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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.

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NASA’s SPHEREx Mission Sends First Space Images Before Full Sky Survey

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April 3, 2025

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NASA’s SPHEREx Mission Sends First Space Images Before Full Sky Survey

NASA’s SPHEREx mission has sent back its first images from space. This marks an important step before it begins the full survey of the sky. The space telescope, which was launched on March 11, 2025, is designed to scan millions of galaxies and collect data in infrared light. On March 27, its detectors captured uncalibrated images that show thousands of light sources, including distant stars and galaxies. The images, processed with added colours for infrared wavelengths, confirm that SPHEREx is operating as expected. Once fully operational, the telescope will take 600 exposures daily and map the entire sky four times during its two-year mission.

Recorded Images Reveals Interesting Details

According to NASA’s SPHEREx mission, the observatory’s six detectors recorded images of the same area of the sky, providing a wide field of view. The top three images represent one portion of the sky, while the bottom three cover the same section. As per the report, the SPHEREx catpured each image with around 100,000 light sources. As per multiple reports, scientists can now learn more about what celestial objects and its distance from Earth with the help of infrared wavelengths. The data from SPHEREx will also help researchers to explore the origins of water in the Milky Way. Moreover, it might also help the scientists to find more clues about the universe’s earliest moments.

Olivier Doré, SPHEREx project scientist at NASA’s Jet Propulsion Laboratory (JPL) and Caltech, told NASA that the telescope is functioning as intended. The infrared light detected by SPHEREx is invisible to human eyes, but colour mapping enables researchers to visualise and analyse it. The observatory’s unique design includes 17 infrared wavelength bands for each detector, creating a total of 102 hues in every six-image capture.

How the Telescope Works

Unlike Hubble or the James Webb Space Telescope, which focuses on specific areas of space, SPHEREx is built for large-scale surveys. It uses spectroscopy to break down light and identify chemical compositions and distances of celestial bodies. Light entering the telescope is divided into two paths, each leading to three detectors. Specialised filters process the incoming wavelengths, allowing for detailed observations of millions of cosmic sources.

Beth Fabinsky, deputy project manager at JPL, said in NASA’s official statement that the successful image capture represents a major milestone. The telescope has also reached its target operating temperature of minus 350 degrees Fahrenheit, crucial for detecting faint infrared signals. Since focusing cannot be adjusted after launch, mission engineers verified the accuracy of the telescope’s optics before sending it into space.

Jamie Bock, principal investigator at JPL and Caltech, confirmed in NASA’s report that the telescope is performing as expected. Engineers will continue testing before the observatory begins routine operations in late April.

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Iceland’s Grindavík town evacuated as volcanic fissure erupts with lava!

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April 3, 2025

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Iceland’s Grindavík town evacuated as volcanic fissure erupts with lava!

A volcanic fissure has emerged near Grindavík on Iceland’s Reykjanes Peninsula after a series of strong earthquakes. Lava has breached the town’s defence barriers. The Icelandic Meteorological Office (IMO) has warned that the fissure may continue to expand. The eruption began along the Sundhnúkur crater row early in the morning. By 9:45 a.m. local time, a fissure stretching nearly 1,200 metres had opened north of Grindavík. The crack is moving southward. Officials have raised the hazard level to the highest risk category.

Evacuations and Road Closures

According to the IMO, a second fissure has appeared inside Grindavík’s protective barriers. Authorities have evacuated the town along with the Blue Lagoon spa. Roads in and out of the area have been shut. Some residents have refused to leave. Local media outlet Visir has reported that emergency services remain on high alert.

Impact of Volcanic Gas

Weather forecasts indicate that volcanic gas will be carried northeastward towards Reykjavík. The capital is located about 40 kilometres away. The IMO has stated that by tomorrow morning, changing wind patterns may direct the gas southwest and eastward. Residents have been told to remain indoors as much as possible while closely monitoring air quality updates. Reykjanes Peninsula has experienced about 11 eruptions since 2021. Eight have occurred along the Sundhnúkur crater row since last year. Scientists continue to monitor the situation closely. Authorities have urged people to avoid the affected region.

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JWST Captures Unseen Details of Exoplanets in HR 8799 and 51 Eridani Systems

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April 3, 2025

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JWST Captures Unseen Details of Exoplanets in HR 8799 and 51 Eridani Systems

Astronomers have released new images of planets within the HR 8799 and 51 Eridani star systems. The James Webb Space Telescope (JWST) was used in a way that was different from standard procedures to achieve these results. Capturing direct images of exoplanets is challenging due to the brightness of host stars, which often obscures planetary details. To allow more light through, researchers adjusted JWST’s coronagraphs. This helps in enhancing the visibility of these distant worlds. This adjustment provided clearer insights into planetary atmospheres and their compositions.

Unconventional Use of JWST’s Coronagraphs

According to a study published in The Astrophysical Journal Letters, lead author William Balmer, a Ph.D. candidate at Johns Hopkins University, explained to Space.com that a thinner part of the coronagraph mask was used. This allowed more starlight to diffract, reducing the risk of completely obscuring planets. Coronagraphs typically block starlight to reveal faint celestial bodies, but this modification provided a balance between removing excessive glare and preserving planetary details.

Key Discoveries and Observations

The JWST’s mid-infrared imaging captured HR 8799 at 4.6 microns. It is a wavelength that is mainly blocked by Earth’s atmosphere. Balmer stated that previous ground-based attempts had failed, demonstrating JWST’s stability in detecting exoplanets. Observations at 4.3 microns were also conducted. This revealed the presence of carbon dioxide. It is a very important step in determining the planetary formation processes. The detected carbon dioxide levels suggested that these planets likely formed through core accretion, gathering heavy elements over time.

Future Research and Expanding Studies

There are many research planned to study the four additional planetary systems. Balmer’s team has been allocated more JWST observation time to confirm whether similar gas giants formed through core accretion. This could offer more insights into the stability of planetary systems and potential habitability of smaller, unseen planets.

For the latest tech news and reviews, follow Gadgets 360 on X, Facebook, WhatsApp, Threads and Google News. For the latest videos on gadgets and tech, subscribe to our YouTube channel. If you want to know everything about top influencers, follow our in-house Who’sThat360 on Instagram and YouTube.


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