Joe Biden has become the Democratic Party’s presumptive presidential nominee, Sky News’ US partner network NBC News projects.
The sitting president is widely expected to face Mr Trump in the election later this year – a re-run of the 2020 vote.
This will be the first time since 1956 that two presidents will go head-to-head.
And the campaign will almost certainly deepen the nation’s political and cultural divides in the eight-month fight for the White House.
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2:20
How does the US election work?
NBC News correspondent Mike Memoli said the network projected Mr Biden won the battleground state of Georgia in the primary elections.
He surpassed the “magic number” of 1,968 delegates to secure the nomination.
Mr Memoli said the result was “not a surprise” given the current president was running against “token opposition” – including Californian Governor Gavin Newsom and Michigan Governor Gretchen Whitmer – who sat out rather than challenge the Mr Biden who had already beaten Mr Trump once before.
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Meanwhile Mr Trump is closing in on the 1,215 delegates needed for the Republican presidential nomination, with contests held in Georgia, Mississippi, Washington and Hawaii on Tuesday.
On Monday, Mr Trump predicted Mr Biden would be the Democratic nominee as he unleashed a new attack on the president’s age.
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“I assume he’s going to be the candidate. I’m his only opponent other than life, life itself,” Mr Trump told CNBC.
Mr Biden directed much of his attention toward the former Republican president during a campaign stop in New Hampshire on Monday night.
He described his opponent as a “serious threat to democracy”.
The campaign has not been without difficulties for both frontrunners.
Mr Trump is facing 91 felony counts in four criminal cases involving his handling of classified documents and his attempt to overturn the 2020 election, among other alleged crimes.
He is also facing increasingly pointed questions about his policy plans and relationships with some of the world’s most dangerous dictators.
And 81-year-old Joe Biden is working to assure a sceptical electorate that he is still physically and mentally able to thrive in the world’s most important job.
He is also dealing with dissent within his party’s progressive base, which is angry he has not done more to stop Israel’s war against Hamas in Gaza.
Mr Biden entered Tuesday 102 delegates short of the 1,968 needed to formally become the presumptive Democratic nominee.
Mr Trump was 137 delegates short of the 1,215 needed to win the Republican nomination at the party’s national convention this summer.
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Image: Vladimir Putin shaking hands with Donald Trump when they met last week. Pic: Reuters
It was a stunning illustration of Mr Trump’s about-face in his approach to peace. For the past six months, a ceasefire has been his priority, but after meeting Mr Putin in Alaska, suddenly it’s not.
Confirmation that he now views the war through Moscow’s eyes.
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2:10
Trump applauds Putin and shares ride in ‘The Beast’ last week
The second was the format itself, with Mr Trump reverting to his favoured ask-what-you-like open-ended Q&A.
In Alaska, Mr Putin wasn’t made to take any questions – most likely, because he didn’t want to. But here, Mr Zelenskyy didn’t have a choice. He was subjected to a barrage of them to see if he’d learnt his lesson from last time.
It was a further demonstration of the special status Mr Trump seems to afford to Mr Putin.
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The third was their phone call. Initially, President Trump said he’d speak to the Kremlin leader after his meeting with European leaders. But it turned out to be during it.
A face-to-face meeting with seven leaders was interrupted for a phone call with one – as if Mr Trump had to check first with Mr Putin, before continuing his discussions.
We still don’t know the full details of the peace proposal that’s being drawn up, but all this strongly suggests that it’s one sketched out by Russia. The White House is providing the paper, but the Kremlin is holding the pen.
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1:25
Trump, Zelenskyy and the suit: What happened?
For Moscow, the aim now is to keep Mr Trump on their path to peace, which is settlement first, ceasefire later.
It believes that’s the best way of securing its goals, because it has more leverage so long as the fighting continues.
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But Mr Putin will be wary that Mr Trump is pliable and can easily change his mind, depending on the last person he spoke to.
So to ensure that his sympathies aren’t swayed, and its red lines remain intact, Russia will be straining to keep its voice heard.
On Monday, for example, the Russian foreign ministry was quick to condemn recent comments from the UK government that it would be ready to send troops to help enforce any ceasefire.
It described the idea as “provocative” and “predatory”.
Moscow is trying to drown out European concerns by portraying itself as the party that wants peace the most, and Kyiv (and Europe) as the obstacle.
But while Mr Zelenskyy has agreed to a trilateral meeting, the Kremlin has not. After the phone call between Mr Putin and Mr Trump, it said the leaders discussed “raising the level of representatives” in the talks between Russia and Ukraine. No confirmation to what level.
Donald Trump wants to set up a face-to-face meeting between Russian President Vladimir Putin and Ukrainian President Volodymyr Zelenskyy. How would that work? And would it accelerate peace in Ukraine?
Zelenskyy and other European leaders made their way to Washington DC. What was their goal? To make sure Trump is still on their side – and to make sure he’s not got too close to Putin and his plans to annex parts of Ukraine after the pair met in Alaska.
How much of a turning point was the White House summit in Russia’s invasion of Ukraine?
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It’s always wise to let the dust settle before reaching conclusions with this presidency.
But on the face of it we are further away from peace now than we were two weeks ago.
The consensus that was held back then was that Vladimir Putin would only relent under maximum pressure. He does not want slivers of territory. He wants the whole of Ukraine extinguished and absorbed into his greater Russia.
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2:23
What’s next for Ukraine?
To stop him, allies agreed an immediate ceasefire was necessary, along with much more painful pressure, namely sanctions hitting his oil industry. Europeans and Republicans in Congress agree on that.
Then Alaska and Donald Trump’s U-turn. No ceasefire and no more severe sanctions. So less pressure.
Yesterday’s reality TV diplomatic circus in Washington has not shifted him on that stance, so he stays it seems now aligned with Mr Putin on those crucial points.
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0:42
Starmer: This needs to be a lasting deal
Making matters worse for Ukraine, allies seem to be accepting it will have to give up land taken by force.
They sweeten the pill by saying of course only Ukraine can decide whether or not to cede territory, but there is now enormous pressure on Ukrainian President Volodymyr Zelenskyy to do so.
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In return there is nebulous and vague talk of security guarantees. European leaders are seizing on the fact Mr Trump did not rule out American troops being involved and hinted at US support for post-war security arrangements.
But that is little consolation for Ukrainians. They point out this president changes his mind as often as his socks and goes back on commitments, even those enshrined in international treaties.
The best that can be said for the White House meeting is it sets up more such meetings.
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Much of yesterday’s events were focused on stroking President Trump’s ego. Many here in Kyiv would prefer he was reminded of a few hard facts about this war. Mr Putin cannot be trusted. Mr Putin wants the end of Ukraine. Mr Putin will only relent under maximum pressure.
Protracted international diplomacy may suit Mr Trump’s craving for attention, but they fear it will only take us further away from peace.