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A major development in stem cell science has been achieved with the creation of a bi-paternal mouse, marking a significant step in reproductive biology. Scientists have successfully engineered a mouse with two male biological parents, which managed to survive into adulthood. This research, conducted by a team of stem cell experts, has addressed longstanding barriers in unisexual mammalian reproduction by modifying specific imprinting genes. The findings, which could have implications for regenerative medicine, highlight the challenges and potential future applications of the technology.

Genetic Modifications Enable Bi-Paternal Development

According to the study published in Cell Stem Cell, led by Wei Li of the Chinese Academy of Sciences (CAS), the team focused on overcoming imprinting-related challenges that previously prevented embryos with same-sex genetic origins from developing fully. Modifications were made to 20 imprinting genes using techniques such as frameshift mutations, gene deletions, and regulatory region edits. These changes allowed some bi-paternal embryos to survive to birth and, in rare cases, reach adulthood.

Co-corresponding author Qi Zhou of CAS explained to phys.org, that imprinting genes have been identified as a key obstacle in unisexual reproduction. Despite previous attempts using ovarian organoids derived from male stem cells, imprinting abnormalities caused severe developmental defects. By directly editing these genes, the research team improved embryonic viability and the stability of pluripotent stem cells.

Survival and Reproductive Challenges Remain

As per reports, only 11.8 percent of the engineered embryos developed to birth, and those that survived exhibited developmental abnormalities, reduced lifespan, and sterility. Guan-Zheng Luo of Sun Yat-sen University, a co-corresponding author, stated that imprinting abnormalities have been confirmed as the primary factor preventing unisexual reproduction in mammals.

Despite the limitations, this approach has demonstrated the potential for refining stem cell-based therapies and improving cloning efficiency. Researchers plan to expand the study to larger mammals, though substantial challenges remain due to differences in imprinting gene patterns across species.

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NASA Scientists Study Crystal Formation in Space For Future Applications

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NASA Scientists Study Crystal Formation in Space For Future Applications

NASA scientists have been studying crystals to optimise the process of crystallisation for decades. Various researchers have conducted research on crystals within the first quarter of the year, the latest being protein crystallisation in microgravity. Alexandra Ros from Arizona State University led the research by launching a protein crystallisation test in the International Space Station (ISS). The experiments are meant to determine the growth of protein crystals in space using newly developed microfluid devices. The research agenda is to examine whether space-grown crystals can achieve better quality than those formed on Earth.

What is Crystallisation, & How Does It Impact Our Lives?

It is the process of freezing of liquid or molten materials in the form of highly organised molecules called crystals. These crystals can be a blend of different types of materials. This world consists of crystal examples everywhere. It would be wrong to say that we don’t live in a world of crystals.

Be it a coffee mug, cellphone or silicon that is used to form the brains of electronics and used in memory chips, everything is a result of crystallisation. Other types of semiconductor crystals are used as detectors for different radiations, such as gamma rays, infrared rays, etc. Lasers used in scanning the product are made of optical crystals. Turbine blades are an example of metal crystals used in the jet engine.

Why and How NASA Studies Crystals?

The scientists studied the growth of zinc selenide crystals in space, with the crystals on Earth, explained NASA. The result from the observations marked the way for the improvement of the operations of infrared wavelength in the high powered lasers. The research findings provide an insight into the strong influence of gravity on the electrical, optical and structural characteristics of the crystals.

Researchers have optimised the crystal usage for several years to study the types of crystals for growing in space.

The crystals grown on Earth have defects such as little cracks; these cracks can damage the properties of the crystals. This marks a strong reason why scientists want to study crystals in space, thus getting a complete microgravitational environment where they can grow better. Convection produced due to the presence of the gravitational force degrades the quality of crystals.

However, this convection is not seen in the environment of microgravity, helping in the better quality crystals. The ISS is now converted to a complete lab for the study of the formation of crystals, which can be further applied in technology and medicine.

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Missing Non-Dark Matter Might Be Hidden Within Hydrogen Gas Clouds

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Missing Non-Dark Matter Might Be Hidden Within Hydrogen Gas Clouds

It is observed that about half of the matter cannot be occupied just by stars and galaxies. Scientists say that hydrogen gas clouds could unveil it. Missing matter of the universe may have finally been detected. It is reported by the astronomers that the stuff revealed and not dark matter accounts for only 15 percent of the total mass of the universe. For years, scientists have rushed into a problem, and they have not been able to find even about half of the normal matter in the galaxies, stars, and other space structures that can be seen.

Research and Discovery

At present, a large international team of researchers led by Simone Ferraro from the University of California, Berkeley, concluded that the hydrogen gas cloud that surrounds most galaxies is more extensive than previously realised by scientists. The extensiveness is so high that it could even be responsible for most of the universe’s missing matter, according to the study, which is published in the online pre-print journal arXiv.

The hunt for the Missing Matter

The researchers used data from the Dark Energy Spectroscopic Instrument (DESI) for the investigation. With this instrument, the team piled images of approx. 7 million galaxies for measuring the mild halos of ionised hydrogen gas at the edges of the galaxies, which cannot be observed by normal methods. So the team analysed the remaining radiation from the Big Bang that is widespread throughout the cosmos. If these faint halos connect the other galaxies, there will be a cosmic web spanning far and will account for the undetected matter in the past.

Black Holes on Duty

This discovery may also change the perspective on the black hole behaviour. Scientists at first thought that blackholes forced out a high volume of gases early in their life cycle. At present, the study says that these black holes are much more frequent in action than earlier thought. Boryana Hadzhiyska, an astronomer, said in the statement that one of the hypothetical theories is that the black holes switch on and off in their duty cycle.

Future Scope

The next step is to use new measurements in existing universe models. Hadzhiyska said, there are many people interested in using our measurements for doing a thorough analysis, including this missed gas.

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Researchers Find Microplastics in Caddisfly Casings From the 1970s

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Researchers Find Microplastics in Caddisfly Casings From the 1970s

An expert team of biologists practising at the Naturalis Biodiversity Centre, a research museum in the Netherlands, has recently discovered evidence of the incorporation of microplastics into caddisfly casings. However, what’s even more interesting is that the use of these microplastics for building the casings has been progressing from as far back as the 1970s. This breaks the traditional understanding of how far back the impact of microplastics goes. If the research is to be believed, microplastics began damaging the environment half a century ago.

What is a Caddisfly?

As per a study published in the journal Science of the Total Environment, this team of biologists exemplified the discovery of microplastics in larval casings at the museum. A caddisfly is a moth-like insect that is found near freshwater habitats like lakes and streams. These are found in most countries across the world. Caddisflies make their home near freshwater streams and deposit their eggs in the form of jelly. Once the larva hatches, cladissfly begin to incorporate materials from their surroundings to protect themselves from predators.

How was the Discovery made?

The discovery commenced when something colourful was witnessed on one larva casing by one of the team members of the biologists. Further investigation confirmed that the colourful component on the larva was microplastic. With this discovery, the biologists decided to observe the other 549 casings from their collection over several decades. As a result of their study, many casings were found to have microplastics on them.

To elaborate further, one of the casings from the year 1986 had multiple blue colored microplastics. Likewise, another casing, dated back to 1971, possessed yellow plastic.

The Researcher’s Perspective

Post-discovering microplastics on cladissfly casing, the researchers suggest that the contamination of the environment has been going on for at least half a century. Significantly, they have proposed the possibility of other species being impacted by the same.

The microplastics present on the casings are compromising the safety of claddisflies as they increase visibility, which raises the chances of getting noticed by the predators. Natural materials used in building casing are being dominated by these microplastics. These factors are putting these creatures at great risk of being found and eaten by fish and birds.

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