risk (OR, 1.6). A 2017 meta-analysis found that "Western" diets increase gastric cancer risk.

However, meta-analytical research of 13 case-control studies and eight studies of the prospective cohort type found that those abiding by "prudent" diets had a lower chance of developing stomach cancer. A priori dietary patterns, dietary indices, and gastric cancer

The relationship between eating habits and stomach cancer risk is complicated and nuanced. There is limited research on the link between high health eating index (HEI) or alternate HEI (AHEI) scores and the risk of stomach cancer.

A comprehensive review and meta-analysis found that higher adherence to HEI and AHEI dietary patterns was associated with a lower risk of total cancer-specific mortality.

New case-control research from Iran found that eating the dietary approaches to stop hypertension (DASH) diet was related to a 54% lower incidence of stomach cancer.

The DASH diet's components, such as excessive salt intake, red meat consumption, and fruits, have been linked to an increased risk of stomach cancer.

A Markov cohort state-transition model projected that a low sodium-DASH diet reduced stomach cancer risk by 25% in men and 21% in women.

Meta-analyses indicate that Mediterranean diet (MD) followers are less likely to develop stomach cancer.

MD vitamins and fibers reduce H. pylori colonization, whereas polyphenol-rich foods and extra-virgin olive oil (EVOO) reduce inflammation by inhibiting free radicals and lowering oxidative stress.

Omega-3 fatty acids reduce triglyceride levels and inflammation, methionine reduces body weight and insulin resistance, branched-chain amino acids improve insulin sensitivity, and short-chain fatty acids reduce trimethylamine N-oxide (TMAO) and inflammation and regulate autoimmunity factors. Patterns based on biological markers

Inflammation increases gastric cancer risk, particularly among men. Pro-inflammatory foods increase the incidence of intestinal and diffuse cancer subtypes.

The upregulation of cytokines and chemokines, which recruit several hematopoietic and progenitor cell types to inflamed stomach tissues, may cause chronic inflammation.

Gastric cancer-related inflammation includes inflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). IL-1 has an anti-tumor impact, whereas IL-6 is associated with tumor progression, invasion, and metastasis.

The ketogenic diet (KD) is associated with anti-cancer treatment in advanced gastric cancer patients. The KD alters glucose metabolism and inhibits insulin signaling and insulin-like growth factor 1 (IGF-1), the primary energy source for tumor cells. KD reduces nicotinamide adenine dinucleotide phosphate (NADPH) generation to increase oxidative stress in tumor cells.

Ad libitum KD therapy inhibits hypoxia-related and growth-driven proteins, influencing tumor progression.

Ketones enter cancer cells by monocarboxylate transporters (MCTs), limit lactate export, reduce cancer survival time, and prevent the activation of NLR family pyrin domain containing 3 (NLRP3), nuclear factor kappa B (NF-kB) and Signal transducer and activator of transcription 3 (STAT3) activation, lowering IL-1β expression.

The review findings indicate that dietary patterns can influence gastric cancer risk by influencing metabolites, gut microbiota, inflammation, and immune function.

Inconsistency in results might be owing to various factors such as meal types, recollection bias, overall energy consumption, and other confounders. Large-scale prospective cohort studies could improve the validity of the findings. Journal reference:

Pu K, Feng Y, Tang Q, Yang G, and Xu C (2024) Review of dietary patterns and gastric cancer risk: epidemiology and biological evidence. Front. Oncol. 14:1333623. doi: 10.3389/fonc.2024.1333623. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1333623/full?utm_source=S-TWT

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UK

Whitakers’ real-life Willy Wonka on shrinkflation and the rise of chocolate-flavour bars

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Whitakers' real-life Willy Wonka on shrinkflation and the rise of chocolate-flavour bars

Britain loves chocolate.

We’re estimated to consume 8.2kg each every year, a good chunk of it at Christmas, but the cost of that everyday luxury habit has been rising fast.

Whitakers have been making chocolate in Skipton in North Yorkshire for 135 years, but they have never experienced price pressures as extreme as those in the last five.

“We buy liquid chocolate and since 2023, the price of our chocolate has doubled,” explains William Whitaker, the real-life Willy Wonka and the fourth generation of the family to run the business.

William Whitaker, managing director of the company
Image:
William Whitaker, managing director of the company

“It could have been worse. If we hadn’t been contracted [with a supplier], it would have trebled.

“That represents a £5,000 per-tonne increase, and we use a thousand tonnes a year. And we only sell £12-£13m of product, so it’s a massive effect.”

Whitakers makes 10 million pieces of chocolate a week in a factory on the much-expanded site of the original bakery where the business began.

Automated production lines snake through the site moulding, cutting, cooling, coating and wrapping a relentless procession of fondants, cremes, crisps and pure chocolate products for customers, including own-brand retail, supermarkets, and the catering trade.

Steepest inflation in the business

All of them have faced price increases as Whitakers has grappled with some of the steepest inflation in the food business.

Cocoa prices have soared in the last two years, largely because of a succession of poor cocoa harvests in West Africa, where Ghana and the Ivory Coast produce around two-thirds of global supply.

A combination of drought and crop disease cut global output by around 14% last year, pushing consumer prices in the other direction, with chocolate inflation passing 17% in the UK in October.

Skimpflation and shrinkflation

Some major brands have responded by cutting the chocolate content of products – “skimpflation” – or charging more for less – “shrinkflation”.

Household-name brands including Penguin and Club have cut the cocoa and milk solid content so far they can no longer be classified as chocolate, and are marketed instead as “chocolate-flavour”.

Whitakers have stuck to their recipes and product sizes, choosing to pass price increases on to customers while adapting products to the new market conditions.

“Not only are major brands putting up prices over 20%, sometimes 40%, they’ve also reduced the size of their pieces and sometimes the ingredients,” says William Whitaker.

“We haven’t done any of that. We knew that long-term, the market will fall again, and that happier days will return.

“We’ve introduced new products where we’ve used chocolate as a coating rather than a solid chocolate because the centre, which is sugar-based, is cheaper than the chocolate.

“We’ve got a big product range of fondant creams, and others like gingers and Brazil nuts, where we’re using that chocolate as a coating.”

The costs are adding up
Image:
The costs are adding up

A deluge of price rises

Brazil nuts have enjoyed their own spike in price, more than doubling to £15,000 a tonne at one stage.

On top of commodity prices determined by markets beyond their control, Whitakers face the same inflationary pressures as other UK businesses.

“We’ve had the minimum wage increasing every year, we had the national insurance rise last year, and sort of hidden a little bit in this budget is a business rate increase.

“This is a small business, we turn over £12m, but our rates will go up nearly £100,000 next year before any other costs.

“If you add up all the cocoa and all the other cost increases in 2024 and 2025, it’s nearly £3m of cost increases we’ve had to bear. Some of that is returning to a little normality. It does test the relevance of what you do.”

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UK

UK to rejoin EU’s Erasmus student exchange scheme – reports

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UK to rejoin EU's Erasmus student exchange scheme - reports

The UK is to rejoin the European Union’s Erasmus student exchange scheme, according to reports.

The popular programme allowed Britons to spend a year studying at European universities as part of their degree, without paying extra fees, and vice versa for their European counterparts.

It ended for British students after Brexit on 1 January 2021 and was replaced by the Turing scheme.

But ministers could announce the UK will rejoin Erasmus from January 2027 as soon today, The Times and The Guardian have reported.

What is the Erasmus programme?

The Erasmus programme is a popular European Union student exchange scheme.

It allows university students to study or undertake internships abroad in other European countries for between two and 12 months.

Students receive grants for travel and living costs and receive university credit for the courses they take abroad.

The programme came to an end for British students after Brexit on 1 January 2021.

The scheme began in 1987 as a university student exchange programme and has grown to include volunteering and vocational training.

How did we get here?

Sir Keir Starmer promised a post-Brexit reset deal with Brussels and announced the government was working on rejoining the programme in May.

Negotiations have included work on “mutually agreed financial terms” for the UK and the EU.

The UK had pushed for a discount on membership fees, which are calculated on the basis of a country’s gross domestic product (GDP), The Times reported.

It said the EU is understood to have offered the government a 30% reduction of fees in the first year of membership.

Labour MP Darren Frith told Sky News’ Politics Hub he would “welcome” such a move.

The Guardian reported that, as well as university-based study exchanges, British students will be able to participate in vocational training placements under the scheme.


Minister on Brexit ‘self-harm’

Cabinet Office minister Nick Thomas-Symonds held talks with Maros Sefcovic, the European Commission’s trade lead, in Brussels last week.

A Cabinet Office spokesman said: “We are not commenting on ongoing talks.”

‘Fantastic opportunities for students’

But the UK’s universities welcomed the apparent breakthrough.

Tim Bradshaw, chief executive of the Russell Group of leading universities, said: “We’re delighted at the UK’s association to Erasmus+.

“With an even greater scope than previous programmes, Erasmus+ opens up fantastic opportunities for students, adult learners and young people to all benefit from new experiences and learning.

“It will also renew the huge contributions that EU students and staff make to life on our university campuses.”

The Lib Dems, who have been campaigning to rejoin Erasmus, welcomed the news.

Leader Sir Ed Davey said: “This is a moment of real opportunity and a clear step towards repairing the disastrous Conservative Brexit deal.”

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Politics

SEC lawsuit puts Shima Capital’s future in question as wind-down message surfaces

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SEC lawsuit puts Shima Capital’s future in question as wind-down message surfaces

Screenshots of an internal email outlining plans to wind down Shima Capital have surfaced online, days after the US Securities and Exchange Commission sued the crypto venture firm and its founder over allegations of investor fraud.

On Nov. 25, the SEC charged Shima Capital Management LLC and its founder, Yida Gao, with making false and misleading statements while raising almost $170 million from investors, the agency announced on Dec. 3.

The complaint, filed in the US District Court for the Northern District of California, alleged that Gao inflated his investment track record in marketing materials used to raise capital for Shima Capital Fund I between 2021 and 2023.

According to the SEC, Gao claimed one prior investment had delivered a 90x return, when the actual return was closer to 2.8x. The regulator also alleged that when discrepancies in the pitch deck were about to be reported publicly, Gao told investors the issues were the result of clerical errors.

SEC alleges $1.9 million undisclosed gain

Separately, the SEC claimed that Gao raised about $11.9 million through a special purpose vehicle tied to BitClout tokens, telling investors that they would be protected by discounted token purchases. While Gao did acquire tokens at a discount, the SEC said he sold them to the SPV at a higher price without disclosing that he personally retained about $1.9 million in profits.

Related: Crypto fundraising sets new record of $3.5B in a single week

In a Wednesday post on X, crypto journalist Kate Irwin shared screenshots of an email allegedly sent by Gao to portfolio founders. In the screenshots, Gao purportedly said he would step down as managing director of Shima Capital and that the fund would undergo an “orderly wind-down.”

Gao’s alleged email to portfolio companies. Source: Kate Irwin

The screenshots purportedly show Gao stating that the SEC and Department of Justice actions are related to his personal conduct, not that of Shima Capital’s portfolio companies, and claiming that no fines have been imposed on the company.

The screenshots also show that independent advisers from FTI Consulting and FTI Capital Management would oversee the wind-down process and monetization of investments, while Shima’s finance team would remain in place. Gao allegedly said he would remain involved with portfolio support “as permitted,” but without management control.

Cointelegraph could not independently verify the email. We reached out to Shima Capital and some of the fund’s portfolio companies for confirmation, but had not received responses at the time of publication.

Related: A beginners guide on raising funds using cryptocurrencies

Shima Capital launched with $200 million debut fund

In 2022, Shima Capital announced the launch of its first venture fund, Shima Capital Fund I, raising $200 million to back early-stage blockchain startups. Founded in 2021 by Gao, the firm said the fund received backing from a range of prominent investors, including Dragonfly Capital, Animoca Brands, OKX Blockdream Capital, Republic and Andrew Yang.