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The head of NHS England has announced she is standing down.

Amanda Pritchard was the first woman to take on the role in 2021, having previously served as NHS England’s chief operating officer, and before that, the former head of Guy’s and St Thomas’ NHS Foundation Trust.

Her decision to step down comes weeks after MPs on the cross-party Commons public accounts and health and social care committees accused her of lacking the “drive and dynamism” to radically reform the service.

It has been a “hugely difficult decision for me to stand down”, she said in a statement on Tuesday.

“I believe now is the right time – with the NHS making continued progress in our recovery, and with the foundations firmly in place to deliver the 10 Year Health Plan.”

She said it had been “an enormous privilege to lead the NHS in England through what has undoubtedly been the most difficult period in its history”.

“The NHS is full of extraordinary people, who do extraordinary things every day for patients,” she said, adding: “I am confident they will continue to achieve incredible things for patients now, and into the future.”

Ms Pritchard giving evidence to MPs earlier this month. Pic: PA
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Ms Pritchard giving evidence to MPs in the House of Commons earlier this month. Pic: PA

MPs on the health and social care committee earlier this month said they were disappointed and frustrated by the “lengthy and diffuse answers” Ms Pritchard and other officials gave them under questioning.

Last week, she admitted “we’re not all brilliant performers at committee hearings” as she was challenged on the issue on BBC Breakfast.

Health Secretary Wes Streeting said Ms Pritchard could be “enormously proud” of her tenure.

He said: “Amanda can be enormously proud of the leadership she has given in the face of the biggest health emergency for our country in modern history, as well as steering NHS England during turbulent political waters and six secretaries of state in her time as chief executive.

“She has led with integrity and unwavering commitment.”

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NHS England said that having discussed everything with Mr Streeting in recent months – and now that the NHS has “turned a corner on recovery from the pandemic and the foundations are in place to make the necessary changes to the centre to best support the wider NHS” – Ms Pritchard had “decided now is the right time to stand down”.

Sir James Mackey will take over as “transition” chief executive from the first of April on a secondment basis, it said.

He is the chief executive of Newcastle Hospitals Foundation Trust and national director of elective recovery.

Ms Pritchard, who is married with three children and studied modern history at St Anne’s College, Oxford, was also deputy chief executive at Chelsea and Westminster NHS Foundation Trust.

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Prediction markets bet on Coinbase-linked Hassett as top Fed pick

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Prediction markets bet on Coinbase-linked Hassett as top Fed pick

Prediction markets Polymarket and Kalshi view Kevin Hassett, US President Donald Trump’s National Economic Council director, as the favorite to replace Jerome Powell as the next Federal Reserve chair.

The odds of Hassett filling the seat have spiked to 66% on Polymarket and 74% on Kalshi at the time of writing. Hassett is widely viewed as crypto‑friendly thanks to his past role on Coinbase’s advisory council, a disclosed seven‑figure stake in the exchange and his leadership of the White House digital asset working group.​

Founder and CEO of Wyoming-based Custodia Bank, and a prominent advocate for crypto-friendly regulations, Caitlin Long, commented on X:

“If this comes true & Hassett does become Fed chairman, anti-#crypto people at the Fed who still hold positions of power will finally be out (well, most of them anyway). BIG changes will be coming to the Fed.”

Source: Polymarket Money

Related: Crypto-friendly Trump adviser Hassett top pick for Fed chair: Report

Kevin Hassett’s crypto credentials

Hassett is a long-time Republican policy economist who returned to Washington as Trump’s top economic adviser and has now emerged as the market-implied frontrunner to lead the Fed.

His financial disclosure reveals at least a seven‑figure Coinbase stake and compensation for serving on the exchange’s Academic and Regulatory Advisory Council, placing him unusually close to the crypto industry for a potential Fed chair.​

Still, crypto has been burned before by reading too much into “crypto‑literate” resumes. Gary Gensler arrived at the Securities and Exchange Commission with MIT blockchain courses under his belt, but went on to preside over a wave of high‑profile enforcement actions, some of which critics branded as “Operation Chokepoint 2.0.”

A Hassett-led Fed might be more open to experimentation and less reflexively hostile to bank‑crypto activity. Still, the institution’s mandate on financial stability means markets should not assume a one‑way bet on deregulation.​

Related: Caitlin Long’s crypto bank loses appeal over Fed master account

Supervision pushback inside the Fed

The Hassett odds have jumped just as the Fed’s own approach to bank supervision has received pushback from veterans like Fed Governor Michael Barr, who earned his reputation as one of Operation Chokepoint 2.0’s key architects.

According to Caitlin Long, while he Barr “was Vice Chairman of Supervision & Regulation he did Warren’s bidding,” and he “has made it clear he will oppose changes made by Trump & his appointees.”

On Nov. 18, the Fed released new Supervisory Operating Principles that shift examiners toward a “risk‑first” framework, directing staff to focus on material safety‑and‑soundness risks rather than procedural or documentation issues.

In a speech the same day, Barr warned that narrowing oversight, weakening ratings frameworks and making it harder to issue enforcement actions or matters requiring attention could leave supervisors slower to act on emerging risks, arguing that gutting those tools may repeat pre‑crisis mistakes.​

Days later, in Consumer Affairs Letter 25‑1, the Fed clarified that the new Supervisory Operating Principles do not apply to its Consumer Affairs supervision program (an area under Barr’s committee as a governor).

If prediction markets are right and a crypto‑friendly Hassett inherits this landscape, his Fed would not be writing on a blank slate but stepping into an institution already mid‑pivot on how hard (and where) it leans on banks.