Connect with us

Published

on

Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.


Affiliate links may be automatically generated – see our ethics statement for details.

Continue Reading

Science

SpaceX Successfully Launches 23 Starlink Satellites on Brand-New Falcon 9 Rocket

Published

on

By

SpaceX Successfully Launches 23 Starlink Satellites on Brand-New Falcon 9 Rocket

SpaceX marked its 60th Falcon 9 flight of 2025 by successfully launching a brand-new Falcon 9 booster rocket on the 20th of May. This rocket carries 23 Starlink V2 Mini satellites into low Earth orbit. Among those, 13 feature Direct to Cell capabilities. Originally, it was targeting 11:58 p.m. EDT on May 19 (0358 UTC on May 20) for the launch, but that try was aborted just before liftoff, for reasons that the company did not immediately explain. It was finally launched on Tuesday (May 20) at 11:19 p.m. EDT (0319 GMT on May 21) from the Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.

About the launch

According to SpaceX’s mission overview, this was the first-ever launch for this particular Falcon 9’s (booster B1095) first stage. While most recent SpaceX missions have reused Falcon 9 boosters , a signature part of the company’s cost-saving and sustainability strategy ,Tuesday’s flight featured a rare first-stage debut.

The rocket successfully completed its initial mission, separating from the upper stage around two and a half minutes after liftoff. About eight minutes later, the booster made a precise landing on the SpaceX drone ship “Just Read the Instructions,” stationed in the Atlantic Ocean. This smooth recovery sets the stage for future reusability of the rocket.

Technical Advancement

Of the 23 satellites onboard, 13 were outfitted with direct-to-cell technology — a feature designed to enable satellite connectivity directly to mobile phones, especially in areas lacking terrestrial infrastructure. After reaching space, the rocket’s second stage performed a short engine burn to circularize the orbit before deploying the satellites about 65 minutes after launch.

Starlink is the largest satellite megaconstellation ever constructed, consisting of about 7,500 operational satellites at the moment. And that number is growing all the time, as Tuesday’s action shows.

Continue Reading

Science

Polaris Wasn’t Always the North Star: How Earth’s Wobble Shifts the Celestial Pole

Published

on

By

Polaris Wasn’t Always the North Star: How Earth’s Wobble Shifts the Celestial Pole

Polaris has been the constant guide for explorers and navigators in the northern hemisphere for thousands of years, hence its other name, the famous North Star. It is significant where it is located near the north rotational axis of Earth, and the whole sky appears to spin about it. But that’s not always been the case, and it won’t always be the case. The planet’s sluggish axial wobble, called precession, makes the pole trace a circle about every 26,000 years, bringing different stars into view over the ages.

How Earth’s 26,000-Year Axial Precession Shifts the North Star Over Time

As per NASA, gravitational forces from the sun and moon affect the rotation of Earth; these produce a bulge at the equator and axial precession. Every 26,000 years or so, this wobble makes a complete circle, and it makes the celestial pole move on a cycle, pointing to stars in sequence over time. Thuban, in the star constellation Draco, was the closest visible in the sky to the celestial pole some 4,700 years ago. The stars, such as Kochab and Pherkad, were the nearest to the pole about 3,000 years ago. Polaris now has the title, but not for very long.

The axis of the Earth will eventually change again, bringing new stars into prominence. In about 2,200 years, Errai in the constellation Cepheus will become the North Star. Alderamin, likewise in Cepheus, will have its turn some 5,000 years from now. Deneb, who will approach the pole once more about 9,800 CE, and Vega, a former pole star, returning in roughly 12,000 years, complete this cycle.
Many of these stars fit identifiable constellations, including Cepheus, Draco, and Ursa Minor. Modern stargazing apps incorporating augmented reality for nighttime sky navigation allow amateur astronomers to trace their positions.

As Polaris continues to shine overhead today, its reign is only temporary. Earth’s steady 26,000-year precessional cycle guarantees that other stars will eventually take its place, proving that even in the cosmos, change is constant.

Continue Reading

Science

Scientists Warn of Inadequate Solar Storm Forecasting: What You Need to Know

Published

on

By

Scientists Warn of Inadequate Solar Storm Forecasting: What You Need to Know

Imagine being told a storm is approaching, but you won’t know how dangerous it truly is until minutes before impact. That’s the reality scientists face with solar storms. Although scientists have improved our ability to monitor coronal mass ejections (CMEs) from the Sun and project their arrival at Earth, the most important consideration — the orientation of the storm’s magnetic field — remains unknown until the very last minute. This direction, referred to as the Bz component, decides whether the CME will pass by with little influence or cause disturbances to satellites, electricity grids, and GPS systems.

Lack of Early Bz Data Leaves Earth Vulnerable to Solar Storms, Scientists Urge Wider Sun Coverage

As per a report on Space.com, solar physicist Valentín Martínez Pillet emphasised that knowing the Bz value earlier could dramatically improve our ability to prepare. Currently, spacecraft like NASA’s ACE and DSCOVR detect Bz only when the CME reaches Lagrange Point 1 (L1), giving us just 15 to 60 minutes’ warning. Martínez Pillet predicts it could take 50 years to achieve the forecasting precision we have for Earth’s weather unless we expand our view of the Sun with new satellites placed at Lagrange points L4, L5, and L3.

Despite having the scientific models needed, Martínez Pillet argues we lack vital real-time data from different solar perspectives. Most observations currently come from a single vantage point — L1, which limits our predictive ability. Missions like ESA’s upcoming Vigil, scheduled for launch in 2031 to L5, aim to fill this gap by detecting the CME’s shape and magnetic orientation from the side, potentially giving up to a week’s notice.

But decades may be too long to wait. History reminds us of the danger: the 1859 Carrington Event caused telegraph failures, and a near miss in 2012 could have caused trillions in damage if it had struck Earth. In a 2013 paper, Dan Baker of LASP warned that a direct hit would have left the modern world technologically crippled.

Today, tools like the Global Oscillation Network Group (GONG) and DSCOVR offer continuous solar monitoring, but their limitations emphasise the need to provide broader coverage. “The Sun isn’t changing,” Martínez Pillet said. “It’s our dependence on technology that’s made us more vulnerable.” Until we build the infrastructure to see solar storms before they hit, we may remain dangerously exposed.

Continue Reading

Trending