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Methods of screening men for prostate cancer will be trialled to save thousands of lives in the UK each year.

Experts have hailed the £42m project called Transform as “a pivotal moment in the history of prostate cancer research”.

Despite the fact that an estimated 12,000 lives a year are lost to prostate cancer, according to Cancer Research UK, there is currently no screening programme.

Previous trials that used prostate-specific antigen (PSA) blood tests and biopsies to screen for the disease showed the method prevented between 8% and 20% of deaths, depending on screening regularity, according to Prostate Cancer UK.

The charity said Transform has the potential to reduce deaths by 40%.

Patients will be recruited from GP practices across the country from next year to take part in the project.

The first phase will involve about 12,500 men and will assess the likes of PSA blood tests, genetic testing and a faster version of the MRI scan – known as a Prostagram – against current NHS diagnostic methods to see which performs best.

Up to 300,000 men will be involved in the trial’s second stage which will test the most promising options based on the results of the first stage.

The team will follow up with patients over at least a decade to track how screening impacted the length and quality of their lives.

At least one in 10 patients invited to take part will be black. This is because black men carry double the risk of developing prostate cancer than other men.

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Dr Matthew Hobbs, director of research at Prostate Cancer UK, said: “We know that earlier diagnosis saves lives, but previous trials haven’t been able to prove that enough men would be saved using PSA tests alone, while they did show that these old screening methods caused significant unnecessary harm to men.

“We must now prove that there are better ways to find aggressive prostate cancer that will save even more lives while causing less harm.”

As well as saving lives in the UK, Dr Hobbs said the trial could also “change practice globally”, with the number of lives saved potentially reaching tens of thousands each year.

He added: “This is a pivotal moment in the history of prostate cancer research and we’re proud to be leading the way and to be supporting some of the best researchers in the world to make it happen.”

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The project has also been backed by £16m of funding from the National Institute for Health and Care Research (NIHR), as well as £1.5m from Movember and support from the Freddie Green and Family Charitable Foundation.

Health minister Andrew Stephenson said: “Screening for the most common cancer in men is complex but we’re backing groundbreaking trials like this to improve diagnostic processes and save thousands more lives.

“Alongside backing cutting-edge research, we are helping more people get diagnosed earlier for cancer and other conditions by rolling out additional tests, checks and scans at 160 locations across England through our community diagnostics centres programme.”

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Passengers travelling to Heathrow Airport face delays on M4 after car catches fire in tunnel

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Passengers travelling to Heathrow Airport face delays on M4 after car catches fire in tunnel

Passengers travelling to Heathrow Airport are facing delays on the road after a vehicle caught fire in a tunnel.

“Due to an earlier vehicle fire, road access to Terminals 2 and 3 is partially restricted,” the airport said in a post on X shortly before 7am.

“Passengers are advised to leave more time travelling to the airport and use public transport where possible.

“We apologise for the disruption caused.”

AA Roadwatch said one lane was closed and there was “queueing traffic” due to a vehicle fire on Tunnel Road “both ways from Terminals 2 and 3 to M4 Spur Road (Emirates roundabout)”.

“Congestion to the M4 back along the M4 Spur, and both sides on the A4. Down to one lane each way through one tunnel…,” it added.

National Highways: East said in an update: “Traffic officers have advised that the M4 southbound spur Heathrow in Greater London between the J4 and J4A has now been reopened.”

The agency warned of “severe delays on the approach” to the airport, recommended allowing extra time to get there and thanked travellers for their patience.

The London Fire Brigade said in a post on X just before at 7.51am it was called “just before 3am” to a car fire in a tunnel near HeathrowAirport.

“Firefighters attended and extinguished the fire, which involved a diesel-powered vehicle. No one was hurt and the airport has now confirmed the tunnel has re-opened.”

Travellers writing on social media reported constrasting experiences, with @ashleyark calling it “complete chaos on all surrounding roads”, but @ClaraCouchCASA said she “went to T5 and got the express to T3”, describing the journey as “very easy and no time delay at all. 7am this morning. Hope this helps others”.

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Man arrested on suspicion of murder after woman shot dead in Talbot Green, South Wales

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Man arrested on suspicion of murder after woman shot dead in Talbot Green, South Wales

A man has been arrested on suspicion of murder after a 40-year-old woman was shot dead in South Wales.

The woman was found with serious injuries just after 6pm on Sunday and died at the scene despite the efforts of emergency services.

She was discovered in the Green Park area of Talbot Green, a town about 15 miles west of Cardiff.

A 42-year-old local man is in police custody.

Detective Chief Inspector James Morris said: “I understand the concern this will cause the local community, and I want to reassure people that a team of experienced detectives are already working at pace to piece together the events of last night.”

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South Wales Police said a number of crime scenes have been set up and road closures are in place.

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Drivers ‘confused’ by transition to electric vehicles, ministers warned

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Drivers 'confused' by transition to electric vehicles, ministers warned

UK drivers are “confused” by the country’s electric car transition, ministers are being warned.

Although most drivers are not hostile towards electric vehicles (EVs), many are confused about what changes are coming and when, according to new research from the AA.

In a survey of more than 14,000 AA members, 7% thought the government was banning the sale of used petrol and diesel cars.

Around a third thought manual EVs exist, despite them all being automatic.

More than one in five said they would never buy an EV.

The government’s plan for increasing the number of electric vehicles being driven in the UK focuses heavily on increasing the supply of the vehicles.

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What you can do to reach net zero

In 2024, at least 22% of new cars and 10% of new vans sold by each manufacturer in the UK had to be zero-emission, which generally means pure electric.

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Each year, those percentages will rise, reaching 80% of new cars and 70% of new vans in 2030.

Manufacturers will face fines of £15,000 per vehicle if electric vehicle sales fall short of 28% of total production this year.

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By 2035, all new cars and vans will be required to be fully zero emission, according to the Department for Transport.

Second-hand diesel and petrol cars will still be allowed to be sold after this date, and their fuel will still be available.

There are more EVs – but will people buy them?

In February, 25% of new cars were powered purely by battery and in January, they made up 21% of all new cars registered in the UK.

But despite the growth of electric sales, manufacturers continue to warn that the market will not support the growth required to hit government EV targets, and called for consumer incentives and the extension of tax breaks.

The AA suggested the government’s plan focuses on “supply but does little to encourage demand for EVs”.

It called on ministers to co-ordinate a public awareness campaign alongside the motoring industry which directly targets drivers who doubt the viability of EVs.

“Our message to government is more needs to be done to make EVs accessible for everyone,” said Jakob Pfaudler, AA chief executive.

Which? head of consumer rights Sue Davis said: “When it comes to making sustainable choices such as switching to an electric car, our research shows that people are often held back by high costs, complex choices or uncertainty.

“The government needs to provide the right information on electric vehicles and other sustainable choices so that people have the confidence to switch.”

A Department for Transport spokesperson said: “We’re investing over £2.3bn to help industry and consumers make a supported switch to EVs.

“This includes installing a public charge point every 28 minutes, keeping EV incentives in the company car tax regime to 2030, and extending 100% first-year allowances for zero-emission cars for another year.

“Second-hand EVs are also becoming cheaper than ever, with one in three available under £20,000 and 21 brand new models available for less than £30,000.

“We’re seeing growing consumer confidence as a result.”

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