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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.


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ISRO Postpones Docking of SpaDeX Satellites Again

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ISRO Postpones Docking of SpaDeX Satellites Again

The Indian Space Research Organisation (ISRO) has postponed its Space Docking Experiment (SpaDex) mission which was scheduled for Thursday, after the satellites drifted more than expected during a manoeuvre, ISRO said in a statement on Wednesday.

This is the second time that the docking experiment has been postponed.
It was originally scheduled for January 7.

In a post on X, ISRO said, “While making a maneuver to reach 225 m between satellites, the drift was found to be more than expected post non-visibility period.”

“The planned docking for tomorrow is postponed. Satellites are safe,” it added.

Earlier, on Monday, the ISRO had postponed the docking of its SpaDex mission program, initially scheduled for January 7, 2025. The new date for the docking has been set for January 9, 2025. ISRO has not provided any specific reason for the schedule change.

On December 30, ISRO achieved a historic feat by launching PSLV-C60 with SpaDeX and innovative payloads.

The SpaDeX mission is a cost-effective technology demonstrator mission for the demonstration of in-space docking using two small spacecraft launched by PSLV. The primary objective of the SpaDeX mission is to develop and demonstrate the technology needed for the rendezvous, docking, and undocking of two small spacecraft (SDX01, which is the Chaser, and SDX02, the Target, nominally) in a low-Earth circular orbit.

Union Minister of State (Independent Charge) of the Ministry of Earth Sciences, Jitendra Singh, last week said that the SpaDeX mission was named “Bharatiya Docking Technology” because it is purely an indigenous mission, and India is carrying out the first such experiment related to docking technology.

The Union MoS further stated that SpaDeX’s mission very much aligns with Prime Minister Narendra Modi’s vision of “Aatmanirbhar Bharat.”

(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)

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Blue Origin New Glenn Set for Launch on January 10 from Cape Canaveral

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Blue Origin New Glenn Set for Launch on January 10 from Cape Canaveral

The highly anticipated debut launch of Blue Origin’s New Glenn rocket has been scheduled for January 10, 2025. The heavy-lift rocket, designed for both commercial and government missions, will take off from Florida’s Cape Canaveral Space Force Station. A launch window of three hours, beginning at 1 a.m. EST, has been announced. The rocket’s inaugural flight marks a significant milestone for Blue Origin as the company aims to validate its capabilities and establish itself as a major player in the space industry.

New Glenn’s Mission and Capabilities

According to Blue Origin, as reported by space.com, the New Glenn rocket is a reusable, 320-foot-tall launch vehicle capable of carrying 50 tons (45 metric tons) to low Earth orbit (LEO). The NG-1 mission will test the company’s Blue Ring spacecraft platform, which is designed to support a variety of orbital payloads. This demonstration will include assessments of communication systems, in-space telemetry, and ground-based tracking capabilities. The payload will remain aboard the rocket’s second stage for a six-hour mission, as stated by Blue Origin.

Booster Recovery and Future Goals

The mission will also attempt a recovery of the rocket’s first stage booster, which will land on a ship stationed in the Atlantic Ocean, as per reports from space.com. The company’s senior vice president, Jarrett Jones, emphasised the importance of the flight, stating that rigorous preparations had been undertaken but that true insights could only be gained through actual launch experiences.

NG-1 is a critical step toward securing certification for U.S. national security missions. A successful outcome would bring Blue Origin closer to fulfilling these high-stakes contracts, further solidifying its position in the competitive aerospace sector.

This launch will serve as a proving ground for the New Glenn system, with valuable data expected to inform future missions and technology advancements.

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Spiders Detect Smells Through Leg Hairs, Claims New Study

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Spiders Detect Smells Through Leg Hairs, Claims New Study

New research has revealed that spiders use specialised hairs on their legs to detect airborne scents, offering fresh insights into the sensory abilities of these arachnids. This discovery has resolved a long-standing question about how spiders, which lack antennae like insects, can identify odours such as pheromones. Male spiders were observed using olfactory hairs, known as wall-pore sensilla, to sense sex pheromones emitted by females. This mechanism underscores their ability to locate potential mates through chemical signals.

Olfactory Sensilla Identified

According to a study, published in the Proceedings of the National Academy of Sciences, the wall-pore sensilla were found on the upper legs of adult male wasp spiders (Argiope bruennichi). These microscopic structures are believed to be critical for detecting pheromones. High-resolution scanning electron microscopy revealed thousands of these sensilla, which were absent in females and juvenile males. This specific distribution supports their role in mate detection. Researchers emphasised to phys.org that these findings have mapped and identified the elusive sensilla, previously thought to be absent in spiders.

Response to Pheromones

Experiments demonstrated the sensitivity of these sensilla to pheromone compounds. Tiny amounts of the substance, such as 20 nanograms, elicited significant neuronal responses. The experiments involved exposing the sensilla to pheromone puffs, and responses were observed consistently across various leg pairs. The researchers concluded that spiders’ olfactory systems rival the sensitivity seen in insects, highlighting their advanced chemical detection capabilities.

Broader Implications

The study explored 19 other spider species and confirmed the presence of wall-pore sensilla in most male spiders, suggesting that this trait evolved multiple times. However, it was noted that some primitive species lack these structures. Future research is expected to investigate how female spiders detect smells, the types of chemicals relevant to their behaviours, and the evolutionary aspects of olfaction in spiders.

This breakthrough provides a foundation for understanding the sophisticated sensory mechanisms that govern spider behaviour.

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