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A lung cancer patient has become the first in the UK to receive a new experimental vaccine to help his body fight the disease.

Janusz Racz, 67, had six syringes of the jab, each containing genetic material for a different part of the tumour, to train five billion cells in his immune system to go on the attack.

The vaccine, codenamed BNT116, is made by BioNTech using the same mRNA technology that underpinned its highly effective COVID jab.

Doctors say it is far more precisely targeted than chemotherapy so shouldn’t have the same collateral damage on healthy cells that causes sometimes overwhelming side effects.

“It’s painless,” Mr Racz said after his first jab.

“It’s much better than chemo, which was hard for me.”

Janusz Racz

Sky News was given exclusive access to University College London Hospital (UCLH) as doctors began the UK arm of a worldwide trial of the vaccine.

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About 130 patients with non-small cell lung cancer will take part in the study, with six hospitals in the UK involved.

“If I was the hundredth or the first [study volunteer] it does not matter for me,” Mr Racz said.

“I believe it will help me – and help other people if the vaccine goes to production faster.

“COVID vaccines helped millions of people. This will also help millions of people.”

Mr Racz was highly active before he became ill, climbing several mountains and running marathons in seven countries. He is so positive about his future that he has set himself the goal of running the London marathon within the next three years.

From Thomas Moore.
Embargoed to 0001 Friday*
A lung cancer patient has become the first in the UK to receive a new experimental vaccine to help his body fight the disease.
Janusz Racz had six syringes of the jab, each containing genetic material for a different part of the tumour, to train 5 billion cells in his immune system to go on the attack.
The vaccine, codenamed BNT116, is made by BioNTech using the same mRNA technology that underpinned its highly effective COVID jab.
Doctors say it is fa

How it works

Cancer has an invisibility cloak, hiding from the immune system. But the vaccine flags key components of the tumour as a threat, hopefully triggering the body to respond by obliterating cancer cells wherever they are.

Early trials on similar vaccines in other cancers have proved promising, with a reduction in tumour size and risk of recurrence.

This is the first time the BioNTech jab has been tested in humans. The trial will confirm whether there are any major side effects before doctors proceed to larger studies to establish clinical effectiveness.

Volunteers will receive dozens of doses over 12 months to keep boosting their immune system.

Dr Sarah Benafif, who is running the clinical trial at UCLH, has high hopes.

“We already have some data that this is quite a well-tolerated type of vaccine,” she said.

“We hope in time we are able to show that the treatment is effective against lung cancer whilst leaving other tissues untouched.”

Read more: BBC presenter Lauren Laverne reveals she has cancer
Cancer: Six people diagnosed every hour because of smoking, charity warns

Non-small cell lung cancer is the most common form of the disease. Most, though not all, cases are caused by smoking.

Many patients are diagnosed at an advanced stage when treatment is less effective. Currently, only around a quarter survive for five years.

Unusually the clinical trial will include patients with early disease who have yet to undergo surgery or radiotherapy, as well as those who have cancer that has spread or returned.

It keeps options open on how best to use the vaccine to improve outcomes for people with cancer.

Vaccines ‘could be revolutionary’

Professor Siow Ming Lee, an oncologist at UCLH and clinical lead for the UK part of the study, said new treatments are desperately needed.

“You’ve got 1.8 million deaths worldwide from lung cancer, many in the developing countries,” he said.

“Hopefully we can start with our first generation of mRNA vaccine, and then roll it out to the rest of the world.”

The NHS has begun screening older smokers for lung cancer in the hope of picking up cases earlier. Anyone with symptoms, including a cough that won’t go away, chest pain and fatigue should see a doctor.

NHS England national cancer director Dame Cally Palmer said: “The NHS has a leading role globally in trialling cancer vaccines and if we are successful, they could be revolutionary in vaccinating people against their own cancers to prevent the cancer recurring after their initial treatment.

“Pioneering work is being undertaken by hospitals throughout the country with their university and industry partners to look at ways of harnessing the body’s own immune system to treat a range of cancers.

“A cancer diagnosis is very worrying, but access to groundbreaking trials – alongside other innovations to diagnose and treat cancers earlier – provides hope. We expect to see thousands more patients taking part in trials over the next few years.”

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VE Day: Veterans to join King for tea party as Keir Starmer praises ‘selfless dedication’

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VE Day: Veterans to join King for tea party as Keir Starmer praises 'selfless dedication'

Veterans are set to join the King for a VE Day tea party today as the prime minister has paid tribute to the “selfless dedication” of the war generation.

Among them will be a 99-year-old who took part in the D-Day landings and a 100-year-old woman who worked in the Special Operations Executive, known as Churchill’s Secret Army.

Director general of the Royal British Legion, Mark Atkinson, said the charity was “proud” to be taking a place “at the heart of these national celebrations and commemorations” on the 80th anniversary of the end of the Second World War.

He said it would be “one of our last opportunities as a nation to pay tribute to those veterans still with us today”.

Evacuees from World War Two and veterans who were still in active conflict after VE Day are among the other guests set to attend the tea party, which will take place in the presence of the King and other members of the Royal Family.

The Royal Family will watch a millitary procession and flypast on Monday. File pic: PA
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The Royal Family will watch a military procession and flypast on Monday. File pic: PA

At 12pm, the Royal Family will observe a military procession, followed by a flypast.

It will be the first major VE Day anniversary without any of the royals who stood on the balcony of Buckingham Palace on the day victory in Europe was declared, after the death of the late Queen Elizabeth II in 2022.

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‘Not just for Britain’

The celebrations come as Prime Minister Sir Keir Starmer praised veterans for their “selfless dedication” and thanked them for a “debt that can never fully be repaid” in an open letter ahead of VE Day.

He said the stories which will be heard this week from those who fought in the Second World War would be a reminder that the victory “was not just for Britain” but was also “a victory for good against the assembled forces of hatred, tyranny and evil”.

Sir Keir said the WW2 veterans “represent the best of who we are” and that without their service “the freedom, peace and joy that these celebrations embody, would not be possible”.

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VE Day veteran tells Sky News what the atmosphere was like when WWII was finally declared over in Europe

Personnel from NATO allies the US, France and Germany will be among those taking part in the procession in London.

The commemorations will begin with the words of Sir Winston Churchill‘s 1945 victory speech, spoken by actor Timothy Spall.

Thousands of people are expected to line the streets of the capital to witness the celebrations.

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Codebreaker’s ‘special’ encounter with Churchill

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When and where to watch VE Day flypast
Augmented reality brings to life the stories of VE Day 80 years on

On the anniversary itself on Thursday, marking exactly 80 years since the Allies formally accepted Germany’s surrender, a service of commemoration will be held at Westminster Abbey, to include a national two minutes’ silence.

Pubs across England and Wales, which usually close at 11pm, will also stay open for an extra two hours to allow punters more time to celebrate.

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Eight arrests in connection with two separate terrorism investigations

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Eight arrests in connection with two separate terrorism investigations

Eight men have been arrested by the Metropolitan Police in two unconnected but “significant” terrorism investigations.

In one operation on Saturday, counter-terror officers arrested five men – four of whom are Iranian nationals – as they swooped in on various locations around the country. All are in police custody.

The Met said the arrests related to a “suspected plot to target a specific premises”.

In an update shortly after midnight, the force said: “Officers have been in contact with the affected site to make them aware and provide relevant advice and support, but for operational reasons, we are not able to provide further information at this time.”

Commander Dominic Murphy, head of the Met’s Counter Terrorism Command, said: “Counter-terrorism policing, supported by police and colleagues from across the country, have conducted arrests in two really significant operations, both of which have been designed to keep the public safe from threats.

“There are several hundred officers and staff working on this investigation, and we will work very hard to ensure we understand the threats to the wider public.”

He refused to say if the plot was related to Israel, but described it as “certainly significant” and said “it is unusual for us to conduct this scale of activity”.

He also asked the public to “avoid speculation and some of the things that are being posted online”.

MI5 director general Ken McCallum said in October that the intelligence agency had responded to 20 “potentially lethal” Iran-backed plots since 2022. He warned of the risk of an “increase or broadening of Iranian state aggression in the UK”.

Read more: Terror arrests came in context of raised warnings about Iran

Children ‘petrified’ by armed police

Rochdale resident Kyle Warren, who witnessed one of the arrests at a neighbouring house, said his children had been playing in the garden when they came running into the house, saying a man in a mask had told them to go inside.

“Obviously, I was a bit worried,” Mr Warren told Sky News’ Lisa Dowd, and so he went into the garden to investigate.

“As we’ve come out, we just heard a massive bang, seen loads of police everywhere with guns, shouting at us to get inside the house.”

Kyle Warren said his children were 'petrified'
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Kyle Warren said his children were ‘petrified’

From upstairs in his house, he then heard “loads of shouting in the house” and saw a man being pulled out of the back of the house, “dragged down the side entry and thrown into all the bushes and then handcuffed”.

There were about 20 to 30 officers with guns, he believes.

“It’s just shocking, really. You don’t expect it on your doorstep.”

His daughters were “petrified… I don’t think they’ve ever seen a gun, so to see 20 masked men with guns running round was quite scary for them”.

Mr Warren, who only moved into his house a year ago, said he had “never really seen anyone going in or out” of the house and actually thought it was empty.

One suspect was arrested in Cheadle Hulme, Greater Manchester. Pic: Sarah Cash
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One suspect was arrested in Cheadle Hulme, Greater Manchester. Pic: Sarah Cash

One suspect was arrested in Cheadle Hulme, Greater Manchester. Pic: Sarah Cash
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One suspect was arrested in Cheadle Hulme, Greater Manchester. Pic: Sarah Cash

Arrests and searches around the country

The Met added officers were carrying out searches at a number of addresses in the Greater Manchester, London and Swindon areas in connection with the investigation.

It said those detained were:

• A 29-year-old man arrested in the Swindon area
• A 46-year-old man arrested in west London
• A 29-year-old man arrested in the Stockport area
• A 40-year-old man arrested in the Rochdale area
• A man whose age was not confirmed arrested in the Manchester area.

Passenger footage of a police van in Stockport over the terrorism arrest SQUARE OR PORTRAIT
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A 29-year-old man was arrested in the Stockport area

Terror arrests in separate investigation

Police also arrested three further Iranian nationals in London on Saturday as part of another, unrelated counter-terror investigation.

The suspects were detained under section 27 of the National Security Act 2023, which allows police to arrest those suspected of being “involved in foreign power threat activity”.

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Home Secretary Yvette Cooper said: “These were two major operations that reflect some of the biggest counter state threat and counter terrorism operations that we have seen in recent years.

“This reflects the complexity of the kinds of challenges to our national security that we continue to face.”

Earlier, she thanked police and security services in a statement, and called the incidents “serious events that demonstrate the ongoing requirement to adapt our response to national security threats”.

Last year, the government placed the whole of the Iranian state – including its intelligence services – on the enhanced tier of the new foreign influence registration scheme.

It means anyone asked by Iran to carry out actions for the state must declare it, or face prison time.

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Terror arrests came in context of raised warnings about Iran, with ongoing chaos in its own backyard

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Terror arrests came in context of raised warnings about Iran, with ongoing chaos in its own backyard

These are two separate and unrelated investigations by counter-terror officers.

But the common thread is nationality – seven out of the eight people arrested are Iranian.

And that comes in the context of increased warnings from government and the security services about Iranian activity on British soil.

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Counter terror officers raid property

Last year, the director general of MI5, Ken McCallum, said his organisation and police had responded to 20 Iran-backed plots presenting potentially lethal threats to British citizens and UK residents since January 2022.

He linked that increase to the ongoing situation in Iran’s own backyard.

“As events unfold in the Middle East, we will give our fullest attention to the risk of an increase in – or a broadening of – Iranian state aggression in the UK,” he said.

The implication is that even as Iran grapples with a rapidly changing situation in its own region, having seen its proxies, Hezbollah in Lebanon and Hamas in Gaza, decimated and itself coming under Israeli attack, it may seek avenues further abroad.

More on Iran

The government reiterated this warning only a few weeks ago, with security minister Dan Jarvis addressing parliament.

“The threat from Iran sits in a wider context of the growing, diversifying and evolving threat that the UK faces from malign activity by a number of states,” Jarvis said.

“The threat from states has become increasingly interconnected in nature, blurring the lines between: domestic and international; online and offline; and states and their proxies.

“Turning specifically to Iran, the regime has become increasingly emboldened, asserting itself more aggressively to advance their objectives and undermine ours.”

Read more:
Anybody working for Iran in UK must register or face jail, government announces

As part of that address, Jarvis highlighted the National Security Act 2023, which “criminalises assisting a foreign intelligence service”, among other things.

So it was notable that this was the act used in one of this weekend’s investigations.

The suspects were detained under section 27 of the same act, which allows police to arrest those suspected of being “involved in foreign power threat activity”.

Those powers are apparently being put to use.

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