Connect with us

Published

on

Apr 12 2024 Kyoto University

Mother Nature is an artist, but her craft of creating animal faces requires more than a paintbrush and palette. Such highly complex shapes originate from their respective transient neural crest cells. 

These embryonic pluripotent cells within the facial primordium-;the early development form-;may be necessary for forming proper facial structures. However, analyzing the molecular mechanisms in such early stages of development poses many technical challenges.

Now, a group of Kyoto University researchers have produced neural crest cell-rich aggregates from human pluripotent stem cells and developed a method to differentiate them in cell populations with a branchial arch-like gene expression pattern.  After the cell populations differentiate into precursors of maxillary and mandibular cells in response to external signaling factors, these populations spontaneously form patterns of the facial primordium."

Yusuke Seto of KyotoU's Institute for Medical and Biological Research

This cartilage-like structure, reminiscent of Meckel's cartilage, is formed locally within the aggregates.

"We aim to establish a model for studying early facial development by using the properties of human pluripotent stem cells to generate in vitro tissue resembling the bronchial arch of the primordial face," adds Ryoma Ogihara, also of the Institute. Related StoriesSpace travel alters human vascular cell function, study findsResearch explores the health benefits of resistant starch in plant-based dietsFeeling lonely? It may affect how your brain reacts to food, new research suggests

Researchers are examining the various developmental processes that cause interspecific and individual differences in facial structure to explain conditions such as craniofacial disorders.

"Using our in vitro model could help us better understand and control signal integration during the fate determination of the branchial arch and cartilage formation in the face and elsewhere. We hope our technology can contribute to the development of cellular materials for new regenerative medicine," adds Mototsugu Eiraku, also of the Institute. Source:

Kyoto UniversityJournal reference:

Seto, Y., et al. (2024). In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells. Nature Communications. doi.org/10.1038/s41467-024-45285-0.

Continue Reading

Politics

Can Streeting stop the doctors strikes?

Published

on

By

Can Streeting stop the doctors strikes?

👉Listen to Politics at Sam and Anne’s on your podcast app👈 

After yesterday’s royal welcome from the King, French President Emmanuel Macron will get down to business today, meeting Prime Minister Sir Keir Starmer for lunch, after PMQs.

But, as Sky News’ Sam Coates and Politico’s Anne McElvoy discuss on this episode, away from the pomp, Sir Keir’s in-tray doesn’t look any less challenging.

It includes a headache for Health Secretary Wes Streeting as resident doctors, formerly known as junior doctors, announce a new strike – and there is as a punchy warning from the OBR on making financial promises to the public.

Also today, the welfare bill returns to the House of Commons, with reports of another rebellion brewing.

Continue Reading

World

Why do so many from around the world try to cross the English Channel?

Published

on

By

Why do so many from around the world try to cross the English Channel?

While the politicians talk, so many people come from around the world to try to get across the Channel on small boats. But why?

Why make such a perilous crossing to try to get to a country that seems to be getting increasingly hostile to asylum seekers?

As the British and French leaders meet, with small boats at the forefront of their agenda, we came to northern France to get some answers.

It is not a new question, but it is peppered with fresh relevance.

Over the course of a morning spent around a migrant camp in Dunkirk, we meet migrants from Gaza, Iraq, Eritrea, South Sudan, Sri Lanka and beyond.

Some are fearful, waving us away; some are happy to talk. Very few are comfortable to be filmed.

All but one man – who says he’s come to the wrong place and actually wants to claim asylum in Paris – are intent on reaching Britain.

They see the calm seas, feel the light winds – perfect conditions for small boat crossings.

John has come here from South Sudan. He tells me he’s now 18 years old. He left his war-torn home nation just before his 16th birthday. He feels that reaching Britain is his destiny.

“England is my dream country,” he says. “It has been my dream since I was at school. It’s the country that colonised us and when I get there, I will feel like I am home.

“In England, they can give me an opportunity to succeed or to do whatever I need to do in my life. I feel like I am an English child, who was born in Africa.”

John, a migrant from South Sudan, speaks to Sky News Adam Parsons
Image:
‘England is my dream country,’ John tells Adam Parsons

He says he would like to make a career in England, either as a journalist or in human resources, and, like many others we meet, is at pains to insist he will work hard.

The boat crossing is waved away as little more than an inconvenience – a trifle compared with the previous hardships of his journey towards Britain.

We meet a group of men who have all travelled from Gaza, intent on starting new lives in Britain and then bringing their families over to join them.

One man, who left Gaza two years ago, tells me that his son has since been shot in the leg “but there is no hospital for him to go to”.

Next to him, a man called Abdullah says he entered Europe through Greece and stayed there for months on end, but was told the Greek authorities would never allow him to bring over his family.

Britain, he thinks, will be more accommodating. “Gaza is being destroyed – we need help,” he says.

Abdullah, a migrant from Gaza, speaking to Sky's Adam Parsons
Image:
Abdullah says ‘Gaza is being destroyed – we need help’

A man from Eritrea tells us he is escaping a failing country and has friends in Britain – he plans to become a bicycle courier in either London or Manchester.

He can’t stay in France, he says, because he doesn’t speak French. The English language is presented as a huge draw for many of the people we talk to, just as it had been during similar conversations over the course of many years.

I ask many of these people why they don’t want to stay in France, or another safe European country.

Some repeat that they cannot speak the language and feel ostracised. Another says that he tried, and failed, to get a residency permit in both France and Belgium.

But this is also, clearly, a flawed survey. Last year, five times as many people sought asylum in France as in Britain.

And French critics have long insisted that Britain, a country without a European-style ID card system, makes itself attractive to migrants who can “disappear”.

Read more:
Channel crossings rise 50% in first six months of 2025
French police forced to watch on as migrants attempt crossing

Please use Chrome browser for a more accessible video player

Migrant Channel crossings hit new record

A young man from Iraq, with absolutely perfect English, comes for a chat. He oozes confidence and a certain amount of mischief.

It has taken him only seven days to get from Iraq to Dunkirk; when I ask how he has made the trip so quickly, he shrugs. “Money talks”.

He looks around him. “Let me tell you – all of these people you see around you will be getting to Britain and the first job they get will be in the black market, so they won’t be paying any tax.

“Back in the day in Britain, they used to welcome immigrants very well, but these days I don’t think they want to, because there’s too many of them coming by boat. Every day it’s about seven or 800 people. That’s too many people.”

“But,” I ask, “if those people are a problem – then what makes you different? Aren’t you a problem too?”

He shakes his head emphatically. “I know that I’m a very good guy. And I won’t be a problem. I’ll only stay in Britain for a few years and then I’ll leave again.”

A young man from Iraq walks away from Sky's Adam Parsons

A man from Sri Lanka says he “will feel safe” when he gets to Britain; a tall, smiling man from Ethiopia echoes the sentiment: “We are not safe in our home country so we have come all this way,” he says. “We want to work, to be part of Britain.”

Emmanuel is another from South Sudan – thoughtful and eloquent. He left his country five years ago – “at the start of COVID” – and has not seen his children in all that time. His aim is to start a new life in Britain, and then to bring his family to join him.

He is a trained electrical engineer, but says he could also work as a lorry driver. He is adamant that Britain has a responsibility to the people of its former colony.

Follow The World
Follow The World

Listen to The World with Richard Engel and Yalda Hakim every Wednesday

Tap to follow

“The British came to my country – colonising, killing, raping,” he said. “And we didn’t complain. We let it happen.

“I am not the problem. I won’t fight anyone; I want to work. And if I break the laws – if any immigrant breaks the laws – then fine, deport them.

“I know it won’t be easy – some people won’t like me, some people will. But England is my dream.”

Continue Reading

Science

Axiom 4 Mission Crew Settles Down at ISS, Begins Conducting Research

Published

on

By

Axiom 4 Mission Crew Settles Down at ISS, Begins Conducting Research

Axiom 4 mission’s crewmates began conducting biomedical research aboard the International Space Station on Tuesday. Expedition 73 and Ax-4 crews found electrical muscle stimulation and cellular immunity. The Cargo transfers and exercise gear maintenance take a day for orbital residents.

Takuya Onishi, Situation Commander from JAXA( Japan Aerospace Exploration Agency), has begun the shift in continuation of his space biology studies. His blood and saliva samples are being collected for storage and processing. Further, he spun the specimens in a centrifuge and placed the blood samples in the freezer. After that, he stowed the samples in the incubator.

JAXA’s Takuya Onishi Leads Cellular Immunity Study with Blood and Saliva Analysis

According to a report from NASA, the samples will be analysed to determine the effect of microgravity on cellular immunity, observe stress-related immune reactions, and learn about how to treat symptoms of immunity. The flight engineers Johnny Kim, Anne McClain, and Nichole Ayers spent their day on orbital lab maintenance and further support activities of the crew. Kim focused mainly on orbital plumbing as he replaced and drained the Tranquillity module.

Ayers checked cables and power components in the Destiny laboratory module and deactivated and placed the microscope. McClain took the cognition test on the laptop and kept on supporting the Ax-4 crew at a time of a busy schedule.

Ax-4 Crew Explores Muscle Stimulation and Space Suit Fabric Efficiency in Microgravity

Veteran astronaut Peggy Whitson and her Ax-4 crewmates Shubhanshu Shukla, Tibor Kapu and UznaÅ„ski-WiÅ›niewski conducted numerous space investigations throughout the lab. The private scientists in their second full week on the station found out that the electrical muscle simulation escalates the space-related and muscle atrophy in space. Ax-4’s other experiments looked at suit fabrics promote thermal comfort with exercising the weightlessness, crew health and agriculture in space.

Sergey Ryzhikov and Alexey Zubritskiy worked together on the Zvezda service module, repairing and organising components on a treadmill, one of the two inside the space station, which included the COLBERT treadmill. Kirill Peskov started his day by going through the biological samples from the crewmates. At the end of his shift, he transfers water from Progress 92 cargo craft and unloads the stuffs of hardware and crew supplies.

For the latest tech news and reviews, follow Gadgets 360 on X, Facebook, WhatsApp, Threads and Google News. For the latest videos on gadgets and tech, subscribe to our YouTube channel. If you want to know everything about top influencers, follow our in-house Who’sThat360 on Instagram and YouTube.


Microsoft Fixes One Zero-Day Vulnerability, 136 Other Flaws With July 2025 Windows Security Update

Related Stories

Continue Reading

Trending