A special 13-article supplement to the peer-reviewed journal Diabetes Technology & Therapeutics (DTT) examines the "Development and Future of Automated Insulin Delivery (AID) Systems.
Included in the supplement is the article titled "A Peek Under the Hood: Explaining the MiniMed™ 780G Algorithm with Meal Detection™ Technology", by Benyamin Grosman, PhD and his Medtronic algorithm team with co-authors Ohad Cohen, MD, and Robert Vigersky, MD, Chief Medical Officer at Medtronic. James Thrasher, MD "Early Real-World Performance of the MiniMed™ 780G Advanced Hybrid Closed-Loop System and Recommended Settings Use in the United States" demonstrating higher time-in-range and low time-below range that is similar to that found in other parts of the world and documented by Pratik Choudhary, MBBS "Celebrating the Data from 100,000 Real-World Users of the MiniMed 780G System in Europe, Middle East and Africa Collected over 3 Years: From Data to Clinical Evidence"
Diana Isaacs, PharmD, from the Cleveland Clinic Diabetes Center, and coauthors contributed the article titled "Removing Barriers, Bridging the Gap and the Changing Role of the HCP with AID Systems." Chantal Mathieu MD, PhD and colleagues from Leuven Belgium and Asli Zeynep Ozdemir Saltik highlight "The Health Economics of Automated Insulin Delivery Systems and the Use of Time in Range in Diabetes Modeling: A Narrative Review".
Also featured in this Supplement is a 3-continent international collaboration from David O'Neal, MD and Dale Morrison, PhD from the University of Melbourne, Desi Zaharieva, PhD from Stanford University and Olivia McCarthy, PhD, and Kirsten Nørgaard, MD, from Copenhagen University and Steno Diabetes Center is the article titled "Exercising Safely with the MiniMed 780G Automated Insulin Delivery System". Greg Forlenza, MD and John Shin, PhD objectively assess how the burden of diabetes management are reduced with the use of the 780G system in the article titled "Reducing Diabetes Burden in Medtronic's Automated Insulin Delivery (AID) Systems".
Jennifer Sherr, MD, PhD and Elizabeth Considine, BS from Yale University review the growing literature on real-world evidence of automated insulin delivery devices in the article titled "Real-world Evidence of Automated Insulin Delivery System Use" finding that they confirm pivotal trial results. Related StoriesEZH2 inhibitors show promise in regenerating insulin-producing cells for type 1 diabetes treatmentStudy reveals higher post-meal insulin responses linked to lower diabetes risk over five yearsCycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat
Robert Vigersky, MD also contributes an article questioning the common use of MARD to characterize the accuracy of a CGM titled "The Myth of MARD: Limitations of MARD in the Clinical Assessment of Continuous Glucose Monitoring Data". Finally, Bruce Buckingham, MD, from Stanford University School of Medicine, and Richard Bergenstal, MD, Executive Director of the International Diabetes Center, co-authored an instructive case study titled "Decreasing the Burden of Carbohydrate Counting and Meal Announcement with Automated Insulin Delivery (AUD), Meal Recognition, and Autocorrection Doses: A Case Study".
"Hybrid Closed-Loop (HCL or AID) Systems have significantly evolved over the past 10 years. The current AID systems not only reduce hypoglycemia especially overnight but also improve overall glucose control and time in range (TIR) beyond 70% and thus reducing diabetes burden. The current 780G system allows lowest target range setting to 100 mg/dl and delivers mini-boluses every 5-minute based on the sensor glucose values," says Satish Garg, MD, Editor-in-Chief of Diabetes Technology & Therapeutics, from the University of Colorado Denver, Barbara Davis Center for Diabetes. Source:
Mary Ann Liebert Inc.Journal reference:
Garg, S. K., & McVean, J. J. (2024). Development and Future of Automated Insulin Delivery (AID) Systems. Diabetes Technology & Therapeutics. doi.org/10.1089/dia.2023.0467
Lola’s Cupcakes, the bakery chain which has become a familiar presence at commuter rail stations and in major shopping centres, is in advanced talks about a sale valuing it at more than £25m.
Sky News has learnt that Finsbury Food, the speciality bakery business which was listed on the London Stock Exchange until being taken over in 2023, is within days of signing a deal to buy Lola’s.
City sources said on Thursday that Finsbury Food was expected to acquire a 70% stake in the cupcake chain, which trades from scores of outlets and vending machines.
Lola’s Cupcakes was founded in 2006 by Victoria Jossel and Romy Lewis, who opened concessions in Selfridges and Topshop as well as flagship store in London’s Mayfair.
The Ministry of Defence is being urged to reveal details of a nuclear incident that took place at Faslane naval base earlier this year.
Figures show that a Category A event occurred at HMNB Clyde between 1 January and 22 April.
The Ministry of Defence (MoD) defines Category A as the most serious – however, it has claimed the incident was categorised as of “low safety significance” and did not pose a risk to the public or result in any radiological impact to the environment.
HMNB Clyde is based on the banks of Gare Loch at Faslane in Argyll and Bute.
It is the Royal Navy’s headquarters in Scotland and is home to Britain’s nuclear submarines, which includes the Vanguard vessels armed with Trident missiles.
Image: A Vanguard nuclear submarine at HM Naval Base Clyde. Pic: PA
Nuclear Site Event Reports (NSERs) detail incidents at nuclear facilities and are classified based on their safety significance and impact.
Responding to a written question earlier this year by SNP MP Dave Doogan, Maria Eagle, minister for defence procurement and industry, confirmed dozens of incidents at Faslane and nearby RNAD Coulport – the storage and loading facility for the Trident programme.
More on Ministry Of Defence
Related Topics:
Nuclear site events (22 April 2024 to 22 April 2025):
• Coulport: 13 Category C and 34 Category D • Faslane: 1 Category A, 5 Category B, 29 Category C, and 71 Category D
Ms Eagle said she could not provide specific details of the Category A or B incidents “as disclosure would, or would be likely to, prejudice the capability, effectiveness or security of any relevant forces”.
She assured Mr Doogan that “none of the events caused harm to the health of any member of staff or to any member of the public and none have resulted in any radiological impact to the environment”.
In a letter to Mr Doogan, UK Defence Secretary John Healey said: “I can confirm that all reported events were categorised as of low safety significance.
“In accordance with the International Nuclear and Radiological Event Scale (lNES) significant safety incidents are categorised at the lowest level – level one of seven.
“Incidents that might fall into this category include equipment failures, human error, procedural failings or near misses where no harm [was] caused to the health of any member of naval base staff, any member of the public, or any resultant radiological impact to the environment.”
In the past week, concerns have been reignited over the environmental and public health impact of the UK’s nuclear weapons programme.
It comes following an investigation by The Guardian and The Ferret, which uncovered radioactive water from RNAD Coulport had leaked into Loch Long due to faulty old pipes back in 2019.
The secrecy battle went on for six years.
The Scottish Environment Protection Agency (SEPA) reported the discharges were “of no regulatory concern”, while the MoD said there had been “no unsafe releases of radioactive material” into the environment.
In response to the “catalogue of failures”, the SNP’s deputy leader is calling for an “urgent explanation” from the UK government as to what actually happened at Faslane.
MSP Keith Brown said: “Nuclear weapons are an ever-present danger and this new information is deeply worrying.
“With repeated reports of serious incidents at Faslane and now confirmed radioactive contamination in Loch Long, it’s clear these weapons are not only poorly maintained but are a direct threat to our environment, our communities, and our safety.
“Worse still, the Labour government is refusing to provide any details about the Category A incident.”
The MoD said it was unable to disclose the details of the incidents reported for “national security reasons”, but stressed all were categorised as of “low safety significance”.
A spokesperson for the MoD said: “We place the upmost importance on handling radioactive substances safely and securely.
“Nuclear Site Event Reports demonstrate our robust safety culture and commitment to learn from experience.
“The incidents posed no risk to the public and did not result in any radiological impact to the environment. It is factually incorrect to suggest otherwise.
“Our government backs our nuclear deterrent as the ultimate guarantor of our national security.”
In July 2025, the European Space Agency’s Mars Express orbiter captured a high-resolution image of Acheron Fossae, a region marked by deep chasms and ridges on Mars’s surface. These features, created by ancient crustal stretching, split the terrain into raised horsts and sunken grabens. Valley floors reveal smooth surfaces carved by slow-moving, ice-rich rock glac…