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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.


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Juno Mission Sheds Light on Jupiter’s Storms and Volcanic Activity on Io

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Juno Mission Sheds Light on Jupiter’s Storms and Volcanic Activity on Io

NASA’s Juno mission has discovered a world of cyclones at Jupiter’s north Jovian pole, a region of cooler stratospheric haze. The cyclones drift to the pole through a process the researchers refer to as “beta drift” via JunoCam and Jovian Infrared Aurora Mapper. The cyclones oscillate around their centres and can drift clockwise around the pole. Juno has also been making recurring flybys of the innermost Jovian moon, Io, revealing evidence of subterranean magma flows below its surface. These cooling flows could explain how Io’s volcanoes erupt, as about 10% of the moon’s subsurface has these flows.

Juno Spots Colliding Jupiter Cyclones and Magma Beneath Io’s Surface

As per the data presented by NASA at the European Geosciences Union General Assembly on April 29, Juno has observed a large central cyclone over 1,800 miles wide, encircled by eight slightly smaller cyclones. These weather systems, blowing at speeds over 100 miles per hour, interact through a phenomenon called beta drifts — similar to Earth’s cyclones but progressing to Jupiter’s pole.

Once enabled, researchers could visualise both visible and thermal activity in Jupiter’s atmosphere. The cyclones stabilise one another and slowly push in the same direction around the pole—in a clockwise direction, as the researchers noted. Jupiter’s cyclones differ from those on Earth since they do not weaken over time at the poles, when the planet has a different atmospheric makeup.

At the same time, exploring Io with Juno has made another discovery: that beneath the surface of the moon lie hidden flows of magma. By pairing infrared and microwave data, scientists picked up warm lava from a large eruption on Dec. 27, 2024. The volcano remained active through Juno’s next flyby in March and is expected to erupt again in May. These discoveries mark the most energetic volcanic eruption ever observed on Io.

The detection of subsurface magma confirms Io’s surface is constantly being renewed. Scientists calculate that 10% of the moon’s interior contains slowly cooling lava. These lava flows help transport heat from Io’s interior to the surface.

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New Study Uncovers Shadowy Origins of Universe’s Most Luminous Phenomena

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New Study Uncovers Shadowy Origins of Universe’s Most Luminous Phenomena

Some of the brightest lights in the universe shine from some of its darkest corners — so-called supermassive black holes. Invisible to the human eye, these high-energy powerhouses light up the cosmos with emissions that are detected by space telescopes. Thousands of such light sources have been discovered with NASA’s Fermi Gamma-ray Space Telescope, which has been observing since 2008. These aren’t just stars — they are active galactic nuclei (AGN) where large gravitational forces fling matter around black holes, creating intense radiation blasts all across the electromagnetic spectrum.

Blazars and AGN Jets Reveal How Black Holes Shape and Light Up the Universe

As per NASA’s report ,observational data, black holes lurk at the centres of most galaxies and are hundreds of thousands to billions of times the mass of the sun. In AGN, gas and dust fall into an inward-spiralling disk. Second, the disks experience friction and magnetic forces that produce light from radio to gamma rays. About one in ten AGN produce powerful jets of particles that move at nearly the speed of light, and it’s still a mystery to scientists how material so close to the event horizon is accelerated in the jets.

, the type of AGN observed depends on its orientation relative to Earth. Radio galaxies shoot their jets sideways, while blazars aim them nearly straight at us, making them appear especially bright in gamma rays. Fermi’s sky surveys show that more than half of the thousands of gamma-ray sources it has recorded are blazars, giving researchers vital clues about the energetic mechanics behind these cosmic light shows.

AGN are more than just bright; scientists are attracted to them for what they tell us about cosmic history. AGN existed in the early universe and were probably important in modulating galaxy evolution. Astrophysicists will use observations and analyses of the conditions directly around these black holes to learn more about the structure and history of the universe itself.

The paradox is acute: black holes are famous for eating up all the light and matter they can latch onto, but they lie behind some of the most luminous phenomena seen in space. Through missions like Fermi, scientists are adjusting the picture of the universe, in which some of its darkest origins can sparkle the most.

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NASA’s Psyche Mission Encounters Pressure Drop, Backup Systems on Standby

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NASA’s Psyche Mission Encounters Pressure Drop, Backup Systems on Standby

The Psyche mission by NASA has gained a small success in its journey to the asteroid belt. Spacecraft used solar electric propulsion to pass through into space easily. This led to a decrease in fuel pressure. The scientists are finding the reason behind this issue to make sure the mission stays as it was planned. Xenon gas is used in the propulsion to eject the electric thrusters. This in turn allows Psyche to move into space efficiently at far distances.

Unexpected Pressure Drop Halts Thruster Firing

As per physics.org, it was studied that Psyche detected a sudden decrease in the pressure of xenon gas, which dropped from 36 psi to 26 psi, on April 1, 2025. According to its programming by NASA, the spacecraft shut down the thrusters automatically to avoid any risk. Spacecraft design allows it to handle the anomalies safely with precautions. Scientists are analysing the data driven by telemetry, to understand the reason behind this pressure drop.

Backup Systems Ready if Needed

The design of the spacecraft has been designed redundantly. Psyche has two identical fuel lines, and the team can access backup when needed. The team has put all the activities at halt till the examination of the system. This limited period hiatus of the mission allowed the spacecraft’s planned course of action till the middle of June at least. This buffer will allow the researchers enough time to detect the issue with no impact on the mission.

Mission Progress Remains on Track

The spacecraft is at a distance of around 238 million kms away from the Earth. After the launch of the spacecraft from Kennedy Space Center in October 2023, thruster operations began in May 2024. There is a flexibility in the design to carry out the mission with ease, after knowing the minor changes or hanging on that is required to do during this long expedition to the asteroid belt.

Next Steps: A Mars Flyby and Beyond

Further, Psyche will be on track for a Mars flyby in 2026. This will help the spacecraft to move ahead till the final point, the metal-rich asteroid Psyche which is placed between Mars and Jupiter. This will begin orbiting the asteroid in 2029.

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