Connect with us

Published

on

The largest and longest study of the obesity drug Wegovy has shown people maintain significant weight loss for at least four years, with fewer serious adverse events than those given placebo ‘dummy’ treatment.

Doctors say the finding will add pressure on UK health authorities, which currently limit treatment to just two years.

Results revealed at an international obesity conference show those given weekly injections of the drug shed pounds for the first 65 weeks of treatment, and then sustained a stable body weight over the longer term.

On average they lost 10.2% of their body weight and 7.7cm from their waist size after four years.

Significantly, even those who were only slightly obese, or who only lost a small amount of weight, still benefited from a reduction in cardiovascular risks, according to results presented at the European Congress on Obesity in Venice and published in the journal Nature Medicine.

Dr Simon Cork, senior lecturer in physiology at Anglia Ruskin University, who wasn’t involved in the study, said the results show for the first time that patients maintain a “weight plateau” if they continue treatment long term.

“Importantly one of the decisions by the UK health service to limit (treatment) to two years was because of questionable long-term cost effectiveness,” he said.

More on Health

He added: “That this data demonstrates improved cardiovascular and metabolic parameters continuing to four years may go some way to negating that argument.

“This study also neatly demonstrates that obesity is a lifelong condition and the decision by NICE to limit prescription to two years does a disservice to patients suffering with obesity.”

A dosage of Wegovy, a drug used for weight loss. Pic: PA
Image:
A dosage of Wegovy, a drug used for weight loss. Pic: PA

The SELECT (Semaglutide and Cardiovascular Outcomes) trial involved 17,604 adults with obesity or who were overweight from 41 countries. None of them had diabetes, but all had previously had a heart attack, stroke or peripheral artery disease.

Over the first two years of the study, the proportion of people who were obese fell sharply from 71% to 43% in the group given Wegovy.

But in those given placebo injections, the rate dropped only slightly, from 72% to 68%.

After three years of treatment, participants had a 20% lower risk of a heart attack, stroke or dying from cardiovascular disease, according to analysis released last year.

Professor Donna Ryan from Pennington Biomedical Research Centre in New Orleans, USA, who led the study, said the weight loss was seen irrespective of age, gender and ethnicity.

“This degree of weight loss in such a large and diverse population suggests that it may be possible to impact the public health burden of multiple obesity-related illnesses,” she said.

“While our trial focused on cardiovascular events, many other chronic diseases including several types of cancer, osteoarthritis, and anxiety and depression would benefit from effective weight management.”

The study showed that serious adverse events were less common in those given the drug than those given placebo.

That was largely because people taking Wegovy were less likely to have cardiac disorders.

But people taking the drug were more likely to have gallbladder stones, and were more likely to stop taking treatment because of gastrointestinal problems such as nausea and diarrhoea.

A second analysis of the same group of patients, led by UK researchers, showed that cardiovascular benefits were seen even in patients who only had mild obesity or lost only modest amounts of weight.

Read more from Sky News:
Wales becomes first UK nation to join metaverse
See best Northern Lights pictures here
Sperm whale ‘phonetic alphabet’ discovered

Follow Sky News on WhatsApp
Follow Sky News on WhatsApp

Keep up with all the latest news from the UK and around the world by following Sky News

Tap here

Professor John Deanfield, from University College London, said the finding had “important” clinical implications.

“Around half of the patients that I see in my cardiovascular practice have levels of weight equivalent to those in the SELECT trial and are likely to derive benefit from taking Semaglutide on top of their usual level of care.

“Our findings show that the magnitude of this treatment effect with semaglutide is independent of the amount of weight lost, suggesting that the drug has other actions which lower cardiovascular risk beyond reducing unhealthy body fat.

“These alternative mechanisms may include positive impacts on blood sugar, blood pressure, or inflammation, as well as direct effects on the heart muscle and blood vessels, or a combination of one or more of these.”

However, the researchers warn there isn’t yet evidence that treatment prevents major cardiovascular events.

Semaglutide, the active ingredient of Wegovy, is part of a growing class of GLP-1 drugs that make people feel full, reducing their calorie intake.

Continue Reading

UK

Zhenhao Zou: More than 20 new potential victims come forward after ‘prolific’ rapist jailed for assaulting 10 women

Published

on

By

Zhenhao Zou: More than 20 new potential victims come forward after 'prolific' rapist jailed for assaulting 10 women

Another 23 female potential victims have reported that they may have been raped by Zhenhao Zou – the Chinese PhD student detectives believe may be one of the country’s most prolific sex offenders.

The Metropolitan Police launched an international appeal after Zou, 28, was convicted of drugging and raping 10 women following a trial at the Inner London Crown Court last month.

Detectives have not confirmed whether the 23 people who have come forward add to their estimates that more than 50 other women worldwide may have been targeted by the University College London student.

Metropolitan Police commander Kevin Southworth said: “We have victims reaching out to us from different parts of the globe.

“At the moment, the primary places where we believe offending may have occurred at this time appears to be both in England, here in London, and over in China.”

Metropolitan Police commander Kevin Southworth
Image:
Metropolitan Police commander Kevin Southworth

Zou lived in a student flat in Woburn Place, near Russell Square in central London, and later in a flat in the Uncle building in Churchyard Row in Elephant and Castle, south London.

Read more: How a student described as ‘smart and charming’ was unmasked as a prolific sexual predator

More on China

He had also been a student at Queen’s University Belfast, where he studied mechanical engineering from 2017 until 2019. Police say they have not had any reports from Belfast but added they were “open-minded about that”.

“Given how active and prolific Zou appears to have been with his awful offending, there is every prospect that he could have offended anywhere in the world,” Mr Southworth said.

“We wouldn’t want anyone to write off the fact they may have been a victim of his behaviour simply by virtue of the fact that you are from a certain place.

“The bottom line is, if you think you may have been affected by Zhenhao Zou or someone you know may have been, please don’t hold back. Please make contact with us.”

***ONLY USE IF HE IS CONVICTED OF AT LEAST TWO RAPES***It is feared Zou may have carried out dozens more sex crimes. Pic: Met Police
Image:
Pic: Met Police

Zou used hidden or handheld cameras to record his attacks, and kept the footage and often the women’s belongings as souvenirs.

He targeted young, Chinese women, inviting them to his flat for drinks or to study, before drugging and assaulting them.

Zou was convicted of 11 counts of rape, with two of the offences relating to one victim, as well as three counts of voyeurism, 10 counts of possession of an extreme pornographic image, one count of false imprisonment and three counts of possession of a controlled drug with intent to commit a sexual offence, namely butanediol.

Please use Chrome browser for a more accessible video player

Moment police arrest rapist student

Mr Southworth said: “Of those 10 victims, several were not identified so as we could be sure exactly where in the world they were, but their cases, nevertheless, were sufficient to see convictions at court.

“There were also, at the time, 50 videos that were identified of further potential female victims of Zhenhao Zou’s awful crimes.

“We are still working to identify all of those women in those videos.

“We have now, thankfully, had 23 victim survivors come forward through the appeal that we’ve conducted, some of whom may be identical with some of the females that we saw in those videos, some of whom may even turn out to be from the original indicted cases.”

Mr Southworth added: “Ultimately, now it’s the investigation team’s job to professionally pick our way through those individual pieces of evidence, those individual victims’ stories, to see if we can identify who may have been a victim, when and where, so then we can bring Zou to justice for the full extent of his crimes.”

Mr Southworth said more resources will be put into the investigation, and that detectives are looking to understand “what may have happened without wishing to revisit the trauma, but in a way that enables [the potential victims] to give evidence in the best possible way.”

The Metropolitan Police is appealing to anyone who thinks they may have been targeted by Zou to contact the force either by emailing survivors@met.police.uk, or via the major incident public portal on the force’s website.

Continue Reading

UK

Girl, 11, who went missing after entering River Thames named

Published

on

By

Girl, 11, who went missing after entering River Thames named

An 11-year-old girl who went missing after entering the River Thames has been named as Kaliyah Coa.

An “extensive search” has been carried out after the incident in east London at around 1.30pm on Monday.

Police said the child had been playing during a school inset day and entered the water near Barge House Causeway, North Woolwich.

A recovery mission is now said to be under way to find Kaliyah along the Thames, with the Metropolitan Police carrying out an extensive examination of the area.

Location of Barge House Causeway, North Woolwich, where 11-year-old girl Kaliyah Coa went into the River Thames on 31/03
Image:
Barge House Causeway is a concrete slope in North Woolwich leading into the Thames

Chief Superintendent Dan Card thanked members of the public and emergency teams who responded to “carry out a large-scale search during a highly pressurised and distressing time”.

He also confirmed drone technology and boats were being used to “conduct a thorough search over a wide area”.

He added: “Our specialist officers are supporting Kaliyah’s family through this deeply upsetting time and our thoughts go out to all those impacted by what has happened.”

More from UK

“Equally we appreciate this has affected the wider community who have been extremely supportive. You will see extra officers in the area during the coming days.”

Read more from Sky News:
What is Trump’s liberation day about?
Woman rescued 91 hours after quake
‘Exceptional’ codebreaker dies at 101

On Monday, Kerry Benadjaoud, a 62-year-old resident from the area, said she heard of the incident from her next-door neighbour, who “was outside doing her garden and there was two little kids running, and they said ‘my friend’s in the water'”.

When she arrived at the scene with a life ring, a man told her he had called the police, “but he said at the time he could see her hands going down”.

Barge House Causeway is a concrete slope that goes directly into the River Thames and is used to transport boats.

Residents pointed out that it appeared to be covered in moss and was slippery.

Continue Reading

UK

Planning reforms to ‘rewire the system’ and get Britain building – all while protecting wildlife

Published

on

By

Planning reforms to 'rewire the system' and get Britain building - all while protecting wildlife

Major developers will only deal with one regulator under planning reforms which ministers say will “rewire the system” to get Britain building – all while protecting the environment. 

A review by former Labour adviser Dan Corry into Britain’s sluggish system of green regulation has concluded that existing environmental regulators should remain in place, while rejecting a “bonfire of regulations”.

But Mr Corry suggested there might be circumstances in which the government look at changing the wildlife and habit rules inherited from the EU, which protect individual species.

Politics latest: Follow live updates

These lie at the centre of the controversy of a £120m bat tunnel – the shed in Aylesbury which protects a rare breed from future high speed trains.

Keir Starmer has declared war on £100m HS2 bat shed – but has he got a solution?
New planning bill could be the government’s most important – but will it work in practice?

The government has now explicitly ruled out any such change in this parliament.

More from Politics

Campaigners have questioned whether the changes go far enough and will make a major difference to the rate and scale of building in the UK.

Speaking to Sky News, Environment Secretary Steve Reed insisted that accepting nine of the recommendations from the Corry review would amount to wholesale reform.

The minister said: “We can get a win-win for economic growth and for nature. And that is why we are moving ahead with proposals such as appointing a lead regulator for major developments so that the developers don’t have to navigate the architecture of multiple regulators.

“They just work for a single regulator who manages all the others on their behalf. Simplifying the online planning portal.

“These are huge changes that will save developers billions of pounds and speed up decisions doing damage to the environment.”

Mr Reed insisted that there would be “no more bat tunnels” built, even though the Corry review suggests that more work needs to be done to look again at the relevant guidance.

It says: “Rapidly reviewing the existing catalogue of compliance guidance, including on protecting bats, will identify opportunities to remove duplication, ambiguity or inconsistency.

“Natural England has already agreed to review and update their advice to Local Planning Authorities on bats to ensure there is clear, proportionate and accessible advice available.”

The review will mean:

• Appointing one lead regulator for every major infrastructure project, like Heathrow expansion

• A review on how nature rules are implemented – but not the rules themselves

• Insisting regulators focus more on government priorities, particularly growth

Economist and former charity leader Mr Corry, who led the review, said it shows that “simply scrapping regulations isn’t the answer”.

“Instead we need modern, streamlined regulation that is easier for everyone to use. While short-term trade-offs may be needed, these reforms will ultimately deliver a win-win for both nature and economic growth in the longer run.”

However, Sam Richards from Britain Remade, a thinktank trying to get Britain growing, said that while the steps are welcome, the number of regulators that report to the environment department would remain the same before and after the review. He questioned whether this would have the impact ministers claimed.

Continue Reading

Trending