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adminBy Dr. Priyom Bose, Ph.D. Reviewed by Danielle Ellis, B.Sc.
What happens after HIV infection?
Evolution of HIV diagnostic assays
Conclusions
References
Further reading
Acquired immunodeficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV) that attacks the body’s immune system, making it vulnerable to all infections. One of the major concerns of the early AIDS epidemic that began in 1981 was the lack of proper diagnostic measures to identify infected individuals.1 Since the development of the first HIV diagnostic assay in 1985, scientists have continued to improve diagnostic accuracy, detection speed, and cost.
Image Credit: Hanna Karpiak/Shutterstock.com What happens after HIV infection?
The immune system produces antibodies after encountering harmful foreign substances or antigens. HIV infects the vital cells associated with immunity, such as macrophages, helper T cells, and dendritic cells, and disrupts their function. The three important HIV antigens are p24, gp 41, and gp 120.2
HIV is a slow-replicating retrovirus that is transmitted through sexual intercourse, sharing an infected needle, or by blood transfer.3 After HIV infection, the viral load cannot be measured immediately due to low plasma load. Typically, the viral RNA can be measured within 10 to 12 days after infection.4
Antibodies to p24 and gp 41 are the first serological markers used to detect HIV infection. IgG antibodies appear approximately three weeks after infection. In the majority of HIV-infected individuals, HIV antibodies appear to circulate within 1 to 2 months of the infection. However, in a few cases, it may take up to six months to appear at a detectable level.5 Evolution of HIV diagnostic assays
Over the years, scientists have developed many immunoassays and nucleic acid amplification tests (NAATs) to accurately and high-throughput HIV diagnosis. These tests are broadly divided into two categories, namely, screening and confirmatory tests. Typically, HIV tests are performed on blood, oral fluids, or urine samples.6
HIV screening is performed by various immunoassays that focus on detecting IgG antibodies against HIV-1 antigens in the serum. Techniques such as Western blot, line immunoassay (LIA), and recombinant immunoblot are used as confirmatory tests.7 Some of the important HIV diagnostic assays are discussed below: Serological testing for HIV
In the mid-1980s, simple serological tests for HIV antibodies were developed based on culture-derived viral antigen preparation.7 These tests enabled HIV diagnosis and assessed blood and blood product supplies. Since the early assays, various serological assays have been developed that aided simple/rapid testing, high-throughput screening, confirmatory tests, incidence determination, and epidemiological surveillance. Since its first development, five generations of enzyme immunoassays (EIAs) have emerged based on varied antigen preparations and detection chemistries.8
First-generation assays: The first-generation EIAs detect IgG antibodies from antigens derived from whole viral lysates of HIV-positive cultures. Since crude antigen lysate contains impurities, this method exhibited reduced specificity and high false positivity. In contrast, immunofluorescence assays or Western blotting (WB) have shown higher specificity and lower false positivity.
Second-generation assays: Second-generation assays involve the use of recombinant proteins or synthetic peptides derived from the immunodominant regions (IDR) of HIV-1 proteins and gp36 of HIV-2, which increases sensitivity and decreases false positivity.
Third-generation assays: Third-generation assays, including the Genetic Systems HIV-1/HIV-2 Plus O EIA, use a variety of antigens to detect HIV-1 and -2 antibodies in the serum. A major advantage of third-generation sandwich format assays is their ability to detect HIV-1 IgM antibodies early, enabling quicker HIV diagnosis.
Fourth-generation assays: The fourth-generation EIAs, including the Abbott Architect HIV Ag/Ab Combo assay, utilize fully automated chemiluminescent microparticle technology that can instantaneously identify antibodies to HIV-1 and HIV-2 and HIV-1 p24 antigen. This technique has further allowed early HIV diagnosis. Other advantages of fourth-generation high-throughput assays are their capacity to perform more than 150 tests per hour and their ability to test specimens immediately upon arrival and generate results within 30 minutes. These assays are suitable for facilities, such as blood banks, that handle high volumes of blood samples.
Fifth-generation assays: Fifth-generation assays, such as the Bio-Rad BioPlex 2200 HIV Ag-Ab assay, use magnetic beads coated with p24 monoclonal antibodies and epitopes specific for HIV-1 and HIV-2. This type of assay has a major advantage in that it can confirm HIV infection in a single test. Interested in Assay Kits? Explore Equipment Here
Despite the advancements in EIA assays, the challenges associated with the generation of false positive results persist. Therefore, EIA-reactive specimen is typically retested with supplemental tests, such as Western Blot. Rapid diagnostic tests Related StoriesSweden exceeds UNAIDS HIV goals but faces new challengesNutrition's pivotal role in combating tuberculosis: addressing N-AIDS for better outcomes
The first HIV rapid test was available in the early 1990s. It determined an individual's serostatus before surgery, maternal labor/delivery, and organ transplant. Rapid diagnostics is based on immunochromatographic technology that uses blood from finger pricks to assess HIV status. 9 This test can provide results in less than 30 minutes and can be used in point-of-care (POC) settings. Since this test presents both false positive and negative results, it is essential to confirm the findings with laboratory-based HIV assays.
The main advantage of this technique is that any non-laboratory staff can perform it in a primary health care center. Even though decentralization of HIV diagnostic services has increased HIV test service in remote areas, it has been challenged by the lack of national guidelines, waste disposal, inventory management, and quality assurance (QA) monitoring.10
HIV self-testing, based on rapid testing methods, has allowed individuals who would otherwise refrain from testing in fear of discrimination to perform the test privately and start proper intervention. The World Health Organization (WHO) has prequalified several HIV rapid tests for HIV self-testing, including the Insti HIV-1/HIV-2 antibody tests and the Oraquick rapid HIV-1/2 antibody test.10 Nucleic acid test (NAT)
The NAT identifies HIV nucleic acid, i.e., either RNA or proviral DNA, in the blood sample. This test is based on the principles of polymerase chain reaction (PCR), nucleic acid sequence-based amplification, or ligase chain reaction.11 This test has proved to be vital in situations when an antibody against HIV is absent in serum. NAT is also performed in newborns of HIV-infected mothers. Unlike other assays, this test can detect HIV even after recent or possible exposure to the virus. Furthermore, NAT can quantify viral load.
Revolutions in Infectious Disease Testing Conclusions
The advancements in HIV diagnostic assays have played a vital role in identifying, staging, and monitoring infected individuals, even when they are under antiretroviral therapy. These assays have played an important role in surveillance and identification of transmission hot spots. Extraordinary progress in HIV testing methodologies has not only reduced false positives but decreased assessment time as well. References Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med. 2011;1(1):a006841. doi: 10.1101/cshperspect.a006841. Foster JE., et al. Viruses as Pathogens: Animal Viruses, With Emphasis on Human Viruses. Viruses. 2018; 157-187. doi.org/10.1016/B978-0-12-811257-1.00007-3 Dasgupta A, Wahed. Human immunodeficiency virus (HIV) and hepatitis testing. Clinical Chemistry, Immunology and Laboratory Quality Control (Second Edition). 2021; 513-533. doi.org/10.1016/B978-0-12-815960-6.00015-7 Konrad BP, et al. On the duration of the period between exposure to HIV and detectable infection. Epidemics. 2017; 20, 73-83. doi.org/10.1016/j.epidem.2017.03.002 Davis LE. Acute viral meningitis and encephalitis. Infections of the Nervous System, 1987; 156-176. doi.org/10.1016/B978-0-407-02293-5.50014-3 Pant PN. Oral fluid-based rapid HIV testing: issues, challenges and research directions. Expert Review of Molecular Diagnostics. 2007; 7 (4), 325-328, DOI: 10.1586/14737159.7.4.325 Abdullah DM, et al. The contemporary immunoassays for HIV diagnosis: a concise overview. Asian Biomed (Res Rev News). 2023;17(1):3-12. doi: 10.2478/abm-2023-0038. Alexander TS. Human Immunodeficiency Virus Diagnostic Testing: 30 Years of Evolution. Clin Vaccine Immunol. 2016;23(4):249-53. doi: 10.1128/CVI.00053-16. Aidoo S, et al. Suitability of a rapid immunochromatographic test for detection of antibodies to human immunodeficiency virus in Ghana, West Africa. J Clin Microbiol. 2001;39(7):2572-5. doi: 10.1128/JCM.39.7.2572-2575.2001. Parekh BS, et al. Diagnosis of Human Immunodeficiency Virus Infection. Clin Microbiol Rev. 2018;32(1):e00064-18. doi: 10.1128/CMR.00064-18. Garrett, P. E. Quality control for nucleic acid tests: Common ground and special issues. Journal of Clinical Virology. 2001; 20(1-2), 15-21. doi.org/10.1016/S1386-6532(00)00150-5
Further ReadingAll HIV ContentThe Economic Impacts of AIDSRecent Advancements in Treating HIV
Last Updated: Nov 29, 2024

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Sports
College football hot seats: Brace yourselves for potential blue-blood turnover
Published
1 min agoon
August 29, 2025By
admin
The college football job market took an expected turn last year.
The headwinds of financial uncertainty, combined with a record number of jobs turning over in 2023, led to a quieter year on the coaching carousel, especially at high-end schools.
Last offseason, there was a dip in head coaching changes at FBS football, with 30 total. The year before, a record 32 jobs turned over, per NCAA statistics.
Notably last offseason, no jobs turned over in the SEC and there was just one in the Big Ten (Purdue). Only West Virginia and UCF turned over in the Big 12, and the ACC had three changes (North Carolina, Wake Forest and Stanford).
None of those jobs would remotely qualify as blue bloods, which has the industry bracing for what could end up being a big year for high-end coaching turnover. The carousel rests for only so long.
That has led to a fascinating tension that will serve as the backdrop for this year’s edition: In an era when a vast majority of schools are scrambling for resources and revenue, are schools ready to pay big buyout money to part with their coaches? For big movement this year, there will have to be one or two big buyouts.
“The signs are that it’s going to be a pretty big year,” said an industry source. “There’s 15 to 20 schools in flux, and it was really light last year. That combination lends itself to a big year.
“But the question is whether 6-6 is worth making a change when you need to find 20-plus million? I think the trend is going to schools looking not to make the decision.”
There’s a counter to that perspective, and it’s a peek at the college basketball market from last year. Places like Indiana, Villanova, Iowa, Minnesota, NC State, Texas and Utah all paid sizable buyouts to kick-start new eras.
“I think people are past the rev share issues,” another industry source said. “They were stalled out last year in the football carousel, but they didn’t have any trouble getting going in the basketball carousel.”
Jimbo Fisher’s football buyout from Texas A&M in 2023 was $76.8 million, which included $19.2 million within 60 days and $7.2 million annually with no offset or mitigation. That’s the Secretariat-at-the-Belmont runaway winner for the biggest in the history of the sport.
The second-biggest public buyout belongs to Auburn, which fired Gus Malzahn in 2020 and owed him $21.7 million.
If this is indeed going to be an active coaching carousel among high-end jobs, the Malzahn number will need to be toppled. And the Fisher buyout has a chance to be as well.
Ultimately, the case for an active coaching carousel starts with big-name jobs that are in flux, the so-called market moves that ripple through the industry. A majority of those potential openings — although not all — would involve heavy lifting from a buyout perspective.
One source pointed out that schools in the SEC and Big Ten will have new line items that could make a big buyout more tenable, as there’s an influx of CFP money coming.
One school told ESPN that it has budgeted an additional $8 million additional for bowl revenue for the new CFP starting in 2026. (The specific amount is tricky, as there’s a flurry of variables that make a finite number tough to pin down.)
That makes the particulars of the buyouts important. How much money is up front? Is there offset and mitigation?
Here’s a look at the jobs with the buyout tension that could set the market, as well as other jobs worth monitoring across each conference.
Jump to a topic:
Big buyouts | Other Big Ten
Other SEC | Other ACC
Big 12 | Group of 5
Big buyouts
USC | Lincoln Riley (26-14 entering Year 4)
Buyout: More than $80 million
Nearly everything has changed since Lincoln Riley came to Los Angeles. Most notably, the results. After an 11-3 debut in 2022, he has gone 8-5 and 7-6 with losses along the way to Maryland, Minnesota and UCLA. The splash of the hire has worn off amid close losses, media clashes and modest expectations for 2025.
His winning percentage with the Trojans is 65.0%, which is lower than Clay Helton’s USC winning percentage (65.7) when he was fired. It’s also nearly 20% worse than his Oklahoma win percentage (84.6).
Many of the core people Riley brought with him from Oklahoma have been removed or seen their roles diminish, with the firing of strength coach Bennie Wylie and the hiring of new general manager Chad Bowden recent examples of significant personnel changes around him.
Athletic director Jennifer Cohen didn’t hire Riley. She also has made clear that there are championship expectations. She has invested accordingly, including a new football performance center that’s under construction and plenty of staff infrastructure and NIL financial gunpowder.
Although firing Riley would generate eye-popping financial headlines, the understanding is that there is offset and mitigation on his deal. That would diminish the number owed him over time. He’s too gifted a playcaller and offensive mind to sit out through the length of his deal, which was originally a 10-year contract that began in the 2023 season. (His buyout to leave is minimal if he chose to go elsewhere, but leaving that much guaranteed money behind would be hard.)
Without high-end results, there will continue to be uncertainty. USC will be favored in its first four games, and then it enters one of the most difficult stretches on any schedule this year — at Illinois, Michigan, at Notre Dame and at Nebraska. (There’s a bye between the trips to South Bend and Lincoln.)
That means by Nov. 1, we’ll get a sense of what Riley truly has built in his fourth season and where his tenure is headed.
The best news for Riley is there’s hope on the way, as USC has the No. 1 recruiting class for 2026, which includes 19 ESPN 300 prospects.
Florida State | Mike Norvell (33-27 entering Year 6)
Buyout: $58 million
This was unthinkable two years ago, when FSU went undefeated in the regular season and won the ACC. But since quarterback Jordan Travis’ injury and the subsequent College Football Playoff snub following 2023, everything has gone wrong for FSU.
In the wake of FSU’s 2-10 season last year, Norvell has overhauled the coaching staff, given up playcalling and brought in new coordinators. Florida State can’t really afford to fire him, but it also can’t afford to trudge through another miserable season like last year.
Norvell also agreed to a restructured new deal, which includes donating $4.5 million of his salary to the program in 2025. Effectively, Norvell took a performance pay cut. (He can earn that back, too, as included in the new deal is a $750,000 bonus for nine wins.)
The 2024 implosion came at a time when Florida State had actively — and awkwardly — been lobbying to find a new conference home. That bluster has died down, and the financials of leaving the ACC are clear. FSU’s need to get back to winning is rooted in those grander ambitions.
What’s important here if FSU does have to move on is that Norvell’s remaining money is subject to offset and mitigation. He’d likely be a strong candidate to coach again, which would blunt some of the financial pain.
Norvell went 23-4 in 2022 and 2023, which built up some grace. Here’s what no one knows: What is enough progress for 2025?
Oklahoma | Brent Venables (22-17 entering Year 4)
Buyout: $36.1 million
Oklahoma extended Venables through the 2029 season in the summer of 2024. The Sooners subsequently went 6-7 in their SEC debut, which led to some scrutiny of that deal.
Venables is popular in Norman, dating back to his time as an assistant. Like many defensive head coaches early in his career, he made a misstep at offensive coordinator that quelled the momentum from OU’s 10-2 season in its Big 12 finale in 2023.
There’s an athletic director shift coming at Oklahoma, with Joe Castiglione retiring. There also has been new blood in the football program, with general manager Jim Nagy coming in this offseason from the Senior Bowl.
This season is a fascinating litmus test for OU’s viability in the SEC. The Sooners have fortified the roster with a significant upgrade at quarterback (John Mateer), expect better health at wide receiver and have made holistic upgrades.
But the reality is that most teams are going to lose half their games in the SEC, and it’d be a poor time for Venables to have a bad year. The Sooners also play seven teams ranked in the preseason Top 25, and that doesn’t include Missouri or Auburn.
Wisconsin | Luke Fickell (13-13 entering Year 3)
Buyout: More than $25 million
Wisconsin ended last year with five straight losses and missed a bowl for the first time since 2001.
Wisconsin extended Fickell after last year, but that didn’t impact his buyout. There’s optimism for a change of trajectory, as Wisconsin is undergoing a schematic shift back to the school’s identity roots as a running offense. It will be a welcomed change after the failed Air Raid experiment.
The factor that has this job coming up in industry circles is Wisconsin’s schedule, which might make it difficult for the Badgers to take a significant step forward. They play at Alabama, at Michigan, Iowa, Ohio State, at Oregon, Washington, at Indiana, Illinois and at Minnesota.
Wisconsin could be a better team but have a similar record. The institutional history, Fickell’s general track record and buyout expense suggest patience is likely.
Other jobs worth monitoring
Big Ten
Maryland: Mike Locksley’s strong run at Maryland took a hairpin turn last year, as the Terps went 4-8, 1-8 in Big Ten play and Locksley admitted he lost the locker room. There’s a lot of goodwill from Locksley’s three consecutive bowl games, which hadn’t happened since Ralph Friedgen’s tenure in 2008. But there’s also a new athletic director, Jim Smith, and an expectation to return to winning. Maryland is heavily favored in its three games to open the year (FAU, Northern Illinois and Towson), which could quiet things. Locksley would be owed $13.4 million if fired, a considerable amount for Maryland. He’d also have 50% of that due in 60 days, a sizable check for a university not flush with cash.
SEC
Auburn: Hugh Freeze faces a classic win-or-else season at Auburn. The Tigers have strong talent upgrades from both the portal and recruiting. But Auburn is not a traditionally patient place, so Freeze’s 11-14 record there needs to improve quickly. He’d be owed just under $15.4 million, which is expensive but not something Auburn would flinch at if there are modest results again. Don’t expect him to be around if Auburn has another losing season.
Arkansas: The goofiest buyout in college sports looms over any potential decision on Sam Pittman. If he’s .500 or above since 2021 — he enters the year 27-24 in that time frame — Arkansas would have to pay him nearly $9.8 million. To keep the buyout at this higher level, he’d need to win five games. If Pittman goes 4-8, the number would be nearly $6.9 million. Credit Pittman, who revived Arkansas from the depths of Chad Morris’ era and keeps on surviving. If he’s above four wins, Arkansas would face scrutiny for issuing such a bizarre contract and the extra money it’d cost the program to fire him.
Florida: The temperature on Billy Napier has cooled considerably, and the Gators have a top-flight quarterback and great expectations again. He’s 19-19 through three seasons, and his buyout remains eye-popping at $20.4 million. (There’s no offset or mitigation on the deal.) Athletic director Scott Stricklin gave Napier a midseason vote of confidence last year by announcing he’d return, and Florida responded with a strong finishing kick by winning four straight to close the year. Stricklin clearly has his back. And per an ESPN source, Stricklin has three additional years added to his contract, which now runs through 2030. That bodes well for Napier, as they are clearly aligned.
ACC
Stanford: General manager Andrew Luck’s first significant hire looms. With interim coach Frank Reich clear that he’s on The Farm short term, Luck needs to decide whether he wants someone from the college ranks or the NFL. What’s unique about this job is that the hire will be made through the shared prism of how Luck sees the identity of the program, not necessarily just a coach coming in and bringing the identity.
Virginia Tech: It’s a classic prove-it year for Brent Pry, who has two years remaining on his original contract. He’d be owed $6.2 million if fired on Dec. 1. He’s 16-21 over three years and 1-12 in one-score games, and Tech’s ambitions are clearly greater than that. Considerable improvement is needed, or Tech will hit reset as the administration appears motivated by the fear of getting left behind in the next iteration of the collegiate landscape. Athletic director Whit Babcock has hired Pry and Justin Fuente, which would mean his future could be in flux if a change comes here. ADs don’t often get to hire three coaches.
Virginia: There was a discernable uptick in investment and aggression by Virginia in the portal this offseason. That’s a sign the pressure is ratcheted up on Tony Elliott, who is 11-23 through three seasons. He entered a job with arguably the worst facilities in power conference football. He also dealt with unspeakable tragedy: the murder of three players in a campus shooting. UVA showed signs of progress last year with five wins, and that needs to continue. Elliott is owed more than $11.1 million if fired on Dec. 1, and UVA is more likely to need to direct that to the roster than a payout.
Cal: Can Cal do better than Justin Wilcox? It’s unlikely, as he has led the team to four bowls since taking over in 2017. Cal has no athletic director, landed in an awkward geographic league and is working to financially catch up to the rest of the sport. Wilcox would be owed $10.9 million if he’s fired, which would seemingly be too rich for Cal to handle. But with so much change afoot, there’s an industry expectation that something could happen here, as Wilcox could also have other suitors.
Big 12
Oklahoma State: The school forced Mike Gundy into a reduced salary and buyout. Those are fluorescent signs of a school preparing to move on, although the buyout remains significant at $15 million. It would be a seminal moment for a school to fire a coach who has more than 100 more wins than the next most successful coach in school history. Gundy is 169-88, but the program fell off a cliff last year at 3-9. The roster doesn’t offer much optimism for drastic improvement, and essentially the entire coaching staff is new. Gundy has done some of his best work with low expectations, and that’s what OSU has in 2025.
Arizona: Arizona’s dip from 10-3 in Jedd Fisch’s first year to 4-8 in Brent Brennan’s first season has led to scrutiny. Also, there has been a new athletic director brought in since Brennan was hired. The buyout price is steep at $10.6 million, but it’s something Arizona is expected to consider if there’s no improvement. It doesn’t help matters for Brennan that rival Arizona State burst into the CFP in Kenny Dillingham’s second year.
Cincinnati: There have been growing pains entering the Big 12 for the Bearcats, who are 4-14 in league play in the first two years. There’s an expectation for continued improvement in Scott Satterfield’s third year, as he went 3-9 in Year 1 and jumped to 5-7 last year. The Bearcats lost their final five games last year. The buyout tab is nearly $12 million, which is a lot for a school that moved its opener against Nebraska to Kansas City for financial reasons.
Baylor: The temperature on Dave Aranda’s seat has cooled exponentially compared with the past two seasons. He snapped a skid of two losing seasons by going 8-5 last year and 6-3 in the Big 12. A change would require a precipitous downturn, as Aranda is beloved in Waco. There’s an unforgiving schedule, however, that opens with Auburn and a trip to SMU. His buyout is in the $12 million range, and it’s unlikely to be tested.
Group of 5
American: The American might have been the biggest surprise in the 2024 coaching carousel, with FAU, Tulsa and Charlotte all firing coaches after just two seasons. Temple, Rice and East Carolina also fired their coaches. Oddly, the worries over revenue share spending didn’t intimidate these schools from making moves.
There’s really only one job squarely in the crosshairs, and that’s Trent Dilfer at UAB, who is 7-17 in two seasons. He’d be owed nearly $2.5 million if dismissed. UAB has struggled to translate its strong run in Conference USA to the American since joining in 2023.
Conference USA: This also projects to be a quieter year in Conference USA, with only Louisiana Tech having a coach potentially in flux. Sonny Cumbie went 5-8 last year after opening with back-to-back 3-9 seasons. He’ll need continued improvement to stick around for that school’s eventual transition to the Sun Belt. He’d be owed nearly $875,000 if let go, as 2026 is the last year of his deal.
MAC: There’s already one MAC job open, after Kenni Burns’ firing this spring at Kent State. There are significant financial challenges both there and at Akron, which also could be in flux with Joe Moorhead entering Year 4 at 8-28. (He’d be owed about $650,000 if fired, which is significant.) There’s still a market for Moorhead as a college offensive coordinator, which could be the pivot if the Zips don’t get moving. (Perhaps the NFL, too.) Overall, this looks like a quieter year in the MAC.
Mountain West: The lack of a contract extension for Jay Norvell at Colorado State is a smoke signal that a decision is coming. He has just one year left on his deal and would be owed $1.5 million if fired before Dec. 1. He also wouldn’t have to pay any money to go elsewhere. Norvell has an administration that didn’t hire him and, despite solid improvement, there will be speculation over his future until something changes contractually. Colorado State went 8-5 last year and 6-1 in the Mountain West. Norvell is 16-21 in his three years.
Sun Belt: Two coaches will be watched closely here. Tim Beck is 14-12 at Coastal Carolina over two seasons, having reached bowls in each of them. He had the misfortune of replacing Jamey Chadwell, who averaged more than 10 wins over his final three seasons. Beck would be owed $1.5 million if Coastal fired him, and Coastal has both a new athletic director and president. Ricky Rahne at Old Dominion is 20-30 overall and still in search of his first winning season there. He has just one year remaining on his deal after this one, a sign that a decision on his future one way or the other is imminent. He’d be owed $600,000 if fired.
Pac-12: None.

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David PurdumAug 29, 2025, 08:54 AM ET
Close- Joined ESPN in 2014
- Journalist covering gambling industry since 2008
The point spread on Saturday’s Texas-Ohio State showdown has been on the move all week, with the Longhorns becoming a favorite at some sportsbooks, including ESPN BET, as of Friday morning.
The Buckeyes opened as a 3-point favorite months ago, but sportsbooks have been reporting a steady stream of money on the Longhorns throughout the summer, causing the line to move toward Texas.
The consensus line was a pick ’em as of noon ET Friday, with ESPN BET and DraftKings listing Texas as a 1.5-point favorite.
Circa, a sportsbook known to cater to professional bettors, had seen enough interest on the Longhorns to move them to a 1-point favorite on Thursday. Derek Stevens, the owner of Circa, said on VSIN that a $550,000 bet on Texas preceded the move to Longhorns -1. The line had ticked back to pick ’em by early Friday at Circa.
“It seems like the public is moving the line,” Chris Bennett, sportsbook director at Circa, told ESPN. “We’ve seen a lot of interest in Texas, but not from the usual suspects, and by that I mean a subset of sharp customers we have a lot of history with.”
The Buckeyes have not been a home underdog since 2018 against Michigan and have been favored by less than three points at Ohio Stadium only once since 2012. If the line closes with Ohio State as the favorite, Texas would become the first team ranked No. 1 in the preseason Associated Press Top 25 to be an underdog in its first game.
“The perception is that Texas is just more experienced than Ohio State,” said Ed Salmons, veteran football oddsmaker for the Westgate SuperBook in Las Vegas. “Arch Manning is considered a much better quarterback than the Ohio State quarterback [Julian Sayin]. Both are such unknowns, no one really knows.”
Salmons said it became obvious over the summer that the betting public was supporting Texas and that, once the line dropped from the opening number of Ohio State -3, it had the potential to move all the way to the Longhorns being the favorite.
“The public right now likes Texas, but we’ll see the day of the game,” Salmons said. “Sometimes you think that, and then all of a sudden you’ll see these big Ohio State bets. It’s a game we’re expecting a ton of handle on.”
The bulk of the betting action, both on the moneyline and spread, was on Texas at Caesars Sportsbook as well, but some of the bigger bettors had not weighed in on the marquee matchup of Week 1.
“There has not been a lot of wise guy action thus far,” said Joey Feazel, lead football trader for Caesars Sportsbook. “I believe that says more to the true variation of this game and not knowing exactly what you are going to get from either side of the ball. I expect we will see some action closer to game time.”
Sports
Miami LB Hayes charged with vehicular homicide
Published
1 min agoon
August 29, 2025By
admin
-
ESPN News Services
Aug 29, 2025, 01:35 PM ET
Miami linebacker Adarius Hayes has been charged with three counts of vehicular homicide and one count of reckless driving with serious bodily injury following an investigation into a May crash that killed three people.
Hayes surrendered to police Friday morning in his hometown of Largo, Florida, officials said, and records show he was booked into the Pinellas County Jail. It was not immediately clear if he retained an attorney.
Miami said Hayes “has been indefinitely suspended from all athletic related activities per athletic department policy” in response to the charges. The Hurricanes declined further comment.
The three people who died as a result of the May 10 afternoon crash — a 78-year-old woman, plus two children ages 10 and 4 — were all in a Kia Soul that collided with a Dodge Durango being driven by Hayes, police said at the time.
The children were ejected from the vehicle, police said, and investigators later found that Hayes was “maneuvering aggressively through traffic shortly before the crash.” He was driving at 78.9 mph in a 40 mph zone at the time of the crash, police said.
Another passenger of the Kia had been hospitalized with serious injuries.
“The investigation concluded that Adarius Hayes’ egregious speed, aggressive and reckless lane changes, and complete disregard for surrounding traffic conditions demonstrated a willful and deliberate disregard for the safety of others, constituting reckless driving. These actions directly led to the tragic deaths of the three victims,” Largo police said in a statement Friday.
The Kia, police said, was “lawfully executing a left-hand turn” when Hayes’ vehicle “made a rapid and dangerous maneuver” and crashed into the car.
Hayes played in 12 games as a freshman for Miami last season, mostly on special teams. He was a four-star recruit coming out of Largo High School.
Largo is about 20 miles east of Tampa and about 15 miles north of St. Petersburg on Florida’s Gulf Coast.
The Associated Press contributed to this report.
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