An effective treatment for chronic wounds that does not involve antibiotics, but an ionized gas to activate a wound dressing, has been developed by a team of international scientists.
The treatment involves the plasma activation of hydrogel dressings (that are commonly used in wound dressings) with a unique mix of different chemical oxidants that are effective in decontaminating and aid healing in chronic wounds.
Researchers from the University of Sheffield and University of South Australia, who led the study, believe the new method is a significant advance in tackling antibiotic resistance pathogens and has the potential to change the treatment of diabetic foot ulcers and internal wounds.
Professor Rob Short, Professor of Chemistry at the University of Sheffield who co-authored the study, said: "More than 540 million people are living with diabetes worldwide, of which 30 per cent will develop a foot ulcer during their lifetime. This is a neglected global pandemic which is set to increase further in the coming years due to a rise in obesity and lack of exercise.
"In England alone between 60,000 and 75,000 people are being treated for diabetic foot ulcers per week. Infection is one of the major risks. Increasingly, many infections do not respond to normal antibiotic treatment due to resistant bacteria which results in 7,000 amputations per year.
"There is an urgent need for innovation in wound management and treatment and it is a real privilege to be part of the international team who have been working on this alternative treatment for over 10 years."
The cost of managing chronic wounds such as diabetic foot ulcers already exceeds $17 billion US dollars annually.
The benefits of cold plasma ionized gas have already been proven in clinical trials, showing it controls not only infection but also stimulates healing. This is due to the potent chemical cocktail of oxidants, namely reactive oxygen and nitrogen species (RONS) it produces when it mixes and activates the oxygen and nitrogen molecules in the ambient air. Related StoriesCould this traditional Thai medicine have wound healing abilities?Research finds link between unhealthy eating and chronic pain severity, calls for comprehensive dietary supportMachine learning reveals key markers for healthy aging, separate from chronic disease risks
Dr Endre Szili, from the University of South Australia who led the study, published this week in the journal Advanced Functional Materials, said: "Antibiotics and silver dressings are commonly used to treat chronic wounds, but both have drawbacks.
"Growing resistance to antibiotics is a global challenge and there are also major concerns over silver-induced toxicity. In Europe, silver dressings are being phased out for this reason."
The international team of scientists have shown that plasma-activating hydrogel dressings with RONS makes the gel far more powerful, killing common bacteria.
Although diabetic foot ulcers were the focus of this study, the technology could be applied to all chronic wounds and internal infections. Despite recent encouraging results in the use of plasma-activated hydrogel therapy (PAHT), we faced the challenge of loading hydrogels with sufficient concentrations of RONS required for clinical use. We have overcome this hurdle by employing a new electrochemical method that enhances the hydrogel activation."
Dr. Endre Szili, University of South Australia
As well as killing common bacteria (E. coli and P. aeruginosa) that cause wounds to become infected, the researchers say that the plasma-activated hydrogels might also help trigger the body's immune system, which can help fight infections.
"Chronic wound infections are a silent pandemic threatening to become a global healthcare crisis," added Dr Szili.
"It is imperative that we find alternative treatments to antibiotics and silver dressings because when these treatments don't work, amputations often occur."
"A major advantage of our PAHT technology is that it can be used for treating all wounds. It is an environmentally safe treatment that uses the natural components in air and water to make its active ingredients, which degrade to non-toxic and biocompatible components."
"The active ingredients could be delivered over a lengthy period, improving treatment, with a better chance of penetrating a tumor.
"Plasma has massive potential in the medical world, and this is just the tip of the iceberg," Dr Szili says.
The next step will involve clinical trials to optimize the electrochemical technology for treatment in human patients. Source:
University of SheffieldJournal references:Sumyea Sabrin, et al. (2024). Electrochemically Enhanced Antimicrobial Action of Plasma‐Activated Poly(Vinyl Alcohol) Hydrogel Dressings. Advanced Functional Materials. doi.org/10.1002/adfm.202314345.
Opinion by: Scott Buchanan, chief operating officer of Bitcoin Depot
A new proposal to install Bitcoin ATMs in federal buildings highlights an important question: Can crypto truly go mainstream without a stronger physical presence? For years, the industry has focused on software and decentralization, but its reluctance to invest in real-world infrastructure is starting to show. Without physical access points, crypto risks becoming an exclusive, insiders-only system, rather than the open alternative it sets out to be.
Everyone loves to talk about decentralization. There’s a good reason behind this. It defines the movement, shapes the technology, and supportsthe vision of a better financial system. While the industry focuses on code and algorithms, it lacks something basic. A decentralized system that exists only online is not genuinely decentralized.
Physical infrastructure is the missing link
Bitcoin’s physical infrastructure is the missing link. Without tools like ATMs, kiosks and access points at traditional retail locations, crypto remains out of reach for millions. Decentralization is not just about removing intermediaries. True decentralization requires expanding access. Without real-world touchpoints, even the most advanced network becomes limited to a closed circle of insiders.
For crypto to become mainstream, it must be easy to reach digitally and physically. That means showing up in places people already go and seamlessly integrating into people’s lives. Many groups in the American population still rely on cash or don’t have access to traditional banks. According to the latest Federal Deposit Insurance Corporation report, around 5.6 million American households don’t have a bank or savings account. Bitcoin ATMs give these users access without needing an app, a bank account or a crash course in blockchain. Most crypto tools today assume a level of financial fluency and infrastructure that millions simply do not have. The result is a digital-only ecosystem that locks out newcomers and widens the divide between early adopters and everyone else.
User-friendly screen in the right place
Physical infrastructure helps address this issue. A Bitcoin ATM in a grocery store or gas station is not just a convenience but a bridge to financial inclusion. It is an invitation to someone who has never bought crypto, telling them they can participate. No bank, no broker, just a user-friendly screen in a familiar place.
These machines also generate new economic activity. Local businesses benefit from increased foot traffic as the kiosks create passive revenue. For many communities, they provide access to a parallel financial system that was previously out of reach. This is a tangible example of crypto’s real-world utility. It is already happening, and it is measurable.
The crypto industry’s blind spot
The industry often treats physical infrastructure like an afterthought. The obsession with building new digital solutions has created a blind spot. Innovation without usability builds systems that serve the few but exclude the many. If someone can buy Bitcoin (BTC) at the same place they buy their morning coffee, that is when crypto stops feeling like an obscure digital asset and starts becoming part of everyday life.
As governments increase regulation, trusted and transparent interfaces will become more important. When operated within regulatory frameworks, Bitcoin ATMs offer a way to provide access between traditional finance and digital assets. They are familiar, easy to monitor and offer a more approachable entry point for the general public.
Like any financial tool, Bitcoin ATMs have drawn scrutiny, particularly in cases where bad actors use them. Rather than dismissing the machines themselves, we should focus on investing in better oversight, stronger consumer education and smarter regulation. The overwhelming majority of people who use Bitcoin ATMs do so for legitimate reasons: to send remittances, to move money securely or to access digital assets without traditional banking barriers. Building trust does not mean avoiding or dismantling physical access, but improving it.
The first time someone uses Bitcoin should not involve reading a white paper or navigating a tutorial. It should be as familiar as using an ATM or tapping a payment terminal. This is not an argument against innovation. Software and protocols will continue to evolve and play an important role. Physical infrastructure provides something those tools cannot: trust through presence. When people can see and use crypto in their neighborhood, at a store they already visit or in a format they already understand, it changes how they think about crypto and who it is for.
According to Coin ATM Radar, there are over 30,000 Bitcoin ATMs in the US. It’s a meaningful start, but still only a small step toward widespread access.
Crypto’s long-term success will depend not just on innovation but also on inclusion. That means building more than networks; it means building presence. When people can interact with crypto in the physical world, it stops being abstract and becomes usable. That is how digital finance becomes everyday finance.
Opinion by: Scott Buchanan, chief operating officer of Bitcoin Depot.
This article is for general information purposes and is not intended to be and should not be taken as legal or investment advice. The views, thoughts, and opinions expressed here are the author’s alone and do not necessarily reflect or represent the views and opinions of Cointelegraph.
The Katana Foundation, a nonprofit focused on decentralized finance (DeFi) development, is launching its private mainnet, aiming to unlock greater crypto asset productivity via deeper liquidity and higher yields for users.
The Katana Foundation launched a DeFi-optimized, private blockchain, Katana, on May 28, incubated by GSR Markets and Polygon Labs, with the public mainnet launch set for June.
The new blockchain will enable users to earn higher yields and explore DeFi in a “unique, optimized yield environment” that unlocks latent value through an ecosystem that makes every digital asset “work harder,” according to an announcement shared with Cointelegraph.
“DeFi users deserve ecosystems that prioritize sustainable liquidity and consistent ‘real’ yields,” wrote Marc Boiron, the CEO of Polygon Labs and core contributor at Katana, adding:
“Katana’s user-centric model turns inefficiencies into advantages, establishing a truly positive-sum environment for builders and participants alike.”
Source: Katana
Katana aims to solve the crypto industry’s liquidity fragmentation issue, which can cause significant price slippage, as one of the main barriers limiting institutional DeFi participation
To reduce the value slippage in DeFi, Katana’s blockchain concentrates the liquidity from numerous protocols and collects yields on all potential sources to create an ecosystem with deeper liquidity and more predictable lending and borrowing rates.
2025 Institutional Investor Digital Assets Survey. Source: EY-Parthenon
Institutional participation in DeFi is set to triple over the next two years to 75% from 24% of 350 surveyed institutional investors, according to management consulting firm EY-Parthenon.
To tackle the growing institutional liquidity needs, Katana’s liquidity pool is composed of multiple protocols, including lending protocol Morpho, decentralized exchange (DEX) Sushi and perpetual DEX Vertex, enabling users to trade “blue-chip assets” without needing crosschain transfers.
Katana has also incorporated Conduit’s sequences and Chainlink’s decentralized oracle network.
Katana to compound DeFi yield from “Ethereum-based opportunities”
Katana aims to boost sustainable yield by building a cohesive DeFi ecosystem. For instance, VaultBridge deploys bridged assets into overcollateralized, curated lending strategies on Ethereum via Mopho to earn yield, which is routed back and compounded on Katana.
The protocol will reinvest network fees and a portion of application revenue back into its ecosystem.
“This reduces reliance on short-term incentives, generates consistent yield, and as it grows, acts as an increasingly stable backstop during periods of volatility and liquidity shocks,” Polygon Labs’ Boiron told Cointelegraph, adding:
“Yield is distributed pro-rata to each chain using VaultBridge protocol based on their share of total deposits into VaultBridge.”
“So if Katana supplies 20% of the total vault deposits, it receives 20% of the yield back,” he added.
Katana will subsequently allocate its share of yield to users through boosted DeFi incentives across “core apps” such as Sushi, Morpho or Vertex. The yield is generated from “Ethereum-based opportunities and then enhanced through Katana’s core applications,” said Boiron.
Polygon Labs’ CEO previously criticized DeFi protocols for fueling a cycle of “mercenary capital” by offering sky-high annual percentage yields (APYs) through token emissions.
Beyond infrastructure-related limitations, regulatory uncertainty remains another significant barrier to institutional DeFi adoption.
2025 Institutional Investor Digital Assets Survey. Source: EY-Parthenon
Regulatory concerns were the main barrier to entry, flagged by 57% of institutional investors as the main reason for not planning to participate in DeFi activities.
Hamas’s Gaza chief Mohammed Sinwar has been “eliminated”, according to Israel’s Prime Minister Benjamin Netanyahu.
But Israeli military sources have said they are not yet able to confirm the death.
Hamas has also not yet confirmed the apparent killing of its leader.
Meanwhile, with Gaza on the brink of famine, the Palestinian ambassador to the United Nations broke down in tears as he spoke of the suffering of its people.
Image: Palestinian ambassador Riyad Mansour broke down in tears as he spoke of the suffering of people in Gaza
Riyah Mansour told the Security Council: “Children are dying of starvation. The images of mothers embracing their motionless bodies. Caressing their hair, talking to them, apologising to them, is unbearable.”
He added: “I have grandchildren.I know what they mean to their families. And to see this situation over the Palestinians without us having hearts to do something is beyond the ability of any normal human being to tolerate. Flames and hunger are devouring Palestinian children. This is why we are so outraged as Palestinians everywhere.”
Sinwar was one of Israel‘s most wanted and the younger brother of the Palestinian militant group’s former leader Yahya Sinwar.
The older sibling was the mastermind of the October 7 2023 attack, which killed 1,200 people in Israel, with around 250 others taken hostage into Gaza.
The attack triggered Israel’s assault on Gaza which decimated the territory, with more than 53,000 people killed, mostly women and children, and over two million displaced, according to health officials, who do not distinguish between civilians and combatants in their tally of fatalities.
Image: Yahya Sinwar was killed by Israel in October 2024. File pic: AP
Speaking to the Knesset on Wednesday, Mr Netanyahu included Mohammed Sinwar in a list of Hamas leaders killed in Israeli strikes. Later, Israel Defence Forces (IDF) sources said they were not yet able to confirm the death.
The prime minister said: “We have killed tens of thousands of terrorists. We killed (Mohammed) Deif, (Ismail) Haniyeh, Yahya Sinwar and Mohammed Sinwar.” He did not elaborate.
Image: Benjamin Netanyahu’s claimed could not be confirmed. Pic: AP
The Israeli military had said it struck a Hamas command centre under the European Hospital in the Sinwars’ hometown of Khan Younis, and it declined to comment on whether Sinwar was targeted or killed.
At least six people were killed in the strike and 40 wounded, Gaza’s health ministry said at the time.
Sinwar rose through ranks
Like his older brother, Mohammed Sinwar joined Hamas after it was founded in the late 1980s as the Palestinian branch of the Muslim Brotherhood. He became a member of the group’s military wing, known as the Qassam Brigades.
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Sinwar rose through the ranks to become a member of its so-called joint chiefs of staff, bringing him close to its longtime commander, Deif, who was killed in a strike last year.
“In the last two days, we have been in a dramatic turn towards a complete defeat of Hamas,” the Israeli leader told the Knesset.
Mr Netanyahu also spoke about how Israel was “taking control of food distribution”, a reference to a new aid distribution system that has been criticised and boycotted by humanitarian groups and the UN.
One killed at site of aid hub
The development comes after one person was killed and 48 others injured when forces opened fire on a crowd that overwhelmed an aid hub in Gaza, according to local health officials.
Palestinians have become increasingly desperate for food after almost three months of Israeli border closures. A blockade has recently been eased.
People broke through fences around the distribution site on Wednesday, and a journalist with the Associated Press said they heard Israeli tank and gunfire, and saw a military helicopter firing flares.
It was not yet known whether the death and injuries were caused by Israeli forces, private contractors or others.
The Israeli and US-backed Gaza Humanitarian Foundation, which set up the hub outside Rafah, said its military contractors had not fired on the crowd but “fell back” before resuming aid operations. Israel said its troops nearby had fired warning shots.
The UN and other humanitarian organisations have rejected the new system, saying it will not meet the needs of Gaza’s 2.3 million people and allows Israel to use food to control the population.
Israel has vowed to seize control of Gaza and fight until Hamas is destroyed or disarmed and exiled, and until the militant group returns the last 58 hostages, including around a third thought to be still alive.
‘This is a man-made catastrophe’
Meanwhile, a US trauma surgeon who has been working in Gaza urged the UN Security Council to not “claim ignorance” about the humanitarian devastation.
Dr Feroze Sidhwa said: “Let’s not forget, this is a man-made catastrophe. It is entirely preventable. Participating in it or not allowing it to happen is a choice.
“This is a deliberate denial of conditions necessary for life: food, shelter, water and medicine. Preventing genocide means refusing to normalise these atrocities.”
The UN World Health Organization has documented around 700 attacks on healthcare facilities in Gaza during the war. Israel accuses Hamas of using hospitals as command centres and to hide fighters.