England’s first artificial cornea transplant hailed a success

Published

6 months ago

June 4, 2024

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A 91-year-old man has become the first person in England to be fitted with a ground-breaking artificial cornea.

Cecil ‘John’ Farley, 91, said his sight was now improving thanks to the procedure, which he underwent after 15 years of suffering from problems with his eyes.

The cornea is the clear outer layer at the front of the eyeball – and is described by the NHS as the “window to the eye”.

A person can suffer from vision problems and pain if the thin transparent covering is damaged by disease or injury – with those affected often left facing a long wait for a human transplant.

However, it is hoped that the artificial device, called EndoArt, will slash waiting times, ease pressure on the NHS and eliminate the risk of the human body rejecting corneas received from an organ donor.

Mr Farley, from Chobham in Surrey, said he was overjoyed by the transplant – in his right eye – because it meant he could continue to see his 83-year-old wife Elizabeth.

He said: “I can still see my wife after 63 years of marriage, we can just carry on as normal and live life as fully as we can.

“It makes your life fuller when your eyes work properly – you don’t realise how debilitating it is until it happens to you.”

Before the surgery, Mr Farley had no vision in his right eye – but his sight has slowly been improving ever since the procedure in February.

He said: “It has made a great difference to my sight. It was very blurred and I couldn’t distinguish a face.

“Now I can see better with it, the brighter the light the better. It’s coming along slowly – they said it could take up to a year.”

The artificial cornea has been compared to a contact lens. The device, which replaces the inner part of the cornea, is surgically attached to the eye by a single stitch and is put in place with a gas bubble.

Patients could see major impact

One of the biggest advantages of using artificial corneas is the huge reduction in waiting time for the procedure. It means patients on the elective backlog who risk further deterioration in their vision can be seen months earlier than they would waiting for a cornea transplant from an organ donor.

But at the moment the artificial cornea operation can only be carried out on patients who meet the “complex eye” criteria. These include patients whose previous human cornea transplant has failed.

Consultant ophthalmologist Tom Poole, who carried out the procedure, is confident the surgery can be rolled out to “virgin eye” patients in the future. These are patients with no previous history of eye surgery.

Mr Poole told me the international ophthalmology community was growing increasingly confident with artificial corneas which are relatively easy to make and their production could be scaled up quite easily.

He and his colleague Hanbin Lee at Frimley Health NHS Foundation Trust have already carried out three more operations since February.

The latest tests on Mr Farley suggest the procedure has been a success. Three more patients have been identified and are listed for surgery.

Only 200 people worldwide, including Mr Farley, have been fitted with an EndoArt so far, but there are hopes it can be more widely rolled out.

Organic cornea transplants usually come from deceased donors. A total of 4,719 were donated to the NHS in 2022/23, according to the latest available figures.

Consultant ophthalmologist Thomas Poole, from Frimley Health NHS Foundation Trust in Surrey, which carried out the procedure, described the artificial cornea as a “great advancement”.

He said there had been fears that Mr Farley was “kind of getting to [his] last hope” after a previous human transplant failed.

Mr Poole said: “I had a very frank discussion with him before and I said: ‘Look, your graft has failed, you’re back on the waiting list. Because your other eye sees quite well, you’re not a high priority on the waiting list and you could be waiting for another year’.

“He’s in his 90s now and said ‘I just can’t wait that long. Is there anything else?’ And so this sprung to mind.

“I had just read a publication on very good reports from this artificial graft and it was that that made me think actually, maybe we could use this for John.”

Mr Poole and his colleague Hanbin Lee have now successfully given four patients artificial corneas in the last two months and the initial results have shown an improvement in vision.

He added: “Looking forward to the future, I think this may end up replacing human corneas for certain types of corneal graft patients.

“In maybe 10 or 20 years’ time – this may become the norm where we don’t need a human cornea, and we can just take one out of the box.”

Mr Farley, a former flooring company owner, said that once his sight is restored he hopes to do practical tasks like repairing a watch.

However, for now, he is content “pottering about”.

UK

Greater Manchester Police makes ‘improvements’ in treatment of women including new rules on strip searches – but questions remain after Sky News investigation

Published

24 mins ago

November 18, 2024

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Greater Manchester Police makes 'improvements' in treatment of women including new rules on strip searches - but questions remain after Sky News investigation

Greater Manchester Police (GMP) says it has made wide-ranging changes to the treatment of women in custody, following a Sky News investigation.

This includes ending the use of police strip searches for “welfare” purposes and ensuring it is a “last resort” when looking for concealed items.

A Sky News investigation in 2023 into the custody practices of GMP led to an inquiry by former victims’ commissioner Dame Vera Baird.

In July 2024, the report found “horror stories” of police making “unlawful” arrests and unnecessary strip searches, sometimes to victims of domestic violence or sexual assault.

A report today by the Greater Manchester mayor’s office welcomes the introduction of new measures including additional training for police officers dealing with domestic violence victims.

However, many victims are unconvinced. One such is Sophie, not her real name, telling her story for the first time.

She tells Sky News that even after the Baird Inquiry found her arrest was “unlawful” and the chief inspector called her treatment “appalling”, the police complaints department subsequently described the arrest as “acceptable”.

Sophie’s experience was investigated by Dame Vera alongside other women who Sky News spoke to last year.

She was arrested at 3am in the summer of 2022, and detained for 11 hours following a trivial complaint made by her ex-partner. Her accuser was designated by the police as a highly violent, domestic abuse perpetrator.

Even so, Sophie was arrested at her home in the middle of the night after her abuser alleged she had broken his car wing mirror, 14 months previously, and that she had bruised his arms on an occasion when he had strangled her.

‘They knew what I was trying to protect myself from’

The man making the allegation was someone who had punched, strangled, pressed his thumbs into Sophie’s eyes and locked her up in the house.

Sophie told Sky News: “He’s got a history of domestic violence; he’s got a history of being incarcerated. They knew what I’d gone through, they knew what I was trying to protect myself from.

“I was in contact regularly with domestic violence support workers who were meeting with police liaison officers. They knew that I had the locks changed. They knew I had an alert on the house and my phone.”

Sophie describes the police arrest as “an extension of his coercion”. She later refused to accept a police caution and was charged with the offence of damaging a wing mirror before a judge threw the case out saying it was not in the public interest.

At a press conference in July this year, Dame Vera said: “I tell you ladies and gentlemen, if someone tried to strangle me, I’d probably bruise his arms as well.”

She said the arresting officers had “locked away their brains” and criticised the custody sergeant who had logged his justification for the arrest as “to protect a vulnerable person”, in reference to the violent man.

A series of ‘failures’

At that time, GMP Chief Constable Stephen Watson said he was “appalled” by Sophie’s treatment.

He told Sky News: “It’s a systemic failure, a leadership failure, a process failure. I do think in individual circumstances it may be a failure of experience.”

And yet, one month after this, the police complaints department wrote to tell Sophie “there were sufficient grounds for your arrest”. The letter told her: “The service provided by the police was acceptable.”

Only after Sophie revealed that her case was part of the Baird Inquiry did the police retract these findings.

In a statement, GMP told Sky News: “The outcome Sophie was provided was incorrect. Having reviewed the handling of the complaint, our head of professional standards gave Sophie a personal apology and we are ensuring there is a full reinvestigation.

“Complaints relating to the Baird review – including Sophie’s – are subject to a fair and thorough examination, without fear or favour, by our Professional Standards Directorate.

“Where an investigation finds there to be a case to answer, we will ensure officers face disciplinary proceedings.

‘1,500 more domestic abuse survivors now getting justice’

“We are working hard to ensure that the people of Greater Manchester – particularly women and girls – can have confidence in their police force. This includes providing trauma-informed training for officers and getting better outcomes for victims – with 1,500 more domestic abuse survivors now getting justice compared to three years ago.

“Our communities can have confidence that the force is robust in maintaining good order and discipline. Those not fit to serve are being removed from GMP with more than 100 officers dismissed on the Chief Constable’s watch.”

However, Sky News has been told that most complaints relating to the Baird Inquiry are subject to ongoing investigation and, so far, no officers have been disciplined or dismissed.

In response to the Baird Inquiry, GMP now has a dedicated female welfare officer in its custody suites and is soon to introduce a new independent oversight panel to scrutinise arrests.

According to the mayor’s office, 24 of the 26 recommendations from the inquiry have been implemented.

Mayor of Greater Manchester Andy Burnham said: “This is a landmark moment in our quest to improve the safety and treatment of women across Greater Manchester.

“It is clear that there is still progress to be made. The deputy mayor and I will continue to hold up a mirror to unacceptable practices wherever we find them.”

Deputy mayor Kate Green added: “While the implementation of these recommendations to date is welcome, it is essential that the improvements brought about are maintained and indeed built upon, and on behalf of the mayor I will continue to scrutinise GMP as it makes progress in these areas.”

However, Sophie feels let down and says if she was in an abusive relationship again, she would think twice about going to the police.

“I wouldn’t just be OK with reporting something now, I would look at the consequences of me doing that, and what could happen as a result of me doing that, and how they would treat me,” she said.

“It’s going to take me longer to get over what happened to me that night in being arrested and being locked up than getting over being slapped or punched.”

Former victims’ commissioner Dame Vera Baird and Greater Manchester mayor Andy Burnham will be speaking to Wilfred Frost on Sky News Breakfast from 7.30am this morning.

UK

Harshita Brella: International manhunt under way for husband after woman’s body found in car boot

Published

6 hours ago

November 17, 2024

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Harshita Brella: International manhunt under way for husband after woman's body found in car boot

An international manhunt is under way for the husband of a murdered woman, whose body was found in the boot of a car.

The body of Harshita Brella was found in east London on Thursday, tens of miles away from her home in Corby.

On Sunday, Northamptonshire Police said they were looking for Pankaj Lamba – who they believe has left the country.

Sky News understands she had been under the protection of a court order designed for victims of domestic abuse.

“Our inquiries lead us to suspect that Harshita was murdered in Northamptonshire earlier this month by her husband Pankaj Lamba,” said chief inspector Paul Cash.

“We suspect Lamba transported Harshita’s body from Northamptonshire to Ilford by car.”

“Fast track” enquires were made after the force was contacted on Wednesday by someone concerned about Ms Brella’s welfare. After she failed to answer the door at her home in Skegness Walk, Corby, a missing person investigation was launched.

Her body was found inside the boot of a vehicle on Brisbane Road, Ilford, in the early hours of Thursday morning.

A post mortem – conducted at Leicester Royal Infirmary on Friday – established she had been murdered.

More than 60 detectives are working on the case, with lines of enquiry including going house to house and property searches, as well as looking at CCTV and ANPR.

“We are of course continuing to appeal for any information that will help us piece together exactly what happened as we work to get justice for Harshita,” said chief inspector Cash.

“I urge anyone listening to or reading this statement, that if you saw anything suspicious in the past week or have any information, no matter how small, please contact us. We would always rather receive well-meaning information that turns out to be nothing as opposed to not receiving it all.”

Force referred to police watchdog

On Saturday, Northamptonshire Police said it had made a mandatory referral to the Independent Office for Police Conduct due to previous contact between the force and the victim.

Northamptonshire Police previously said officers had been conducting investigations at three locations: Skegness Walk and Sturton Walk in Corby and Brisbane Road, Ilford, where Ms Brella’s body was found.

East Midlands Special Operations Major Crime Unit (EMSOU) and Northamptonshire Police said they were working “around the clock to establish the circumstances behind her death, including the exact location and timeframe in which it took place”.

UK

King Richard III given Yorkshire accent using state-of-the-art technology

Published

6 hours ago

November 17, 2024

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King Richard III given Yorkshire accent using state-of-the-art technology

State-of-the-art technology has been used to create a voice for King Richard III – giving him a Yorkshire accent.

A digital avatar of the medieval king’s head went on display in front of excited history fans at York Theatre Royal.

Richard III was king of England from 1483 until his death at the Battle of Bosworth in 1485, at the age of 32.

His remains were found in a car park in Leicester in 2012 by historian Philippa Langley.

Speaking about the recreation, she said: “We’ve got leading experts in their fields who have been working on this for 10 years and so everything has been meticulously researched, meticulously evidenced, so you are seeing the most accurate portrayal of Richard III”.

A team based at Face Lab at Liverpool John Moores University created the avatar based on the reconstruction of Richard III’s head with the help of a craniofacial expert.

Experts from various fields helped put the pieces of the puzzle together, including speech and language therapy, dentistry, forensic psychology and archaeology.

His voice has been created by Professor David Crystal, a leading linguist in 15th-century pronunciation. He admitted that it’s impossible to know exactly how he spoke, but this is as close as they will get.

The king was born in Northampton but spent a lot of his life in Yorkshire. His parents were also from the north of England.

Vocal coach Yvonne Morley-Chisholm spent a decade researching how the monarch would have sounded. She worked with the actor Thomas Dennis who was chosen as his body and face were such a good physical match.

Speaking to Sky News, she said people will be shocked at how different he sounded compared with traditional portrayals of the king on stage and screen.

The coach and actor also examined the king’s letters and diary so that “as you pronounced a word that’s how you would write it”.

The voice shows the change in pronunciation over the centuries – from regional variations to the Queen’s English.

History fans at the unveiling were delighted with the accent, with one telling Sky News: “Northerners are known to be happy, positive, all those lovely qualities.”

Born in Northampton but a northerner through and through, technology has brought the king’s speech back to life