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Iran claims it has shot down two Israeli jets and that its response to Friday night’s attacks on nuclear and military infrastructure has begun.

The reports emerged as smoke was seen rising from Tel Aviv as Iran launched missiles at the Israeli city.

Air raid sirens had been heard across Tel Aviv and Jerusalem as the missiles neared Israel.

Footage has shown Israel’s Iron Dome air defence system – which uses radars to detect and intercept short-range rockets, missiles and drones – stopping Iranian missiles from striking the city.

However, video also suggests some missiles made it through. According to Israeli medics, a total of 34 people were taken to hospital in the Tel Aviv metropolitan area.

In a statement at around 1:50am on Saturday local time (11:50pm on Friday UK time), the Israel Defense Forces said: “In the past hour, dozens of missiles have been launched from Iran toward the State of Israel. Some of the missiles were intercepted.

“Search and Rescue forces are currently operating in a number of locations across the country in which reports of fallen projectiles were received.”

Meanwhile, the Iranian Army had earlier said in a statement that its “defence forces successfully hit and destroyed two F-35 fighter jets belonging to the zionist entity, in addition to a large number of small drones”.

“The fate of the two fighter pilots remains unknown and is being investigated,” the statement added.

Follow live: Israel-Iran conflict updates

The escalation in the region comes after Israel launched a huge attack on Iran on Friday, which it says was aimed at degrading the country’s nuclear ambitions and weakening its military.

Israel was able to target key facilities and kill top generals and scientists.

It said it airstrikes were necessary before its adversary got any closer to building an atomic weapon.

As Israel braced itself for a retaliation, the IRNA state news agency in Iran confirmed this evening that the country’s response had begun.

It came as a reporter with the Iranian Tasnim news agency said missiles had been fired from Shiraz and Isfahan in Iran towards Israel.

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Sky News correspondent Mark Stone, who used to be based in Jerusalem, has said Iran is trying to “overwhelm the Iron Dome defence system, which has to be manually reloaded again and again”.

He added: “[The Iron Dome] can be overwhelmed. We saw a number of instances in the videos a moment ago where it was clearly overwhelmed and some of those ballistic missiles hit targets in Tel Aviv.”

Three American officials have told Sky’s US partner network NBC News that the US military helped Israel down some Iranian missiles this evening.

As the barrage of missiles was fired at Israel, Iran’s supreme leader Ayatollah Ali Khamenei wrote on X: “The Zionist regime (Israel) will not remain unscathed from the consequences of its crime.

“The Iranian nation must be guaranteed that our response will not be half-measured,” he said, adding Iran will “inflict heavy blows” on Israel.

Mr Khamenei also said that Israel has initiated a war and that Tehran will not allow it to conduct “hit and run” attacks without grave consequences.

It came before Israeli Prime Minister Benjamin Netanyahu called on Iranians to stand up to the regime in Tehran and help Israel “clear the path for you to achieve your freedom”.

In a video released during Iran’s missile attack on Israel, Mr Netanyahu said Israel had taken out a “large portion” of Iran’s ballistic missile arsenal and its “most significant enrichment facility”.

“More is on the way,” he added. “The regime does not know what hit them, or what will hit them. It has never been weaker. This is your opportunity to stand up and let your voices be heard.”

The Israeli military has told people they can now leave air raid shelters but must stay near them in case of further attacks.

The Israel Defence Forces issued instructions earlier this evening telling residents to stay in shelters and minimise movement in open areas.

UK Prime Minister Sir Keir Starmer and US President Donald Trump have agreed the mounting conflict between Iran and Israel should be resolved by “diplomacy and dialogue”.

The two leaders spoke on Friday evening, as western nations began a diplomatic flurry to calm the conflict between Israel and Iran.

Sir Keir earlier urged Mr Netanyahu to de-escalate and work towards a “diplomatic resolution”.

Meanwhile, Mr Trump urged Iran to quickly reach an agreement on curbing its nuclear program as Israel vowed to continue its bombardment of the country.

Mr Trump framed the volatile moment in the Middle East as a possible “second chance” for Iran’s leadership to avoid further destruction “before there is nothing left and save what was once known as the Iranian Empire.”

The US president had urged Mr Netanyahu not to attack Iran.

The two leaders had what was described as a heated 40-minute exchange by telephone last Monday.

Speaking just hours before the attack, Mr Trump said he feared such action would destroy US hopes of an agreement with Iran to curtail its nuclear programme.

Tributes have been paid to victims of the Air India plane crash, including a couple and their three children and a man returning home after scattering his wife’s ashes.

Flight 171 was carrying 242 people when it struck a medical college hostel less than a minute after taking off from Ahmedabad airport, in western India, bound for Gatwick on Thursday.

Among those on board were 169 Indian nationals, 53 Britons, seven Portuguese nationals and one Canadian, the airline said.

It has confirmed 241 of those on the Boeing 787 Dreamliner were killed in the crash, with just one survivor – a British man from Leicester. Twenty-nine people on the ground were also killed, taking the total number of victims to 270, officials have said.

Tributes to those who died in the worst aviation crash in a decade are now being shared.

Arjun Patoliya

The 37-year-old had been to India to fulfil his wife Bharti’s “final wish” to scatter her ashes in her hometown in Gujarat, after she died following a battle with cancer.

He was returning home to his young daughters in north London, according to a GoFundMe page set up for the girls.

It says: “In a span of just 18 days, two young sisters – only 4 and 8 years old – have lost both of their beloved parents.”

Dr Prateek Joshi and his family

Dr Joshi, a radiologist at the Royal Derby Hospital, was on the flight with his wife, Dr Komi Vyas, and their three children, Mirayal, Nakul and Pradyut.

In a post on Facebook, Derby Hindu Temple said: “We pray to Lord Shiva to grant eternal peace to the departed souls and to give strength to the bereaved family to bear this immense loss.”

Dr Joshi’s colleague Dr Rajeev Singh described him as “a wonderful man, friend, husband and father, and an exceptional radiologist who was highly respected in his field”.

“It is hard to accept that a man with such a passion for life, and his beautiful young family, have been taken in this way,” his statement continued.

“His passing has left a profound void, not only in his professional contributions but in the warmth and spirit that he gave to the world every day.”

Akeel Nanabawa, his wife Hannaa Vorajee and their four-year-old daughter

The family of three from Gloucester were “widely loved and deeply respected”, their family said in a statement issued through their imam.

Mr Nanabawa ran a recruitment firm and Ms Vorajee volunteered at a local Islamic school and was a director for an organisation promoting understanding of Islam, Imam Abdullah Samad said.

Their daughter, Sara Nanabawa, was four years old.

The imam, who is headteacher at the school Sara had just started attending, told Sky News: “She had a smile like the rays of the sun, she would light up the room.

“She was exactly what her parents would have wanted her to be. She took a lot of good qualities from her parents. Staff at the school are absolutely devastated.”

He said of her parents: “They were widely loved and deeply respected. His quiet generosity, her warmth and kindness, and their daughter’s bright, joyful spirit made a lasting impact on everyone who knew them.”

Mariam and Javed Ali Syed and their two children

The couple and their two children – five-year-old Zayn and four-year-old Amani – were returning from a holiday in India, Ms Ali Syed’s sister-in-law told the Telegraph.

The mother-of-two reportedly worked for Harrods for a decade while Mr Ali Syed is reported to have worked at a London hotel.

Speaking to the Telegraph, Yasmine Hassan said of the couple’s two children: “They are so small, they are five and four. And it’s just thinking how scared they must have been.”

Renjitha Gopakumaran Nair

The 40-year-old nurse and mother of two worked at Queen Alexandra Hospital in Portsmouth.

A Facebook page for nurses from India said she was originally from Thiruvalla, Kerala, and touched “countless lives with her care and compassion”.

Ajay Kumar Ramesh

Mr Ramesh was seated in a different row to his brother, Vishwash Kumar Ramesh, whose survival is being hailed as a miracle.

Speaking outside the family home in Leicester, Jay, a relative of the brothers, said Vishwash asked about Ajay when he contacted his father after the tragedy.

Jay said: “After the crash, he spoke to his dad worrying about his brother saying, ‘Where’s Ajay’?”

Raxa Modha, her daughter-in-law and infant grandson

A member of Raxa Modha’s family has told Sky News she was in India for a religious ceremony after the death of her husband two months ago.

She had travelled with her daughter-in-law Yasha and infant grandson Rudra.

All three of them were from Wellingborough, Northamptonshire.

Read more:
What we know so far
Aviation experts review crash video
Sole survivor recounts deadly crash

Sisters Heer and Dhir Baxi

The siblings, both in their early twenties, were returning home to London after surprising their grandmother for her birthday.

Their cousin Ishan Baxi, who lives in Ahmedabad, said both women had an “amazing aura” and wanted to “roam the world”.

He said: “I am unable to control my tears even now also just because I was close to them, you just imagine what emotions parents are going through right now and think about guilt the grandma would feel right now.

“I just want God to bless those souls, all dreams, promises, aspirations vanished in seconds.”

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Fiongal and Jamie Greenlaw-Meek

The couple, who ran a spiritual wellness centre in Ramsgate, Kent, filmed themselves laughing and joking at the airport just moments before boarding the plane.

The former editor of This Morning has paid tribute to Fiongal, who appeared on the show earlier this year, and his partner.

Martin Frizell said on Instagram: “I remember his visit to the studio in January, he was passionate about auras and although I’m a sceptical sort, his vibrancy and sheer enthusiasm won folk over.”

Adam and Hasina Taju, and Altafhusen Patel

Adam Taju, 72, and his wife Hasina, 70, were flying with their son-in-law Altafhusen, the couple’s granddaughter told the BBC.