A 32-year-old woman is cancer-free after undergoing the UK’s first liver transplant for advanced bowel cancer.
Bianca Perea, a trainee lawyer from Manchester, was diagnosed with the most advanced kind of bowel cancer in November 2021, with doctors telling her they aimed to prolong her life rather than find a cure.
But, alongside other treatments including targeted drug therapy, chemotherapy and surgery, the transplant has been a huge success and Ms Perea now has no signs of cancer anywhere in her body.
Ms Perea first visited her GP in Wigan after feeling constipated and bloated. After tests, a colonoscopy and a biopsy, she was diagnosed with stage four bowel cancer, which had spread to all eight segments of her liver.
Ms Perea accepted the diagnosis, but said she refused to believe the outlook was so bleak.
“I don’t want to sound kind of ignorant or arrogant or anything like that but I just didn’t feel in my gut that that was going to be it,” she said.
Her mother asked about a possible transplant at that stage but was told it was not a feasible treatment.
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Ms Perea had 37 rounds of a targeted drug called panitumumab plus chemotherapy for two and a half years.
She had an excellent response to the treatment, which meant she was able to have an operation in May 2023 to remove the bowel tumour.
But scans showed she still had tumours in her liver, which could not be operated on.
Image: Bianca with her beloved dog. Pic: PA
Nevertheless, because her response to chemotherapy had been so good and her bowel cancer was seemingly gone, doctors began to look at liver transplants.
Ms Perea was added to the transplant list in February 2024 and was lucky enough to find a donor last summer.
Image: An NHS Blood and Transplant Small Human Organ in Transit box at St George’s Hospital in Tooting, west London. File pic: PA
She said: “Within four weeks of going under the knife, I was able to drive and walk the family dogs, it was really quite incredible.
“To go from being told I’d only have a short time to live to now being cancer-free is the greatest gift.
“I’ve been given a second chance at life and I’m going to grab it with both hands. I am so grateful to the family who agreed to donate their loved one’s liver.
“I do believe this is a cure. They’re always hesitant to say that, obviously, but I am cancer-free right now.”
Now, Ms Perea is looking forward to going on holiday this year and is working on improving her fitness.
“My liver is doing really well,” she said. “I get tests on that, and I’ve just had my second scan and that’s all clear, so it’s really good.”
Dr Kalena Marti, Ms Perea’s oncologist, said: “To see that Bianca has had such a positive outcome is wonderful.
“When we looked at the tumour cells in her liver after it had been removed, they weren’t active.
“This is excellent news, and we hope that this means that the cancer won’t come back.”
She added: “Advanced bowel cancer is complex and there are lots of different types of the disease, so what works for one person might not work for another. As a result, it’s important that we continue to develop new treatments.
“Thanks to the generosity of organ donors and their loved ones, we can now access liver transplants for some patients, which is fantastic.”
You can watch a full interview with Ms Perea at 8.30am this morning on Sky News Breakfast.
Counter-terrorism police are investigating after an incident involving a crossbow and a firearm left two women injured in Leeds.
Police were called to Otley Road at 2.47pm on Saturday to reports of a “serious incident involving a man seen with weapons”, West Yorkshire Police said.
Officers arrived at the scene to find two women injured – and a 38-year-old man with a self-inflicted injury. All three were taken to hospital, with the man held under arrest, but their injuries are not believed to be life-threatening.
“Two weapons have been recovered from the scene, which were a crossbow and a firearm,” Counter Terrorism Policing North East said in a statement.
The incident happened on the ‘Otley Run’ pub crawl, with one venue saying it was closed for the evening due to “unforeseen circumstances”.
Image: Officers guard one of the crime scenes
Image: Officers inside the cordon in Leeds
Counter Terrorism Policing’s statement added: “Due to the circumstances surrounding the incident, Counter Terrorism Policing North East have taken responsibility for leading the investigation with the support of West Yorkshire Police.
“Extensive enquiries continue to establish the full circumstances and explore any potential motivation.”
Home Secretary Yvette Cooper described it as a “serious violent incident” and said she was being kept updated by police.
“Thank you to the police and emergency services for their swift response,” she said. “My thoughts are with the victims and all those affected by this attack.”
This breaking news story is being updated and more details will be published shortly.
Wrexham AFC have been promoted for the third season in a row.
The North Wales-based side has gone from the National League to the Championship in just three seasons, under its Hollywood owners Ryan Reynolds and Rob McElhenney.
Wrexham were second in the table and had a run of eight games unbeaten ahead of their match against Charlton Athletic on Saturday, which they won 3-0.
Image: Wrexham’s James McClean lifts the League One trophy. Pic: PA
Image: Wrexham’s Dan Scarr celebrates with the fans on the pitch after Wrexham won promotion to the Championship. Pic: PA
It is the first time any club has been promoted for three consecutive seasons within the top five tiers of English football.
The third oldest association football club in the world, Wrexham AFC was bought by Reynolds and McElhenney in 2020, and has since been the subject of a Disney+ documentary, Welcome To Wrexham.
Reynolds, wearing a Wrexham sweatshirt, and McElhenney were pictured celebrating each goal, and after the game, as the fans came onto the pitch at the SToK Cae Ras (Racecourse Ground) to celebrate the victory with the players.
Image: Wrexham co-owners Rob McElhenney (L) and Ryan Reynolds and Ryan’s wife Blake Lively, before the match. Pic: PA
Both stars came onto the pitch after the supporters returned to the stands.
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Speaking to Sky Sports, McElhenney praised those behind the scenes, referring to “so many that don’t get the credit they deserve, people who aren’t talked about”.
Reynolds said bringing success back to the club “seemed like an impossible dream” when they arrived in North Wales in 2020.
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Image: Wrexham’s Sam Smith celebrates in front of the fans after Wrexham won promotion to the Championship. Pic: PA
He put the three promotions down to “the coaching staff, the greatest dressing room” and an “all for one, one for all” attitude throughout the club, adding he was “speechless with their commitment and their emotion”.
As for the mouth-watering prospect of another promotion to the promised land of the Premier League, the pair agreed it was “for tomorrow”, before ending the interview with a joint mic-drop.
Veteran striker Steven Fletcher said, “as soon as I came to this club, I knew it was something special. We want to go again. We’ll reset in the summer, take a break and go again”.
Just Stop Oil (JSO) insists it’s been “successful” – as its members ceremoniously hang up their orange high-vis vests during a march in central London.
Since the group formed three years ago, it’s drawn attention and criticism for its colourful, controversial protests, which ranged from disrupting sporting events to throwing soup on Vincent van Gogh’s Sunflowers, and climbing on gantries over the M25. It sprayed orange paint over Stonehenge, and cost police forces tens of millions of pounds.
Those days are now behind it; to the relief of many.
As a few hundred activists marched through London on Saturday, blocking roads as they went; taxi drivers blared their horns and football fans shouted abuse from the pavement.
The PA News Agency filmed the moment a white minivan seemed to drive towards a group of protesters blocking the road.
Protesters shouted “I’m being pushed back!” to police, while the driver could be heard shouting “What about my right to get home?” to the officers gathered.
But JSO never set out to be popular. And it believes its tactics – though hated – have been successful; thanks to the new Labour government’s commitment to not issue new oil or gas exploration licences.
That’s why, it says, its ceasing direct action.
Image: JSO hangs up its high-vis jackets in central London on Saturday
Image: A washing line of high-vis jackets signifies JSO’s disbanding
“This moment marks the success of the JSO campaign – our demand was to end new oil and gas licences and that is now government policy.
“As a result of which four billion barrels of oil are being kept under the North Sea. The campaign has reached a natural end.”
Dr Oscar Berglund, senior lecturer in international public and social policy, disagrees that JSO is disappearing because it’s been “successful”.
He told Sky News policing strength and public perception might have more to do with it.
“They have very low levels of popularity. About 17% of the British population are kind of broadly supportive of what Just Stop Oil do. And that’s too low to recruit.
“It’s difficult to recruit members to something that is that unpopular, and then that a lot of people for good reason I think have kind of stopped believing in that kind of disruption as a means to achieve meaningful change.”
Group triggers specific new protest laws
One thing it did change is the law.
Policing commentator Graham Wettone tells us: “Obstruction of the highway, obstruction of rail networks for example, these are specific offences now.
“It’s given the police more tactics, more methods, more offences they can consider, even stopping and searching somebody who may have something to either lock themselves on or glue themselves to something.”
Image: A JSO activist holds a picture of an imprisoned colleague
Emma Smart was held in prison for her activism with both Insulate Britain and Just Stop Oil.
“The high-vis might be going away,” she tells me, “but we aren’t.”
“These people aren’t going anywhere, we are still committed, dedicated, terrified by the failings of this government and governments around the world.”
Image: JSO activists throw orange paint at van Gogh’s sunflowers
Image: Orange smoke set off by JSO protesters at Stonehenge
She hopes for a time of reflection before it returns in a new form but says the need for climate activism is stronger than ever.
She also believes that while most people dislike JSO tactics, it still raises awareness of the cause and might even push people to more moderate campaign groups.
Just Stop Oil came behind other, similarly controversial climate campaign groups like Insulate Britain and Extinction Rebellion, and as it says goodbye, its disruptive methods have been seized upon by other organisations like the Pro-Palestinian Youth Justice.
The infamous Just Stop Oil orange vests might be going away, but the individual activists, their cause and campaign tactics feel here to stay.