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Hundreds of children with a rare and severe form of epilepsy are hoping a new drug being rolled out on the NHS may provide a better quality of life.

Fenfluramine has been recommended by the National Institute for Health and Care Excellence (NICE) for patients aged two and over with Lennox-Gastaut syndrome (LGS).

LGS is a rare and severe form of epilepsy that starts in early childhood and is resistant to many treatments.

It is thought that between one and two percent of the 60,000 children in England with epilepsy have LGS.

Fenfluramine is the first non-cannabis-based treatment approved for LGS, according to NHS officials.

The drug is taken as an oral liquid medicine daily and works by increasing the levels of serotonin in the brain to reduce seizures.

Clinical trials suggest fenfluramine can cut the frequency of seizures that cause patients to lose consciousness and muscle control, known as drop seizures, by 26.5% on average.

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Previously, the only NICE-recommended treatment for LGS was the cannabidiol Epidyolex with the medication clobazam, which was approved in 2019.

Professor Stephen Powis, national medical director at NHS England said the latest recommendation offers patients and their families “new hope”.

“For children and families living with Lennox-Gastaut syndrome, every day can be challenging, facing unpredictable and life-limiting seizures, and this new treatment option on the NHS will now offer new hope, giving many the chance for greater stability and a better quality of life.

“It’s fantastic news for hundreds of families that there’s a proven, evidence-based new medicine that can be taken at home to help control and reduce their child’s seizures and, for example, lower the risk of them experiencing injuries and needing to go to hospital,” he said.

What is epilepsy?

Epilepsy is a condition that affects the brain and causes frequent seizures.

It can start at any age, but usually starts in childhood or in people over 60.

Seizures are bursts of electrical activity in the brain that temporarily affect how it works. They can cause a wide range of symptoms.

Symptoms include:

• uncontrollable jerking and shaking, known as a “fit”;

• losing awareness;

• becoming stiff;

• strange sensations, such as a “rising” feeling in the belly, unusual smells or tastes, and a tingling feeling in your limbs;

• collapsing.

Seizures can be triggered in numerous ways including flashing lights, sleep deprivation, misuse of drugs or missing medications.

The condition affects more than 600,000 people in the UK.

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NHS England is using its Innovative Medicines Fund to fast-track the treatment to eligible patients.

Helen Knight, director of medicines evaluation at NICE, added: “The often distressing and life-limiting nature of this very difficult-to-control epilepsy means that any new treatment options are particularly welcome.

“In recommending fenfluramine, the independent committee took into account the rarity and severity of Lennox Gastaut syndrome, the significant impact it has on the quality of life of people with the condition and their families and carers, and the high need for effective treatments, particularly for people who aren’t able to take cannabidiol with clobazam.”

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Jenny Hall: ‘Increasing concern’ for missing runner as major police search carried out

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Jenny Hall: 'Increasing concern' for missing runner as major police search carried out

A major police search is taking place for a runner who has been missing for three days – as officers say they are becoming “increasingly concerned”.

Jenny Hall, 23, was last seen leaving her home in Barracks Farm, Tow Law, County Durham, in her car just after 3pm on Tuesday.

In an update on Friday, Durham Constabulary said her last known location was on the B6278 between Stanhope and Eggleston – where her red Ford Focus was parked.

Jenny Hall. Pic: Durham Constabulary
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Pic: Durham Constabulary

Sniffer dogs are being used in the area, with the search concentrated on running trails between Eggleston and Hamsterley used regularly by Ms Hall.

Several expert mountain rescue search teams and air support have joined the operation.

More than 100 miles of track have been searched in the Teesdale area by officers, the rural community and local landowners.

Digital intelligence officers have also carried out extensive enquiries into Ms Hall’s mobile phone, smart watch and running apps, but the force said “none have yielded any results unfortunately”.

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Police focused on areas ‘Jenny likes to run through’

Chief Inspector Dean Haythornthwaite said in a statement: “We have become increasingly concerned for Jenny since she was reported missing on Tuesday and have been exploring all lines of enquiry, including dozens from members of the public.

“We are focusing our search on areas we know Jenny likes to run through and we are determined to do everything we can to find her.

“I would like to thank everyone who is working around-the-clock in our search and efforts to reunite Jenny with her family.”

Ms Hall is described as white and 6ft tall with dark brown hair.

She was last seen wearing a blue hoodie with a John Deere logo and dark jogging bottoms.

Her family told police she may have been carrying a green jacket and had her hair up in a ponytail.

Anyone who believes they may have seen Ms Hall or has any relevant information about her whereabouts is asked to contact police.

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Salman Rushdie attack: Hadi Matar found guilty of attempted murder after stabbing author multiple times on stage

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Salman Rushdie attack: Hadi Matar found guilty of attempted murder after stabbing author multiple times on stage

A man has been found guilty of attempted murder for attacking author Sir Salman Rushdie.

The 77-year-old British-American writer was stabbed multiple times as he was preparing to give a speech in New York in 2022.

He was blinded in his right eye in the incident, suffered a severely damaged hand, and spent months recovering.

Following a trial in Chautauqua County Court, a jury convicted 27-year-old Hadi Matar of attempting to murder Sir Salman, after less than two hours of deliberations.

He was also found guilty of assault for wounding Henry Reese, who was on stage with Sir Salman at the time.

Matar gave no obvious reaction to the verdict, and quietly muttered “free Palestine” as he was led out of the courtroom in handcuffs.

Hadi Matar charged with severely injuring author Salman Rushdie in a 2022 knife attack, speaks to his defence team in Chautauqua County court in Mayville.
Pic: AP
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Hadi Matar was found guilty by a jury after less than two hours of deliberations. Pic: AP

The court heard Matar ran on to the stage at the Chautauqua Institution where the author was about to speak on 12 August 2022, and stabbed him in front of an audience.

The Indian-born writer, who spent most of the 1990s in hiding in the UK after receiving death threats over his 1988 novel The Satanic Verses, was stabbed about 15 times.

Sir Salman was attacked in the head, neck, torso, and left hand. He also suffered damage to his liver and intestines.

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From 2024: Salman Rushdie recalls stabbing

‘I was dying’

During the trial, Sir Salman described the moment Matar attacked him and told the court: “I only saw him at the last minute.

“I was aware of someone wearing black clothes, or dark clothes and a black face mask. I was very struck by his eyes, which were dark and seemed very ferocious to me.

“I thought he was hitting me with his fist but I saw a large quantity of blood pouring onto my clothes.

“He was hitting me repeatedly. Hitting and slashing.”

The writer then said he felt “a sense of great pain and shock,” and added: “It occurred to me that I was dying. That was my predominant thought.”

The court also heard that Mr Reese, the co-founder of Pittsburgh’s City of Asylum, had suffered a gash to his forehead in the attack.

‘Attack was unprovoked’

During closing arguments earlier on Friday, District Attorney Jason Schmidt showed the jury a video of the attack and said: “I want you to look at the unprovoked nature of this attack.

“I want you to look at the targeted nature of the attack. There were a lot of people around that day but there was only one person who was targeted.”

Matar’s defence team argued prosecutors did not prove he intended to kill the writer, with Andrew Brautigan telling the jury: “You will agree something bad happened to Mr Rushdie, but you don’t know what Mr Matar’s conscious objective was.”

Mr Schmidt said that while it was not possible to read Matar’s mind, “it’s foreseeable that if you’re going to stab someone 10 or 15 times about the face and neck, it’s going to result in a fatality”.

The judge set a sentencing date of 23 April, when Matar could be jailed for up to 25 years.

Read more from Sky News:
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‘Severed hand’ found near school in Dublin

Matar faces a separate, federal indictment from prosecutors in the US attorney’s office in western New York alleging that he attempted to murder Sir Salman as an act of terrorism.

He is also accused of providing material support to the armed group Hezbollah in Lebanon, which the US has designated as a terrorist organisation.

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Miah brothers jailed for grooming and sexually abusing girls in Leeds and Barrow-in-Furness

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Miah brothers jailed for grooming and sexually abusing girls in Leeds and Barrow-in-Furness

Three brothers have been jailed after underage girls in Leeds and Barrow-in-Furness were sexually abused and raped over a number of years.

The trio were convicted in October last year, with the abuse taking place between 1996 and 2010.

Shaha Amran Miah, 49, known as Jai; Shaha Alman Miah, 47, known as Ali; and Shah Joman Miah, 38, known as Sarj all pleaded not guilty.

Sarj has since admitted his crimes. However, the judge said it could be a cynical attempt for leniency and did not give him any credit.

Shaha Amran Miah, Shaha Joman Miah and Shaha Alman Miah. Pic: Cumbria Police
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Shaha Amran Miah, Shaha Joman Miah and Shaha Alman Miah. Pic: Cumbria Police

They were sentenced on Friday to the following:

Shaha Amran Miah – life with a minimum term of 20 years and 338 days.

Shaha Alman Miah – 10 years in prison and four years on licence.

Shah Joman Miah – life with a minimum term of 21 years and 232 days.

Preston Crown Court heard Sarj and Jai regularly sexually abused two children at a Leeds mosque over many years, beginning when the victims were seven.

The three also preyed on vulnerable and underage girls at a flat above their family’s takeaway in Barrow, Cumbria, between 2008 and 2010.

They gave them cigarettes, alcohol, food and even hair extensions in what barrister Tim Evans KC called a “classic grooming technique”.

He said the brothers worked as a team and “created an environment in Barrow in which each of them could abuse young girls”.

Judge Unsworth KC said they had shattered the lives of their victims and hid in plain sight in the Cumbria town.

Multiple schoolgirls in their uniforms were regularly seen at the takeaway, the judge said, with Jai acting ruthlessly to stop them going to the police.

The court heard Sarj would take one of the girls to a hotel for sex about twice a month and became increasingly controlling – to the point she remains on medication and is terrified of seeing him in the street.

Read more from Sky News:
Woman who claimed to be Madeleine McCann charged with stalking
Boyfriend of murder victim Ashley Dale jailed in Liverpool

A witness told Sky News the men abused their victims in a dingy room above the takeaway that “looked like a crackhouse” and had mattresses on the floor and sheets covering the windows.

“They knew exactly how young they were,” she said. “They didn’t only have one girlfriend each… they had multiple.”

Shaha Amran Miah was found guilty of 16 sexual offences against three girls, including rape, as well as two charges of intimidation and one of kidnap.

Shaha Alman Miah was found guilty of three counts of sexual activity with a child.

Shah Joman Miah was convicted of sexually abusing three children. There were nine counts of rape of a child among his 40 offences.

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