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A blood test could be just as good at detecting the signs of Alzheimer’s disease as painful and invasive lumbar punctures, research suggests.

Measuring levels of a protein called p-tau217 in the blood could be just as accurate at detecting signs of the progressive condition, experts say.

The protein is a marker for biological changes in the brain for people with Alzheimer’s disease, which is a form of dementia.

The new findings have the potential to “revolutionise” diagnosis for people who are suspected to have Alzheimer’s, experts say.

It could also be better than a range of other tests currently under development.

In the study of 786 people, the researchers were able to use the ALZpath p-tau217 test to identify patients as likely, intermediate and unlikely to have Alzheimer’s disease.

** HOLD FOR RELEASE/PUBLICATION DATE TBD FOR MEDICAL WRITER MARILYNN MARCHIONE STORY ** Dr. William Burke goes over PET brain scan Tuesday, Aug. 14, 2018 at Banner Alzheimers Institute in Phoenix. It may be too late to stop Alzheimer's in people who already have some mental decline but Banner is conducting two studies that target the very earliest brain changes while memory and thinking skills are still intact in hope of preventing the disease. (AP Photo/Matt York).
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Images from an Alzheimer’s brain scan. File pic: AP

“This study is a hugely welcome step in the right direction as it shows that blood tests can be just as accurate as more invasive and expensive tests at predicting if someone has features of Alzheimer’s disease in their brain,” said Dr Richard Oakley, associate director of research and innovation at the Alzheimer’s Society.

“Furthermore, it suggests results from these tests could be clear enough to not require further follow-up investigations for some people living with Alzheimer’s disease, which could speed up the diagnosis pathway significantly in future.

“However, we still need to see more research across different communities to understand how effective these blood tests are across everyone who lives with Alzheimer’s disease.”

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Test could turn tide on devastating disease

This is a significant step towards a screening test for Alzheimer’s.

It detects a protein in the blood that is also found in the brains of people with the disease.

And the Swedish researchers say it is as accurate as existing tests.

At the moment Alzheimer’s is diagnosed either with special PET brain scans or samples of spinal fluid. The NHS doesn’t have enough machines or specialist staff to do that at the scale required.

It means that even if people ever get a diagnosis, it often comes when the disease has significantly progressed.

That matters because there are drugs coming down the tracks that have been shown in clinical trials to significantly slow the decline in memory and brain function.

But they have to be given at an early stage to be effective. That’s why doctors are excited about this test.

It needs to be validated in bigger clinical trials and in a diverse population.

But the hope is that in the near future it could be offered every few years to everyone over 50 to turn the tide on a devastating disease.

‘Huge potential’

Currently the only way to prove someone has a build-up of the proteins in the brain is to have a lumbar puncture or amyloid PET scan, which are available in only about one in 20 NHS memory clinics.

A lumbar puncture involves a needle being inserted into the lower back, between the bones in the spine.

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November 2022: New Alzheimer’s drug may be too late for some

Dr Sheona Scales, director of research at Alzheimer’s Research UK, said: “This study suggests that measuring levels of a protein called p-tau217 in the blood could be as accurate as currently used lumbar punctures for detecting the biological hallmarks of Alzheimer’s disease, and superior to a range of other tests currently under development.

“This adds to a growing body of evidence that this particular test has huge potential to revolutionise diagnosis for people with suspected Alzheimer’s.”

However, she said a better picture is needed of how these types of blood tests perform day-to-day in real-world healthcare systems.

The study from Dr Nicholas Ashton at the University of Gothenburg, and colleagues, is published in the Jama Neurology journal.

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Sanctioning of ministers adds to Israel’s growing ostracisation over Gaza and West Bank

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Sanctioning of ministers adds to Israel's growing ostracisation over Gaza and West Bank

This is a major step from Britain and a number of other countries against Israel, and one that puts them at odds with Washington.

It adds to the growing ostracisation of Israel over its war in Gaza and conduct in the occupied West Bank.

Read more: UK government sanctions Israeli ministers

Itamar Ben Gvir and Bezalel Smotrich.
Pic: AP
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Itamar Ben Gvir and Bezalel Smotrich. Pic: AP

Bezalel Smotrich is Israel’s far-right finance minister, a Jewish settler and someone who has denied the existence of Palestinians as a people.

He has most recently said “not a grain of wheat” should be allowed to enter Gaza, saying it will be “entirely destroyed” and its people should be encouraged to leave in great numbers to go to other countries.

smotrich
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Mr Smotrich. File pic

Itamar Ben-Gvir, the country’s far-right national security minister, was once convicted of supporting a Jewish terrorist organisation and advocated the expulsion of Palestinians from their lands.

A file picture of Itamar Ben Gvir, center. Pic: AP
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Mr Ben Gvir. File pic: AP

Their critics will say their sanctioning has been a long time coming, is largely symbolic, and will achieve little.

The British government singles out Israel’s conduct in the West Bank as grounds for its action against the two men.

Extremist Jewish settlers have run rampant across the occupied territories under Benjamin Netanyahu‘s government, with 1,900 recorded acts of violence against Palestinians since January last year.

Israeli Prime Minister Benjamin Netanyahu gives a speech in Jerusalem, Israel on April 27, 2025. ( The Yomiuri Shimbun via AP Images )
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Benjamin Netanyahu. File pic: The Yomiuri Shimbun/AP

The Netanyahu government has approved a record number of new Jewish settlements in the West Bank. Under international law, all settlements on occupied land are illegal.

Politics latest: Sanctions ‘a major step’

Israel is increasingly isolated over its war in Gaza and actions on the West Bank.

The International Criminal Court has issued arrest warrants for Mr Netanyahu and other senior figures over alleged war crimes.

A number of countries and observers have deemed its conduct in Gaza as genocidal.

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Israel described the sanctions as unacceptable and outrageous.

However, critics will wonder why the Israeli prime minister is not sanctioned himself for keeping two such deeply controversial figures in his government.

There is, though, a good reason for keeping them.

Without them, his fragile coalition would almost certainly fall from power. The price for that though is only increasing.

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Court shown footage of alleged Hainault sword attacker unboxing samurai weapon

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Court shown footage of alleged Hainault sword attacker unboxing samurai weapon

Police have released video footage of the alleged killer of a 14-year-old boy unboxing a samurai sword and calling the weapon “freaking sexy”.

Marcus Monzo, 37, denies murdering teenager Daniel Anjorin and attempting to kill four others during a 20-minute rampage in Hainault, east London, on 30 April last year.

Jurors at the Old Bailey have been shown a four-minute video clip from 4 April, which was recovered from his iPhone after his arrest.

The Spanish-Brazilian national, from Newham in east London, appears to be reviewing a sword he says was “handmade in Japan” and “took more than a month to reach me”.

Marcus Arduini Monzo with a samurai sword that was shown to the jury in his trail at the Old Bailey,
Pic: Metropolitan Police/PA
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Monzo says sword is ‘freaking sexy’. Pic: Metropolitan Police/PA

Dressed in a yellow hoodie, black shorts, toe socks and flipflops, and wearing headphones, he is standing on black mats next to a ginger cat he calls the “Wizard”.

A martial arts-style punching bag and another sword on a skateboard can be seen in the background.

“This just came through… Ninja stuff,” he says before opening a long box containing a sword. “So I’m sort of obliged to do some ninja stuff with the Wizard.”

Monzo also says “freaking sexy” and “ooh” as he lunges and makes different moves with the sheathed sword.

The court has previously heard Monzo was a “talented martial artist”.

Prosecutors said he “killed and skinned” his cat before driving his grey Ford Transit van at speed into pedestrian Donato Iwule.

Daniel Anjorin was attacked in Hainault, northeast London, and suffered fatal wounds on 30 April last year. Pic: Metropolitan Police.
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Daniel Anjorin was killed in attack. Pic: Metropolitan Police.

He then struck him in the neck with the same weapon used to kill Daniel, who suffered “essentially a near-decapitation”, the jury was earlier told.

PC Yasmin Mechem-Whitfield was also repeatedly struck with the 60cm blade, before Monzo entered a nearby house and attacked a couple inside, then struck another police officer, it is alleged.

Monzo has pleaded guilty to two counts of possessing an offensive weapon – a katana sword and a tanto katana sword.

He denies charges of murder, attempted murder, wounding with intent, aggravated burglary and possession of a bladed article.

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The jury has been told there is no issue about who carried out the attacks and that Monzo was under the influence of cannabis at the time.

But prosecutors say his psychotic state was self-induced and does not meet the threshold for diminished responsibility.

The trial continues.

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The Midlands crime gang who created ‘assassination kits’ – and how police tracked them down

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The Midlands crime gang who created 'assassination kits' - and how police tracked them down

A crime gang who made “assassination kits” containing handguns and silencers were busted after an extensive police investigation.

Four men are awaiting sentence after armed officers swooped on the operation and discovered tools and machinery for making viable firearms.

Ronald Knowles, of Milton Avenue in Alfreton, Derbyshire, acquired blank-firing handguns and ammunition, which he then altered so they could fire live bullets.

Each ‘assassination kit’ containied a handgun, silencer, magazine and ammunition wrapped in latex gloves. Pic: Nottinghamshire Police
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Each ‘assassination kit’ contained a handgun, silencer, magazine and ammunition wrapped in latex gloves. Pic: Nottinghamshire Police


Police say he was part of a “well-established and far-reaching criminal enterprise”.

Gary Hardy, of The Birches, Ravenshead, Nottinghamshire, organised and controlled the supply of these “assassination kits”, police said.

Each kit was individually packaged containing a handgun, silencer, magazine and ammunition wrapped in latex gloves.

These were then sent to Steven Houston, of Breach Oak Lane, Corley, Warwickshire, who supplied these weapons to members of the criminal underworld.

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Officers carried out a lengthy proactive investigation to determine the scale of the operation. Pic: Nottinghamshire Police
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Pic: Nottinghamshire Police

These included a known criminal, Jason Hill, of Derby Road, Risley, Derbyshire. Officers raided Hill’s house where they found two handguns, two silencers and ammunition in a safe hidden in the garden.

“They were creating, packaging, and distributing firearms that were designed to kill, there is no doubt about this,” Detective Chief Inspector Mark Adas, from Nottinghamshire Police, said, adding that evidence revealed at least 33 firearms had been manufactured in Knowles’ factory.

“Each handgun had been threaded to fit a silencer, which allowed the gun to be used discreetly at close quarters, meaning any potential targets would be lucky to escape with their lives.”

Each assassination kit included 10 rounds of converted ammunition and the seizure of more than 800 blank firing rounds and nearly 800 lead pellets indicated the group had the potential to supply up to 80 further firearms packages.

DCI Adas said the men had no idea police were “tracing their every step” to build a case against them.

“The full impact of this investigation will never be seen – that’s because we are unable to count the number of lives we may have saved,” he added.

Ronald Knowles dropped a bag to his side containing an unconverted handgun, ammunition, and a throwing star, police say. Pic: Nottinghamshir
Image:
Ronald Knowles dropped a bag to his side containing an unconverted handgun, ammunition, and a throwing star, police say. Pic: Nottinghamshir

In August 2023, after lengthy investigation, police stopped a vehicle in Measham, Leicestershire. Inside, they found a white box containing four of the “assassination kits”.

Detectives linked the guns to both Hardy and Knowles and swooped on Knowles’ property, where they say he was found in his back garden setting fire to evidence.

Knowles, 64, pleaded guilty to conspiracy with others to sell or transfer a firearm, conspiracy to possess a firearm with intent to endanger life or enable another person to do so, and conspiracy with others to convert a thing into a firearm.

Hardy, 61, was found guilty of conspiracy with others to sell or transfer a firearm, conspiracy to possess a firearm with intent to endanger life or enable another person to do so, and conspiracy with others to convert a thing into a firearm.

Houston, 64, was found guilty of conspiracy with others to sell or transfer a firearm, conspiracy to possess a firearm with intent to endanger life or enable another person to do so, and conspiracy with others to convert a thing into a firearm.

Hill, 23, pleaded guilty to possession of a firearm with intent by means thereof to endanger life or to enable another person by means thereof to endanger life.

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