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Regime change in Iran is “unacceptable” and the assassination of the country’s supreme leader would “open the Pandora’s box”, the Kremlin has said.

In a rare interview with a foreign media organisation, Kremlin spokesman Dmitry Peskov told Sky News that Russia would react “very negatively” if Ayatollah Ali Khamenei was killed.

The comments came as US President Donald Trump said he will decide within two weeks whether America will join Israel’s military campaign against Tehran, after earlier speculating on social media about killing the Iranian leader.

Dmitry Peskov
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Dmitry Peskov speaks to Sky News

“The situation is extremely tense and is dangerous not only for the region but globally,” Mr Peskov said in an interview at the Constantine Palace in Saint Petersburg.

“An enlargement of the composition of the participants of the conflict is potentially even more dangerous.

“It will lead only to another circle of confrontation and escalation of tension in the region.”

Supreme Leader Ayatollah Ali Khamenei and Russian President Vladimir Putin meeting in Tehran, Iran, Tuesday, July 19, 2022. AP
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Putin and Khamenei meeting in Tehran in 2022. Pic: AP

They are the Kremlin’s strongest comments yet regarding the Israel-Iran conflict, which has stoked fears in Moscow that it could be on the verge of losing its closest ally in the Middle East.

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Russia has deepened its ties with Iran since invading Ukraine, and the two countries signed a strategic partnership in January.

“[Regime change in Iran] is unimaginable. It should be unacceptable, even talking about that should be unacceptable for everyone,” Mr Peskov said, in a thinly veiled reference to Washington.

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But Mr Peskov refused to be drawn on what action Russia would take if Khamenei was killed, saying instead it would trigger action “from inside Iran”.

“It would lead to the birth of extremist moods inside Iran and those who are speaking about [killing Khamenei], they should keep it in mind. They will open the Pandora’s box.”

Vladimir Putin’s offers to mediate an end to the conflict have so far been rejected by Mr Trump, who said on Wednesday that he told the Russian president to “mediate your own [conflict]”, in reference to Russia’s war against Ukraine.

Mr Peskov denied the American president’s words were insulting, adding: “Everyone has a different language.

“President Trump has his own unique way of speaking and his unique language. We are quite tolerant and expect everyone to be tolerant of us.”

President Donald Trump meets with members of the Juventus soccer club in the Oval Office of the White House, Wednesday, June 18, 2025, in Washington. (AP Photo/Alex Brandon)
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Trump’s attempts to broker peace between Ukraine and Russia have so far not been fruitful. Pic: AP

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The Trump administration’s own mediation efforts to end the war in Ukraine have failed to yield any major breakthroughs, despite two rounds of direct talks between Moscow and Kyiv.

Moscow has stepped up its aerial bombardment of Ukraine in recent weeks and continues to reject Volodymyr Zelenskyy’s calls for a 30-day ceasefire.

“Now we have a strategic advantage. Why should we lose it? We are not going to lose it. We are going further. We’re advancing and we’ll continue to advance,” Mr Peskov said.

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Russia has previously said it would only commit to a ceasefire if Kyiv stops receiving foreign military support, fearing that a pause in the fighting would offer Ukraine a chance to rearm and regroup its forces.

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Russia ‘relentlessly terrorises’ Kyiv, says Zelenskyy

Asked if Moscow could commit to not using a ceasefire in the same way, Mr Peskov said: “A ceasefire is a ceasefire, and you stop.

“But America is not saying that ‘we’ll quit any supplies’. Britain is not saying that as well. France is not saying that as well. This is the problem.”

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Trump announces weapons deal with NATO to help Ukraine – as he gives Putin 50-day ultimatum

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Trump announces weapons deal with NATO to help Ukraine - as he gives Putin 50-day ultimatum

Donald Trump has agreed to send “top of the line weapons” to NATO to support Ukraine – and threatened Russia with “severe” tariffs if it doesn’t agree to end the war.

Speaking with NATO secretary general Mark Rutte during a meeting at the White House, the US president said: “We’ve made a deal today where we are going to be sending them weapons, and they’re going to be paying for them.

“This is billions of dollars worth of military equipment which is going to be purchased from the United States,” he added, “going to NATO, and that’s going to be quickly distributed to the battlefield.”

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Weapons being sent include surface-to-air Patriot missile systems and batteries, which Ukraine has asked for to defend itself from Russian air strikes.

Donald Trump and NATO secretary general Mark Rutte in the White House. Pic: Reuters
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Pic: Reuters

Mr Trump also said he was “very unhappy” with Russia, and threatened “severe tariffs” of “about 100%” if there isn’t a deal to end the war in Ukraine within 50 days.

The White House added that the US would put “secondary sanctions” on countries that buy oil from Russia if an agreement was not reached.

It comes after weeks of frustration from Mr Trump against Vladimir Putin’s refusal to agree to an end to the conflict, with the Russian leader telling the US president he would “not back down” from Moscow’s goals in Ukraine at the start of the month.

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Trump says Putin ‘talks nice and then bombs everybody’

During the briefing on Monday, Mr Trump said he had held calls with Mr Putin where he would think “that was a nice phone call,” but then “missiles are launched into Kyiv or some other city, and that happens three or four times”.

“I don’t want to say he’s an assassin, but he’s a tough guy,” he added.

Earlier this year, Mr Trump told Ukrainian leader Volodymyr Zelenskyy “you’re gambling with World War Three” in a fiery White House meeting, and suggested Ukraine started the war against Russia as he sought to negotiate an end to the conflict.

After Mr Trump’s briefing, Russian senator Konstantin Kosachev said on Telegram: “If this is all that Trump had in mind to say about Ukraine today, then all the steam has gone out.”

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Meanwhile, Mr Zelenskyy met with US special envoy Keith Kellogg in Kyiv, where they “discussed the path to peace” by “strengthening Ukraine’s air defence, joint production, and procurement of defence weapons in collaboration with Europe”.

He thanked both the envoy for the visit and Mr Trump “for the important signals of support and the positive decisions for both our countries”.

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At least 30 dead and 100 injured as armed groups clash in Syria, officials say

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At least 30 dead and 100 injured as armed groups clash in Syria, officials say

At least 30 people have been killed in the Syrian city of Sweida in clashes between local military groups and tribes, according to Syria’s interior ministry.

Officials say initial figures suggest around 100 people have also been injured in the city, where the Druze faith is one of the major religious groups.

The interior ministry said its forces will directly intervene to resolve the conflict, which the Reuters news agency said involved fighting between Druze gunmen and Bedouin Sunni tribes.

It marks the latest episode of sectarian violence in Syria, where fears among minority groups have increased since Islamist-led rebels toppled President Bashar al Assad in December, installing their own government and security forces.

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In March, Sky’s Stuart Ramsay described escalating violence within Syria

The violence reportedly erupted after a wave of kidnappings, including the abduction of a Druze merchant on Friday on the highway linking Damascus to Sweida.

Last April, Sunni militia clashed with armed Druze residents of Jaramana, southeast of Damascus, and fighting later spread to another district near the capital.

But this is the first time the fighting has been reported inside the city of Sweida itself, the provincial capital of the mostly Druze province.

The Syrian Observatory for Human Rights (SOHR) reports the fighting was centred in the Maqwas neighbourhood east of Sweida and villages on the western and northern outskirts of the city.

It adds that Syria’s Ministry of Defence has deployed military convoys to the area.

Western nations, including the US and UK, have been increasingly moving towards normalising relations with Syria.

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UK aims to build relationship with Syria

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Read more from Sky News:
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Concerns among minority groups have intensified following the killing of hundreds of Alawites in March, in apparent retaliation for an earlier attack carried out by Assad loyalists.

That was the deadliest sectarian flare-up in years in Syria, where a 14-year civil war ended with Assad fleeing to Russia after his government was overthrown by rebel forces.

The city of Sweida is in southern Syria, about 24 miles (38km) north of the border with Jordan.

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Meredith Kercher’s killer faces new trial over sexual assault allegations

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Meredith Kercher's killer faces new trial over sexual assault allegations

The man convicted of the murder of British student Meredith Kercher has been charged with sexual assault against an ex-girlfriend.

Rudy Guede, 38, was the only person who was definitively convicted of the murder of 21-year-old Ms Kercher in Perugia, Italy, back in 2007.

He will be standing trial again in November after an ex-girlfriend filed a police report in the summer of 2023 accusing Guede of mistreatment, personal injury and sexual violence.

Guede, from the Ivory Coast, was released from prison for the murder of Leeds University student Ms Kercher in 2021, after having served about 13 years of a 16-year sentence.

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Since last year – when this investigation was still ongoing – Guede has been under a “special surveillance” regime, Sky News understands, meaning he was banned from having any contact with the woman behind the sexual assault allegations, including via social media, and had to inform police any time he left his city of residence, Viterbo, as ruled by a Rome court.

Guede has been serving a restraining order and fitted with an electronic ankle tag.

The Kercher murder case, in the university city of Perugia, was the subject of international attention.

Ms Kercher, a 21-year-old British exchange student, was found murdered in the flat she shared with her American roommate, Amanda Knox.

The Briton’s throat had been cut and she had been stabbed 47 times.

(L-R) Raffaele Sollecito, Meredith Kercher and Amanda Knox. Pic: AP
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(L-R) Raffaele Sollecito, Meredith Kercher and Amanda Knox. File pic: AP

Ms Knox and her then-boyfriend, Raffaele Sollecito, were placed under suspicion.

Both were initially convicted of murder, but Italy’s highest court overturned their convictions, acquitting them in 2015.

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