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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.


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A Planet with a Death Wish: How HIP 67522 b Is Forcing Its Star to Explode

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A Planet with a Death Wish: How HIP 67522 b Is Forcing Its Star to Explode

Scientists have caught a planet with a death wish, which is an alien world, orbiting very near to its star, and so speedy that it is causing the star to go to its death with bursting explosions. HIP 67522 b is the planet, and it is of the same size as Jupiter with a seven-day orbit around its host star. These orbits are disturbing the magnetic field of the star and causing enormous blasting eruptions to blow back the planet and make it wrinkled. This is the first time that a planet is influencing the host star, as the astronomers reported in a study published on July 2, 2025, in the Journal Nature.

A Planet with a Death Wish: HIP 67522 b’s Fiery Orbit

As per the study by NASA, Ekaterina Ilin, the first author of the study and an astrophysicist at the Netherlands Institute for Radio Astronomy, said that the planet was observed to trigger the energetic flares. It has been predicted by the scientists that the waves are setting off explosions that are going to happen.

Magnetic Chaos: Planet Triggering Star’s Explosions

Stars are burning plasma, gigantic balls with charged particles or ions that move on their surface to form strong magnetic fields. Since the magnetic fields cannot cross each other, sometimes these field knots suddenly snap to launch flares of radiation known as solar flares, which are often accompanied by coronal mass ejections, also known as surface plasma.

As many planets have a magnetic field, scientists have long wondered whether the planets, having close orbits near their stars, might disturb these strong magnetic fields and trigger the explosions. For years, scientists have observed whether the planets can influence the magnetic behaviour of their host stars, especially the ones that are close to their orbits.

A New Era of Star-Planet Relationship Studies

A planet with a strong magnetic field orbits around a star which has a delicate magnetic field, then it might be bombarded with solar radiation. These interactions helps int he study of star and planet bond and further the evolution of atmospher and magnetic field.

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Webb Telescope Spots Possible Jellyfish Galaxy 12 Billion Light-Years Away

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Webb Telescope Spots Possible Jellyfish Galaxy 12 Billion Light-Years Away

Astronomers have discovered a new “jellyfish” galaxy about 12 billion light-years away using the James Webb Space Telescope. It appears to have tentacle-like streams of gas and stars trailing off one side, a signature feature of jellyfish galaxies. These galaxies develop such trails via ram pressure stripping as they move through dense cluster environments, triggering star formation in the stripped gas. The find was made by Ian Roberts of Waterloo University, and details are described in a preprint on arXiv. More analysis is needed to confirm the classification, but early signs strongly suggest this object is indeed a jellyfish galaxy.

What Are Jellyfish Galaxies?

According to NASA, jellyfish galaxies are so named because of the long, trailing streams of gas and young stars that extend from one side of the galaxy. This phenomenon occurs when a galaxy moves rapidly through the hot, dense gas in a cluster, and ram pressure strips material away. The stripped gas forms a wake behind the galaxy, and this wake often lights up with bursts of new star formation. At the same time, the process can deprive the galaxy’s core of gas, potentially slowing star formation in the galaxy’s center.

Because the jellyfish stage is short-lived on cosmic timescales, astronomers rarely catch galaxies in this act. Studying jellyfish galaxies gives scientists insight into how dense environments affect galaxy evolution and star formation.

Discovery and Future Research

The researchers caution that the galaxy’s apparent “tentacles” may partly be an artifact of the imaging method. If confirmed, this object (COSMOS2020-635829) would be the most distant known jellyfish galaxy, offering a rare glimpse of how ram pressure stripping and cluster-driven quenching operated in the early cosmos. As the study authors note, finding a jellyfish at z>1 reinforces the idea that these environmental effects were already at work near the peak of cosmic star formation.

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Mars Dust Devils May Spark Lightning, Might Pose Risks to Rovers: Study

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Mars Dust Devils May Spark Lightning, Might Pose Risks to Rovers: Study

Dust devils on Mars – swirling columns of dust and air that often scour the Red Planet’s surface – may be crackling with electricity, a new computer-modeling study suggests. Researchers led by Varun Sheel simulated how Mars’s dry atmosphere and frictional dust collisions charge up grains inside a vortex. They found these fields could grow so strong that brief lightning-like discharges might occur. This electrification is a concern for surface missions, since charged dust could cling to rover wheels, solar panels and antennas, blocking sunlight and interfering with communications.

Formation and Features of Martian Dust Devils

According to the study, dust devils form when the Sun heats Mars’s surface, causing warm air to rise and spin into vortices. Colder air rushes inward along the ground, stretching the rising column upward and whipping dust high into the sky. Because Mars has lower gravity and a thinner atmosphere than Earth, its dust devils can tower much higher, three times larger than storms on Earth. NASA’s Viking mission first detected Martian dust devils; later rovers like Curiosity and Perseverance have filmed them sweeping across the dusty plains. These whirlwinds clean off solar panels – as happened with Spirit in 2005 – but more often they stir up fine dust that can coat instruments.

Electrification and Risks to Rovers

Dust grains in Martian whirlwinds can pick up charge through collisions (a triboelectric effect). Sheel’s models predict that this charge separation can create strong electric fields inside a dust devil. These fields could even exceed Mars’s atmospheric breakdown threshold (around 25 kV/m), enough to spark lightning in the vortex. NASA’s Perseverance rover recorded what appears to be a small triboelectric discharge when a dust devil passed overhead.

Even without lightning, any static buildup is problematic. As planetary scientist Yoav Yair notes, “Electrified dust will adhere to conducting surfaces such as wheels, solar panels and antennas,” potentially reducing sunlight reaching panels and jamming communications. Rovers may need new design features or procedures to handle this unusual Martian weather.

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