A lung cancer patient has become the first in the UK to receive a new experimental vaccine to help his body fight the disease.
Janusz Racz, 67, had six syringes of the jab, each containing genetic material for a different part of the tumour, to train five billion cells in his immune system to go on the attack.
The vaccine, codenamed BNT116, is made by BioNTech using the same mRNA technology that underpinned its highly effective COVID jab.
Doctors say it is far more precisely targeted than chemotherapy so shouldn’t have the same collateral damage on healthy cells that causes sometimes overwhelming side effects.
“It’s painless,” Mr Racz said after his first jab.
“It’s much better than chemo, which was hard for me.”
Sky News was given exclusive access to University College London Hospital (UCLH) as doctors began the UK arm of a worldwide trial of the vaccine.
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About 130 patients with non-small cell lung cancer will take part in the study, with six hospitals in the UK involved.
“If I was the hundredth or the first [study volunteer] it does not matter for me,” Mr Racz said.
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“I believe it will help me – and help other people if the vaccine goes to production faster.
“COVID vaccines helped millions of people. This will also help millions of people.”
Mr Racz was highly active before he became ill, climbing several mountains and running marathons in seven countries. He is so positive about his future that he has set himself the goal of running the London marathon within the next three years.
How it works
Cancer has an invisibility cloak, hiding from the immune system. But the vaccine flags key components of the tumour as a threat, hopefully triggering the body to respond by obliterating cancer cells wherever they are.
Early trials on similar vaccines in other cancers have proved promising, with a reduction in tumour size and risk of recurrence.
This is the first time the BioNTech jab has been tested in humans. The trial will confirm whether there are any major side effects before doctors proceed to larger studies to establish clinical effectiveness.
Volunteers will receive dozens of doses over 12 months to keep boosting their immune system.
Dr Sarah Benafif, who is running the clinical trial at UCLH, has high hopes.
“We already have some data that this is quite a well-tolerated type of vaccine,” she said.
“We hope in time we are able to show that the treatment is effective against lung cancer whilst leaving other tissues untouched.”
Non-small cell lung cancer is the most common form of the disease. Most, though not all, cases are caused by smoking.
Many patients are diagnosed at an advanced stage when treatment is less effective. Currently, only around a quarter survive for five years.
Unusually the clinical trial will include patients with early disease who have yet to undergo surgery or radiotherapy, as well as those who have cancer that has spread or returned.
It keeps options open on how best to use the vaccine to improve outcomes for people with cancer.
Vaccines ‘could be revolutionary’
Professor Siow Ming Lee, an oncologist at UCLH and clinical lead for the UK part of the study, said new treatments are desperately needed.
“You’ve got 1.8 million deaths worldwide from lung cancer, many in the developing countries,” he said.
“Hopefully we can start with our first generation of mRNA vaccine, and then roll it out to the rest of the world.”
The NHS has begun screening older smokers for lung cancer in the hope of picking up cases earlier. Anyone with symptoms, including a cough that won’t go away, chest pain and fatigue should see a doctor.
NHS England national cancer director Dame Cally Palmer said: “The NHS has a leading role globally in trialling cancer vaccines and if we are successful, they could be revolutionary in vaccinating people against their own cancers to prevent the cancer recurring after their initial treatment.
“Pioneering work is being undertaken by hospitals throughout the country with their university and industry partners to look at ways of harnessing the body’s own immune system to treat a range of cancers.
“A cancer diagnosis is very worrying, but access to groundbreaking trials – alongside other innovations to diagnose and treat cancers earlier – provides hope. We expect to see thousands more patients taking part in trials over the next few years.”
Changes to how death certificates are issued in England and Wales have made the grieving process more “stressful”, according to bereaved families.
Anne Short died on New Year’s Eve, only a few months after she was diagnosed with cancer.
Her son Elliot, 30, from Newport, South Wales, says the grieving process was made harder after having to wait eight weeks to hold her funeral.
“Quite frankly, it’s ridiculous, when you’re already going through all this pain and suffering as a family,” he told Sky News.
“You can’t move on, you can’t do anything, you can’t arrange anything, you can’t feel that they’re at peace, you can’t put yourself at peace, because of a process that’s been put in that nobody seems to know anything about at the moment.”
That process has been introduced by the government to address “concerns” about how causes of death were previously scrutinised, following high-profile criminal cases such as those of Harold Shipman and Lucy Letby.
Up until last September, causes of death could be signed off by a GP, but now they have to be independently scrutinised by a medical examiner, before a death certificate can be issued.
Image: Anne Short
‘I felt helpless’
Mr Short said he was ringing “twice a day” for a progress update, but that it was “going through too many sets of hands”.
Until the death certificate was issued, Ms Short’s body could not be released into the care of the funeral director.
“The main stress for me was knowing that she was up there [at the hospital] and I couldn’t move her, so I felt helpless, powerless,” he said.
“I felt like I’d let her down in a lot of ways. I know now, looking back, that there’s nothing that we could have done, but at the time it was adding a lot of stress. I just wanted her out of there.”
Image: Elliot Short had to wait eight weeks to hold his mother’s funeral
‘Something has to be done’
Mr Short fears there’s a risk the new process might defeat its purpose.
“There’s other people that I know that have lost since, where it’s been in a care home or something like that, where they haven’t been happy with the care they’ve had, but they haven’t raised that because you’re in this bubble of grief and you just want to get it done,” he said.
“Something has to be done about that because I think it just drags on the grief and there’s obviously a danger then of it being against the reasons why they’re trying to do it.”
Arrangements after the death of his father less than two years ago was a “much easier process”, according to Mr Short.
“I lost my father as well 15 months before, so we went through the process prior to this coming in and we had the death certificate, he died at home, but we had it within three days,” he added.
Image: Elliot Short
‘State of limbo’
James Tovey is the sixth generation of his family running Tovey Bros, a funeral director in Newport.
He told Sky News that the delays were having a “huge impact” on the business and that the families they serve were being “left in a state of limbo” for weeks after their bereavement.
“I would say that most funerals will take place perhaps two to four weeks after the person’s passed away, whereas now it’s much more like four to six weeks, so it is quite a significant difference,” he said.
“It’s one thing on top of an already distressing time for them and we’re frustrated and upset for [the families] as much as anybody else and it’s just annoying that we can’t do anything about it.”
Image: James Tovey
Mr Tovey said that the reform was “very useful” and he remained supportive of it.
“It’s just the delays. I’m sure they can do something about that over time, but it’s just waiting for that to happen, and I wish that could be addressed sooner rather than later,” he added.
“It does put pressure on other people, it’s not just ourselves, it’s pressure on the hospitals, on crematoria, on the registrar service and everyone else involved in our profession.
“But of course all of us we’re there to serve the families, and we’re just upset for them and wish we could do more to help.”
Image: The organisation representing funeral directors has called for “urgent action”
The National Association of Funeral Directors said some areas of England and Wales are experiencing much shorter delays than others, but has called for “urgent action”.
Rachel Bradburne, its director of external affairs, said the system was “introduced for all the right reasons” but that it was “not working as well as we need it to”.
“Funeral directors are relaying stories of delays, frustration, and bottlenecks on a daily basis, and urgent action is required to review and recalibrate the new system,” she added.
‘Unintended consequences’
Dr Roger Greene is the deputy chief executive of bereavement charity AtALoss.
He told Sky News that the delays were “one of the unintended consequences of what’s a well-intended reform of a system”.
“What has actually happened is that the number of deaths now requiring independent scrutiny has trebled,” he said.
“So in England and Wales in 2023, the last full year of data, there were nearly 200,000 deaths reported to a coroner, whereas there were 600,000 deaths.
“Now, what is the change in the process is that all deaths now need to be reported for independent scrutiny.”
Image: Dr Roger Greene
Dr Greene said there may be ways the system could be “tweaked a little bit”, such as giving medical examiners the ability to issue an interim death certificate.
“We believe that people can process grief well if they’re given the opportunity and they’ve got a proper understanding,” he added.
“But the systems that we have in the country need to be able to work as well with that diversity of faith and culture.”
‘Vital improvements’
Jason Shannon, lead medical examiner for Wales, told Sky News he recognised “the importance of a seamless, accurate and timely death certification process”.
“Medical examiners are one part of the wider death certification process and were introduced to give additional independent safeguards as well as to give bereaved people a voice, which they hadn’t had before,” he added.
“Medical examiners have no role in determining where the body of a family’s relative is cared for and except in a minority of deaths where a coroner needs to be involved, that decision should be one that a family is fully empowered to make in a way that is best for them.”
A Welsh government spokesperson said they “would like to apologise to any families who have experienced delays in receiving death certificates”.
The government said it was working with the lead medical examiner and the NHS in Wales “to understand where the delays are” and how to provide bereaved families with “additional support”.
A spokesperson for the Department of Health and Social Care said it recognised there were “some regional variations in how long it takes to register a death”.
They added that the changes to the death certification process “support vital improvements to patient safety and aim to provide comfort and clarity to the bereaved”.
Social media influencers are fuelling a rise in misogyny and sexism in the UK’s classrooms, according to teachers.
More than 5,800 teachers were polled as part of the survey by the NASUWT teaching union, and nearly three in five (59%) of teachers said they believe social media use has contributed to a deterioration in pupils’ behaviour.
The findings have been published during the union’s annual conference, which is taking place in Liverpool this weekend.
One motion that is set to be debated at the conference calls on the union’s executive to work with teachers “to assess the risk that far-right and populist movements pose to young people”.
Andrew Tate was referenced by a number of teachers who took part in the survey, who said he had negative influence on male pupils.
One teacher said she’d had 10-year-old boys “refuse to speak to [her]…because [she is] a woman”.
Another teacher said “the Andrew Tate phenomena had a huge impact on how [pupils at an all-boys school] interacted with females and males they did not see as ‘masculine'”.
While another respondent to the survey said their school had experienced some incidents of “derogatory language towards female staff…as a direct result of Andrew Tate videos”.
Last month, Prime Minister Sir Keir Starmer hosted a discussion in Downing Street on how to prevent young boys from being dragged into a “whirlpool of hatred and misogyny”.
The talks were with the creators of Netflix drama Adolescence, which explored so-called incel culture.
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3:15
Starmer meets Adolescence creators
‘An urgent need for action’
Patrick Roach, the union’s general secretary, said “misogyny, racism and other forms of prejudice and hatred…are not a recent phenomenon”.
He said teachers “cannot be left alone to deal with these problems” and that a “multi-agency response” was needed.
“There is an urgent need for concerted action involving schools, colleges and other agencies to safeguard all children and young people from the dangerous influence of far-right populists and extremists,” Mr Roach added.
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A spokesperson for the Department for Education (DfE) said: “Education can be the antidote to hate, and the classroom should be a safe environment for sensitive topics to be discussed and where critical thinking is encouraged.
“That’s why we provide a range of resources to support teachers to navigate these challenging issues, and why our curriculum review will look at the skills children need to thrive in a fast-changing online world.”
Former Rochdale player Joe Thompson has died aged 36.
His former club said it was “devastated” to learn of his death.
Thompson, who retired in 2019, was diagnosed with cancer for a third time last year.
In its statement, Rochdale FC said he died “peacefully at home on Thursday, with his family by his side”.
He made over 200 appearances for Rochdale, who he joined from Manchester United‘s academy in 2005.
The club posted a tribute on X, describing the former midfielder as “a warm personality who had a deep connection with our club from a young age”.
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In her tribute on Instagram, Thompson’s wife Chantelle said he had “made such an impact on so many people” and he was “the most incredible husband, son, brother, friend and father”.
During his career, he played for Tranmere Rovers, Bury and Carlisle United, with spells on loan at Wrexham and Southport.
He was first diagnosed with Hodgkin lymphoma in 2013, while playing for Tranmere.
When Thompson rejoined Rochdale from Carlisle in 2016 the disease soon returned, but he confirmed he was cancer free in June 2017.
Two years later, he announced his retirement at the age of 29, saying his body had been pushed “to the limit” having twice undergone treatment for cancer.
Last year, he revealed he had been diagnosed with stage four lymphoma which had spread to his lungs.