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A combination of targeted drugs, offering a chemotherapy-free approach to leukaemia, have been hailed a “milestone” in cancer care by scientists following a groundbreaking UK trial.

Potentially offering better outcomes for some patients as well as being more tolerable, it could reshape the way chronic lymphocytic leukaemia (CLL) – the most common form of leukaemia in adults – is treated.

The Flair trial took place at 96 cancer centres across the UK.

Researchers from Leeds wanted to assess whether two targeted cancer drugs could perform better than standard chemotherapy among patients with CLL.

Some 786 people with previously untreated CLL were randomly assigned to receive standard chemotherapy; a single targeted drug, ibrutinib, or two targeted drugs taken together, ibrutinib and venetoclax, with treatment guided by personalised blood tests.

Ibrutinib is a type of drug known as a cancer growth blocker. It works by stopping signals that cancer cells use to divide and grow.

Venetoclax blocks the functions of a protein found in CLL cells.

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Researchers found that after five years, 94% of patients who received ibrutinib plus venetoclax were alive with no disease progression.

That compared with 79% for those on ibrutinib alone and 58% for those on standard chemotherapy, according to the study, which has been published in the New England Journal of Medicine and presented to the European Haematology Association congress in Milan, Italy.

Meanwhile 66% of patients on the new combination had no detectable cancer in their bone marrow after two years, compared with none of the people who received ibrutinib alone and 48% on chemotherapy.

Experts said that the new treatment regime was also tolerated better than traditional treatments.

‘An era of truly personalised medicine’

Dr Talha Munir, consultant haematologist at Leeds Teaching Hospitals NHS Trust, who led the study said: “Flair trial is a milestone.

“We have shown that a chemotherapy-free approach can be not only more effective but also more tolerable for patients.

“By tailoring individualised treatment based on how well the cancer responds, we’re moving into an era of truly personalised medicine.”

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Catherine Whitfield, 63, from Farnley, West Yorkshire, was diagnosed with CLL in 2018 after she noticed symptoms including bleeding gums, constant illness and neck pain.

She signed up to the trial, which was coordinated by the Leeds Cancer Research UK Clinical Trials Unit at the University of Leeds and sponsored by the University of Leeds.

She said: “After three years of treatment, I am still MRD negative – that means no cancer cells.

“I lost my husband to cancer. I have seen how hard it could be.

“My first thought after my diagnosis was, I will never see my grandchildren being born and growing up.

“Now I have two grandchildren, Drew and Alaia, and they are a delight and highlight the joys of a healthy life.”

‘Kinder, more targeted treatment’

Ms Whitfield added: “The way this trial was explained, it just made sense.

“Also, the thought of chemotherapy was scary to me. The trial felt right. And it was.”

Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, which funded the trial along with AbbVie, and Johnson and Johnson, said: “The results of the Flair trial show that we can provide kinder, more targeted treatment for chronic lymphocytic leukaemia, which gives people with CLL more precious time with their loved ones.

“We’re hopeful that the results of the Flair trial will power new treatment options for leukaemia and other blood cancers, thanks to the efforts of researchers in Leeds and across the UK working together on this trial.”

CLL is the most common form of leukaemia in adults, affecting the blood and bone marrow.

While it cannot usually be cured, it can be managed with treatment.

There are around 4,000 new CLL cases in the UK every year.

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Budget 2025: Reeves urged to ‘make the case’ for income tax freeze – as PM hits out at defenders of ‘failed’ policy

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Budget 2025: Reeves urged to 'make the case' for income tax freeze - as PM hits out at defenders of 'failed' policy

Rachel Reeves needs to “make the case” to voters that extending the freeze on personal income thresholds was the “fairest” way to increase taxes, Baroness Harriet Harman has said.

Speaking to Sky News political editor Beth Rigby on the Electoral Dysfunction podcast, the Labour peer said the chancellor needed to explain that her decision would “protect people’s cost of living if they’re on low incomes”.

In her budget on Wednesday, Ms Reeves extended the freeze on income tax thresholds – introduced by the Conservatives in 2021 and due to expire in 2028 – by three years.

The move – described by critics as a “stealth tax” – is estimated to raise £8bn for the exchequer in 2029-2030 by dragging some 1.7 million people into a higher tax band as their pay goes up.

Rachel Reeves, pictured the day after delivering the budget. Pic: PA
Image:
Rachel Reeves, pictured the day after delivering the budget. Pic: PA

The chancellor previously said she would not freeze thresholds as it would “hurt working people” – prompting accusations she has broken the trust of voters.

During the general election campaign, Labour promised not to increase VAT, national insurance or income tax rates.

Sir Keir Starmer has insisted there’s been no manifesto breach, but acknowledged people were being asked to “contribute” to protect public services.

He has also launched a staunch defence of the government’s decision to scrap the two-child benefit cap, with its estimated cost of around £3bn by the end of this parliament.

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Prime minister defends budget

‘A moral failure’

The prime minister condemned the Conservative policy as a “failed social experiment” and said those who defend it stand for “a moral failure and an economic disaster”.

“The record highs of child poverty in this country aren’t just numbers on a spreadsheet – they mean millions of children are going to bed hungry, falling behind at school, and growing up believing that a better future is out of reach despite their parents doing everything right,” he said.

The two-child limit restricts child tax credit and universal credit to the first two children in most households.

The government believes lifting the limit will pull 450,000 children out of poverty, which it argues will ultimately help reduce costs by preventing knock-on issues like dependency on welfare – and help people find jobs.

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Budget winners and losers

Speaking to Rigby, Baroness Harman said Ms Reeves now needed to convince “the woman on the doorstep” of why she’s raised taxes in the way that she has.

“I think Rachel really answered it very, very clearly when she said, ‘well, actually, we haven’t broken the manifesto because the manifesto was about rates’.

“And you remember there was a big kerfuffle before the budget about whether they would increase the rate of income tax or the rate of national insurance, and they backed off that because that would have been a breach of the manifesto.

“But she has had to increase the tax take, and she’s done it by increasing by freezing the thresholds, which she says she didn’t want to do. But she’s tried to do it with the fairest possible way, with counterbalancing support for people on low incomes.”

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She added: “And that is the argument that’s now got to be had with the public. The Labour members of parliament are happy about it. The markets essentially are happy about it. But she needs to make the case, and everybody in the government is going to need to make the case about it.

“This was a difficult thing to do, but it’s been done in the fairest possible way, and it’s for the good, because it will protect people’s cost of living if they’re on low incomes.”

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Twenty two stadiums and 4.5 million tickets – home nations submit bid for 2035 Women’s World Cup

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Twenty two stadiums and 4.5 million tickets - home nations submit bid for 2035 Women's World Cup

The football associations of England, Northern Ireland, Scotland and Wales have officially launched and released more details about their joint bid for the 2035 Women’s World Cup.

If the bid is successful, it would be the first football World Cup hosted in the UK since 1966, and the largest single-sport event ever staged in the country.

The bid includes 22 proposed stadiums – 16 in England, three in Wales, two in Scotland and one in Northern Ireland – across 16 host cities.

Organisers claim it would be the most accessible tournament ever, with 63 million people living within two hours of a proposed venue.

They predict the tournament would generate 4.5 million ticket sales and have a projected global TV audience of 3.5 billion.

The tournament would involve 104 matches contested by 48 teams over 39 days, with 48 team base camp training sites, 82 venue-specific training sites and 32 FIFA Fan Festival Sites proposed.

In April, FIFA president Gianni Infantino revealed that the home nations had submitted the only valid bid for tournament.

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In a joint statement, the CEOs of the various football associations, said: “We are proud of the growth that we’ve driven in recent years across the women’s and girls’ game.”

They added that: “A Women’s World Cup in the UK has the power to turbo charge the women’s and girls’ game both in the UK and globally.”

Where would the matches be played?

The bid details the host cities and stadiums as follow:

• Belfast – The Clearer Twist National Stadium at Windsor Park

• Birmingham – The Sports Quarter Stadium and Villa Park

• Brighton & Hove – The American Express Stadium

• Bristol – Ashton Gate

• Cardiff – Cardiff City Stadium and Principality Stadium

• Edinburgh – Easter Road

• Glasgow – Hampden Park

• Leeds – Elland Road

• Liverpool – The Hill Dickinson Stadium

• London – Chelsea FC Stadium, Emirates Stadium, Selhurst Park, Tottenham Hotspur Stadium and Wembley Stadium connected by EE

• Manchester – Etihad Stadium

• Trafford – Old Trafford

• Newcastle – St James’ Park

• Nottingham – The City Ground

• Sunderland – Stadium of Light

• Wrexham – STōK Racecourse

However, some of the stadiums mentioned above were merely the ones put forward in the official bid and are likely to change after the construction of new stadiums are completed.

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Have you seen this nutcracker? CCTV shows thief stealing festive statue in Edinburgh

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Have you seen this nutcracker? CCTV shows thief stealing festive statue in Edinburgh

The manager of an Edinburgh cocktail bar will speak to police today over the “catastrophic” theft of an eight-foot tall nutcracker figure from outside his venue.

In what can only be described as a total nightmare before Christmas, a person riding an e-bike guaranteed a place on the naughty list by stealing the Copper Blossom’s festive statue on Monday.

They are seen on CCTV placing the soldier across their lap and riding off into the night down George Street towards St Andrew Square.

The thief was wearing a dark hoodie
Image:
The thief was wearing a dark hoodie

Speaking to The UK Tonight on Sky News, manager Paul Paxton said it was a massive financial blow for his bar.

“The individual nutcrackers are about £900 each,” he revealed.

The stolen one is named Nolan, while his “brother” Nelson remains “safe and sound”.

They were part of the Copper Blossom’s outdoor Christmas display, and Nelson has now been moved into the foyer.

Mr Paxton said he would be speaking to police about their investigation, with sightings having been reported “around Edinburgh” later on the night of the incident.

Nolan, who the owner described as “massive”, was taken at around 10.10pm. The CCTV footage shows the thief removing the statue and dragging it on to their bike.

You can see Nolan being taken away in this shot
Image:
You can see Nolan being taken away in this shot

As if losing a £900 nutcracker wasn’t bad enough, a table costing hundreds of pounds was also broken.

“It’s pretty catastrophic,” said Mr Paxton.

The bar had originally put out an appeal that said “if you return it, we’re all good” – but he admitted he doesn’t expect Nolan’s return any time soon.

Paul Paxton is dwarfed by his nutcracker soldiers
Image:
Paul Paxton is dwarfed by his nutcracker soldiers

And while he’d “never want someone to go into harm’s way”, he told Jayne Secker he was a little disappointed no witnesses alerted him or his staff to the theft.

“There were about 12 or 13 people who walked past,” he said.

“Even if someone had run in, that could have helped. It wasn’t a quick process – he fell off his bike.

“A heads-up would have been lovely.”

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