From Broken String Biosciences May 7 2024 Reviewed by Danielle Ellis, B.Sc.
Broken String Biosciences (“Broken String”), a genomics company driving development of the next generation of more precise, safe, and effective cell and gene therapies, today announced it has entered a research collaboration with the Francis Crick Institute, a world-leading biomedical discovery institute dedicated to understanding the biology underlying health and disease.
In partnership with leading researchers at the Crick, the project aims to develop novel applications for Broken String’s proprietary DNA break-mapping platform, INDUCE-seq™, beyond its established capabilities in gene-editing. The research will be focused on leveraging the technology to investigate the impact of genomic instability in the development of amyotrophic lateral sclerosis (ALS). ALS is a progressive and debilitating neurodegenerative disease, causing gradual loss of the ability to control voluntary movements and basic bodily functions.
The collaboration is focused on understanding the contribution of genome stability to ALS, combining the interests of Prof Simon Boulton and Dr Nishita Parnandi at the Crick focused on genome stability and DNA double-strand break (DSB), with Prof Rickie Patani and Dr Giulia Tyzack, interested in understanding the underlying mechanism of ALS disease mechanism. Recognizing the utility of the novel INDUCE-seq platform developed by Broken String’s R&D team, led by Professor Simon Reed, the Crick and Broken String teams aim to collaborate to demonstrate and further validate the INDUCE-seq technology in this setting.
The majority of ALS cases (~90%) are considered sporadic1. Whilst there has been progress to better understand the genes and biological markers associated with the disease, very little is understood about the causes, with current treatment strategies focused on symptom management and slowing disease progression. Combining world-leading research from the Crick with Broken String’s expertise in genomics, sequencing, and bioinformatics, the partnership provides a unique opportunity to expand application of the Company’s INDUCE-seq technology in a key area of clinical unmet need, to support improved diagnosis and treatment of ALS.
The partnership has been secured via the Francis Crick Institute’s Business Engagement Fund, a new initiative supported by The Medical Research Council (MRC-UKRI), that is designed to encourage collaborations with small-to-medium sized enterprises (SMEs) and strengthen the Crick’s engagement with industry. Related StoriesBroken String Biosciences INDUCE-seq platform demonstrates impact of structural DNA changes on specificity of CRISPR-Cas9 gene editingBroken String Biosciences strengthens senior leadership team to accelerate product development and commercializationBroken String Biosciences closes $15M series A funding round
Dr. Simon Boulton, Principal Group Leader, the Boulton Lab (DSB Repair Metabolism) at the Francis Crick Institute, said: “Our research is focused on exploring how cells repair damage to their DNA, and how failures in this process lead to disease. Following exploratory work with Professor Reed, we were keen to collaborate with Broken String. We are excited to leverage the INDUCE-seq platform’s unique capabilities in directly measuring and quantifying DNA double-strand breaks, and applying this to deepen our understanding of diseases that have genomic instability as a contributing factor, such as ALS.”
Felix Dobbs PhD, CEO, Broken String Biosciences, commented: “This collaboration with the Crick Institute is validation of our differentiated approach to DNA break-mapping; enabling our team to support world-leading research with insights provided through our INDUCE-seq platform. It demonstrates a fantastic opportunity to apply our expertise across other key research areas to support the advancement of human health.” He added: “There is an unmet clinical need for effective ALS treatments, as well as strategies for earlier diagnosis that can significantly improve patient outcomes. We look forward to working closely with Dr Boulton and Professor Patani’s groups to support this critical research area and continue building out our application focuses.”
A judge has ruled that nearly £20m is to be paid out to 16 survivors of the Manchester Arena bombing who were children at the time of the tragedy.
Twenty-two people were murdered and hundreds injured in the suicide bombing at an Ariana Grande concert at Manchester Arena on 22 May, 2017.
Amounts of between £2,770 and £11.4m were agreed at a hearing on Thursday at the Manchester Civil Courts of Justice for 16 youngsters, all aged under 16 at the time of the attack.
The total amount to be paid comes in at £19,928,150.
Some of the youngsters suffered “catastrophic” and life-changing injuries, and others suffered psychological damage after 22-year-old Salman Abedi detonated a backpack bomb leaving the concert.
The claims were made against, and will be paid by, the defendants in the case – those responsible for the safe and secure running of the arena event.
Image: People hold a minute of silence in a square in central Manchester, on 25 May 2017. Pic: AP
Those contributing to the settlement include: SMG Europe Holdings, which managed the venue; Showsec International Ltd, responsible for crowd management; and British Transport Police (BTP) and Greater Manchester Police (GMP), responsible for policing the area.
A public inquiry into the bombing, led by Sir John Saunders, found that chances to prevent the attack had been missed, and also noted “serious shortcomings” in security and individual failings.
On Thursday, Judge Nigel Bird approved the 16 claims – agreed between their lawyers and the defendants – as they all involved children or those without mental capacity.
The 16 survivors and their families cannot be identified, due to a court order.
It is understood that following the hearing, claims by another 352 people, all adults deemed to have capacity, including the families of the 22 who lost loved ones, will now be agreed between lawyers for the claimants and the defendants.
Those agreements have been made out-of-court, so no details of any public money to be paid out by public bodies BTP and GMP have been made public.
Image: Pic: AP
The four organisations have apologised to the bereaved families and to the survivors, lawyers for the claimants said, and have admitted their failures.
Judge Bird told the hearing: “Each of these cases has a common link, that is injuries and loss suffered, arising out of a single and unimaginable act of terrorism committed on the evening of May 22 2017 at the end of a concert attended by very many young people and their families.”
“The love and care a parent gives to an injured child is beyond monetary value,” he added.
Judge Bird also paid tribute to the “courage, dedication and fortitude” of the families involved in each case, adding: “Each through their quiet determination has brought about promises of change in the hope that in the future, other families need not go through what they have been through.”
After the hearing, a joint statement was issued from the legal teams at Hudgell Solicitors, Slater & Gordon and Broudie Jackson Canter, the three main firms representing the claimants.
Image: Figen Murray, mother of 29-year-old victim Martyn Hett. Pic: PA
The statement said: “This is not a day of celebration. It is a moment to acknowledge the mistakes that were made and the unimaginable suffering our clients have endured over the past eight and a half years.
“We now expect all parties to honour their commitment to do what they can to prevent those same mistakes from happening again.”
Martyn’s Law, named in memory of Martyn Hett, 29, who was killed in the attack, has since been implemented, to better protect public venues from terror attacks.
Pribula, who spent this season at Missouri after transferring from Penn State, has informed the Tigers’ coaching staff that he plans to enter the transfer portal, sources confirmed to ESPN on Thursday.
Pribula doesn’t plan to play for the Tigers (8-4) when they take on No. 19 Virginia (10-3) in the TaxSlayer Gator Bowl on Dec. 27 (7:30 p.m. ET, ABC), sources told ESPN’s Pete Thamel.
Pribula, a senior from York, Pennsylvania, helped the Tigers to a 6-1 start this season, with the only loss coming against then-No. 8 Alabama. But then he was hurt early in the third quarter of a 17-10 loss at Vanderbilt on Oct. 25. His left ankle was placed in an air cast and trainers carted him off the field.
Doctors determined that Pribula dislocated the ankle but didn’t fracture it. He missed two games before returning to play in a 17-6 loss at then-No. 8 Oklahoma. He also played in the Tigers’ 31-17 win at Arkansas in Missouri’s regular-season finale.
In 10 games, Pribula completed 67.4% of his passes for 1,941 yards with 11 touchdowns and nine interceptions. He also ran for 297 yards with six scores.
Pribula battled Sam Horn for the starting job in training camp, and both quarterbacks were expected to play in the opener. Horn, however, suffered a fractured right leg on his first play of the game in a 61-6 win against FCS program Central Arkansas and missed the rest of the season.
Freshman Matt Zollers ran the offense when Horn and Pribula were sidelined, and coach Eli Drinkwitz said Thursday that Zollers will start in the Gator Bowl.
Pribula, who was ranked the No. 8 dual-threat quarterback in the class of 2022 by ESPN, spent his first two seasons at Penn State. He left the Nittany Lions before their CFP first-round game in December 2024 after starter Drew Allar announced he was returning in 2025.
CBS Sports first reported Pribula’s intention to transfer.
All four starters have signed deals with the school to return under new coach Pete Golding next year, a source told ESPN, ahead of the Rebels’ first-ever College Football Playoff game.
The Rebels are working to retain their key returning players amid former coach Lane Kiffin’s move to LSU and the impending opening of the transfer portal window on Jan. 2. Kiffin is taking several assistant coaches and staffers with him to Baton Rouge.
Echoles earned second-team All-SEC honors and leads all Power 4 defensive tackles with 26 pressures this season, according to ESPN Research. Perkins was a third-team All-SEC selection in 2024 after recording a team-high 10.5 sacks.
The Rebels are also attempting to bring back star running back Kewan Lacy, the SEC’s second-leading rusher, and starting quarterback Trinidad Chambliss has said he’ll weigh his options if he receives an NCAA waiver for an additional season of eligibility.
Kiffin left for SEC rival LSU on Nov. 30 and will not coach Ole Miss in the CFP. Golding, the Rebels’ defensive coordinator for the past three years, was promoted to permanent head coach.
The No. 6 seed Rebels host No. 11 Tulane on Saturday (3:30 p.m. ET, TNT/HBO Max/truTV) in their first-round game, a rematch of a nonconference meeting the Rebels won 45-10 on Sept. 20.