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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.

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Ancient Bronze Statues Unearthed from Etruscan Healing Spring in Italy

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December 20, 2024

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Ancient Bronze Statues Unearthed from Etruscan Healing Spring in Italy

Bronze statues, including depictions of snakes and a child priest, have been uncovered from a hot spring at San Casciano dei Bagni in Italy, according to the Italian Ministry of Culture, as per reports. The site, located around 120 kilometres northwest of Rome, has been excavated since 2019 and is believed to have been used for sacred rituals dating back to the third century B.C. The spring, originally used by the Etruscans and later adopted by the Romans, was a place where votive offerings were made in hopes of divine protection or healing, as per reports.

Discovery of Snake Statues and Other Artefacts

Bronze snake statues, some measuring up to 90 centimetres in length, were among the latest findings during the 2024 excavation, as reported by the excavation team. These statues were discovered in the deeper layers of the spring and are thought to have symbolised protection for the sacred waters. Other artefacts include a nude male figure inscribed with the name “Gaius Roscius” and a child priest holding a ball, which may have been used in divination rituals.

Preserved Organic Remains Found

The excavation also revealed well-preserved organic remains, such as eggs with visible yolks, pine cones, and plant matter. According to the Italian Ministry of Culture, in a statement, these items may have been used in rituals symbolising rebirth and regeneration. The preservation of these items is attributed to their rapid burial in sediment.

Expert Perspective

Alexandra Carpino, an art history professor at Northern Arizona University, commented in an email to Live Science that these findings are among the most significant discoveries of the 21st century. The range of artefacts provides insights into the role of healing sanctuaries in ancient societies.

Ongoing Research at the Site

Research continues at San Casciano dei Bagni, with scholars examining the inscriptions and artefacts to uncover more about the Etruscan and Roman use of the spring.

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Study Explores Sun’s Magnetic Field Changes and Solar Wind Acceleration

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Study Explores Sun’s Magnetic Field Changes and Solar Wind Acceleration

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December 20, 2024

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Study Explores Sun’s Magnetic Field Changes and Solar Wind Acceleration

In The Astrophysical Journal, a University of Michigan-led study detailed how the Sun’s magnetic field evolves as it moves through space, providing insights into solar wind acceleration. Using data from rare alignments of the Parker Solar Probe and Solar Orbiter, researchers observed that the Sun’s magnetic field transitions from sharp oscillations to smoother waves, with the surrounding solar wind gaining velocity. This discovery could enhance predictions of space weather, which impacts Earth’s technology and infrastructure.

Observations from Aligned Solar Probes

As per reports, the study focused on magnetic switchbacks—sharp bends in the Sun’s magnetic field. These phenomena influence the solar wind, a stream of charged particles that can disrupt power grids, communication systems, and satellites. The Parker Solar Probe, stationed within 30 solar radii (Rs) of the Sun, and the Solar Orbiter, located further out at 130 Rs, provided comparative measurements of magnetic fields and plasma moments.

The findings revealed that magnetic switchbacks smooth out into microstreams with 30 percent fewer reversals as they move outward, while the surrounding proton velocity increased by 10 percent. Researchers attributed this to magnetic relaxation, where magnetic energy is converted into kinetic energy, accelerating the solar wind.

Insights for Space Weather Forecasting

According to Shirsh Soni, research fellow in climate and space sciences at the University of Michigan and corresponding author of the study, in a statement, this marks the first direct observation of switchback magnetic energy decreasing with distance. He stated in reports that the collaboration between the Parker Solar Probe and Solar Orbiter has been crucial for understanding the Sun’s magnetic processes.

Mojtaba Akhavan-Tafti, associate research scientist at the University of Michigan, highlighted the broader implications, in his statement, noting that magnetic switchbacks reveal the Sun’s dynamic energy processes and their influence on the solar system. Researchers aim to investigate whether magnetic energy transfers also generate heat, potentially solving mysteries about the solar wind’s heating.

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FAST Telescope Detects New Pulsar PSR J1922+37 in Open Cluster NGC 6791

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December 20, 2024

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FAST Telescope Detects New Pulsar PSR J1922+37 in Open Cluster NGC 6791

A new pulsar, PSR J1922+37, has been discovered with a spin period of 1.92 seconds using the Five-hundred-metre Aperture Spherical Radio Telescope (FAST) in China, according to a report. The finding was made in the direction of the open cluster NGC 6791. If confirmed as a member of this cluster, it would be the first pulsar identified in an open cluster, a breakthrough in pulsar and stellar cluster research, according to sources.

Key Details of PSR J1922+37

The finding was reported in a paper published Dec. 11 on the arXiv preprint server. As per reports, the pulsar PSR J1922+37 has been observed with a dispersion measure of 85 pc/cm³ and a flux density of approximately 7.0 µJy. Its position aligns closely with the location of NGC 6791, with an offset of 14 arcminutes from the cluster’s centre. The estimated distance of the pulsar, 15,600 light-years, is consistent with the cluster’s distance range, which is calculated to be between 13,100 and 16,000 light-years.

According to the study, led by Xiao-Jin Liu of Beijing Normal University, the dense stellar environment of NGC 6791 increases the likelihood of pulsars being present within the cluster. Researchers have suggested that precise measurements of PSR J1922+37’s distance and proper motion will be necessary to confirm its association with NGC 6791.

Potential for Further Discoveries

The researchers indicated that NGC 6791’s compact and high surface brightness environment could host additional pulsars. An estimate provided in the study predicts that as many as nine pulsars may exist within this cluster. The team noted that further observations using advanced techniques could help verify these predictions.

The report further highlights that the discovery has been described as a significant development in the understanding of pulsars within open clusters, an area of study previously limited due to low stellar density in such regions. Verification of PSR J1922+37’s cluster membership will require additional studies, including proper motion analysis to establish a definitive connection.

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