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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.

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Iran’s Folded Rocks Reveal Ancient Tectonic Power at Asia-Europe Boundary

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April 21, 2025

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Iran’s Folded Rocks Reveal Ancient Tectonic Power at Asia-Europe Boundary

The deformed rocks of Iran are formed due to strong mountain ridges and valleys in the Greater Caucasus mountain range, southwest of the Caspian Sea. Between 10 million and 50 million years ago, its growth was marked by sedimentary layers crushed during the first impact between the Arabian and Eurasian tectonic plates. The vividly coloured rocks produced by the sedimentary layers gathered over millennia range in tone from terracotta to greenish to bluish. Using satellite pictures, NASA’s Jet Propulsion Laboratory and Earth Observatory have shown how the landscape tended to cluster over time.

One image depicts the different strata layers, vegetation, and the Zanjan-Tabriz freeway linking Tehran and Poznan. Interestingly, another image is of the Qezel Ozan River, which provides agricultural water in the region. The region is still converging, and fresh research suggests that a slab of oceanic crust is being shredded beneath Iraq and Iran.

Iran’s Folded Rocks Expose Arabia-Eurasia Tectonic Collision

According to reported NASA experts, a tectonic clash between the continents — known as Eurasia and Arabia — crunched these vividly hued strata of rock into massive folds. Located southwest of the Caspian Sea, Iran’s folded rocks are mountain ridges and valleys from the Greater Caucasus mountain chain. The disrupted rocks are made of sedimentary layers that were tilted and folded after the first collision between the Arabian and Eurasian tectonic plates, which is estimated to have occurred 10 to 50 million years ago.

Under Iraq and Iran, some of the oceanic crust between the Arabian and Eurasian plates is breaking apart, according to current research, which results in an anomalous silt accumulation at the surface. The complexity of the Earth’s surface and the Qezel Ozan River, combined with the Neotethys oceanic plate pulling the area down, account for this.

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Astronomers Discover Potential ‘Dark Galaxy’ Near the Milky Way

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Astronomers Discover Potential ‘Dark Galaxy’ Near the Milky Way

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April 21, 2025

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Astronomers Discover Potential ‘Dark Galaxy’ Near the Milky Way

Astronomers might have discovered a dark galaxy, primarily made up of dark matter, in the local universe. Dark galaxies are theoretical starless systems that could provide valuable insight for galaxy formation models. The candidate was in a massive, rapidly moving gas cloud, first discovered in the 1960s. At high resolution, the methyl formate cloud appeared to be a tight knot of gas, potentially forming a dark galaxy. But not all astronomers are convinced. It’s more likely to be a regular gas cloud at the edge of the Milky Way, says the astronomer Tobias Westmeier.

The study was published in Science Adviser. It reveals that since the early 2000s, a few possible dark galaxies have been discovered close to the Milky Way. However, multiple studies have suggested that these alleged dark galaxies were misclassified. The study further highlights that the hypothetical dark galaxy evolved this way after a collision with cosmic gas close to our galaxy. Finding dark galaxies could enable better computer simulations and provide fresh insight into galaxy development.

Astronomers Discover Dark Galaxy Candidate Near Milky Way

According to the report, a hypothetical dark galaxy was revealed amid the field of dark matter in the early eras of the history of the universe. Better knowledge of the development of black galaxies, systems devoid of stars, is what astronomers aim for. First spotted half a century ago, a massive, fast-moving gas cloud showed new promise when scientists detected it. High-resolution cloud observations revealed a tiny gas cluster possibly matching a dark galaxy. Jin-Long Xu from the Chinese Academy of Sciences in Beijing told Science News that the finding marks the first of a potential black galaxy in the nearby universe.

Still, not all scientists agree with the dark galaxy designation of the clump. The report further notes that Westmeier thinks the object is most likely a regular gas cloud at the Milky Way’s edge. The idea dates back to identifying some purported black galaxies in orbit as far back as the early 2000s.

The latest discoveries came from observations with three radio telescopes, including high-resolution photos from the Five-Hundred-meter Aperture Spherical Telescope (FAST) in southern China. In much of the cluster, the scientists shadowed the velocity and direction of hydrogen gas and then deduced distance, which they found to be 900,000 light-years from Earth.

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NASA Scientists Study Crystal Formation in Space For Future Applications

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April 19, 2025

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NASA Scientists Study Crystal Formation in Space For Future Applications

NASA scientists have been studying crystals to optimise the process of crystallisation for decades. Various researchers have conducted research on crystals within the first quarter of the year, the latest being protein crystallisation in microgravity. Alexandra Ros from Arizona State University led the research by launching a protein crystallisation test in the International Space Station (ISS). The experiments are meant to determine the growth of protein crystals in space using newly developed microfluid devices. The research agenda is to examine whether space-grown crystals can achieve better quality than those formed on Earth.

What is Crystallisation, & How Does It Impact Our Lives?

It is the process of freezing of liquid or molten materials in the form of highly organised molecules called crystals. These crystals can be a blend of different types of materials. This world consists of crystal examples everywhere. It would be wrong to say that we don’t live in a world of crystals.

Be it a coffee mug, cellphone or silicon that is used to form the brains of electronics and used in memory chips, everything is a result of crystallisation. Other types of semiconductor crystals are used as detectors for different radiations, such as gamma rays, infrared rays, etc. Lasers used in scanning the product are made of optical crystals. Turbine blades are an example of metal crystals used in the jet engine.

Why and How NASA Studies Crystals?

The scientists studied the growth of zinc selenide crystals in space, with the crystals on Earth, explained NASA. The result from the observations marked the way for the improvement of the operations of infrared wavelength in the high powered lasers. The research findings provide an insight into the strong influence of gravity on the electrical, optical and structural characteristics of the crystals.

Researchers have optimised the crystal usage for several years to study the types of crystals for growing in space.

The crystals grown on Earth have defects such as little cracks; these cracks can damage the properties of the crystals. This marks a strong reason why scientists want to study crystals in space, thus getting a complete microgravitational environment where they can grow better. Convection produced due to the presence of the gravitational force degrades the quality of crystals.

However, this convection is not seen in the environment of microgravity, helping in the better quality crystals. The ISS is now converted to a complete lab for the study of the formation of crystals, which can be further applied in technology and medicine.

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