Methods of screening men for prostate cancer will be trialled to save thousands of lives in the UK each year.
Experts have hailed the £42m project called Transform as “a pivotal moment in the history of prostate cancer research”.
Despite the fact that an estimated 12,000 lives a year are lost to prostate cancer, according to Cancer Research UK, there is currently no screening programme.
Previous trials that used prostate-specific antigen (PSA) blood tests and biopsies to screen for the disease showed the method prevented between 8% and 20% of deaths, depending on screening regularity, according to Prostate Cancer UK.
The charity said Transform has the potential to reduce deaths by 40%.
Patients will be recruited from GP practices across the country from next year to take part in the project.
The first phase will involve about 12,500 men and will assess the likes of PSA blood tests, genetic testing and a faster version of the MRI scan – known as a Prostagram – against current NHS diagnostic methods to see which performs best.
Up to 300,000 men will be involved in the trial’s second stage which will test the most promising options based on the results of the first stage.
The team will follow up with patients over at least a decade to track how screening impacted the length and quality of their lives.
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At least one in 10 patients invited to take part will be black. This is because black men carry double the risk of developing prostate cancer than other men.
Dr Matthew Hobbs, director of research at Prostate Cancer UK, said: “We know that earlier diagnosis saves lives, but previous trials haven’t been able to prove that enough men would be saved using PSA tests alone, while they did show that these old screening methods caused significant unnecessary harm to men.
“We must now prove that there are better ways to find aggressive prostate cancer that will save even more lives while causing less harm.”
As well as saving lives in the UK, Dr Hobbs said the trial could also “change practice globally”, with the number of lives saved potentially reaching tens of thousands each year.
He added: “This is a pivotal moment in the history of prostate cancer research and we’re proud to be leading the way and to be supporting some of the best researchers in the world to make it happen.”
The project has also been backed by £16m of funding from the National Institute for Health and Care Research (NIHR), as well as £1.5m from Movember and support from the Freddie Green and Family Charitable Foundation.
Health minister Andrew Stephenson said: “Screening for the most common cancer in men is complex but we’re backing groundbreaking trials like this to improve diagnostic processes and save thousands more lives.
“Alongside backing cutting-edge research, we are helping more people get diagnosed earlier for cancer and other conditions by rolling out additional tests, checks and scans at 160 locations across England through our community diagnostics centres programme.”
Tasers can be used in prisons for the first time to tackle “unacceptably high” levels of violence, as part of a new trial.
Justice Secretary Shabana Mahmood has said she is “determined to keep prison staff safe”.
Specialist officers from two bases in Oxfordshire and Doncaster can now be deployed to incidents in adult male prisons in England and Wales, equipped with Tasers.
Image: In a demonstration hostage situation, officers used pyrotechnics to distract an aggressive inmate
Image: Officers tackled an aggressive ‘inmate’ after he was distracted by pyrotechnics in the demonstration
Reporters attending a demonstration were shown how they could be used in certain scenarios, where there is a threat to safety, including hostage situations or riots, and where multiple people are involved in “mass disorder”.
One demonstration involved four prisoners who had become disruptive in the exercise yard.
After staff were forced to withdraw, three inmates turned on one and it was deemed there was an “immediate threat to life.”
Officers gave verbal warnings before deploying the Tasers at a distance.
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This trial will use the Taser 7 model, which is what police officers currently use.
It can generate 50,000 volts when triggered, but drops to about 1,500 volts when hitting the target.
In a separate hostage situation, officers used pyrotechnics which produced loud bangs and smoke to distract an aggressive “inmate” before putting them in handcuffs.
Image: An ‘inmate’ is tackled by a security officer during a simulation
At first, specialist national officers from the two bases can be deployed if such incidents occur.
It’s understood at the moment these teams get 800 callouts a year – averaging just over two a day.
The trial will run until enough data is collected to determine whether Tasers should be rolled out more widely.
Ms Mahmood said she intends to have further updates in the autumn and will “consider” whether local staff inside jails can use them.
“From my perspective, this is very much the beginning,” she said.
Violence in prisons has been rising. In the 12 months to December there were 10,605 assaults on staff, a rise of 13% on the year before and a new peak. Serious assaults were also up 10% on the previous 12 months.
Image: A security officer demonstrates the Taser in use
Earlier this year, Manchester Arena bomb plotter Hashem Abedi attacked prison staff at the high-security jail HMP Frankland, using hot cooking oil and homemade, or improvised, weapons.
The justice secretary said the incident at Frankland “forced the pace” of further measures to tackle violence.
Southport killer Axel Rudakubana also allegedly attacked a member of staff at HMP Belmarsh by pouring hot water over them from inside his cell.
The Prison Officers Association (POA) union urged ministers to consider protective equipment and stab vests for staff.
Last month, the government announced the use of body armour at certain units in high-security jails, which house some of the most dangerous inmates.
But while “grateful” for a “step in the right direction”, the POA don’t think the new measure goes far enough – and instead want specialist staff inside jails trained to use Tasers.
“It is pointless a national response being several hours away if, locally, Taser is needed to immediately preserve life and combat threat,” Mark Fairhurst, the POA’s national chairman said.
Whitehall wants to consider the “lessons” from this trial before any potential further rollout.
Ms Mahmood pointed out that while Tasers have been used for many years by the police, “a custodial setting is different to usage in other scenarios”.
Paul Gallagher, the older brother of Oasis stars Noel and Liam, has been charged with multiple offences including rape.
The Metropolitan Police said Gallagher, 59, of East Finchley, north London, has been charged with rape, coercive and controlling behaviour, three counts of sexual assault, three counts of intentional strangulation, two counts of making a threat to kill and assault occasioning actual bodily harm.
The offences are reported to have taken place between 2022 and 2024. The charges follow an investigation which began last year, the force added in a statement.
A woman is being supported by specially-trained officers, the statement continued.
Paul Gallagher, who is about one year older than Noel and seven years older than Liam, has never been involved in Oasis.
He is due to appear at Westminster Magistrates’ Court on 27 August.