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The dark granite block in a children’s cemetery in Bristol tells an incomplete story: “Trelissa Whitbread, born 3rd of Feb 1988. She lived 2 hours.”

Deborah Mann has not returned to the grave of her firstborn for 30 years but today has come with her daughter, Branwen, to tell her the story. “It shouldn’t have happened,” she says quietly.

Ms Mann had four pregnancies. Her first two children, Trelissa and Kaverne, died shortly after birth. Ms Mann believes their deaths were caused by an epilepsy drug she was taking called sodium valproate, prescribed by her GP.

After a long gap she would go on to have two more children, both girls, who were diagnosed with what is now recognised as foetal valproate syndrome, which has left them with life-long physical and neurological problems.

Ms Mann tells Sky News: “I asked so many questions and was told ‘this is just the way things are.’ It can’t be the way things are when you lose two babies. How can it be the way things are?”

Deborah Mann
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Deborah Mann

Five years ago, valproate was among three medical products including the pregnancy test drug Primodos and medical device pelvic mesh, that were found to have caused “avoidable harm” to patients.

The report was clear that valproate could cause lifelong disabilities to the children of mothers taking the drug when pregnant.

The independent review, chaired by Baroness Julia Cumberlege, strongly criticised the industry and regulators and made a series of recommendations, including the creation of a redress scheme for victims in all three groups.

On valproate, it stated: “Nothing can undo the harm that has been done to these individuals, but steps can be taken to make their lives easier.”

Deborah Mann and her daughter Branwen visit Trelissa's grave
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Deborah Mann and her daughter Branwen visit Trelissa’s grave

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20,000 children exposed to drug while in womb

Five years on there is still no such scheme for any of the campaign groups. In the week of developments in the Post Office scandal and infected blood, here is another scandal no less significant.

An estimated 20,000 children were exposed to sodium valproate while in the womb.

UK regulator the MHRA says an increased risk of neonatal loss is not currently a recognised adverse reaction, but it does warn of a range of congenital problems caused by the drug that are increasingly likely the higher the dose.

Sky News has also seen a study from 1972 which shows high doses of sodium valproate could be embryo-lethal in rats. At times Ms Mann was being prescribed 5,000mg, which is double the highest recommended dose.

Ms Mann worries about the future of her surviving children. She says of the government: “It’s financially better to pretend they don’t even exist. So many children are harmed, so many children that will not have their needs addressed as they grow older.”

At the time of birth her eldest daughter Rhonwen’s medical records state “valproate levels caused foetal and patient damage,” which included deafness.

Branwen, 29
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Branwen, 29

Daughter worries about being a mother as she can pass condition on

Ms Mann wasn’t initially told about the cause of her daughter’s problems, even when she was pregnant with her next child Branwen.

The 29-year-old told Sky News: “I have tight ankles, tight legs, tight hips and I have a weak lower back. I have to wear splints every day to be sure I can keep walking, and I have to do exercises every day. I have autism, Asperger’s syndrome.”

She goes on to list a series of brain problems that must be scanned every two years, “to make sure nothing’s grown or moved.”

She was bullied at school for her appearance, and she worries about being a mother as she can pass the condition on to her children.

She said: “I feel very let down by the government. I feel let down by the people who promised they would help us, that they will help ensure that we have a better quality of life.”

‘Somebody at last had listened’

Others the Cumberlege review wanted to get redress for “avoidable harm” were children born with malformations after their mothers used the drug Primodos.

These hormone-packed pills were prescribed as a pregnancy test to thousands of women in the 1960s and 70s and are alleged to have caused a range of malformations to babies, from shortened limbs to heart defects, which the manufacturer denies.

Marie Lyon, lead campaigner for the Association for Children Damaged by Hormone Pregnancy Tests
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Marie Lyon, lead campaigner for the Association for Children Damaged by Hormone Pregnancy Tests

Lead campaigner for the Association for Children Damaged by Hormone Pregnancy Tests (ACDHPT), Marie Lyon, told Sky News: “Our families were utterly overjoyed that somebody at last had listened, and Julia Cumberlege did a thorough review. Our expectations were wow! This is it now. An apology from the health secretary, all these years and we’ve finally got there, and then nothing.

“Five years and may I say, five years and 31 deaths. That’s how many of our members have died since that report was published in 2020 and we’ve still not received justice. It’s a disgrace.”

Baroness Cumberlege also recommended the government create a redress scheme for women left debilitated by pelvic mesh implants.

Kath Sansom, founder of the Sling The Mesh campaign group
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Kath Sansom, founder of the Sling The Mesh campaign group

‘The government are dragging their feet’

Kath Sansom, founder of the Sling The Mesh campaign group, told Sky News: “There are women in there who can’t walk any more, who need a stick or a mobility scooter – they’ve lost jobs, marriages, pensions. Some have had to sell their homes, and it feels really unfair that we are still waiting for a reply on redress.

“The government are dragging their feet. We keep being told that they are working on it at pace – but the phrase within the group is – a snail’s pace.”

The Department of Health and Social Care said: “The harm caused by pelvic mesh continues to be felt today” and “we are fully focused on how best to support patients and prevent future harm.”

“Health Minister Baroness Gillian Merron met patients affected and has committed to providing a further update.”

Government considering recommendations

The government says it is considering the recommendations by the patient safety commissioner last year for a redress scheme, but it’s notable there is no timescale and no reference to the harm caused by valproate or Primodos in their statement.

Dr Alison Cave, chief safety officer at the Medicines and Healthcare products Regulatory Agency (MHRA), said: “Patient safety is our highest priority and no one should stop taking valproate without seeking advice from their healthcare professional.

“Valproate is a highly teratogenic medicine and there is evolving evidence for harms in males, which is why the Commission on Human Medicines (CHM) recommended new regulatory measures to reduce the known harms from valproate, including the significant risk of serious harm to the baby if taken during pregnancy and the risk of impaired fertility in male.”

Sanofi, manufacturers of sodium valproate, told us: “We have always worked closely with the MHRA and fully met all our legal and regulatory obligations in relation to valproate which is an essential medicine used to treat a serious and potentially life-threatening condition.

“Sanofi has at all times provided information regarding valproate that reflects current knowledge as approved by MHRA.

“We are committed to working with all concerned stakeholders to continue educating about the risks and precautions for the appropriate use of valproate.”

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No 10 appointed Mandelson despite security concerns, Sky News understands

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No 10 appointed Mandelson despite security concerns, Sky News understands

The security services expressed concern about the appointment of Lord Mandelson as ambassador to Washington, but No 10 went ahead anyway, Sky News understands.

Downing Street today defended the extensive vetting process which senior civil servants go through in order to get jobs, raising questions about whether or not they missed something or No 10 ignored their advice.

Politics Live: Mandelson sacked as US ambassador following ‘new information’

Sky News has been told by two sources that the security services did flag concerns as part of the process.

No 10 did not judge these concerns as enough to stop the ambassadorial appointment.

It is not known whether all of the detail was shared with Prime Minister Sir Keir Starmer personally.

Sky News has been told some members of the security services are unhappy with what has taken place in Downing Street.

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Lord Mandelson is close to Sir Keir’s chief of staff, Morgan McSweeney, who is known to have been keen on the appointment – and the pair spoke regularly.

No 10 says the security vetting process is all done at a departmental level with no No 10 involvement.

Shadow foreign secretary Priti Patel described the revelations as “extraordinary”.

“For Keir Starmer, and his Chief of Staff Morgan McSweeney, to have appointed Lord Mandelson despite concerns being raised by the security services shows a blatant disregard of all national security considerations and their determination to promote their Labour Party friends,” she said in a statement.

“Starmer leads a crisis riddled government consumed by a chaos of his own making, because he puts his Party before the needs of our country.

“The country deserves the honest truth this spineless prime minister refuses to give them.”

Priti Patel described the revelations as 'extraordinary'.
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Priti Patel described the revelations as ‘extraordinary’.

Lord Mandelson was sacked as the UK’s ambassador to the US by Sir Keir earlier on Thursday over his ties to disgraced financier Jeffrey Epstein.

The prime minister, who selected Lord Mandelson for the role, made the decision after new emails revealed the Labour peer sent messages of support to Epstein even as he faced jail for sex offences in 2008.

In one particular message, Lord Mandelson had suggested that Epstein’s first conviction was wrongful and should be challenged.

Read more:
Starmer sacks Mandelson as US ambassador
Analysis: Mandelson is never far from a scandal

The Foreign Office said the emails showed “the depth and extent of Peter Mandelson’s relationship with Jeffrey Epstein is materially different from that known at the time of his appointment”.

The decision to sack the diplomat was made by the prime minister and Foreign Secretary Yvette Cooper on Thursday morning, Sky News understands.

This was after Sir Keir had reviewed all the new available information last night.

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Harriet Harman, Ruth Davidson, and Beth Rigby react to the news of Lord Mandelson’s sacking.

It comes after a string of allegations around the diplomat’s relationship with Epstein, which emerged in the media this week, including a 2003 birthday message in which he called the sex offender his “best pal”.

Further allegations were then published in The Telegraph on Wednesday morning, suggesting that Lord Mandelson had emailed Epstein to set up business meetings following the latter’s conviction for child sex offences in 2008.

Additional emails were then published detailing how the diplomat wrote to Epstein the day before he went to prison in June 2008 to serve time for soliciting sex from a minor. Lord Mandelson said: “I think the world of you.”

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Mandelson is never far from a scandal – and this time he’s been sacked

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Mandelson is never far from a scandal - and this time he's been sacked

Peter Mandelson, the UK ambassador to the US, has been sacked from his role as scrutiny builds over his relationship with disgraced financier Jeffrey Epstein.

The diplomat’s most famous quotation sums up his attraction to the rich and famous and his fondness for the trappings of wealth.

“We are intensely relaxed about people getting filthy rich,” he told tech executives when he was Sir Tony Blair’s trade and industry secretary in 1998.

“As long as they pay their taxes,” he added hurriedly, the former spin doctor known as the “Prince of Darkness” acutely aware of the risk of damaging headlines.

Keir Starmer and Peter Mandelson. Pic: PA
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Keir Starmer and Peter Mandelson. Pic: PA

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Now, less than nine months after his controversial appointment by Sir Keir Starmer as UK ambassador, his association with convicted sex offender Epstein suggests once again that he appears unable to avoid scandal.

Aged 71, Lord Mandelson – awarded a peerage by Gordon Brown in 2008 – had to resign from Sir Tony’s cabinet twice, first over an undeclared bank loan and then over intervening in a passport application by a top Indian businessman.

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Over four decades, nearly all on the front line of British politics, he has been a consummate political networker, but he has also been one of the most divisive figures in public life and his appointment last December was seen by critics as an act of cronyism by Sir Keir.

Acknowledging that Lord Mandelson was a controversial and divisive figure, Sir Tony declared in 1996: “My project will be complete when the Labour Party learns to love Peter Mandelson.”

Read more: Starmer sacks Mandelson as US ambassador

The Washington role is seen as the most glittering and important diplomatic post in the UK government. The perks of the job include the luxurious ambassador’s residence in Massachusetts Avenue, a magnificent Queen Anne mansion designed by top architect Sir Edwin Lutyens.

When he appointed him as ambassador, Sir Keir saw Lord Mandelson as a skilful and persuasive link to the president, with his trade experience from his time as a cabinet minister and Brussels commissioner a vital qualification for the job.

Never one for false modesty, Lord Mandelson claims that when he first walked into the Oval Office the president said to him: “God, you’re a good-looking fellow, aren’t you?”

Lord Mandelson can be credited with several diplomatic triumphs in Washington. He played a vital role in ensuring the UK escaped the worst of Trump’s tariffs and he was instrumental in securing a much sought-after trade deal between the UK and the US.

And his silky PR skills were displayed when during Sir Keir’s first visit to the White House in February the PM theatrically pulled out of his inside pocket a letter from King Charles inviting the present to visit the UK.

It was a classic Lord Mandelson stunt and confirmed he’d lost none of the flair for presentation he’d first deployed when he was Labour leader Neil Kinnock’s spin doctor in the 1980s.

Lord Mandelson’s high-profile political career began as a TV producer until his appointment as Labour’s director of communications under Neil Kinnock in 1985.

He was seen as a brilliant if ruthless spin doctor, who masterminded the birth of New Labour but would berate newspaper editors when unfavourable stories were written by their political journalists.

Another classic Lord Mandelson attempt to kill an embarrassing story was to tell the journalist who wrote or broadcast it in a sneering voice: “That is a story that I believe will remain an exclusive.”

He became MP for Hartlepool in 1992 and helped propel Sir Tony to the leadership of the party after John Smith’s death in 1994, a move that led to a bitter feud with Mr Brown.

There’s an amusing story about Mandelson in Hartlepool, which he claims is a myth and blames Mr Kinnock for. It’s claimed he ordered “some of that delicious guacamole” in a fish and chip shop, mistaking mushy peas for avocado dip.

It was a perfect Lord Mandelson story, ridiculing his metropolitan tastes and ignorance of working-class life. But he claims the mistake was made by a young American woman student who was helping Labour’s campaign.

Tony Blair and Lord Mandelson in 2000. Pic: Paul Faith/PA
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Tony Blair and Lord Mandelson in 2000. Pic: Paul Faith/PA

His first cabinet job, trade and industry secretary in 1998, lasted only five months after he was forced to quit after failing to declare a home loan from Labour millionaire Geoffrey Robinson to his building society.

His resignation was similar in one respect to the demise of former deputy prime minister Angela Rayner last week, in that it was over irregularities in buying a property: in Hove in her case, in fashionable Notting Hill in his.

He bounced back as Northern Ireland secretary in 1999 and was said to enjoy the luxury of Hillsborough Castle, which went with the job. But he was forced to resign a second time over claims he helped businessman Srichand Hinduja with an application for UK citizenship.

When he held his seat in Hartlepool in the 2001 general election, Mandelson made a passionate and defiant victory speech at his count in which he declared: “I’m a fighter, not a quitter.”

Yet three years later he did quit as an MP, when he became a trade commissioner in Brussels, serving a four-year term during which he had a spectacular row with French president Nicolas Sarkozy, who accused him of selling out French farmers in trade talks.

There were more controversies arising from his time in Brussels. In 2006, it was reported that he received a free cruise on a yacht from an Italian mogul who was said to have benefited from tariffs on Chinese shoes when Mandelson was EU trade commissioner.

Former Labour leader Neil Kinnock (L) with Peter Mandelson. Pic: PA
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Former Labour leader Neil Kinnock (L) with Peter Mandelson. Pic: PA

Reports also claimed he had been lent a private jet by banking and business tycoon Nat Rothschild. And it was later reported that he had a holiday in August 2008 on the yacht of Russian oligarch Oleg Deripaska off the Greek island of Corfu.

Mr Deripaska was said to have benefited from a cut in EU aluminium tariffs introduced by Mandelson. But prime minister Brown said Mandelson’s dealings with Mr Deripaska had been “found to be above board”.

After Brussels came perhaps his most spectacular and unexpected political comeback, when in 2008 his old foe Gordon Brown, by now prime minister but facing challenges to his leadership, brought him back as business secretary with a peerage.

A year later, Mr Brown awarded him the grand title, previously held by Michael Heseltine under John Major, of first secretary of state, a position he held until Labour’s election defeat in 2010.

To this day, Lord Mandelson remains a devoted Blairite rather than a soulmate of Mr Brown. And in the run-up to Sir Keir’s election victory last year he was back in the fold, offering advice on campaigning and policy.

He got his reward with the plum job of ambassador in Washington. But his links to a very American scandal, involving the disgraced financier and sex offender Epstein, have pushed him out of political life. Again.

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Why didn’t Keir Starmer fire Peter Mandelson yesterday?

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Why didn't Keir Starmer fire Peter Mandelson yesterday?

Peter Mandelson’s position was completely unsustainable, but it took Sir Keir Starmer 24 hours after everybody else to realise the inevitable.

In the chaotic interim, this generated the extraordinary spectacle of No10 saying that they had full confidence in their man in Washington because – and it feels incredible to type this – No10 had been fully aware that the peer had an extended relationship with a convicted paedophile after the point he had been to jail in the US, and was content with this situation.

An incredible state of affairs.

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This is why the issue has become a matter of Starmer‘s judgement almost as much as Peter Mandelson‘s.

Indeed, there were echoes here of the Chris Pincher affair that led to Boris Johnson’s downfall – a leader stubbornly defending acts which revolted the bulk of the party, in a tone deaf act of self-harm.

And revolted, they were.

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Almost the entire Labour Party was reacting with horror at the revelation, and even more so at the defence.

Less than 24 hours before his departure, Starmer was saying: “The ambassador has repeatedly expressed his deep regret for association with him, he’s right to do so. I have confidence in him and he’s playing an important role in the UK-US relationship.”

Words of certainty – but done once again without access to full facts.

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Mandelson sacked as US ambassador

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Starmer sacks Mandelson as US ambassador
Analysis: Mandelson is never far from a scandal

Dangerously, the PM was also defending a vetting process which would by implication put him in possession of facts that should have ruled Mandelson out of that job.

“Full due process has gone through when the appointment was made,” he said.

Now the line from a junior foreign office minister is that Mandelson hadn’t told him. So either the vetting failed or this isn’t quite accurate.

My understanding is that no one in government knows the last time Mandelson did see Epstein – the absence of certainty on that key fact must have set off alarm bells.

Right now, No10 will be thinking and hoping that, with just six days to go until the state visit by Donald Trump, which was meant to be organised by Mandelson, people will not focus too much on this question.

However, given the current rate of one big beast in government being sacked every week, this will ultimately land at Starmer’s feet.

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