You know it as soon as the college football schedule drops. The game that’s circled, the player you love to hate, the rival coach who seems to especially delight in destroying your team’s season.

We’re getting into the dog days of summer, with the only relief being the crisp autumn days of the college football season are rapidly approaching. But that means the enemies are lining up at the gates.

Today, we’re doing recon on where each post-spring top 25 team stands and who stands in their way. These are each teams’ potential future villains, the coaches, players and teams that have the chance to make the whole season go south. — Dave Wilson

1. Penn State: Ryan Day

Penn State coach James Franklin and the Nittany Lions have been unable to get over the hump against Ohio State, especially since Day took over in Columbus. The Nittany Lions have dropped six straight to Day, culminating with last year’s defeat, as fourth-ranked Ohio State rallied to topple the third-ranked Nittany Lions in State College 20-13. This season, Day will have a new starting quarterback and inexperience on both sides of the ball coming off last year’s national championship. Penn State will counter with one of the most experienced teams in the country, headlined by veteran quarterback Drew Allar and running backs Nicholas Singleton and Kaytron Allen. Franklin even hired away Day’s defensive coordinator, Jim Knowles. The Nittany Lions travel to Columbus on Nov. 1 in a showdown that figures to carry major playoff implications. — Jake Trotter

Clemson’s arch enemy for this season is obvious: Sellers. The Tigers watched the South Carolina quarterback dodge defenders, break tackles and keep one play after another alive last season in a stunning Gamecocks win that nearly derailed Clemson’s season. Clemson will be looking for revenge, of course, but new defensive coordinator Tom Allen will be more focused on finding answers for the elusive Sellers. There are lofty expectations at Clemson this season, and the Tigers don’t necessarily need a win over South Carolina to achieve them, but nobody will sleep soundly in the state if the 2025 defense coughs up another win to its biggest rival. — David Hale

3. Texas: Oklahoma

In Week 1, the Longhorns get a rubber match against an Ohio State team that eliminated Texas from the playoff last season, but the results of this game leave a lot of runway for either team to get back into this year’s postseason. Yet, there is no bigger test every year for Texas than Oklahoma in Dallas. This one’s a bit of a mystery, with the Sooners bringing in new offensive coordinator Ben Arbuckle and quarterback John Mateer, who played high school football in the Dallas area, from Washington State. The new-look Sooners could either be a launching point or a big speed bump in the SEC schedule for a Longhorns team with national championship aspirations. — Dave Wilson

4. Georgia: Alabama

The last coach Georgia fans ever wanted to see on the other sideline is doing television. Nick Saban was 5-1 against Kirby Smart, but even with Saban in his first year of retirement last season, Alabama still beat Georgia in a wild 41-34 game in Tuscaloosa the final weekend of September. Georgia has lost nine of the past 10 games in the series and hasn’t beaten Alabama in the regular season since 2007, Saban’s first season in Tuscaloosa, when the Mark Richt-coached Bulldogs won 26-23 in overtime. Georgia has vaulted to elite status under Smart, but a second straight loss to DeBoer — especially with this year’s game being played in Athens — wouldn’t sit well with anybody in Athens. — Chris Low

5. Ohio State: Sherrone Moore

Michigan coach Sherrone Moore has become a problem for the Buckeyes. He might not wear the villain outfit quite as well as predecessor Jim Harbaugh did, but Moore’s rise in coaching — as Wolverines offensive line coach, offensive coordinator and now head coach — has coincided with Ohio State’s longest losing streak (four games) to its archrival since 1991. Moore served as acting head coach during Harbaugh’s Big Ten-imposed suspension in 2023, as Michigan punched its ticket to the Big Ten championship game. He then earned the permanent role and pulled off one of the more stunning upsets in the history of The Game in November in Columbus. The story of Moore’s coaching career at Michigan is really just beginning, but he has already demonstrated his ability to win the biggest games. — Adam Rittenberg

6. LSU: Daytime home games

LSU fans have been known to curse day games, especially in the sweltering September heat. It’s at night when Tiger Stadium (and typically LSU’s football team) shines. In 2025, the only SEC home game that LSU will definitely play at night is the league opener against Florida on Sept. 13. Home games against South Carolina and Texas A&M fall into the “flex” window, meaning they could start as early as 3:30 p.m. ET or as late as 8 p.m. ET. Since 2000, LSU is 112-15 in Saturday night home games at Tiger Stadium. Brian Kelly has faced just two nationally ranked SEC opponents in day games at Tiger Stadium and is 1-1. — Low

7. Notre Dame: Miami

No Notre Dame players were alive for the 1988 clash with Miami, and Fighting Irish coach Marcus Freeman was only 2 years old. But longtime Domers will always view the U as a true villain, and new Miami quarterback Carson Beck, the transfer from Georgia, sparks a range of reactions. Notre Dame scored a signature win in the CFP semifinal at the Sugar Bowl against a Georgia squad that had lost Beck to injury. When healthy, Beck is talented enough to villainize a Notre Dame defense replacing standouts Xavier Watts, Jack Kiser, Rylie Mills and others and appearing in its first game under new coordinator Chris Ash. Early season games are one of the only knocks against Freeman, who has dropped at least one September game in each of his three seasons as Irish coach. Notre Dame needs a strong start with its two most talented opponents — Miami and Texas A&M — leading off the schedule. — Rittenberg

8. Oregon: Ohio State

Is it too simple to say Ohio State? Maybe just Jeremiah Smith after he caught seven passes for 187 yards and two touchdowns in the Rose Bowl drubbing that the Buckeyes put on the Ducks to end their undefeated season? The good news for Dan Lanning & Co. (or bad depending on how you look at it) is that Oregon will not face Ohio State in the regular season this season and a rematch could only occur in the Big Ten title game or in the College Football Playoff. Penn State enters the fray this season as a much-hyped conference contender that the Ducks will have to face and yet it feels like Oregon and Ohio State are still the cream of the crop for the conference and are likely to continue seeing each other on the sport’s biggest stages. — Paolo Uggetti

9. Alabama: Vanderbilt

Remember when Saban won 100 straight games against unranked opponents, the longest such streak in the AP poll era? Now, all of a sudden, the Crimson Tide are 2-3 against their past five unranked foes, a stretch that started with a stunning 40-35 loss at Vanderbilt last season, which came only a week after DeBoer beat No. 2-ranked Georgia in his SEC opener as Alabama’s head coach. It was the first time Alabama had lost to Vanderbilt since 1984. Alabama will get its shot at payback this season on Oct. 4 when Vanderbilt visits Bryant-Denny Stadium. The loss to Vanderbilt a year ago ignited what was the first three-loss regular season for Alabama since 2010. Judging by some of the comments from Alabama players this offseason, nobody will need to remind the Tide when the Commodores are coming to town. — Low

10. BYU: Utah

It’s always Utah. The “Holy War” frequently manages to surprise us. A year ago, BYU was coming off a 5-7 season and Utah was considered the Big 12 favorite. This time, we have a full reversal: The Utes are the ones coming off a disappointing 5-7 campaign and the Cougars are ranked the highest of any Big 12 team on this list. (Granted, this ranking doesn’t account for the sudden uncertainty BYU is dealing with at the QB position.) We’ll already have a decent idea of BYU’s capabilities by the time Utah visits Provo in Week 8, but the Holy War could serve as a Big 12 title elimination game, and it will definitely impact the tenor of the season for both teams. It always does. — Connelly

Purdue didn’t generate many highlights in 2024, but it gave Illinois a major scare at Memorial Stadium, erasing a 24-3 deficit to force overtime before falling 50-49. Among the Boilermakers’ stars that day was tight end Max Klare, who recorded his first 100-yard receiving performance, finishing with 133 yards on six catches. Klare, like most of Purdue’s best players, transferred following the team’s coaching change. He landed at Ohio State, which will visit Memorial Stadium on Oct. 11. Illinois certainly will be aware of Klare but also must contain Heisman Trophy contender Jeremiah Smith and several other standout wide receivers, if it wants any chance at knocking off the defending national champions. — Rittenberg

12. Arizona State: Regression

Arizona State had one of the hottest teams in the country at the end of 2024 and returns far more of last year’s production than most. The Sun Devils appear primed for a run at a repeat Big 12 title. The problem: No one repeats in the Big 12. ASU’s biggest archrival could simply be regression to the mean. Among current members, the past six teams to reach the Big 12 championship before 2024 — 2020 Iowa State, 2021 Baylor, 2021 Oklahoma State, 2022 Kansas State, 2022 TCU and 2023 Oklahoma State — went a combined 28-9 in one-score finishes during their title runs. The following seasons, they went a combined 9-22 in such games. ASU went 6-2 in one-score finishes last season. It’s really hard to do that twice in a row, and in the Big 12 it appears impossible. — Connelly

13. South Carolina: LSU

South Carolina has its share of hated rivals — Georgia, Clemson, anyone else who plays “Sandstorm” during timeouts — but as the Gamecocks look to make a playoff run in 2025, enemy No. 1 might well be LSU. The Bayou Bengals have dominated South Carolina over the years, holding an 18-2 all-time record and winning eight straight matchups dating to 1995. More recently, LSU escaped Columbia with a 36-33 win last season in which the Gamecocks blew a four-point lead with less than 2 minutes to play. That loss ultimately cost South Carolina a playoff bid, but the Gamecocks feel certain they’re a far better team than they were then. If they can exact some revenge this time, it’ll be a big step toward reaching those lofty goals. — Hale

14. Iowa State: Kansas State

There’s no such thing as a Week 0 elimination game, but we get the closest thing to it in Dublin to start the 2025 season. The annual (for now) Farmageddon battle between ISU and Kansas State will take place in particularly green pastures this time, and it will pit two preseason top 20 teams with major Big 12 title hopes. Last year, the Cyclones’ defense played a perfect fourth quarter against the Wildcats, allowing just one yard in 12 snaps to win 29-21 and advance to the conference title game. This time, someone will be 0-1 in conference play before Week 1 even arrives. This is about as big a season opener as you could hope for. — Connelly

15. SMU: TCU

SMU was 3-17 against TCU coaches in the Dennis Franchione/Gary Patterson era, then Sonny Dykes won two straight against the Frogs in Dallas. Once he defected for the purple pastures of Fort Worth, he then won his first two against the Mustangs. Last year, however, SMU got its revenge in a 66-42 pummeling of TCU in a game in which Dykes was ejected. This year, the two teams, which have met 103 times, are scheduled for their last Iron Skillet game for the foreseeable future. This one will have some heat. — Wilson

16. Texas Tech: Baylor

Red Raiders coach Joey McGuire got his start in college coaching at Baylor under Matt Rhule and was promoted under Dave Aranda. He left in midseason in 2021 when he got the Tech job. While trying to right the ship in Lubbock, he’s gone 1-2 against Aranda, including a 59-35 home loss last season. Since Mike Leach was fired, the Red Raiders are 5-10 against the Bears, a team they’ll need to eclipse with their big ambitions to sit atop the Big 12. — Wilson

17. Indiana: UCLA

Coach Curt Cignetti and the Hoosiers did a great job of retaining players and coaches from a 2024 team that won a school-record 11 games and reached the CFP. But two who got away — a coach and a player — landed with UCLA, which visits Indiana on Oct. 25. New Bruins offensive coordinator Tino Sunseri coached Indiana quarterback Kurtis Rourke last year and had spent the previous three seasons on Cignetti’s staff at James Madison. He might know the secrets to attacking Indiana’s defense. Defensive back Jamier Johnson transferred from Indiana to UCLA after recording 35 tackles and an interception last fall for the Hoosiers. Johnson, who began his college career at Texas, will be part of a reshaped UCLA secondary. — Rittenberg

18. Kansas State: Iowa State

As mentioned above, it’s all about the season opener against Iowa State. It will be the first opportunity for quarterback Avery Johnson and K-State to prove that last year’s all-or-nothing offense has matured a bit. The Wildcats averaged 37.6 points in wins and only 15.8 in losses. They scored TDs on 75% of red zone drives in wins and 42% in losses. They committed more turnovers in the four losses (nine) than in the nine wins (seven). You could almost say that this means K-State’s biggest archrival is K-State. Regardless, Week 0 is enormous. Turnovers and later-down failures cost it dearly against Iowa State last season, and it gets an immediate opportunity to right one of 2024’s wrongs. — Connelly

19. Florida: Georgia

Florida has plenty of teams it considers rivals, but only one on the schedule this season has beaten the Gators four years in a row. That would be Georgia, which has absolutely dominated them since Kirby Smart took over the program in 2016. Smart is 7-2 against Florida, and just like that record, has finished ahead of Florida in the SEC standings seven times. We all know the Gators closed last season strong with big wins over LSU and Ole Miss, but the true litmus test for where this program is — and whether it can return to elite status under coach Billy Napier — is the Georgia game. — Adelson

20. Michigan: Ohio State

Even though the Wolverines have won four straight in the series, Ohio State remains Michigan’s archvillain for obvious reasons. The Buckeyes rattled off eight straight wins before Michigan coach Jim Harbaugh turned the tide in 2021 with the first of the four straight victories. Coach Sherrone Moore salvaged an up-and-down, first full season with a stunning 13-10 victory over Ohio State in Columbus last year. Much of that Ohio State national championship team has moved on to the NFL. But the postgame flag-plant fracas at the Horseshoe last year reinforced why this bitter rivalry has never carried more vitriol for either side. The last thing the Wolverines want this season is to watch Ohio State return the favor by planting its flag on the Block M at the Big House. — Trotter

21. Miami: Syracuse

Georgia Tech is not on the schedule this year or that would be the slam dunk choice. We could go with the obvious “traditional arch nemesis” Notre Dame, which is visiting South Florida for the first time since 2017. But there is another team that gets to wear the villain hat, if only for this season: Syracuse. That’s right, the team that beat Miami 42-38 in the 2024 regular-season finale to keep the Hurricanes out of the ACC championship game visits Hard Rock Stadium on Nov. 8. While both rosters have turned over since that game, the head coaches remain the same and there might be some added fuel to the fire. — Adelson

22. Louisville: Kentucky

In 2022, Louisville was 10-1 and favored against rival Kentucky. The Cardinals lost. In 2021, they were 7-4 and lost. It was an all-too-familiar story. Since 2016, Louisville has lost as a favorite against its rival three times — often sullying otherwise impressive seasons. Last year, the Cardinals had no such worries as they beat up on the Wildcats, who were slogging through a down season, but Jeff Brohm & Co. know the history too well to assume that will be the start of a trend. There are tougher and bigger games on Louisville’s schedule this season, but none that will mean more than beating those hated Cats. — Hale

23. Texas A&M: Steve Sarkisian

Sarkisian has done a masterful job reloading Texas to meet its potential. Last year, he took the Longhorns into Kyle Field and spoiled the Aggies’ chances of getting into the SEC championship game, and this year, A&M visits Austin for the first time since 2010 where Arch Manning hysteria dominates the headlines and the Longhorns will be seeking a coronation for a playoff run. Sarkisian, an avowed fan of college rivalries and traditions, will look to push all the right buttons to ignite his team. — Wilson

24. Ole Miss: Mississippi State

Don’t get anybody in Oxford started on those “dreaded” cowbells clanging away from fans of the “school down south.” That school being bitter rival Mississippi State, whose former coach, Dan Mullen, used to refer to Ole Miss as the “school up north.” Either way, nobody in the SEC is particularly fond of the Mississippi State cowbells, in no way a banned artificial noisemaker. Yes, that’s a joke. But to Ole Miss fans, they would rather hear nails scratching on a chalkboard. The good news for the Rebels is that they’ve lost only once in the past five games between the schools but will get a heavy dose of the cowbells this Nov. 28 in Starkville. — Low

25. Oklahoma: Texas

In the Wishbone era, and then once again after Bob Stoops took over then ceded way to Lincoln Riley, the Oklahoma quarterback position made college football kings. In recent years, Landry Jones, Baker Mayfield, Kyler Murray, Jalen Hurts, Caleb Williams and Dillon Gabriel all put up huge numbers. But the Sooners have fallen back a little and Texas is rolling into the Cotton Bowl with its own football royalty in Arch Manning. Oklahoma needs to right the ship, and all eyes will be on Dallas and where the program stands in the SEC era. — Wilson