Preventative cancer therapies can cause the disease to ‘hibernate’ and return later, research suggests
Preventative treatment designed to stop the recurrence of breast cancer can actually cause the cancer cells to mutate and ‘hibernate’, only to grow again years later, according to new findings.
Researchers who set out to explain why breast cancer can return years after initial treatment have found that hormone therapies used to prevent breast cancer from recurring, can trigger changes in some cells.
These changes cause the cells to lie dormant instead of dying off, and the cells “wake up” years later, causing a relapse that is harder to treat.
But the study has found there may be a way to target these “sleeping” breast cancer cells before they wake up, offering new hope for patients with oestrogen receptor positive (ER+) breast cancer – which makes up 80% of all breast cancers.
Luca Magnani, professor of epigenetic plasticity at The Institute of Cancer Research, London, said: “After surgery to remove primary oestrogen receptor positive breast cancer, patients are given five to 10 years of hormone therapy which aims to kill any remaining cancer cells.
“We know that this doesn’t work for all patients though, as their breast cancer can return years, or even decades later.
“We wanted to better understand why breast cancer does return so we can hopefully find ways to stop it – so people don’t have to live in fear or face the devastating news of a relapse.
“Our research identified a key mechanism used by cancer cells to evade therapy by remaining in a dormant state, hibernating before they ‘wake up’ years later and begin to rapidly divide again.”
The study, published in the journal Cancer Discovery, found that inhibiting an enzyme known as G9a prevented cancer cells from becoming dormant and killed the cells that were already hibernating.
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Dr Tayyaba Jiwani, science engagement manager at Cancer Research UK – which funded the research, said: “Breast cancer survival has doubled in the UK over the last 50 years thanks to better detection and screening, but there are still more than 11,000 deaths from this type of cancer every year.
“Although at an early stage, the findings reveal potential new targets for the development of innovative treatments that prevent breast cancer from coming back.”
Breast cancer is the second most common cause of cancer death among UK women, behind lung cancer, with around 11,400 deaths every year (2017-2019), Cancer Research UK said.
In 2022-23, almost 19,000 women across England were diagnosed with the disease thanks to the NHS screening programme.
All flights were halted at Edinburgh Airport this morning due to an IT issue affecting its air traffic control provider.
In a post on X, formerly Twitter, the airport later announced service had resumed.
Its post read: “Flights have now resumed following the IT issue with our air traffic provider.
“We thank passengers for their patience and understanding.”
But passengers continue to feel the effects.
A Delta Air Lines flight from New York to Edinburgh was diverted to Dublin after going into a holding pattern over the Scottish capital.
And a live arrivals board on the airport’s website showed multiple flights diverted, delayed and cancelled.
Arrivals board at Edinburgh Airport. Pic: Edinburgh Airport
Morven McCall and Cody Stevenson, both 19, were due to fly easyJet from Edinburgh to Amsterdam on their first trip away together.
Morven told Sky News: “We literally just got into the airport and as soon as we walked through the door there was an announcement that it had been cancelled.
“I was ill over the summer and had to cancel two holidays already, this was our first time going away together. We are just gutted and stressed.”
Follow live: Latest updates as flights halted
Arrivals at Edinburgh Airport. File pic: PA
One passenger was on a plane when they found out.
They said: “We boarded our flight and pushed back on time for an 8.45 (am) departure, then sat for a while before the pilot told us what was happening.
“He updated us a couple of times, cabin crew are brilliant at handing out water etc, and I’m surprised that everyone appears to be upbeat. But then you do wonder how long for, just been told we’re hoping to be in the air in 20 minutes.”
Another passenger told us: “The first news was from the airport announcement as we were halfway through boarding, saying the airfield was closed due to air traffic control down.
“No one knew what was going on. We’d already been delayed a bit before boarding, with no reason. I suspect problems started about 9am.”
It comes after an earlier announcement that all flights had been halted.
“No flights are currently operating from Edinburgh Airport,” the previous statement said.
“Teams are working on the issue and will resolve as soon as possible.”
There was no timeframe for recovery initially, Sky News learned.
It’s understood by PA that the issue was not linked to today’s Cloudflare outage.
Edinburgh Trams also posted on X, writing: “If you’re travelling with us to @EDI_Airport this morning, please be aware that flights are not currently operating.”
The airport urged passengers to contact their airline for the latest information on flights.
An average of 43,000 passengers per day use the airport, which is served by 37 airlines flying to 155 destinations.
A former doctor has been charged over alleged sexual assaults on 38 patients in his care.
Nathaniel Spencer, 38, has been charged with 15 counts of sexual assault, 17 counts of assault by penetration, nine counts of sexual assault of a child under 13, three counts of assault a child under 13 by penetration and one count of attempted assault by penetration.
It follows a police investigation into alleged sexual offences between 2017 and 2021.
Staffordshire Police said in a statement the charges come after a complex investigation by the Public Protection Unit into sexual offences at the Royal Stoke University Hospital, in Stoke-on-Trent, and Russells Hall Hospital, in Dudley.
North Staffordshire Justice Centre
Ben Samples, deputy chief crown prosecutor for the West Midlands CPS Complex Casework Unit and Serious Violence, Organised Crime and Exploitation Unit, said: “We have decided to prosecute Nathaniel Spencer for a number of serious sexual offences allegedly carried out against patients while he was working as a doctor – including assault by penetration and sexual assault against a child.
“Our prosecutors have worked at length to support a detailed and complex investigation by Staffordshire Police, carefully reviewing the available evidence to establish that there is sufficient evidence to bring the case to trial and that it is in the public interest to pursue criminal proceedings.”
Spencer, from Birmingham, will appear at North Staffordshire Justice Centre on 20 January 2026.
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