Scientists Revive Dire Wolves Using Ancient DNA and Modern Gene Editing
Three live dire wolf pups have been born using reconstructed DNA. The extinct species had last roamed North America around 12,500 years ago. The milestone was reached by a Dallas-based biotech firm that focuses on genetic conservation. Ancient DNA samples from fossilised remains were analysed. Modern gene-editing tools were used to mimic key characteristics of the extinct predator. These pups were brought to life by implanting modified embryos into domestic dog surrogates. The young wolves have been named Romulus, Remus and Khaleesi.
Ancient DNA edited in lab to recreate species
According to a study shared by Colossal Biosciences, DNA samples had been collected from two ancient dire wolf fossils. One was a 13,000-year-old tooth, while the other was a 72,000-year-old skull fragment. These fragments were compared to modern wolf relatives and grey wolves were chosen for DNA alteration because of their evolutionary proximity. Gene sequences that were found only in dire wolves were isolated. These were introduced into the DNA of grey wolves through targeted editing.
Cloning technique used to implant embryos
The altered genetic material was inserted into grey wolf egg cells after removing their original nuclei. These prepared cells were placed inside domestic dogs. Each surrogate received multiple embryos. Interestingly, only one embryo survived in each of the first two dogs. Both gave birth by caesarean section, while the third pup was born in a second round of implantation.
Physical traits match fossil record
The new pups have been observed to develop features consistent with known dire wolf fossils. Thick white coats, larger teeth and body structure have been reported. These results came from identifying changes in 14 genes. The gene edits were introduced using CRISPR technology.
The same company had previously cloned red wolves. The team had also created “woolly mice” as part of a mammoth revival effort. The successful dire wolf birth marks a new phase in gene-driven species restoration.
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The scientists have found methane in the atmosphere of WISEA J181006.18 −101000.5, the T dwarf closest to Earth. The study was published in the online preprint journal arXiv on March 28, and the final, revised version was published on November 17. The WISE1810 is a metal-poor T dwarf planet, which is situated at a distance of 29 light years from the Earth. The effective temperature of the dwarf is reported to be within the range of 800–1,300 K.
Methane Signature Surprises Astronomers
According to a Phys.org report, the finding is made greatly possible by the present 10.4-m Gran Telescopio Canarias (GTC). The detection of methane in the atmosphere of the dwarf planet has further made its classification as T-type instead of L-type, which was earlier suggested in previous studies, the publication notes. The study further reveal that there are no traces of carbon monoxide and potassium in the atmosphere of the WISE1810.
The study further highlights that the carbon abundance in the planet is estimated to be -1.5 dex, while the effective temperature could be around 1,000 K. The author of the paper further revealed that the low metallicity of the T dwarf planet could be due to the non-detection of atomic potassium. However, a lower temperature could also boost this effect, the report further highlights. The study also found that WISE1810 has a heliocentric velocity of -83 km/s.
The 10.4-m Gran Telescopio Canarias (GTC) supplies a significant contribution to finishing WISEA J181006.18−101000 observations. Interestingly, the previous observations of the dwarf platent suggested that the atmosphere of the dwarf planet was dominated by hydrogen and water vapour. Moreover, the study further reveals that findings indicates WISE1810 could more likely to be associated with the Milky Way’s thick disk, despite its very low metallicity.
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An underground structure beneath central United States has been observed dragging surface materials deep into the Earth. This movement has been linked to an old piece of crust lodged far below the Midwest. Researchers have said this action is pulling rocks from across the continent towards a funnel-shaped region. It is believed this process is causing parts of the crust to thin as material is drawn downward. This phenomenon has been found to affect areas beyond the immediate region.
Underground slab tied to crust loss beneath Midwest
According to the study published in Nature Geoscience, the phenomenon has been tied to the remains of a long-subducted tectonic plate known as the Farallon slab. This slab, which sits around 660 kilometres below the surface, was identified as the driving force behind what scientists refer to as cratonic thinning. Cratons are known to be the stable core regions of continental crust and upper mantle that usually do not undergo change.
The seismic mapping project was led by Junlin Hua during his postdoctoral work at The University of Texas at Austin. He now serves as a professor at the University of Science and Technology of China. In a statement, Hua explained that a wide region is showing signs of thinning. He stated that the study has brought forward a new explanation behind this change.
New seismic method uncovers ‘dripping’ lithosphere
To observe the changes taking place beneath North America, researchers used a method known as full-waveform inversion. This seismic imaging approach allowed them to map the subsurface in high detail. According to Thorsten Becker, Geophysics Chair at UT Austin, this technique offered a better understanding of the link between deep mantle regions and the lithosphere above.
Computer simulations were used to confirm the effect. When the slab was included, the downward movement was visible. When removed, no such feature appeared.
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