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A US woman has become the first person in the world to undergo a pig kidney transplant and also have a mechanical heart pump surgically implanted.

Lisa Pisano’s combination of heart and kidney failure had left her too ill to qualify for a traditional transplant.

The 54-year-old, from New Jersey, became the first woman and only the second patient ever to receive a genetically-modified pig kidney when she “took a chance”.

In a world first, Ms Pisano allowed doctors at NYU Langone Transplant Institute in New York to implant a mechanical pump to keep her heart beating and then a few days later to transplant a pig kidney.

She said: “I was at the end of my rope. I just took a chance.

“And you know, worst case scenario, if it didn’t work for me, it might have worked for someone else and it could have helped the next person.”

Her husband Todd said: “With this surgery I get to see my wife smile again.”

Last month, it was revealed a 62-year-old man became the first person to be transplanted with a pig kidney.

Other transplant experts are said to be closely watching the progress of Ms Pisano, who doctors said was recovering well.

Dr Robert Montgomery, director of NYU Langone Transplant Institute, recalled there were cheers in the operating room as the organ immediately started making urine.

Pic: AP
Lisa Pisano looks at photos of her dog after her surgeries at NYU Langone Health in New York on Monday, April 22, 2024. Doctors transplanted a pig kidney into Pisano, who was near death, part of a dramatic pair of surgeries that also included a fix for her failing heart. (AP Photo/Shelby Lum)
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Ms Pisano is said to be recovering well. Pic: AP

Speaking about the early results of the surgery, he added: “It’s been transformative.”

But Dr Nader Moazami, the NYU cardiac surgeon who implanted the heart pump, warned “we’re not off the hook yet”.

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The two surgeries took place within eight days and needed emergency permission from US health agency, the Food And Drug Administration.

More than 100,000 people are on the transplant waiting list in the US – most need a kidney, but thousands die waiting.

Raising hopes of filling the shortage of donated organs, several biotech companies are genetically modifying pigs so their organs are more human-like and less likely to be destroyed by people’s immune system.

Ms Pisano’s case is the latest in a string of attempts to make animal-to-human transplantation a reality.

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‘Weak’ and ‘decaying’: Donald Trump gives withering verdict on European allies

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'Weak' and 'decaying': Donald Trump gives withering verdict on European allies

Donald Trump’s bruising assessment of Europe as “weak” and “decaying” is a bitter blow to nations already reeling from the release of his national security strategy.

At the end of the 45-minute interview with Politico, EU leaders might be forgiven for thinking, with friends like these, who needs enemies?

“Europe doesn’t know what to do,” Trump said, “They want to be politically correct, and it makes them weak.”

Trump meets leaders from Ukraine, Germany, France, the UK, Italy, and Finland, as well as the EU and NATO, in August Pic: Reuters
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Trump meets leaders from Ukraine, Germany, France, the UK, Italy, and Finland, as well as the EU and NATO, in August Pic: Reuters

On the contrary, I would imagine some choice words were being uttered in European capitals as they waded through the string of insults.

First up, the US president criticised European leaders for failing to end the war between Russia and Ukraine.

“They talk but they don’t produce. And the war just keeps going on and on,” he said.

The fact that the Russians have shown no real commitment to stopping the invasion they started is not mentioned.

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EU Flags at the European Commission Building. Pic: iStock
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EU Flags at the European Commission Building. Pic: iStock

Instead, the blame is laid squarely at the feet of Ukraine and its allies in Europe.

“I think if I weren’t president, we would have had World War III,” Trump suggested, while concluding that Moscow is in the stronger position.

Critics claim that the White House has emboldened the Kremlin and brought Putin in from the cold with a summit and photo opportunities.

Trump highlights the fact that his return to office forced many European NATO members to increase defence spending drastically.

Trump meeting European leaders in the Oval Office in August. Pic: @RapidResponse47
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Trump meeting European leaders in the Oval Office in August. Pic: @RapidResponse47

On this, he is correct – the growing insecurity around how long America can be relied on has brought security into sharp focus.

The release of the new US national security strategy has only added to the feelings of unease.

German Chancellor Friedrich Merz on Tuesday claimed some of its contents were unacceptable from a European point of view.

“I see no need for America to want to save democracy in Europe. If it was necessary to save it, we would manage it on our own,” he told a news conference in Rhineland-Palatinate, the German state where Trump’s paternal grandfather was born.

Meeting between, left to right, Keir Starmer of the UK, Volodymyr Zelenskyy of Ukraine, Emmanuel Macron of France, Donald Tusk of Poland, and Friedrich Merz of Germany. Pic: AP
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Meeting between, left to right, Keir Starmer of the UK, Volodymyr Zelenskyy of Ukraine, Emmanuel Macron of France, Donald Tusk of Poland, and Friedrich Merz of Germany. Pic: AP

The leader of the EU’s biggest power also said that the new US strategy was not a surprise and largely chimed with the vice president’s speech at the Munich Security Conference in February.

For this reason, Merz reiterated that Europe and Germany must become more independent from America for their security policies.

However, he noted, “I say in my discussions with the Americans, ‘America first’ is fine, but America alone cannot be in your interests.”

For his part, while Trump said he liked most of Europe’s current leaders, he warned they were “destroying” their countries with their migration policies.

He said: “Europe is a different place, and if it keeps going the way it’s going, Europe will not be…in my opinion, many of those countries will not be viable countries any longer. Their immigration policy is a disaster”.

He added: “Most European nations… they’re decaying.”

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Again, the comments echoed his security strategy, which warned immigration risked “civilisation erasure” in Europe.

There’s no doubt immigration is a major concern for many of the continent’s leaders and voters.

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Zelenskyy meets European leaders

However, irregular crossings into the EU fell 22% in the first 10 months of 2025 according to Frontex, a fact which seems to have passed the president and his team by.

“Within a few decades at the latest, certain Nato members will become majority non-European”, his security document warned.

It also suggested “cultivating resistance” in Europe “to restore former greatness” leading to speculation about how America might intervene in European politics.

Trump appeared to add further clarification on Tuesday, saying while he did not “want to run Europe”, he would consider “endorsing” his preferred candidates in future elections.

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This comment will also ruffle feathers on the continent where the European Council President has already warned Trump’s administration against interfering in Europe’s affairs.

“Allies do not threaten to interfere in the domestic political choices of their allies,” Antonio Costa said on Monday.

“The US cannot replace Europe in what its vision is of free expression… Europe must be sovereign.”

So, what will happen now, and how will Europe’s leaders respond?

If you are hoping for a showdown, you will likely be disappointed.

Like him or loathe him, Europe’s leaders need Trump.

They need the might of America and want to try to secure continued support for Ukraine.

While the next few days will be filled with politely scripted statements or rejections of the president’s comments, most of his allies know on this occasion they are probably best to grin and bear it.

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Luigi Mangione had handgun, silencer and ‘manifesto’ in backpack during arrest, police say

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Luigi Mangione had handgun, silencer and 'manifesto' in backpack during arrest, police say

Police officers found a handgun, a silencer and a red notebook described as a “manifesto” when they arrested Luigi Mangione.

The 27-year-old was arrested in December 2024 and charged with killing UnitedHealthcare chief executive Brian Thompson in New York City.

Mangione‘s lawyers want to block prosecutors from showing or telling jurors at his eventual trial in Manhattan about statements he allegedly made and items they said police seized from his backpack during his arrest at a McDonald’s in Pennsylvania.

The objects include a 9mm handgun prosecutors say matches the one used in the killing, a silencer, a magazine with bullets wrapped in underwear and a notebook in which they say Mangione described his intent to “wack” a healthcare executive.

Mangione with his attorney. Pic: Reuters
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Mangione with his attorney. Pic: Reuters

The defence contends the items should be excluded because police did not get a warrant before searching Mangione’s backpack.

Prosecutors deny claims Mangione was illegally searched and questioned.

They also want to suppress some statements he made to police, such as allegedly giving a false name, because officers asked him questions before telling him he had a right to remain silent.

Last week, Mangione watched surveillance videos of the killing of Mr Thompson, 50, as he walked to a New York City hotel for his company’s annual investor conference.

Mangione has pleaded not guilty to state and federal murder charges.

The state charges carry the possibility of life in prison, while federal prosecutors are seeking the death penalty.

This week’s hearing concerns only the state case, but Mangione’s lawyers want to bar evidence from both cases.

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In September, a judge dismissed two terrorism counts against Mangione, finding prosecutors had not presented enough evidence Mangione intended to intimidate health insurance workers or influence government policy.

Trial dates are yet to be set in either the state or federal cases.

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Are Trump’s allies behind hostile takeover bid of Warner Bros?

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Are Trump's allies behind hostile takeover bid of Warner Bros?

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A new White House National Security Strategy gives us an insight into how Donald Trump views the world, and the US’s place within it.

Is this America rejecting Europe and uprooting the established world order?

Two massive media companies go head-to-head to buy Warner Bros in a media shake-up that will have a massive impact on the film and TV industry.

The Supreme Court seems poised to expand the president’s powers which could see the structure of the federal government significantly changed.

You can also watch all episodes on our YouTube channel.

Email us on trump100@sky.uk with your comments and questions.

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