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Thousands of men are to be checked for prostate cancer in one of the first large-scale European trials of smart screening.

The pilot study, starting next week in Ireland, will combine a blood test with personal risk factors and an MRI scan to increase the accuracy of screening men in their 50s and 60s.

Up to now health experts have rejected population screening in the belief that the benefits of earlier cancer detection were outweighed by the risks that some men could have unnecessary biopsies and risky treatment they don’t need.

But the PRAISE-U study is an attempt to save lives in a more targeted way, filtering out men who don’t have cancer at an early stage, so they don’t come to any harm.

David Galvin, the head of the study and a surgeon at the Mater Hospital in Dublin, told Sky News that a safe, effective screening strategy was urgently needed.

“There is a tsunami of elderly patients coming towards us,” he said.

“There’s going to be a sharp rise in prostate cancer unless we have a way to detect the disease early and not burden our health care services with vast numbers of scans and biopsies.”

David Galvin, consultant urologist at The Mater Hospital in Dublin
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David Galvin, consultant urologist at The Mater Hospital in Dublin

Thousands diagnosed too late

Prostate cancer is the most common cancer in men in Ireland. In the UK it is now the most common of all cancers, causing more deaths than breast cancer.

There are no symptoms in the early stages. Around 12,000 men a year in the UK alone are diagnosed too late to cure.

Studies have shown that a blood test for a prostate protein called PSA can diagnose cases at an earlier stage, reducing deaths by 40%.

But not all men with cancer have high levels of the PSA protein.

And conversely, high levels can also be caused by other prostate conditions, infections, exercise and sexual activity.

An example of a prostate tumour seen on a MRI scan
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An example of a prostate tumour seen on a MRI scan

The unreliability of the test has held back its use for screening.

But in the Irish pilot study, men will be scored by their PSA level and whether they have other risk factors such as black ethnicity or a family history.

Those at low risk will be retested in future.

Around half of the men will undergo a detailed MRI scan of their prostate to check for tumours – and only half those will then need a biopsy, in which a needle is inserted to extract cells for a precise diagnosis.

Professor Galvin said the multi-stage screening meant only those who really need a biopsy will have one.

“I worked out that if you have the PSA test, there’s about a 1 in 40 chance that you will ultimately need a biopsy.

“The other 39 men are reassured that testing is all normal and they don’t have any clinically significant disease.”

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‘I got away with it by the skin of my teeth’

The PRAISE-U study is backed by the European Association of Urology and funded by the EU.

Around 8,000 men in Waterford and two areas of Dublin will be randomly invited for screening over the next year.

Tony Ward, a rugby legend and one of the best number 10s to play for Ireland, was diagnosed with an aggressive prostate cancer just over a decade ago. Even now he needs daily treatment and regular scans.

He told Sky News screening to detect cancer at an earlier stage is desperately needed.

“It’s everything, it’s massive,” he said.

“I did not have the early diagnosis, but I got away with it by the skin of my teeth.”

Thomas Moore speaking to Tony Ward
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Thomas Moore speaking to Tony Ward

‘Very curable cancer kills 12,000 men every year’

The UK’s National Screening Committee, which advises the Department of Health, is reviewing the evidence on prostate cancer screening. But it’s already taken two years, and a decision still isn’t due until the end of 2025.

Chiara De Biase, director of health services, equity and improvement from Prostate Cancer UK, said men were dying unnecessarily as a result.

She said: “12,000 men die every year from what is – when caught in its earliest stages – a very, very curable cancer.

“We think the evidence [for screening] is there and we can’t see why this has taken so long.”

Chiara De Biase, from Prostate Cancer UK
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Chiara De Biase, director of health services, equity & improvement from Prostate Cancer UK

A spokesperson for the UK government’s Department of Health and Social Care said: “Prostate cancer patients are waiting too long for diagnosis and treatment, and we are determined to change that.

“Our National Cancer Plan will transform the way we treat cancer, making the UK a world leader in cancer survival by fighting the disease on all fronts, through improving research, diagnosis, screening, treatment and prevention.

“The UK National Screening Committee is reviewing the evidence for prostate cancer screening programmes, including targeted approaches for men at higher risk.”

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Jenny Hall: ‘Increasing concern’ for missing runner as major police search carried out

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Jenny Hall: 'Increasing concern' for missing runner as major police search carried out

A major police search is taking place for a runner who has been missing for three days – as officers say they are becoming “increasingly concerned”.

Jenny Hall, 23, was last seen leaving her home in Barracks Farm, Tow Law, County Durham, in her car just after 3pm on Tuesday.

In an update on Friday, Durham Constabulary said her last known location was on the B6278 between Stanhope and Eggleston – where her red Ford Focus was parked.

Jenny Hall. Pic: Durham Constabulary
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Pic: Durham Constabulary

Sniffer dogs are being used in the area, with the search concentrated on running trails between Eggleston and Hamsterley used regularly by Ms Hall.

Several expert mountain rescue search teams and air support have joined the operation.

More than 100 miles of track have been searched in the Teesdale area by officers, the rural community and local landowners.

Digital intelligence officers have also carried out extensive enquiries into Ms Hall’s mobile phone, smart watch and running apps, but the force said “none have yielded any results unfortunately”.

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Police focused on areas ‘Jenny likes to run through’

Chief Inspector Dean Haythornthwaite said in a statement: “We have become increasingly concerned for Jenny since she was reported missing on Tuesday and have been exploring all lines of enquiry, including dozens from members of the public.

“We are focusing our search on areas we know Jenny likes to run through and we are determined to do everything we can to find her.

“I would like to thank everyone who is working around-the-clock in our search and efforts to reunite Jenny with her family.”

Ms Hall is described as white and 6ft tall with dark brown hair.

She was last seen wearing a blue hoodie with a John Deere logo and dark jogging bottoms.

Her family told police she may have been carrying a green jacket and had her hair up in a ponytail.

Anyone who believes they may have seen Ms Hall or has any relevant information about her whereabouts is asked to contact police.

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Salman Rushdie attack: Hadi Matar found guilty of attempted murder after stabbing author multiple times on stage

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Salman Rushdie attack: Hadi Matar found guilty of attempted murder after stabbing author multiple times on stage

A man has been found guilty of attempted murder for attacking author Sir Salman Rushdie.

The 77-year-old British-American writer was stabbed multiple times as he was preparing to give a speech in New York in 2022.

He was blinded in his right eye in the incident, suffered a severely damaged hand, and spent months recovering.

Following a trial in Chautauqua County Court, a jury convicted 27-year-old Hadi Matar of attempting to murder Sir Salman, after less than two hours of deliberations.

He was also found guilty of assault for wounding Henry Reese, who was on stage with Sir Salman at the time.

Matar gave no obvious reaction to the verdict, and quietly muttered “free Palestine” as he was led out of the courtroom in handcuffs.

Hadi Matar charged with severely injuring author Salman Rushdie in a 2022 knife attack, speaks to his defence team in Chautauqua County court in Mayville.
Pic: AP
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Hadi Matar was found guilty by a jury after less than two hours of deliberations. Pic: AP

The court heard Matar ran on to the stage at the Chautauqua Institution where the author was about to speak on 12 August 2022, and stabbed him in front of an audience.

The Indian-born writer, who spent most of the 1990s in hiding in the UK after receiving death threats over his 1988 novel The Satanic Verses, was stabbed about 15 times.

Sir Salman was attacked in the head, neck, torso, and left hand. He also suffered damage to his liver and intestines.

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From 2024: Salman Rushdie recalls stabbing

‘I was dying’

During the trial, Sir Salman described the moment Matar attacked him and told the court: “I only saw him at the last minute.

“I was aware of someone wearing black clothes, or dark clothes and a black face mask. I was very struck by his eyes, which were dark and seemed very ferocious to me.

“I thought he was hitting me with his fist but I saw a large quantity of blood pouring onto my clothes.

“He was hitting me repeatedly. Hitting and slashing.”

The writer then said he felt “a sense of great pain and shock,” and added: “It occurred to me that I was dying. That was my predominant thought.”

The court also heard that Mr Reese, the co-founder of Pittsburgh’s City of Asylum, had suffered a gash to his forehead in the attack.

‘Attack was unprovoked’

During closing arguments earlier on Friday, District Attorney Jason Schmidt showed the jury a video of the attack and said: “I want you to look at the unprovoked nature of this attack.

“I want you to look at the targeted nature of the attack. There were a lot of people around that day but there was only one person who was targeted.”

Matar’s defence team argued prosecutors did not prove he intended to kill the writer, with Andrew Brautigan telling the jury: “You will agree something bad happened to Mr Rushdie, but you don’t know what Mr Matar’s conscious objective was.”

Mr Schmidt said that while it was not possible to read Matar’s mind, “it’s foreseeable that if you’re going to stab someone 10 or 15 times about the face and neck, it’s going to result in a fatality”.

The judge set a sentencing date of 23 April, when Matar could be jailed for up to 25 years.

Read more from Sky News:
Pope ‘not out of danger,’ doctors say
‘Severed hand’ found near school in Dublin

Matar faces a separate, federal indictment from prosecutors in the US attorney’s office in western New York alleging that he attempted to murder Sir Salman as an act of terrorism.

He is also accused of providing material support to the armed group Hezbollah in Lebanon, which the US has designated as a terrorist organisation.

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Miah brothers jailed for grooming and sexually abusing girls in Leeds and Barrow-in-Furness

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Miah brothers jailed for grooming and sexually abusing girls in Leeds and Barrow-in-Furness

Three brothers have been jailed after underage girls in Leeds and Barrow-in-Furness were sexually abused and raped over a number of years.

The trio were convicted in October last year, with the abuse taking place between 1996 and 2010.

Shaha Amran Miah, 49, known as Jai; Shaha Alman Miah, 47, known as Ali; and Shah Joman Miah, 38, known as Sarj all pleaded not guilty.

Sarj has since admitted his crimes. However, the judge said it could be a cynical attempt for leniency and did not give him any credit.

Shaha Amran Miah, Shaha Joman Miah and Shaha Alman Miah. Pic: Cumbria Police
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Shaha Amran Miah, Shaha Joman Miah and Shaha Alman Miah. Pic: Cumbria Police

They were sentenced on Friday to the following:

Shaha Amran Miah – life with a minimum term of 20 years and 338 days.

Shaha Alman Miah – 10 years in prison and four years on licence.

Shah Joman Miah – life with a minimum term of 21 years and 232 days.

Preston Crown Court heard Sarj and Jai regularly sexually abused two children at a Leeds mosque over many years, beginning when the victims were seven.

The three also preyed on vulnerable and underage girls at a flat above their family’s takeaway in Barrow, Cumbria, between 2008 and 2010.

They gave them cigarettes, alcohol, food and even hair extensions in what barrister Tim Evans KC called a “classic grooming technique”.

He said the brothers worked as a team and “created an environment in Barrow in which each of them could abuse young girls”.

Judge Unsworth KC said they had shattered the lives of their victims and hid in plain sight in the Cumbria town.

Multiple schoolgirls in their uniforms were regularly seen at the takeaway, the judge said, with Jai acting ruthlessly to stop them going to the police.

The court heard Sarj would take one of the girls to a hotel for sex about twice a month and became increasingly controlling – to the point she remains on medication and is terrified of seeing him in the street.

Read more from Sky News:
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Boyfriend of murder victim Ashley Dale jailed in Liverpool

A witness told Sky News the men abused their victims in a dingy room above the takeaway that “looked like a crackhouse” and had mattresses on the floor and sheets covering the windows.

“They knew exactly how young they were,” she said. “They didn’t only have one girlfriend each… they had multiple.”

Shaha Amran Miah was found guilty of 16 sexual offences against three girls, including rape, as well as two charges of intimidation and one of kidnap.

Shaha Alman Miah was found guilty of three counts of sexual activity with a child.

Shah Joman Miah was convicted of sexually abusing three children. There were nine counts of rape of a child among his 40 offences.

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