Mangione has not yet been asked to enter a plea to the federal charges.
Here’s what we know about him.
Wealth, private school and Ivy League education
Mangione was born and raised in Maryland and has links to San Francisco and Hawaii.
His social media lists him as being from Towson, a well-to-do area to the north of the city of Baltimore.
He is the grandson of a wealthy property developer and philanthropist and the cousin of a current Maryland state legislator.
He attended Gilman School – a private all-boys school in Baltimore. The school’s annual fees are up to $37,690 (around £29,000) and it boasts alumni including NFL stars and former senators.
After graduating in 2016, Mangione went to the University of Pennsylvania, one of America’s elite Ivy League schools.
According to his social media, he studied computer science and launched a group named UPGRADE (UPenn Game Research and Development Environment).
A university spokesperson said he earned undergraduate and graduate degrees there.
He later co-founded his own computer game company, which focused on small, simplistic games.
Image: Mangione went to a prestigious Ivy League university. Pic: LinkedIn
‘No complaints – a great guy’
According to his LinkedIn page, Mangione moved to California in 2020 and worked for the car-buying website TrueCar. The firm’s boss said he left last year.
Mangione currently lists himself as from Honolulu on LinkedIn, with pictures on Instagram showing him on the Hawaiian island.
In the first half of 2022, he reportedly lived at Surfbreak, a co-living space aimed at remote workers in Honolulu’s Waikiki neighbourhood.
“Luigi was just widely considered to be a great guy. There were no complaints,” Josiah Ryan, a spokesperson for Surfbreak’s owner, told the AP news agency.
“There was no sign that might point to these alleged crimes they’re saying he committed.”
Mr Ryan said Mangione left to get surgery on the US mainland for chronic back pain he suffered from since childhood.
Document reveals back condition
Mangione wrote about his health issue online, saying he has spondylolisthesis – a condition where one of the bones in the spine slips forwards.
He details the severity of his “injury” as “low grade two” and goes into fitness goals, diet advice and notes about the condition.
Image: The suspect’s notes say he has back condition spondylolisthesis
Image: His X banner image shows a back X-ray
It’s unclear if the condition is linked to the motive, which police have not publicly identified, but it gives context about his health issues.
Analysis of his Goodreads profile also shows he read books including Crooked: Outwitting The Back Pain Industry and Getting On The Road To Recovery, and Why We Get Sick: The Hidden Epidemic At The Root Of Most Chronic Disease – And How To Fight It.
A banner image on his X account also features an X-ray of a lower back with screws.
Law enforcement officials told NBC News they are looking at whether the X-ray is Mangione’s or from a relative and whether it’s connected to the shooting.
‘Violence is necessary to survive’
Mangione appears to have had an active social media presence.
His X account regularly shared and reposted pieces about topics such as artificial intelligence (AI), philosophy, and the future of humanity.
His Goodreads account also gave a four-star review to Industrial Society And Its Future – by notorious US terrorist Theodore Kaczynski.
The piece, which rails against technological advancement, became known as the Unabomber Manifesto after its author began a mail bombing campaign which lasted nearly 20 years.
Three people were killed and dozens were injured before Kaczynski’s arrest in 1996.
The Goodreads review said: “When all other forms of communication fail, violence is necessary to survive. You may not like his methods, but to see things from his perspective, it’s not terrorism, it’s war and revolution.
“‘Violence never solved anything’ is a statement uttered by cowards and predators.”
Image: Luigi Mangione. Pic: Facebook
Why are some calling Mangione a ‘hero’?
A search of social media sites such as Reddit reveals a thread of people who are sympathetic to the suspect.
Highly rated comments on the site include: “Screw the McDonald’s employee that ratted him out” and “Only a matter of time till shirts with #FreeLuigi start popping up”.
To many, these are shocking comments about someone accused of carrying out a cold-blooded killing. But what’s behind them?
Many in the US pay thousands in expensive insurance premiums to cover themselves and their family, while others rely on the Medicare federal insurance programme.
Support for Mangione appears to come from resentment over this and accusations that companies go to great lengths to avoid paying for treatments in order to maximise their profits.
“He got charged with murder quicker than insurance companies deny claims”, said a comment on Reddit with nearly 7,000 likes.
One post that went viral on X before the suspect’s arrest was from Anthony Zenkus, a Columbia University professor.
He wrote: “We mourn the deaths of the 68,000 Americans who needlessly die each year so that insurance company execs like Brian Thompson can become multimillionaires.”
Image: Police shared this picture of the suspect following the shooting. Pic: NYPD
A chart shared widely on X claims to show denial rates by UnitedHealthcare exceed those of competitors, using data from consumer finance website ValuePenguin. This is consistent with publicly available data from 2023 analysed by Sky News.
Other people online appear to be angry about what they say is the disparity between the resources put into Mr Thompson’s case and how less well-off people are treated.
One comment on Reddit with 4,000 likes says: “The murdered guy in death, like in life, is still sucking up a huge undeserved and unwanted portion of resources.
“How many underprivileged people’s murders are going unsolved because NYPD and the feds are spending millions on this overpaid, rich, morally questionable millionaire’s murder.”
Arrested in McDonald’s with ‘ghost gun’
Mangione was detained in a Pennsylvania McDonald’s after a five-day search, carrying a gun that matched the one used in the shooting and a fake ID, police said.
He was arrested in Altoona, around 230 miles (370km) west of New York, after a tip-off from a McDonald’s employee who recognised him from the police appeals.
Mangione also had a fake New Jersey ID matching one used by the suspect to check into a hostel before the killing, said New York police commissioner Jessica Tisch.
He was found carrying a “handwritten document” that Ms Tisch said “spoke to both his motivation and mindset”.
Joseph Kenny, New York’s chief of detectives, said it appeared to show “some ill-will towards corporate America”.
Pennsylvania prosecutor Peter Weeks said Mangione was found with a passport and $10,000 (£7,840) – $2,000 of it in foreign currency.
‘Message’ on bullets
Brian Thompson, 50, was chief executive of UnitedHealthcare – the fourth-largest public company in the US behind Walmart, Amazon, and Apple – and was paid about $10m (£7.8m) a year.
It’s the largest provider of Medicare Advantage plans and manages insurance for employers and state and federally funded programmes.
Mr Thompson – who was married with two sons – was shot on 4 December as he was walking to a New York hotel where his company was holding an investors’ conference.
Image: CCTV showed a person shooting Mr Thompson from behind. Pic: NYPD/Reuters
As Mr Thompson walked towards the Hilton hotel on Sixth Avenue, a gunman appeared behind him from between parked cars.
He was shot in the back and calf and died from his injuries.
The words “defend”, “deny”, and “depose” were written on the cases of bullets found at the scene – similar to the title of a book that criticises health insurance companies.
Mr Thompson’s wife said he was an “incredibly loving father to our two sons” and a “loving, generous, talented man who truly lived life to the fullest”.
UnitedHealthcare called him a “highly respected colleague and friend to all who worked with him”.
Venezuela’s President Nicolas Maduro has accused the US of a coup attempt after Donald Trump approved CIA operations in the country to tackle alleged drug trafficking.
Mr Trump confirmed his decision, first revealed by The New York Times, as he said large amounts of drugs were entering the US from Venezuela– much of it trafficked by sea.
“We are looking at land now, because we’ve got the sea very well under control,” he said.
When asked why the coastguard wasn’t asked to intercept suspected drug trafficking boats, which has been a longstanding US practice, Mr Trump said the approach had been ineffective.
“I think Venezuela is feeling heat,” he said.
Image: Donald Trump at the White House on Wednesday evening. Pic: Reuters
Maduro hits back
He declined to answer whether the CIA has the authority to execute Mr Maduro, who denies accusations from Washington that he has connections to drug trafficking and organised crime.
The US has offered a $50m (£37m) reward for information leading to his arrest.
“How long will the CIA continue to carry on with its coups?” he asked after Mr Trump’s comments on Wednesday evening, saying calls for regime change harkened back to “failed eternal wars” in Afghanistan and Iraq.
In a message to the American people, he said in English: “Not war, yes peace. The people of the US, please.”
Image: President Nicolas Maduro. Pic: Reuters
US targets ‘drug boats’
Mr Trump also alleged Venezuela had sent a significant number of prisoners, including individuals from mental health facilities, into the US, though he did not specify the border through which they reportedly entered.
On Tuesday, he announced America had targeted a small boat suspected of drug trafficking in waters off the Venezuelan coast, resulting in the deaths of six people.
According to the president’s post on social media, all those killed were aboard the vessel.
Image: Footage of the strike was released by Donald Trump on social media. Pic: Truth Social
The incident marked the fifth such fatal strike in the Caribbean, as the Trump administration continues to classify suspected drug traffickers as unlawful combatants to be confronted with military force.
War secretary Pete Hegseth authorised the strike, according to Mr Trump, who released a video of the operation.
The black-and-white footage showed a small boat seemingly stationary on the water. It is struck by a projectile from above and explodes, then drifts while burning for several seconds.
Mr Trump said the “lethal kinetic strike” was in international waters and targeted a boat travelling along a well-known smuggling route.
There has also been a significant increase in US military presence in the southern Caribbean, with at least eight warships, a submarine, and F-35 jets stationed in Puerto Rico.
‘Bomb the boats’: Bold move or dangerous overreach?
It’s a dramatic – and risky – escalation of US strategy for countering narcotics.
Having carried out strikes on Venezuelan “drug boats” at sea, Trump says he’s “looking a” targeting cartels on land.
He claims the attacks, which have claimed 27 lives, have saved up to 50,000 Americans.
By framing bombings as a blow against “narcoterrorists”, he’s attempting to justify them as self-defence – but the administration has veered into murky territory.
Under international law, such strikes require proof of imminent threat – something the White House has yet to substantiate.
Strategically, Trump’ss militarised approach could backfire, forcing traffickers to adapt, and inflaming tensions with Venezuela and allies wary of US intervention.
Without transparent evidence or congressional oversight, some will view the move less like counterterrorism and more like vigilantism on the seas.
The president’s “bomb the boats” rhetoric signals a shift back to shock and awe tactics in foreign policy, under the banner of fighting drugs.
Supporters will hail it as a bold, decisive move, but to critics it’s reckless posturing that undermines international law.
The strikes send a message of strength, but the legal, moral and geopolitical costs are still being calculated.
A 39-year-old man died in hospital alone, miles from his family, after being detained by US immigration officials.
Ismael Ayala-Uribe, who had lived in the US since he was four, fell ill while in an immigration detention centre in California.
Image: Ismael Ayala-Uribe was well known in the local Latino community
He complained of a fever and had a persistent cough in the weeks before he died, according to his mother Lucia.
She said he was initially treated by medical staff inside the detention centre but was returned to his cell.
He was eventually taken to hospital for a scheduled surgery to remove an abscess on his buttocks, but died before he was able to have the operation.
His family were never told he was in hospital, learning of his death via a knock on the door from police.
“They’re the ones that notified us that he had passed,” his brother, Jose Ayala, told Sky News.
“We were not even aware that he was in the hospital or even had a scheduled surgery. Then we got a knock on our door a little after 5.30 one morning.
“I believe he would still be alive today if he was never detained. He got sick while in detention, and they did not seem to take care of him.”
Image: Ismael’s brother Jose speaks to Sky News
Why was he detained?
Mr Ayala-Uribe’s death raises questions about the conditions inside the centre he was held in, and if a sudden surge of immigrants being detained by this administration has left the system stretched beyond breaking point.
He had moved to the US from Mexico with his family as a child.
He did have DACA – deferred action for childhood arrivals – status, granted to those who have arrived while under the age of 18. But this was removed in 2016, after he was convicted of drink-driving.
In August, he was arrested by immigration agents at a car wash in California where he had worked for 15 years.
He was held for five weeks at Adelanto, a privately owned, run-for-profit, immigrant detention centre. A lawyer for his family said he was, as far as they are aware, a healthy man before he was detained and had no medical need.
But Mr Ayala-Uribe’s mother, who was visiting him every eight days and speaking to him on the phone a couple of times a day, said she noticed him getting progressively unwell.
Image: Ismael’s brother and mother, Lucia
“He started with lots of fever,” Ms Ayala said. “He said they weren’t listening to him. The last time I saw him his face was drained, he told me he was not OK, he told me he couldn’t take it any more.”
Beginning to cry, wiping away tears, she added: “I feel powerless that I couldn’t do anything to help my son.
“I never imagined I was going to bury one of my sons. It feels terrible, they took a piece of my heart away.
“I would like something to change. If we cannot save him, at least we can save others that are still inside.”
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6:34
Inside Trump’s immigration raids
ICE defends detention treatment
The cause of Mr Ayala-Uribe’s death is still under investigation.
Sky News requested comment from the company which owns the detention centre where he was held, and they deferred to ICE, the US immigration and customs enforcement agency.
In a statement, ICE said: “Comprehensive medical care is provided from the moment individuals arrive and throughout the entirety of their stay.
“At no time during detention is a detained illegal alien denied emergency care.”
The Trump administration says it’s targeting criminals and people in the US illegally. But campaigners say Mr Ayala-Uribe’s death should not be viewed in isolation.
Image: Images from Ismael’s funeral service
Since Donald Trump took office, at least 15 people have died in immigration detention.
Democrat senators Jon Ossoff and Raphael Warnock wrote a letter to the homeland security secretary, Kristi Noem, asking for more information about these deaths.
The senators claimed 10 people had died between January and June, and that it was the highest rate in the first six months of any year publicly available.
Sarah Houston, a lawyer for the Immigrant Defenders Law Centre, claims immigrants are being mistreated in custody.
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4:48
ICE raids: ‘This is like Vietnam’
“This administration’s main goal is to harm, to torture individuals and to try to force them out,” she said.
“The great increase we see in human rights abuses, in deaths, is a direct result of the administration’s decision to pack these detention centres as much as they can.”
Mr Ayala-Uribe’s funeral was held this week. Dozens of extended family and friends wore t-shirts bearing his face. A mariachi band played as his casket was lowered into the ground and his mother heaved with sobs.
As they absorb their loss, the effort to carry out the biggest mass deportation operation in US history continues.
An aircraft carrying US defence secretary Pete Hegseth has had to make an “unscheduled landing” in the UK.
The jet was about 30 minutes into its journey back to the US after a NATO defence ministers’ meeting in Brussels, when it suffered a “depressurisation issue”.
Sean Parnell, chief Pentagon spokesman, confirmed the aircraft had been diverted to the UK due to a crack in the aircraft windscreen.
He posted on X: “On the way back to the United States from NATO’s Defence Ministers meeting, Secretary of War Hegseth’s plane made an unscheduled landing in the United Kingdom due to a crack in the aircraft windshield.
“The plane landed based on standard procedures, and everyone onboard, including Secretary Hegseth, is safe.”
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The aviation news website Airlive reported the Boeing C-32A – a military version of the Boeing 757 – had a “depressurisation issue”.
It went on to land at RAF Mildenhall in Suffolk at about 7.10pm.
Mr Hegseth had been at a meeting of NATO defence ministers which was also attended by UK Defence Secretary John Healey.
In February, a US Air Force plane carrying secretary of state Marco Rubio and the Senate foreign relations committee chairman, Senator Jim Risch, was similarly forced to return to Washington DC after an issue with the cockpit windscreen.