The idea of scientists bringing pre-historic creatures back to life with some clever DNA trickery might sound familiar to fans of the 1993 Hollywood blockbuster Jurassic Park.
But for Colossal Biosciences – a company that hopes to reintroduce extinct species such as the dodo and the mammoth – it is more than just a film script.
It’s a reality – and one that could be just years away.
“We’ve got all the technology we need,” says Ben Lamm, chief executive of the firm, based in Dallas, Texas.
“It is just a focus of time and funding. But we are 100% confident [we can bring back] the Tasmanian tiger, the dodo, and the mammoth.”
The science behind the project is simple: Work out the genes that make an extinct animal what it is, and then replicate those genes using the DNA of a close existing relative.
“It’s almost reverse Jurassic Park,” says Mr Lamm, speaking to Sky News.
“In the film, they were filling in the holes in the dinosaur DNA with frog DNA.
“We are leveraging artificial intelligence and other tools to identify the core genes that make a mammoth a mammoth and then engineering them into elephant genomes.”
Advertisement
Image: Ben Lamm, founder and chief executive of Colossal Biosciences. Pic: Colossal
That is the technical part.
But there are some other practical hurdles for Colossal to overcome, namely how, once you have mammoth cells, do you birth a real-life mammoth?
The answer, according to Colossal, is in the womb of an Asian elephant.
But it is a process that could take nearly two years, even after they have worked out how to do it.
“[Each of the] different projects [the mammoth, dodo, and Tasmanian tiger] have different challenges – the mammoth is really around gestation – which is around 22 months,” says Mr Lamm.
“The dodo gestation is pretty great – we are using surrogate chickens. The hardest part is cultivating the primordial germ cells.”
Image: Colossal plans to create cells of extinct animals by genetically engineering the cells of their closest living relatives. Pic: Colossal
Image: Pic: Colossal
‘Feeling good about 2028’
So after around 4,000 years of extinction, when could we see the return of the mighty mammoth – a creature that fell victim to human hunting and the changing conditions brought about by the end of the last Ice Age.
“We are well into the editing phase,” says Mr Lamm.
“We don’t have mammoths yet, but we still feel very good about 2028.”
Away from the lab, led by Eriona Hysolli, Colossal’s head of biological sciences, there are other issues to overcome – including where the newly returned species will live once they are born.
Image: Eriona Hysolli, head of biological sciences at Colossal Biosciences. Pic: Colossal
Mr Lamm says the company is already working with local governments, conservation groups, indigenous people groups, private land lowers, and the public at large, to prepare for the animals to be returned to their natural habitat.
“Our ultimate goal is to put all the animals we make back into the wild,” he says.
‘New tools in the fight’ to protect nature
Colossal says the work is not just about rewilding animals previously lost to the world.
The company is currently working with Dr Paul Ling at Baylor College of Medicine in Houston, Texas, to create a vaccine to eradicate the deadly EEHV virus – which kills around 20% of baby elephants each year.
It is also working closely with the University of Alaska and the University of Stockholm on radiocarbon dating of American mammoths as well as sequencing their genome – the largest study of its type ever undertaken.
Mr Lamm also hopes that, through Colossal’s research, the company can tackle issues facing the world today, including a drop in biodiversity.
“I think we have a duty to this planet that we’ve been given – we are tending towards a loss of up to 50% biodiversity if we don’t do anything,” he says.
“Modern conservation is great, but we need new tools in the fight.
“Work on de-extinction goes hand-in-hand with species preservation, and if Colossal makes a couple of technologies, then maybe it will provide those tools.”
‘Jurassic Park helps people understand our work’
As for the Jurassic Park comparisons, well, there is one small issue, according to Mr Lamm.
In the Steven Spielberg-directed epic, the scientists use DNA embedded in fossilised mosquitoes in amber combined with frog DNA to bring dinosaurs back to life.
Image: The scientists in Jurassic Park combined dinosaur DNA embedded in fossilised mosquitoes. Pic: PA
“Amber is not a good holder of DNA,” Mr Lamm says.
“But it’s a very entertaining movie and I think Jurassic Park made a lot of people interested in science. I saw it when I was younger and I was like: ‘Wow genetics is cool’.
“It did a lot to explain to the masses that genetic engineering is a thing and something that can be used in powerful ways, and I do think more people understand Colossal because of that.”
The company is also working on a film of its own, and, luckily for everyone, it’s not a dystopian thriller like Jurassic Park.
It has teamed up with award-winning director James Reed, a specialist in nature films, to document its “de-extinction” work.
“It’s really exciting. When you are doing anything bold, it is important to communicate and be transparent, and there’s nothing more transparent than having cameras around all the time,” says Mr Lamm.
A senior official in former president Joe Biden’s administration has told Sky News that he has no doubt that Israel has committed war crimes in Gaza.
Speaking to the Trump 100 podcast, Matthew Miller, who, as a state department spokesman, was the voice and face of the US government’s foreign policy under Mr Biden, revealed disagreements, tensions and challenges within the former administration.
In the wide-ranging conversation, he said:
• It was “without a doubt true that Israel has committed war crimes”; • That Israeli soldiers were not being “held accountable”; • That there were “disagreements all along the way” about how to handle policy; • And that he “would have wanted to have a better candidate” than Mr Biden for the 2024 election.
Mr Miller served as the state department spokesman from 2023 until the end of Mr Biden’s presidential term. From the podium, his job was to explain and defend foreign policy decisions – from Ukraine to Gaza.
“Look, one of the things about being a spokesperson is you’re not a spokesperson for yourself. You are a spokesperson for the president, the administration, and you espouse the positions of the administration. And when you’re not in the administration, you can just give your own opinions.”
Now out of office, he offered a candid reflection of a hugely challenging period in foreign policy and US politics.
Please use Chrome browser for a more accessible video player
1:37
Miller: Israel ‘committed war crimes’
Gaza disagreements
Asked about Gaza, he revealed there were “small and big” disagreements within the Biden administration over the US-Israeli relationship.
“There were disagreements all along the way about how to handle policy. Some of those were big disagreements, some of those were little disagreements,” he said.
Pushed on rumours that then-secretary of state Antony Blinken had frustrations with Mr Biden over both Gaza and Ukraine policy, Mr Miller hinted at the tensions.
Spreaker
This content is provided by Spreaker, which may be using cookies and other technologies.
To show you this content, we need your permission to use cookies.
You can use the buttons below to amend your preferences to enable Spreaker cookies or to allow those cookies just once.
You can change your settings at any time via the Privacy Options.
Unfortunately we have been unable to verify if you have consented to Spreaker cookies.
To view this content you can use the button below to allow Spreaker cookies for this session only.
“I’ll probably wait and let the secretary speak for himself… but I will say, speaking generally, look, it is true about every senior official in government that they don’t win every policy fight that they enter into. And what you do is you make your best case to the president.
“The administration did debate, at times, whether and when to cut off weapons to Israel. You saw us in the spring of 2024 stop the shipment of 2,000-pound bombs to Israel because we did not believe they would use those in a way that was appropriate in Gaza.”
Through the spring and summer of 2024, the Biden administration was caught between its bedrock policy of the unconditional defence of its ally Israel and the reality of what that ally was doing in Gaza, with American weapons.
Mr Mill said: “There were debates about whether to suspend other arms deliveries, and you saw at times us hold back certain arms while we negotiated the use of those arms…
“But we found ourselves in this really tough position, especially in that time period when it really came to a head… We were at a place where – I’m thinking of the way I can appropriately say this – the decisions and the thinking of Hamas leadership were not always secret to the United States and to our partners.”
Image: Matthew Miller during a news briefing at the state department in 2023. Pic: AP
He continued: “And it was clear to us in that period that there was a time when our public discussion of withholding weapons from Israel, as well as the protests on college campuses in the United States, and the movement of some European countries to recognise the state of Palestine – appropriate discussions, appropriate decisions – protests are appropriate – but all of those things together were leading the leadership of Hamas to conclude that they didn’t need to agree to a ceasefire, they just needed to hold out for a little bit longer, and they could get what they always wanted.”
“Now, the thing that I look back on, that I will always ask questions of myself about, and I think this is true for others in government, is in that intervening period between the end of May and the middle of January [2025], when thousands of Palestinians were killed, innocent civilians who didn’t want this war, had nothing to do with it, was there more that we could, could have done to pressure the Israeli government to agree to that ceasefire? I think at times there probably was,” Mr Miller said.
Asked for his view on the accusation of genocide in Gaza, he said: “I don’t think it’s a genocide, but I think it is without a doubt true that Israel has committed war crimes.”
Challenged on why he didn’t make these points while in government, he said: “When you’re at the podium, you’re not expressing your personal opinion. You’re expressing the conclusions of the United States government. The United States government had not concluded that they committed war crimes, still have not concluded [that].”
Image: Anthony Blinken, left, with then US President Joe Biden. Pic: AP
He went on to offer a qualification to his accusation.
“There are two ways to think about the commission of war crimes,” he said.
“One is if the state has pursued a policy of deliberately committing war crimes or is acting recklessly in a way that aids and abets war crimes. Is the state committing war crimes?
“That, I think, is an open question. I think what is almost certainly not an open question is that there have been individual incidents that have been war crimes where Israeli soldiers, members of the Israeli military, have committed war crimes.”
The Israeli government continues to strongly deny all claims that it has committed war crimes in Gaza.
On Joe Biden’s election hopes
Mr Miller also offered a candid reflection on the suitability of Mr Biden as a candidate in the 2024 US election. While Mr Biden initially ran to extend his stay in the White House, he stepped aside, with Kamala Harris taking his place as the Democratic candidate.
“Had I not been inside the government, had I been outside the government acting kind of in a political role, of course, I would have wanted to have a better candidate,” he said.
“It’s that collective action problem where no one wants to be the first to speak out and stand up alone. You stand up by yourself and get your head chopped off, stand up together, you can take action.
“But there was never really a consensus position in the party, and there was no one that was willing to stand up and rally the party to say this isn’t going to work.
“I don’t think there is anyone on the White House staff, including the most senior White House staffers, who could have gone to Joe Biden in the spring of 2023 or at any time after that and told him: ‘Mr President, you are not able to do the duties of this job. And you will not win re-election.’ He would have rejected that outright.”
Please use Chrome browser for a more accessible video player
1:00
Biden’s presidency in 60 seconds
The Trump presidency
On the Donald Trump presidency so far, he offered a nuanced view.
He described Mr Trump’s Middle East envoy Steve Witkoff as “an extremely capable individual” but expressed his worry that he was being manipulated by Russian President Vladimir Putin.
“I know the people in the Biden administration who worked with him during the first negotiations for Gaza ceasefire thought that he was capable.
“I think at times he doesn’t know what he doesn’t know. And you see that especially in the negotiations to end the war in Ukraine, where you see him go into a meeting with Vladimir Putin and come out spouting Russian propaganda… I think he would benefit from a little diplomatic savvy and some experienced diplomats around him.”
Image: Trump’s Middle East envoy Steve Witkoff, left, with Vladimir Putin. Pic: Sputnik/AP
He continued: “But I do think it’s extremely important that when people sit down with an envoy of the United States they know that that envoy speaks for the President of the United States and it is very clear that Witkoff has that and that’s an extremely valuable asset to bring to the table.”
On the months and years ahead under Mr Trump, Mr Miller said: “The thing that worries me most is that Donald Trump may squander the position that the United States has built around the world over successive administrations of both parties over a course of decades.
“I don’t think most Americans understand the benefits that they get to their daily lives by the United States being the indispensable nation in the world.
“The open question is: will the damage that he’s doing be recoverable or not?”
A 16-year-old transgender athlete who is the focus of a US sports row has won two golds and a silver at the California high school track and field championship.
AB Hernandez was born a boy but has transitioned and now competes against girls.
And the teenager’s inclusion in the girls category in the high jump, long jump and triple jump became a national conversation.
Critics, including parents, conservative activists and President Trump, had called for Hernandez to be barred from competing.
Image: AB Hernandez poses with her medals. Pic: AP
In the city of Clovis on Saturday, she took part under a new rule change brought in by the state’s interscholastic federation, under which an extra student was allowed to compete and win a medal in the events where Hernandez qualified.
And it meant there were two winners when she finished first.
Hernandez shared first place in the high jump with Jillene Wetteland and Lelani Laruelle.
All three cleared a height of 5ft 7in (1.7m), but Hernandez had no failed attempts, while the other two had each logged one failure.
Hernandez also had a first-place finish in the triple jump, sharing the top spot with Kira Gant Hatcher, who trailed her by more than half a metre.
Image: AB Hernandez shares the first-place spot on the podium with Kira Gant Hatcher during the triple jump medal ceremony. Pic: AP
Also, Hernandez came second in the long jump with Brooke White.
Plane protest
During Hernandez’s qualifying events on Friday, a plane flew over the stadium trailing a banner, which read: “No boys in girls’ sports.” It was organised and paid for by two women’s advocacy groups.
A small protest also took place on the road outside. “Save girls’ sports,” one poster read. “XX does not equal XY,” read another.
Image: A plane, paid for by women’s advocacy groups, flew a banner over the stadium that read: ‘No boys in girls’ sports’
Transgender inclusion is a thorny issue but a vote winner for Donald Trump, who campaigned last year with a promise to “kick out men from women’s sport”.
And Mr Trump has threatened to withdraw federal funding from California over Hernandez’s participation in this weekend’s athletics event.
Image: Pic: AP
‘Pilot entry process’
The California Interscholastic Federation had earlier said it was launching a “pilot entry process” to allow more girls to participate in the championship.
It only applied to the three events in which Hernandez competed.
The rule change may be the first attempt nationally by a high school sports governing body to expand competition when trans athletes are participating.
If a transgender athlete wins a medal, their ranking would not displace a “biological female” student from also medalling, the federation confirmed, and it will be reflected in the records.
Follow the World
Listen to The World with Richard Engel and Yalda Hakim every Wednesday
A man has been charged with two counts of murder after people at a US rally in support of Israeli hostages were targeted with petrol bombs and a makeshift flamethrower.
Despite the charges, authorities are yet to confirm if anyone has died as a result of the attack – and there has been no update on the condition of injured victims.
Four women and four men aged between 52 and 88 were injured and taken to hospitals after being targeted by a man shouting “Free Palestine” in Boulder, Colorado, police said.
The force said the injuries ranged from “very serious” to “more minor” and one of them was in a critical condition.
The FBI says it was a targeted “act of terrorism” and named the suspect as 45-year-old Mohamed Soliman from El Paso County, Colorado.
Soliman has also been charged with one count of attempted murder, one count of first-degree assault, one count of causing serious injury to an at-risk adult or someone over 70 and one count of using explosives or incendiary devices.
Two senior law enforcement officials earlier told Sky News’ US partner network that Soliman is an Egyptian national who seemingly acted alone. They said he has no previous significant contact with law enforcement.
More from US
An initial review of Soliman’s possible social media accounts has not answered questions about a motive or point to any particular ideology, the two senior law enforcement officials said.
The White House has described the suspect as an “illegal alien” who had received a work permit under the Biden administration despite overstaying a tourist visa.
Image: The suspect was seen clutching two glass bottles
Eyewitnesses said the suspect threw Molotov cocktails, an improvised bomb made from a bottle filled with petrol and stuffed with a piece of cloth to use as a fuse, into people attending the demonstration.
He also used a “makeshift flamethrower” during the attack, according to Mark Michalek, special agent in charge of the FBI’s Denver field office.
Police chief Steve Redfearn said the attack happened around 1.26pm on Sunday and that initial reports were that “people were being set on fire”.
“When we arrived we encountered multiple victims that were injured, with injuries consistent with burns,” Mr Redfearn told the media.
Boulder’s police chief said the attack happened as a “group of pro-Israel people” were peacefully demonstrating.
The walk is held regularly by a volunteer group called Run For Their Lives, which aims to raise awareness of the hostages who remain in Gaza.
Image: The suspect was arrested at the scene in Boulder
Video from the scene showed a bare-chested man shouting and clutching two bottles after the attack.
Other footage showed him being held down and arrested by police as people doused one of the victims with water.
Nearby there appears to be a large black burn mark on the ground.
A large part of downtown Boulder was cordoned off as sniffer dogs and the bomb squad searched for potential devices.
Lynn Segal, an eyewitness, said: “These shoots of fire, linear, about 20 feet long, spears of fire, two of them at least, came across right into the group, about 15 feet from me.”
The 72-year-old said two neighbours of hers, a husband and wife in their 80s, were at the demonstration. She added that the wife was one of the victims and appeared to be the most seriously injured.
“They’re both elders in their 80s, and you can’t take something like this assault to your body as easily as someone younger.”
Image: A bomb disposal robot with law enforcement on a Boulder street. Pic: AP
A statement from Boulder’s Jewish community said “an incendiary device was thrown at walkers at the Run for Their Lives walk on Pearl Street as they were raising awareness for the hostages still held in Gaza”.
Israeli Prime Minister Benjamin Netanyahu issued a statement on Monday saying he, his wife and the nation of Israel were praying for the full recovery of the people wounded in the “vicious terror attack” in Colorado.
“This attack was aimed against peaceful people who wished to express their solidarity with the hostages held by Hamas, simply because they were Jews,” he said.
US Senate Minority Leader Chuck Schumer, a prominent Jewish Democrat , said it was an antisemitic attack.
“This is horrifying, and this cannot continue. We must stand up to antisemitism,” he said on X.
Image: Topless man being pinned down by police
Image: Police lead a sniffer dog around cars. Pic: AP
Tensions are simmering in the US over Israel’s war in Gaza.
There has been an increase in antisemitic hate crime, as well as moves by some supporters of Israel to brand pro-Palestinian protests as antisemitic.
President Trump’s administration has detained protesters without charge and pulled funding from elite universities that have permitted such demonstrations.