Connect with us

Published

on

As the popularity of semaglutide weight loss medications continues to grow, so does the rate of potentially dangerous overdoses, experts are warning. 

Reported overdoses of semaglutide products such as Ozempic and Wegovy more than doubled between 2022 and 2023, according to Americas Poison Centers in Virginia.

“U.S. Poison Centers have documented 3,316 exposures to products containing semaglutide through Dec. 31, 2023, more than two times the number of cases reported in 2022,” Dr. Kait Brown, clinical managing director of Americas Poison Centers, told Fox News Digital via email.

“These cases include exposures to prescription semaglutide, compounded semaglutide and counterfeit semaglutide,” he said. 

“Most of these cases are associated with accidental therapeutic errors in adults.” Whats causing the overdoses?

Semaglutide medications are intended to be given in a low dose and increased slowly over a four-week period, according to Dr. Seth Kipnis, director of bariatic and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center in Neptune, New Jersey. 7 Reported overdoses of Ozempic and Wegovy doubled between 2022 and 2023, according to Americas Poison Centers in Virginia. REUTERS

“If people jump right to the high dose, they will have more initial negative side effects,” he told Fox News Digital. 

In some cases, people who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication, the doctor noted.

People with a semaglutide prescription should follow the manufacturers and prescribing physician’s instructions, Kipnis advised.  7 This photo combo provided by the FDA shows an authentic Ozempic needle, left and a counterfeit needle, right. AP

“The dose is weekly,” he said. “If it is taken daily, it is too much.”

Dr. Maryann Amirshahi, co-medical director of the National Capital Poison Center in Washington, D.C., confirmed that there has been a large overall increase in semaglutide overdoses reported to poison centers nationally. 

“In addition, I have noticed a similar increase at my individual center,” Amirshahi, who is also professor of emergency medicine at the Georgetown University School of Medicine, told Fox News Digital. 7 Injection pens of Novo Nordisk’s weight-loss drug Wegovy are shown in this photo. REUTERS

The doctor attributes the increase to several factors, chiefly the “huge increase” in semaglutide prescribing.

“Secondarily, it is available in several different forms, which can cause confusion,” Amirshahi noted. 

“Ozempic is a dial-up pen with multiple doses while Wegovy is a single-dose pen.” 7 A person is seen injecting themselves with an Ozempic needle at their home. REUTERS

Another source of confusion is that many people are using compounded products. 

“Compounded versions have their own unique risks when it comes to a potential overdose, especially when theyre dispensed in multi-dose vials,” noted Alyssa Billingsley, PharmD, Missouri-based director of pharmacy content at GoodRx.

“These injections are often dispensed in vials, so theres a greater opportunity for dosing errors since youre measuring out your specific dose with a syringe,” she warned.  7 People who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication. REUTERS

“In some cases, the vial may contain as much as 10 times the amount of semaglutide as a single-use injection pen.” Warning signs and symptoms

The most commonly reported overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea, Brown noted. 

“Some people have reported hypoglycemia (low blood sugar), which can be life-threatening,” she said.

Symptoms of low blood sugar include confusion, tremor, lightheadedness and palpitations, according to Amirshahi. 

“Semaglutide slows stomach emptying, which can lead to nausea, vomiting and abdominal pain,” she said.

In some cases, the stomach becomes almost paralyzed, a condition called gastroparesis, which can lead to dehydration, abnormal electrolytes and kidney damage, said Amirshahi.  7 Pens for the diabetes drug Ozempic sit on a production line. REUTERS

Another potential effect of semaglutide overdose is inflammation of the pancreas. 

“Symptoms of pancreatitis are very similar and can include nausea, vomiting, abdominal pain and dehydration,” Amirshahi noted. 

These signs and symptoms can also occur among patients taking normal doses of the medication as well as in overdoses, she added.

While any drug overdose can be serious, experts noted that taking too much semaglutide is rarely fatal. 

“Semaglutide is generally well-tolerated in overdose compared to other diabities medications,” Amirshahi said.

7 The most common overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea.  REUTERS

However, for people who develop gastroparesis or pancreatitis, potential complications can include dehydration and kidney damage. 

“While low blood sugar is rare with semaglutide overdose, if it is not detected and treated early, it can lead to seizures,” Amirshahi added.

Kipnis noted that in terms of adverse effects, “anything is possible when an FDA-approved drug is taken inappropriately.” Start your day with all you need to know

Morning Report delivers the latest news, videos, photos and more. Enter your email address

Please provide a valid email address.

By clicking above you agree to the Terms of Use and Privacy Policy.

Thanks for signing up!
Never miss a story. Check out more newsletters What to do in an overdose event

Anyone who is taking a prescribed semaglutide should have a primary care physician or medical provider to provide close follow-up support, especially in the first several weeks as the dose increases, Kipnis advised. 

Although there is no specific antidote for a semaglutide overdose, the primary course of action is to treat the abdominal symptoms with nausea and pain medications, correct electrolytes, and give fluids for dehydration, said Amirshahi.

“We also treat the low blood sugar by giving glucose or dextrose,” she said. “The care is really supportive until the effects of the medication wear off.”

In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, Billingsley noted. 

“For example, severe vomiting can result in serious dehydration and electrolyte imbalances, which can be dangerous if left untreated,” she told Fox News Digital. “Severe cases of hypoglycemia can also be life-threatening.”

To prevent an overdose, Billingsley said to make sure you feel comfortable and confident using the injection pen and selecting your specific dose. 

“Understand how often you should be injecting your dose, and consider using alarms, medication reminder apps, or other tools to help keep you on track,” she recommended. “Your pharmacist can be a helpful resource if any questions come up.”

For emergency assistance, call Poison Help at 1.800.222.1222 to speak with a poison expert or visit PoisonHelp.org for support and resources.

When contacted by Fox News Digital regarding the potential for overdoses, Novo Nordisk, maker of Ozempic and Wegovy, provided a statement.

“Novo Nodisk is the only company in the U.S. with FDA-approved products containing semaglutide, identified under the trade names Wegovy, Ozempic and RYBELSUS, and should only be prescribed after a close consultation between a health care provider and a patient and should only be taken under the supervision of a health care provider,” the company said.

It added, “Novo Nordisk stands behind the safety and efficacy of our FDA-approved semaglutide medicines when used as indicated and when taken under the care of a licensed health care professional.”

Continue Reading

US

National Guard will begin carrying firearms in Washington DC, official says

Published

on

By

National Guard will begin carrying firearms in Washington DC, official says

National Guard troops deployed to Washington DC in an effort to mitigate crime will begin carrying firearms, an official has said.

Defence secretary Pete Hegseth ordered the authorisation of roughly 2,000 National Guard troops to begin carrying weapons.

The majority of the guard members will carry M17 pistols, their service-issued weapons, while a small number will be armed with M4 rifles, reports Sky’s US partner organisation, NBC News.

The troops are authorised to use their weapons for self-protection.

A White House official told NBC News that despite being armed, as of Saturday night, the National Guard troops in DC are not making arrests, and will continue to work on protecting federal assets.

The troops were largely deployed from outside the state and were framed by President Trump as a concerted effort to tackle crime and homelessness in the nation’s capital.

Such deployments are not common, and are typically used in response natural disasters or civil unrest.

More from US

Democrats have bashed the deployment as partisan in nature, accusing Mr Trump of trying to exert his presidential authority through scare tactics and said his primary targets have been cities with black leadership.

Armed members of the South Carolina National Guard patrol outside of Union Station. Pic: AP
Image:
Armed members of the South Carolina National Guard patrol outside of Union Station. Pic: AP

Pentagon plans to deploy US army to Chicago

Yesterday it was reported that the Pentagon was drafting plans to deploy the US army in Chicago, the largest city in the state.

The governor of Illinois then accused Mr Trump of “attempting to manufacture a crisis” and “abusing his power to distract from the pain he is causing working families”.

Read more from Sky News:
Man and boy arrested after restaurant fire
Fast-track asylum appeals process to be introduced

Officials familiar with the proposals told the Washington Post that several options were being weighed up by the US defence department, including mobilising thousands of National Guard troops in Chicago as early as September.

Mr Trump had told reporters on Friday that “Chicago is a mess”, before attacking the city’s mayor, Brandon Johnson, and hinting “we’ll straighten that one out probably next”.

Continue Reading

US

Flesh-eating screwworm parasite detected in person in US for first time

Published

on

By

Flesh-eating screwworm parasite detected in person in US for first time

A case of the flesh-eating screwworm parasite has been detected in a person in the United States for the first time.

The parasitic flies eat cattle and other warm-blooded animals alive, with an outbreak beginning in Central America and southern Mexico late last year.

It is ultimately fatal if left untreated.

The case in the US was identified in a person from Maryland who had travelled from Guatemala.

Beth Thompson, South Dakota’s state veterinarian, told Reuters on Sunday that she was notified of the case within the
last week.

A Maryland state government official also confirmed the case.

The person was treated and prevention measures were implemented, Reuters reports.

The Centres for Disease Control and Prevention (CDC) and the Maryland Department of Health did not immediately respond to requests for comment.

What is screwworm?

The female screwworm fly lays eggs in the wounds of warm-blooded animals and once hatched, hundreds of screwworm larvae use their sharp mouths to burrow through living flesh.

It can be devastating in cattle and wildlife, and has also been known to infect humans.

Treatment is onerous, and involves removing hundreds of larvae and thoroughly disinfecting wounds. They are largely survivable if treated early enough.

The confirmed case is likely to rattle the beef and cattle futures market, which has seen record-high prices because of tight supplies.

The US typically imports more than a million cattle from Mexico each year to process into beef. The screwworm outbreak could cost Texas – the biggest cattle-producing state – $1.8bn (£1.3bn) in livestock deaths, labour costs and medication
expenses.

A view shows a calf after being sprayed with a disinfectant spray to prevent screwworm. Pic: Reuters
Image:
A view shows a calf after being sprayed with a disinfectant spray to prevent screwworm. Pic: Reuters

The United States Department of Agriculture (USDA) has set traps and sent mounted officers along the border, but it has faced criticism from some cattle producers and market analysts for not acting faster to pursue increased fly production via a sterile fly facility.

What is a sterile fly facility?

The case also comes just one week after the US agriculture secretary, Brooke Rollins, travelled to Texas to announce plans to build a sterile fly facility there in a bid to combat the pest. Ms Rollins had pledged repeatedly to keep screwworm out of the country.

Read more:
Trump seeking to ‘manufacture a crisis’ in Chicago
Menendez brothers denied parole

A sterile fly facility produces a large number of male flies and sterilises them – these males are then released to mate with wild female insects, which collapses the wild population over time. This method eradicated screwworm from the US in the 1960s.

Mexico has also taken efforts to limit the spread of the pest, which can kill livestock within weeks if not treated. It had started to build a $51m sterile fly production facility.

The USDA has previously said 500 million flies would need to be released weekly to push the fly back to the Darien Gap, the stretch of rainforest between Panama and Colombia.

Continue Reading

UK

Urgent letter to home secretary over violence against women and girls strategy – as it omits child abuse

Published

on

By

Urgent letter to home secretary over violence against women and girls strategy - as it omits child abuse

Ten child protection organisations have written an urgent letter to the home secretary expressing concern about the omission of child sexual abuse from the government’s violence against women and girls strategy, following a Sky News report. 

Groups including the NSPCC, Barnardo’s and The Children’s Society wrote to Yvette Cooper to say that violence against women and girls (VAWG) and child sexual abuse are “inherently and deeply connected”, suggesting any “serious strategy” to address VAWG needs to focus on child sexual abuse and exploitation.

The letter comes after Sky News revealed an internal Home Office document, titled Our draft definition of VAWG, which said that child sexual abuse and exploitation is not “explicitly within the scope” of their strategy, due to be published in September.

Poppy Eyre when she was four years old
Image:
Poppy Eyre when she was four years old

Responding to Sky News’ original report, Poppy Eyre, who was sexually abused and raped by her grandfather when she was four, said: “VAWG is – violence against women and girls. If you take child sexual abuse out of it, where are the girls?”

The Centre of Expertise on Child Sexual Abuse, which is funded by the Home Office and a signatory to the letter, estimates 500,000 children in England and Wales are sexually abused every year.

The NSPCC “welcome” the government’s pledge to halve VAWG in a decade, but is “worried that if they are going to fulfil this commitment, the strategy absolutely has to include clear deliverable objectives to combat child sexual abuse and exploitation too”, the head of policy, Anna Edmundson, told Sky News.

Poppy is a survivor of child sexual abuse
Image:
Poppy is a survivor of child sexual abuse

She warned the government “will miss a golden opportunity” and the needs of thousands of girls will be “overlooked” if child sexual abuse and exploitation is not “at the heart of its flagship strategy”.

The government insists the VAWG programme will include action to tackle child sexual abuse, but says it also wants to create a distinctive plan to “ensure those crimes get the specialist response they demand”.

“My message to the government is that if you’re going to make child sexual abuse a separate thing, we need it now,” Poppy told Sky News.

Read more from Sky News:
Why Donald Trump believes he ‘deserves the Nobel Peace Prize’
Bank holiday temperatures to climb close to 30C before rain arrives

Rape Crisis, which is one of the largest organisations providing support to women in England and Wales, shares these concerns.

It wants plans to tackle child sexual abuse to be part of the strategy, and not to sit outside it.

“If a violence against women and girls strategy doesn’t include sexual violence towards girls, then it runs the risk of being a strategy for addressing some violence towards some females, but not all,” chief executive Ciara Bergman said.

A Home Office spokesperson said the government is “working tirelessly to tackle the appalling crimes of violence against women and girls and child sexual exploitation and abuse, as part of our Safer Streets mission”.

“We are already investing in new programmes and introducing landmark laws to overhaul the policing and criminal justice response to these crimes, as well as acting on the recommendations of Baroness Casey’s review into group-based Child Sexual Exploitation, and the Independent Inquiry into Child Sexual Abuse,” they added.

Continue Reading

Trending