Connect with us

Published

on

As the popularity of semaglutide weight loss medications continues to grow, so does the rate of potentially dangerous overdoses, experts are warning. 

Reported overdoses of semaglutide products such as Ozempic and Wegovy more than doubled between 2022 and 2023, according to Americas Poison Centers in Virginia.

“U.S. Poison Centers have documented 3,316 exposures to products containing semaglutide through Dec. 31, 2023, more than two times the number of cases reported in 2022,” Dr. Kait Brown, clinical managing director of Americas Poison Centers, told Fox News Digital via email.

“These cases include exposures to prescription semaglutide, compounded semaglutide and counterfeit semaglutide,” he said. 

“Most of these cases are associated with accidental therapeutic errors in adults.” Whats causing the overdoses?

Semaglutide medications are intended to be given in a low dose and increased slowly over a four-week period, according to Dr. Seth Kipnis, director of bariatic and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center in Neptune, New Jersey. 7 Reported overdoses of Ozempic and Wegovy doubled between 2022 and 2023, according to Americas Poison Centers in Virginia. REUTERS

“If people jump right to the high dose, they will have more initial negative side effects,” he told Fox News Digital. 

In some cases, people who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication, the doctor noted.

People with a semaglutide prescription should follow the manufacturers and prescribing physician’s instructions, Kipnis advised.  7 This photo combo provided by the FDA shows an authentic Ozempic needle, left and a counterfeit needle, right. AP

“The dose is weekly,” he said. “If it is taken daily, it is too much.”

Dr. Maryann Amirshahi, co-medical director of the National Capital Poison Center in Washington, D.C., confirmed that there has been a large overall increase in semaglutide overdoses reported to poison centers nationally. 

“In addition, I have noticed a similar increase at my individual center,” Amirshahi, who is also professor of emergency medicine at the Georgetown University School of Medicine, told Fox News Digital. 7 Injection pens of Novo Nordisk’s weight-loss drug Wegovy are shown in this photo. REUTERS

The doctor attributes the increase to several factors, chiefly the “huge increase” in semaglutide prescribing.

“Secondarily, it is available in several different forms, which can cause confusion,” Amirshahi noted. 

“Ozempic is a dial-up pen with multiple doses while Wegovy is a single-dose pen.” 7 A person is seen injecting themselves with an Ozempic needle at their home. REUTERS

Another source of confusion is that many people are using compounded products. 

“Compounded versions have their own unique risks when it comes to a potential overdose, especially when theyre dispensed in multi-dose vials,” noted Alyssa Billingsley, PharmD, Missouri-based director of pharmacy content at GoodRx.

“These injections are often dispensed in vials, so theres a greater opportunity for dosing errors since youre measuring out your specific dose with a syringe,” she warned.  7 People who overdose may be getting the medication from a source other than a local doctor or taking someone else’s prescribed medication. REUTERS

“In some cases, the vial may contain as much as 10 times the amount of semaglutide as a single-use injection pen.” Warning signs and symptoms

The most commonly reported overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea, Brown noted. 

“Some people have reported hypoglycemia (low blood sugar), which can be life-threatening,” she said.

Symptoms of low blood sugar include confusion, tremor, lightheadedness and palpitations, according to Amirshahi. 

“Semaglutide slows stomach emptying, which can lead to nausea, vomiting and abdominal pain,” she said.

In some cases, the stomach becomes almost paralyzed, a condition called gastroparesis, which can lead to dehydration, abnormal electrolytes and kidney damage, said Amirshahi.  7 Pens for the diabetes drug Ozempic sit on a production line. REUTERS

Another potential effect of semaglutide overdose is inflammation of the pancreas. 

“Symptoms of pancreatitis are very similar and can include nausea, vomiting, abdominal pain and dehydration,” Amirshahi noted. 

These signs and symptoms can also occur among patients taking normal doses of the medication as well as in overdoses, she added.

While any drug overdose can be serious, experts noted that taking too much semaglutide is rarely fatal. 

“Semaglutide is generally well-tolerated in overdose compared to other diabities medications,” Amirshahi said.

7 The most common overdose symptoms include nausea, vomiting, abdominal pain, dizziness and diarrhea.  REUTERS

However, for people who develop gastroparesis or pancreatitis, potential complications can include dehydration and kidney damage. 

“While low blood sugar is rare with semaglutide overdose, if it is not detected and treated early, it can lead to seizures,” Amirshahi added.

Kipnis noted that in terms of adverse effects, “anything is possible when an FDA-approved drug is taken inappropriately.” Start your day with all you need to know

Morning Report delivers the latest news, videos, photos and more. Enter your email address

Please provide a valid email address.

By clicking above you agree to the Terms of Use and Privacy Policy.

Thanks for signing up!
Never miss a story. Check out more newsletters What to do in an overdose event

Anyone who is taking a prescribed semaglutide should have a primary care physician or medical provider to provide close follow-up support, especially in the first several weeks as the dose increases, Kipnis advised. 

Although there is no specific antidote for a semaglutide overdose, the primary course of action is to treat the abdominal symptoms with nausea and pain medications, correct electrolytes, and give fluids for dehydration, said Amirshahi.

“We also treat the low blood sugar by giving glucose or dextrose,” she said. “The care is really supportive until the effects of the medication wear off.”

In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, Billingsley noted. 

“For example, severe vomiting can result in serious dehydration and electrolyte imbalances, which can be dangerous if left untreated,” she told Fox News Digital. “Severe cases of hypoglycemia can also be life-threatening.”

To prevent an overdose, Billingsley said to make sure you feel comfortable and confident using the injection pen and selecting your specific dose. 

“Understand how often you should be injecting your dose, and consider using alarms, medication reminder apps, or other tools to help keep you on track,” she recommended. “Your pharmacist can be a helpful resource if any questions come up.”

For emergency assistance, call Poison Help at 1.800.222.1222 to speak with a poison expert or visit PoisonHelp.org for support and resources.

When contacted by Fox News Digital regarding the potential for overdoses, Novo Nordisk, maker of Ozempic and Wegovy, provided a statement.

“Novo Nodisk is the only company in the U.S. with FDA-approved products containing semaglutide, identified under the trade names Wegovy, Ozempic and RYBELSUS, and should only be prescribed after a close consultation between a health care provider and a patient and should only be taken under the supervision of a health care provider,” the company said.

It added, “Novo Nordisk stands behind the safety and efficacy of our FDA-approved semaglutide medicines when used as indicated and when taken under the care of a licensed health care professional.”

Continue Reading

US

US Army 250th anniversary parade taking place in Washington – watch live

Published

on

By

US Army 250th anniversary parade taking place in Washington - watch live

A parade marking the US Army’s 250th anniversary – and President Trump’s 79th birthday – is under way.

You can watch the event in the livestream above.

President Trump said it was going to be a “big day” and admitted: “We want to show off a little bit.”

Today is the first time in more than 30 years that tanks have rolled through the US capital.

Officials have estimated around 200,000 people could turn out, including protesters, plus 6,600 soldiers, 150 vehicles and 50 aircraft.

However, it appears far fewer have turned out – possibly due to the poor weather – and the president has warned any protesters who interfere “will be met with very big force”.

Soldiers march past the viewing podium in Washington. Pic: AP
Image:
Pic: AP

Soldiers from the 82nd Airborne Division, dress in World War II era uniforms. Pic: AP
Image:
Pic: AP

President Donald Trump and first lady Melania Trump. Pic: AP
Image:
Pic: AP

A child waves as a tank passed. Pic: Reuters
Image:
Pic: Reuters

Mr Trump is watching alongside the first lady and defence secretary as troops and military hardware file past – accompanied at times by up tempo rock music.

The event started half an hour early due to forecasted heavy rain, with cloud forcing the cancellation of a flypast by fighter jets.

Helicopters such as Apaches, Chinooks and Black Hawks are still taking part however.

Donald Trump, Pete Hegseth and first lady Melania Trump gesture while they listen to the anthem. Pic: Reuters
Image:
Pic: Reuters

Military parachutists give off red smoke as they descend. Pic: Reuters
Image:
Pic: Reuters

A soldier makes a heart symbol with his hands. Pic: Reuters
Image:
Pic: Reuters

Military parachutists from the Golden Knights began the parade by swooping in, and some of the soldiers are parading in historic uniforms, complete with horses and wagons.

Vehicles from the Second World War era are also taking part.

President Trump stood and saluted many of the passing soldiers. He is said to have got the idea for the parade after being impressed with France’s Bastille Day celebrations during a visit in 2017.

Metal plates have been put down on some of Washington’s streets to protect the tarmac against the heaviest tanks – the 60-ton M1 Abrams.

Even so, the US Army has set aside several million dollars in case of any damage.

The last time such a major display took place in the US was 1991 when tanks and troops paraded to celebrate the ousting of Saddam Hussein’s army from Kuwait.

A child waves as a tank passed. Pic: Reuters
Image:
Pic: Reuters

People ride in a tank. Pic: Reuters
Image:
Pic: Reuters

Soldiers in period-style uniforms. Pic: Reuters
Image:
Pic: Reuters

The event has been criticised by some for being something more associated with a dictatorial regime such as Russia or North Korea.

An estimated cost as high as $45m (£33.33m) has also raised eyebrows given the administration’s efforts to slash the budget of many federal departments.

Among the critics is California governor Gavin Newsom, who has been trading barbs with Mr Trump since the outbreak of riots in LA.

“And we all know, this Saturday, he’s ordering our American heroes – the United States military – forcing them to put on a vulgar display to celebrate his birthday, just as other failed dictators have done in the past,” he said.

President Trump raises his fist as a tank passes. Pic: AP
Image:
Pic: AP

A tank and soldiers. Pic: Reuters
Image:
Pic: Reuters

A period era brass band marches past playing trumpets. Pic: Reuters
Image:
Pic: Reuters

The show of military might also comes as more than 1,500 protests against the Trump administration, organised under the slogan ‘No Kings’, have been planned across the US on Saturday.

Los Angeles is the scene of one demonstration, with police firing tear gas to disperse people and US Marines stationed outside the city’s federal building.

Tension is high in America’s second-biggest city after recent raids by immigration officers sparked unrest this week.

People hold Mexican flags during a No Kings Day protest against Trump's policies in LA. Pic: Reuters
Image:
Pic: Reuters

People run from tear gas in LA. Pic: Reuters
Image:
Tear gas was fired on the streets of LA. Pic: Reuters

Continue Reading

Politics

Bitcoin must upgrade or fall victim to quantum computing in 5 years

Published

on

By

Bitcoin must upgrade or fall victim to quantum computing in 5 years

Bitcoin must upgrade or fall victim to quantum computing in 5 years

Unless Bitcoin upgrades its core cryptography in the next five years, the trust it has built over 16 years could be wiped out by a single quantum attack. Urgent upgrades are needed to protect the world’s leading cryptocurrency.

Continue Reading

UK

Air India plane crash victim’s son says he’ll relive his mother’s last moments ‘to the day I die’

Published

on

By

Air India plane crash victim's son says he'll relive his mother's last moments 'to the day I die'

The son of an Air India plane crash victim, who was sitting one row behind the man who survived, has told Sky News he will relive “her last moments” until the day he dies.

Manju Mahesh Patel, 79, was on the London Gatwick-bound plane when it crashed in Ahmedabad shortly after take-off on Thursday.

She was sitting in seat 12D on flight AI 171, the row behind the only person to survive the crash who was sitting in 11A.

In an interview with Sky News, Chirag Mahesh Patel, Manju’s son, said he hopes his mother’s death was “instant” and “painless”.

“To the day I die I will think, ‘what were her last moments?’,” he said.

Pointing to a framed family photograph of Ms Patel at the family home, he added: “I want to remember mum like this.

More on India

“I don’t want to have to go and identify a burnt corpse, your own parent. How does someone, how do you ever get over that? That will be with me, that’s with me for life.”

Ms Patel had been staying in Ahmedabad for the past few months doing charity work at a temple. She was due to be picked up by her son at Gatwick on Thursday night.

The family say they want to remember Manju like this
Image:
A family photo of Chirag Mahesh Patel with his mother

Read more on Air India crash:
Air India’s lone survivor is nothing short of miracle

Gloucester family among dead
Everything we know about the crash

In tears, Mr Patel described his mother as “very strong” and a woman “who really loved her family”.

“The thing about my mum,” he said, “is her bond with her faith. It’s unbreakable.

“She had ultimate faith… and in times of stress she would always say God’s name… So, I know that upon take-off, I know that she was saying his name.”

Please use Chrome browser for a more accessible video player

What could have caused the India plane crash?

Mr Patel said that when he realised his mother was on the flight it was just “a normal day” and “it didn’t seem real”.

He said the last time he had spoken to her he had reminded her to take her diabetes medicine and had then missed a call from her at 4am to say she had arrived at the airport.

He described “the most heartbreaking thing” was how much Ms Patel was looking forward to seeing her grandchildren, saying “it was everything to her”.

She had told him she packed her suitcase with lollipops for her six-year-old grandson, and special crisps for her 15-year-old older grandchild.

Manju with her six-year-old grandson
Image:
Ms Patel with her six-year-old grandson

“It’s unimaginable even in my worst nightmare,” he said. “And the thing that kills me… is she was so looking forward to seeing us… she kept saying I bought this for you, I bought that, I bought the things for the kids.”

Mr Patel and his wife are due to fly to India on Saturday night to provide a DNA sample to help identify his mother’s remains.

He expressed his anger at what he called a “disgusting” and “appalling” lack of communication from Air India – which he said passed his details to a hospital but never contacted him personally.

He described feeling “neglected” by the airline, which he said would only offer him an Air India flight – and no help organising accommodation.

Mr Patel said he refused to get on the Gatwick flight back to Ahmedabad and has booked with another provider to travel to India instead.

Manju with her elder grandchild
Image:
Ms Patel with her elder grandchild

“I said [to the airline] all of this happened on Thursday, you’re telling me on Friday afternoon, do you want that flight this evening? That one crashed? The one coming back where 172 goes out? They asked do you want Air India 172? I said how can you ask me that. My mum just died on Air India.”

Mr Patel said he wanted “answers” and transparency in any air accident investigation.

Air India said in a statement: “Air India stands in solidarity with the families of the passengers who tragically lost their lives in the recent accident. Our teams on the ground are doing everything possible to extend care and support during this incredibly difficult time.

“As part of our continued efforts, Air India will be providing an interim payment of ₹25 lakh or approximately £21,000 each to the families of the deceased and to the survivor, to help address immediate financial needs. This is in addition to the ₹1 crore or approximately £85,000 support already announced by Tata Sons.

“All of us at Air India are deeply saddened by this loss. We mourn with the families, loved ones, and everyone affected.”

Please use Chrome browser for a more accessible video player

Families in India wait for bodies of relatives

The company’s chief executive and managing director Campbell Wilson said in a video message posted on social media that over 200 “trained caregivers” were now in place to offer dedicated assistance to families, along with counselling and other services.

He said Air India was in the process of completing precautionary safety checks on Boeing 787 aircraft as directed by regulator the Directorate General of Civil Aviation (DGCA), which would “be completed within the timelines prescribed by the regulator”.

👉 Listen to Sky News Daily on your podcast app 👈

Mr Wilson said he had also visited the crash site and said other members of the management team would remain present “for as long as it takes”.

The aircraft’s data recorder, often referred to as a black box, has been recovered and will form part of the investigation into the worst aviation crash in a decade.

‘He was too young’: Families grieve those lost in Air India crash

By Lisa Dowd, Midlands correspondent, in Derby

It was an emotional service at Derby’s Geeta Bhawan Hindu temple, as dozens of friends, colleagues and neighbours gathered to remember Dr Prateek Joshi, his wife Komi, their daughter Miraya, and twin sons Nakul and Pradyut.

Some wiped tears from their eyes, as a colleague was asked spontaneously to pay tribute to Dr Joshi, who had been bringing his family to live in the city, when the Air India flight they were on crashed seconds after take-off.

People cry at Geeta Bhawan Hindu temple during a service in Derby for Dr Prateek Joshi, his wife Komi, their daughter and twin sons

“He was too young, too much still to give, too much still to be done, too much to offer,” his friend told worshippers.

“He was taken from us in a very cruel and abrupt way, and his family as well, and we all think about his family back in India who is missing a son, missing a daughter-in-law and missing all their grandchildren who they’ll never see growing up.”

Derby South MP Catherine Atkinson said Dr Joshi, who was a radiologist at the Royal Derby hospital, had been “contributing to our NHS and the health of so many in our city and beyond”.

She said his wife was a pathologist who had resigned from her job in India.

“I won’t forget the photograph of them on the plane, full of optimism about their new adventure,” she said, as her voice broke.

“The losses make us all hug our families and loved ones a little closer and remind us how precious our time together is.”

A tribute to Dr Prateek Joshi, his wife Komi, their daughter Miraya, and twin sons Nakul and Pradyut, at Geeta Bhawan Hindu temple in Derby

Dr Joshi was described as a “warm, smiling man, full of joy” who enjoyed walking in the Peak District and who had discovered “a love of fish and chips”.

His neighbour and colleague Manoj Ramtohal told Sky News Dr Joshi always had time for people.

“He was very caring and very polite, very friendly, you couldn’t meet a better man than Prateek,” he said.

“We lost a very, very talented doctor.”

Continue Reading

Trending